Cell-free circulating mitochondrial DNA content and risk of hepatocellular carcinoma in patients with chronic HBV infection

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Li, Ling ^a   Hann, Hie Won ^a   Wan, Shaogui ^a,b   Hann, Richard S ^a   Wang, Chun ^a,c   Lai, Yinzhi ^a   Ye, Xishan ^a   Evans, Alison ^a   Myers, Ronald E ^a   Ye, Zhong ^a   Li, Bingshan ^d   Xing, Jinliang ^e   Yang, Hushan ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b HENAN UNIVERSITY   (China)

^c NANTONG UNIVERSITY   (China)

^d VANDERBILT UNIVERSITY   (United States)

^e FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ADULT; AGE; AGED; BLOOD; CARCINOMA, HEPATOCELLULAR; CASE CONTROL STUDY; CHRONIC HEPATITIS B; COMPLICATION; DRINKING; FEMALE; GENETICS; HUMAN; LIVER CIRRHOSIS; LIVER NEOPLASMS; LONGITUDINAL STUDY; MALE; MIDDLE AGED; ODDS RATIO; PATHOLOGY; RETROSPECTIVE STUDY; RISK FACTOR; SEX DIFFERENCE; SMOKING; STATISTICAL MODEL;

ADULT; AGE FACTORS; AGED; CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; DNA, MITOCHONDRIAL; DRINKING; FEMALE; HEPATITIS B, CHRONIC; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; LOGISTIC MODELS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; ODDS RATIO; RETROSPECTIVE STUDIES; RISK FACTORS; SEX FACTORS; SMOKING;

EID: 84963828892     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep23992     Document Type: Article

References (43)

