Electron cryotomography reveals ultrastructure alterations in platelets from patients with ovarian cancer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 46, 2015, Pages 14266-14271

  Wang, Rui ^a   Stone, Rebecca L ^b   Kaelber, Jason T ^a   Rochat, Ryan H ^a   Nick, Alpa M ^b   Vijayan, K Vinod ^a   Afshar Kharghan, Vahid ^a   Schmida, Michael F ^a   Sood, Anil K ^b,c,d   Chiu, Wah ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Cryotomography; Electron; Microtubule|cancer; Platelet

Indexed keywords

ARTICLE; BLOOD SAMPLING; CANCER PATIENT; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRON CRYOTOMOGRAPHY; ELECTRON MICROSCOPE; ELECTRON MICROSCOPY; FEMALE; HUMAN; HUMAN CELL; MICROTUBULE; MITOCHONDRION; OVARY CANCER; PLATELET AGGREGATION ASSAY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; THROMBOCYTE; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTE STRUCTURE; THROMBOCYTE VOLUME; THROMBOCYTOSIS; BLOOD; CLINICAL TRIAL; CRYOELECTRON MICROSCOPY; OVARY TUMOR; PATHOLOGY; ULTRASTRUCTURE;

TUMOR MARKER;

BIOMARKERS, TUMOR; BLOOD PLATELETS; CRYOELECTRON MICROSCOPY; FEMALE; HUMANS; MICROTUBULES; MITOCHONDRIA; OVARIAN NEOPLASMS;

EID: 84963913050     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1518628112     Document Type: Article

References (38)

1. Leslie M (2010) Cell biology. Beyond clotting: The powers of platelets. Science 328(5978):562-564.
2. Patel-Hett S, et al. (2008) Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules. Blood 111(9):4605-4616.
3. Gay LJ, Felding-Habermann B (2011) Contribution of platelets to tumour metastasis. Nat Rev Cancer 11(2):123-134.
4. Bambace NM, Holmes CE (2011) The platelet contribution to cancer progression. J Thromb Haemost 9(2):237-249.
5. Borsig L (2008) The role of platelet activation in tumor metastasis. Expert Rev Anticancer Ther 8(8):1247-1255.
6. Holmes CE, Levis JE, Ornstein DL (2009) Activated platelets enhance ovarian cancer cell invasion in a cellular model of metastasis. Clin Exp Metastasis 26(7):653-661.
7. Levin J, Conley CL (1964) Thrombocytosis Associated with Malignant Disease. Arch Intern Med 114:497-500.
8. Stone RL, et al. (2012) Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med 366(7):610-618.
9. Labelle M, Begum S, Hynes RO (2011) Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 20(5):576-590.
10. Jurasz P, Alonso-Escolano D, Radomski MW (2004) Platelet-cancer interactions: Mechanisms and pharmacology of tumour cell-induced platelet aggregation. Br J Pharmacol 143(7):819-826.
11. Goubran HA, Stakiw J, Radosevic M, Burnouf T (2014) Platelet-cancer interactions. Semin Thromb Hemost 40(3):296-305.
12. Gungor T, Kanat-Pektas M, Sucak A, Mollamahmutoglu L (2009) The role of thrombocytosis in prognostic evaluation of epithelial ovarian tumors. Arch Gynecol Obstet 279(1):53-56.
13. White JG, Krumwiede M (2007) Some contributions of electron microscopy to knowledge of human platelets. Thromb Haemost 98(1):69-72.
14. White JG (2004) Electron microscopy methods for studying platelet structure and function. Methods Mol Biol 272:47-63.
15. White JG (1998) Use of the electron microscope for diagnosis of platelet disorders. Semin Thromb Hemost 24(2):163-168.
16. Lucic V, Leis A, Baumeister W (2008) Cryo-electron tomography of cells: Connecting structure and function. Histochem Cell Biol 130(2):185-196.
17. Boudreau LH, et al. (2014) Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. Blood 124(14):2173-2183.
18. Shao J (1993) Linear Model Selection by Cross-Validation. J Am Stat Assoc 88(422): 486-494.
19. Yee DL, Sun CW, Bergeron AL, Dong JF, Bray PF (2005) Aggregometry detects platelet hyperreactivity in healthy individuals. Blood 106(8):2723-2729.
20. Tocheva EI, Li Z, Jensen GJ (2010) Electron cryotomography. Cold Spring Harb Perspect Biol 2(6):a003442.
21. Jacobs MR (2002) In vivo veritas: In vitro macrolide resistance in systemic Streptococcus pneumoniae infections does result in clinical failure. Clin Infect Dis 35(5):565-569.
22. Jensen GJ, Briegel A (2007) How electron cryotomography is opening a new window onto prokaryotic ultrastructure. Curr Opin Struct Biol 17(2):260-267.
23. van Nispen tot Pannerden H, et al. (2010) The platelet interior revisited: Electron tomography reveals tubular alpha-granule subtypes. Blood 116(7):1147-1156.
24. Blair P, Flaumenhaft R (2009) Platelet alpha-granules: Basic biology and clinical correlates. Blood Rev 23(4):177-189.
25. Charafeddine AH, et al. (2012) Platelet-derived CD154: Ultrastructural localization and clinical correlation in organ transplantation. Am J Transplant 12(11):3143-3151.
26. Zharikov S, Shiva S (2013) Platelet mitochondrial function: From regulation of thrombosis to biomarker of disease. Biochem Soc Trans 41(1):118-123.
27. Schwertz H, et al. (2010) Anucleate platelets generate progeny. Blood 115(18): 3801-3809.
28. Holmes CE, Ramos-Nino ME, Littenberg B (2010) An association between anti-platelet drug use and reduced cancer prevalence in diabetic patients: Results from the Vermont Diabetes Information System Study. BMC Cancer 10:289.
29. Liu J, Wright ER, Winkler H (2010) 3D visualization of HIV virions by cryoelectron tomography. Methods Enzymol 483:267-290.
30. Suloway C, et al. (2009) Fully automated, sequential tilt-series acquisition with Leginon. JStructBiol167(1):11-18.
31. Nickell S, et al. (2005) TOM software toolbox: Acquisition and analysis for electron tomography. J Struct Biol 149(3):227-234.
32. Dai W, et al. (2013) Visualizing virus assembly intermediates inside marine cyanobacteria. Nature 502(7473):707-710.
33. Rigort A, et al. (2012) Automated segmentation of electron tomograms for a quantitative description of actin filament networks. J Struct Biol 177(1):135-144.
34. Mastronarde DN (2005) Automated electron microscope tomography using robust prediction of specimen movements. J Struct Biol 152(1):36-51.
35. Iancu CV, Wright ER, Heymann JB, Jensen GJ (2006) A comparison of liquid nitrogen and liquid helium as cryogens for electron cryotomography. J Struct Biol 153(3): 231-240.
36. Kremer JR, Mastronarde DN, McIntosh JR (1996) Computer visualization of threedimensional image data using IMOD. J Struct Biol 116(1):71-76.
37. Frangakis AS, Hegerl R (2001) Noise reduction in electron tomographic reconstructions using nonlinear anisotropic diffusion. J Struct Biol 135(3):239-250.
38. Tang G, et al. (2007) EMAN2: An extensible image processing suite for electron microscopy. J Struct Biol 157(1):38-46.