Less is more: increased gonadotropin use for ovarian stimulation adversely influences clinical pregnancy and live birth after in vitro fertilization

Fertility and Sterility

Volumn 89, Issue 6, 2008, Pages 1694-1701

  Pal, Lubna ^a   Jindal, Sangita ^a   Witt, Barry R ^b   Santoro, Nanette ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

clinical pregnancy; cycle cancellation; gonadotropin stimulation; In vitro fertilization; live birth; spontaneous miscarriage

Indexed keywords

ESTRADIOL; FOLLITROPIN; GONADOTROPIN;

ADULT; ARTICLE; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; FEMALE; FERTILIZATION IN VITRO; FOLLICULAR PHASE; FOLLITROPIN BLOOD LEVEL; HUMAN; LIVE BIRTH; MAJOR CLINICAL STUDY; OOCYTE; OUTCOME ASSESSMENT; OVARY FUNCTION; PREGNANCY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SPONTANEOUS ABORTION; STATISTICAL SIGNIFICANCE; TERTIARY HEALTH CARE;

ADULT; CRYOPRESERVATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO TRANSFER; ESTRADIOL; FEMALE; FERTILIZATION IN VITRO; FOLLICLE STIMULATING HORMONE; GONADOTROPINS; HUMANS; INFERTILITY, FEMALE; MIDDLE AGED; OOCYTE RETRIEVAL; OVARIAN HYPERSTIMULATION SYNDROME; OVULATION INDUCTION; PREGNANCY; PREGNANCY OUTCOME;

EID: 44449149669     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2007.05.055     Document Type: Article

References (25)

1. Toner J.P., Philput C.B., Jones G.S., and Muasher S.J. Basal follicle stimulating hormone level is a better predictor of in vitro fertilization performance than age. Fertil Steril 55 (1991) 784-791
2. Check J.H., Peymer M., and Lurie D. Effect of age on pregnancy outcome without assisted reproductive technology in women with elevated early follicular phase serum follicle stimulating hormone levels. Gynecol Obstet Invest 45 (1998) 217-220
3. Chuang C.C., Chen C.D., Chao K.H., Chen S.U., Ho H.N., and Yang Y.S. Age is a better predictor of pregnancy potential than basal follicle stimulating hormone levels in women undergoing in vitro fertilization. Fertil Steril 79 (2003) 63-68
4. El-Toukhy T., Khalaf Y., Hart R., Taylor A., and Braude P. Young age does not protect against the adverse effects of reduced ovarian reserve-an eight year study. Hum Reprod 17 (2002) 1519-1524
5. Scott R.T., Opsahl M.S., Leonardi M.R., Neall G.S., Illions E.H., and Navot D. Life table analysis of pregnancy rates in a general infertility population relative to ovarian reserve and patient age. Hum Reprod 10 (1995) 1706-1710
6. Nasseri A., Mukerjee T., Grifo J.A., Noyes N., Krey L., and Copperman A.B. Elevated day 3 serum follicle stimulating hormone and/or estradiol may predict fetal aneuploidy. Fertil Steril 71 (1999) 715-718
7. van Montfrans J.M., van Hooff M.H., Martens F., and Lambalk C.B. Basal FSH, estradiol and inhibin B concentrations in women with a previous Down's syndrome affected pregnancy. Hum Reprod 17 (2002) 44-47
8. Freeman S.B., Yang Q., Allran K., Taft L.F., and Sherman S.L. Women with a reduced ovarian complement may have an increased risk for a child with Down's syndrome. Am J Hum Genet 66 (2000) 1680-1683
9. Levi A.J., Raynault M.F., Bergh P.A., Drews M.R., Miller B.T., and Scott Jr. R.T. Reproductive outcome in patients with diminished ovarian reserve. Fertil Steril 76 (2001) 666-669
10. Abdalla H., and Thum M.Y. An elevated basal FSH reflects a quantitative rather than a qualitative decline of the ovarian reserve. Hum Reprod 19 (2004) 893-898
11. Gurbuz B., Yalti S., Ozden S., and Ficicioglu C. High basal estradiol level and FSH/LH ratio in unexplained recurrent pregnancy loss. Arch Gynecol Obstet 270 (2004) 37-39
12. Hanoch J., Lavy Y., Holzer H., Hurwitz A., Simon A., Revel A., et al. Young low responders protected from untoward effects of reduced ovarian response. Fertil Steril 69 (1998) 1001-1004
13. Faddy M.J., and Gosden R.G. A model confirming the decline in the follicle numbers to the age of menopause in women. Hum Reprod 11 (1996) 1484-1486
14. Hock D.L., Louie H., Shelden R.M., Ananth C.V., and Kemmann E. The need to step up the gonadotropin dosage in the stimulation phase of IVF treatment predicts a poor outcome. J Assist Reprod Genet 15 (1998) 427-430
15. Tan S.L., Child T.J., Cheung A.P., Fluker M.R., Yuzpe A., Casper R., et al. A randomized, double-blind, multicenter study comparing a starting dose of 100 IU or 200 IU of recombinant follicle stimulating hormone (PuregonR) in women undergoing controlled ovarian hyperstimulation for IVF treatment. J Assist Reprod Genet 22 (2005) 81-88
16. van Hooff M.H., Alberda A.T., Huisman G.J., Zeilmaker G.H., and Leerentveld R.A. Doubling the human menopausal gonadotrophin dose in the course of an in vitro fertilization treatment cycle in low responders: a randomized study. Hum Reprod 8 (1993) 369-373
17. Edwards R.G., Lobo R.A., and Bouchard P. Why delay the obvious need for milder forms of ovarian stimulation?. Hum Reprod 12 (1997) 399-401
18. Department of Health and Social Services, Centers for Disease Control and Prevention. 2004 Assisted Reproductive Technology (ART) Report. Updated February 2, 2007. Available at: http://www.cdc.gov/ART/ART2004/index.htm. Accessed June 13, 2007.
19. Miller B.G., and Armstrong D.T. Superovulatory doses of pregnant mare serum gonadotropin cause delayed implantation and infertility in immature rats. Biol Reprod 25 (1981) 253-260
20. Ertzeid G., and Storeng R. Adverse effects of gonadotrophin treatment on pre- and postimplantation development in mice. J Reprod Fertil 96 (1992) 649-655
21. Ertzeid G., Storeng R., and Lyberg T. Treatment with gonadotropins impaired implantation and fetal development in mice. J Assist Reprod Genet 10 (1993) 286-291
22. Roberts R., Iatropoulou A., Ciantar D., Stark J., Becker D.L., Franks S., et al. Follicle-stimulating hormone affects metaphase I chromosome alignment and increases aneuploidy in mouse oocytes matured in vitro. Biol Reprod 72 (2005) 107-118
23. Kaleli S., Yanikkaya-Demirel G., Erel C.T., Senturk L.M., Topcuoglu A., and Irez T. High rate of aneuploidy in luteinized granulosa cells obtained from follicular fluid in women who underwent controlled ovarian hyperstimulation. Fertil Steril 84 (2005) 802-804
24. 120 expression in the mouse uterus during the peri-implantation period. Hum Reprod 2002; 17:1643-8.
25. Warburton D. Biological aging and the etiology of aneuploidy. Cytogenet Genome Res 111 (2005) 266-272