Endoplasmic reticulum stress of Kupffer cells involved in the conversion of natural regulatory T cells to Th17 cells in liver ischemia-reperfusion injury

Journal of Gastroenterology and Hepatology (Australia)

Volumn 31, Issue 4, 2016, Pages 883-889

  Gao, Jialin ^a   Jiang, Zhonghua ^b   Wang, Shuai ^a   Zhou, Yuan ^a   Shi, Xiaolei ^a   Feng, Min ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b First People's Hospital of Yancheng   (China)

Author keywords

Endoplasmic reticulum stress; Ischemia reperfusion injury; Kupffer cells; Regulatory T cells; Th17 cells

Indexed keywords

GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INTERLEUKIN 17; INTERLEUKIN 6; STAT3 PROTEIN; X BOX BINDING PROTEIN 1;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL ISOLATION; COCULTURE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; KUPFFER CELL; LIVER INJURY; LIVER ISCHEMIA; MOUSE; MOUSE MODEL; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REPERFUSION INJURY; TH17 CELL; ANIMAL; DISEASE MODEL; IMMUNOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; LIVER; PATHOLOGY; VASCULARIZATION;

ANIMALS; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM STRESS; INTERLEUKIN-6; KUPFFER CELLS; LIVER; MICE, INBRED ICR; REPERFUSION INJURY; T-LYMPHOCYTES, REGULATORY; TH17 CELLS;

EID: 84963864113     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.13163     Document Type: Article

References (26)

1. Zhai Y, Busuttil RW, Kupiec-Weglinski JW. Liver ischemia and reperfusion injury: new insights into mechanisms of innate-adaptive immune-mediated tissue inflammation. Am. J. Transplant. 2011; 11: 1563-9.
2. Dara L, Ji C, Kaplowitz N. The contribution of endoplasmic reticulum stress to liver diseases. Hepatology 2011; 53: 1752-63.
3. Rao J, Yue S, Fu Y et al. ATF6 mediates a pro-inflammatory synergy between ER stress and TLR activation in the pathogenesis of liver ischemia-reperfusion injury. Am. J. Transplant. 2014; 14: 1552-61.
4. Maier PJ, Zemoura K, Acuna MA, Yevenes GE, Zeilhofer HU, Benke D. Ischemia-like oxygen and glucose deprivation mediates down-regulation of cell surface gamma-aminobutyric acid B receptors via the endoplasmic reticulum (ER) stress-induced transcription factor CCAAT/enhancer-binding protein (C/EBP)-homologous protein (CHOP). J. Biol. Chem. 2014; 289: 12896-907.
5. Grootjans J, Hodin CM, de Haan JJ et al. Level of activation of the unfolded protein response correlates with Paneth cell apoptosis in human small intestine exposed to ischemia/reperfusion. Gastroenterology 2011; 140: 529-39 e3.
6. Vilatoba M, Eckstein C, Bilbao G et al. Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis. Surgery 2005; 138: 342-51.
7. Yue S, Rao J, Zhu J et al. Myeloid PTEN deficiency protects livers from ischemia reperfusion injury by facilitating M2 macrophage differentiation. J. Immunol. 2014; 192: 5343-53.
8. Shen XD, Ke B, Uchida Y et al. Native macrophages genetically modified to express heme oxygenase 1 protect rat liver transplants from ischemia/reperfusion injury. Liver Transpl. 2011; 17: 201-10.
9. Cao X. Immunology in China: the past, present and future. Nat. Immunol. 2008; 9: 339-42.
10. Feng M, Wang Q, Zhang F, Lu L. Ex vivo induced regulatory T cells regulate inflammatory response of Kupffer cells by TGF-beta and attenuate liver ischemia reperfusion injury. Int. Immunopharmacol. 2012; 12: 189-96.
11. Feng M, Li G, Qian X et al. IL-17A-producing NK cells were implicated in liver injury induced by ischemia and reperfusion. Int. Immunopharmacol. 2012; 13: 135-40.
12. Feng M, Wang Q, Wang H, Wang M, Guan W, Lu L. Adoptive transfer of hepatic stellate cells ameliorates liver ischemia reperfusion injury through enriching regulatory T cells. Int. Immunopharmacol. 2014; 19: 267-74.
13. Horwitz DA, Zheng SG, Gray JD. Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other. Trends Immunol. 2008; 29: 429-35.
14. Zhou X, Kong N, Wang J et al. Cutting edge: all-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu. J. Immunol. 2010; 185: 2675-9.
15. Zheng SG, Wang J, Horwitz DA. Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6. J. Immunol. 2008; 180: 7112-6.
16. Feng M, Wang Q, Wang H, Guan W. Tumor necrosis factor-alpha preconditioning attenuates liver ischemia/reperfusion injury through preserving sarco/endoplasmic reticulum calcium-ATPase function. J. Surg. Res. 2013; 184: 1109-13.
17. Rao J, Qian X, Li G et al. ATF3-mediated NRF2/HO-1 signaling regulates TLR4 innate immune responses in mouse liver ischemia/reperfusion injury. Am. J. Transplant. 2015; 15: 76-87.
18. Ren F, Duan Z, Cheng Q et al. Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10-mediated immune regulatory mechanism. Hepatology 2011; 54: 687-96.
19. Kono H, Fujii H, Ogiku M et al. Role of IL-17A in neutrophil recruitment and hepatic injury after warm ischemia-reperfusion mice. J. Immunol. 2011; 187: 4818-25.
20. Bamboat ZM, Ocuin LM, Balachandran VP, Obaid H, Plitas G, DeMatteo RP. Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion. J. Clin. Invest. 2010; 120: 559-69.
21. Thornton AM, Korty PE, Tran DQ et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J. Immunol. 2010; 184: 3433-41.
22. Verhagen J, Wraith DC. Comment on "Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells". J. Immunol. 2010; 185: 7129; author reply 30.
23. Akimova T, Beier UH, Wang L, Levine MH, Hancock WW. Helios expression is a marker of T cell activation and proliferation. PLoS One 2011; 6: e24226.
24. Gottschalk RA, Corse E, Allison JP. Expression of Helios in peripherally induced Foxp3+ regulatory T cells. J. Immunol. 2012; 188: 976-80.
25. Elkord E. Comment on "Expression of Helios in peripherally induced Foxp3+ regulatory T cells". J. Immunol. 2012; 189: 500; author reply -1.
26. Lu L, Feng M, Gu J et al. Restoration of intrahepatic regulatory T cells through MMP-9/13-dependent activation of TGF-beta is critical for immune homeostasis following acute liver injury. J. Mol. Cell Biol. 2013; 5: 369-79.