1. Jemal, A. et al. Global cancer statistics. CA Cancer J Clin. 61, 69-90 (2011).
2. Kim, W. R. Epidemiology of hepatitis B in the United States. Hepatology. 49, S28-34 (2009).
3. Fu, X. et al. Relative telomere length: a novel non-invasive biomarker for the risk of non-cirrhotic hepatocellular carcinoma in patients with chronic hepatitis B infection. Eur J Cancer. 48, 1014-1022 (2012).
4. Koppenol, W. H., Bounds, P. L. & Dang, C. V. Otto Warburgs contributions to current concepts of cancer metabolism. Nat Rev Cancer. 11, 325-337 (2011).
5. Chen, X. J. & Butow, R. A. The organization and inheritance of the mitochondrial genome. Nat Rev Genet. 6, 815-825 (2005).
6. Wallace, D. C. Mitochondrial DNA mutations in disease and aging. Environ Mol Mutagen. 51, 440-450 (2010).
7. Larsen, N. B., Rasmussen, M. & Rasmussen, L. J. Nuclear and mitochondrial DNA repair: similar pathways? Mitochondrion. 5, 89-108 (2005).
8. Taylor, R. W. & Turnbull, D. M. Mitochondrial DNA mutations in human disease. Nat Rev Genet. 6, 389-402 (2005).
9. Lee, H. C. et al. Somatic mutations in the D-loop and decrease in the copy number of mitochondrial DNA in human hepatocellular carcinoma. Mutat Res. 547, 71-78 (2004).
10. Yin, P. H. et al. Alteration of the copy number and deletion of mitochondrial DNA in human hepatocellular carcinoma. Br J Cancer. 90, 2390-2396 (2004).
11. Yamada, S. et al. Correlation between copy number of mitochondrial DNA and clinico-pathologic parameters of hepatocellular carcinoma. Eur J Surg Oncol. 32, 303-307 (2006).
12. Vivekanandan, P., Daniel, H., Yeh, M. M. & Torbenson, M. Mitochondrial mutations in hepatocellular carcinomas and fibrolamellar carcinomas. Mod Pathol. 23, 790-798 (2010).
13. Fleischhacker, M. & Schmidt, B. Circulating nucleic acids (CNAs) and cancer-a survey. Biochim Biophys Acta. 1775, 181-232 (2007).
14. Schwarzenbach, H., Hoon, D. S. & Pantel, K. Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer. 11, 426-437 (2011).
15. Gonzalez-Masia, J. A., Garcia-Olmo, D. & Garcia-Olmo, D. C. Circulating nucleic acids in plasma and serum (CNAPS): applications in oncology. Onco Targets Ther. 6, 819-832 (2013).
16. Yu, M., Wan, Y. F. & Zou, Q. H. Cell-free circulating mitochondrial DNA in the serum: a potential non-invasive biomarker for Ewings sarcoma. Arch Med Res. 43, 389-394 (2012).
17. Zhang, Q. et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 464, 104-107 (2010).
18. Cossarizza, A. et al. Increased plasma levels of extracellular mitochondrial DNA during HIV infection: a new role for mitochondrial damage-associated molecular patterns during inflammation. Mitochondrion. 11, 750-755 (2011).
19. Sursal, T. et al. Plasma bacterial and mitochondrial DNA distinguish bacterial sepsis from sterile systemic inflammatory response syndrome and quantify inflammatory tissue injury in nonhuman primates. Shock. 39, 55-62 (2013).
20. Nakahira, K. et al. Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. PLoS Med. 10, e1001577 (2013).
21. Bianchi, N. O., Bianchi, M. S. & Richard, S. M. Mitochondrial genome instability in human cancers. Mutat Res. 488, 9-23 (2001).
22. Chen, T. et al. The mitochondrial DNA 4, 977-bp deletion and its implication in copy number alteration in colorectal cancer. BMC Med Genet. 12, 8 (2011).
23. Lin, C. S. et al. The role of mitochondrial DNA alterations in esophageal squamous cell carcinomas. J Thorac Cardiovasc Surg. 139, 189-197 e184 (2010).
24. Bonner, M. R. et al. Mitochondrial DNA content and lung cancer risk in Xuan Wei, China. Lung Cancer. 63, 331-334 (2009).
25. Lee, H. C. & Wei, Y. H. Mitochondrial DNA instability and metabolic shift in human cancers. Int J Mol Sci. 10, 674-701 (2009).
26. Yu, M. et al. Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients. IUBMB Life. 59, 450-457 (2007).
27. Liao, L. M. et al. Mitochondrial DNA copy number and risk of gastric cancer: a report from the Shanghai Womens Health Study. Cancer Epidemiol Biomarkers Prev. 20, 1944-1949 (2011).
28. Xing, J. et al. Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma. J Natl Cancer Inst. 100, 1104-1112 (2008).
29. Hsu, C. C., Lee, H. C. & Wei, Y. H. Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma. World J Gastroenterol. 19, 8880-8886 (2013).
30. Yu, M., Wan, Y. & Zou, Q. Decreased copy number of mitochondrial DNA in Ewings sarcoma. Clin Chim Acta. 411, 679-683 (2010).
31. Chang, S. C. et al. Mitochondrial D-loop mutation is a common event in colorectal cancers with p53 mutations. Int J Colorectal Dis. 24, 623-628 (2009).
32. Singh, K. K., Ayyasamy, V., Owens, K. M., Koul, M. S. & Vujcic, M. Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis. J Hum Genet. 54, 516-524 (2009).
33. Zhao, S. et al. Association of mitochondrial DNA content in peripheral blood leukocyte with hepatitis B virus-related hepatocellular carcinoma in a Chinese Han population. Cancer Sci. 102, 1553-1558 (2011).
34. Warburg, O. On the origin of cancer cells. Science. 123, 309-314 (1956).
35. Jahr, S. et al. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res. 61, 1659-1665 (2001).
36. Kanduc, D. et al. Cell death: apoptosis versus necrosis (review). Int J Oncol. 21, 165-170 (2002).
37. Brenner, C., Galluzzi, L., Kepp, O. & Kroemer, G. Decoding cell death signals in liver inflammation. J Hepatol. 59, 583-594 (2013).
38. Dunn, C. et al. Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. J Exp Med. 204, 667-680 (2007).
39. Iida, M. et al. Relation between serum levels of cell-free DNA and inflammation status in hepatitis C virus-related hepatocellular carcinoma. Oncology reports. 20, 761-765 (2008).
40. Diaz, L. A., Jr. & Bardelli, A. Liquid biopsies: genotyping circulating tumor DNA. J Clin Oncol. 32, 579-586 (2014).
41. Kohler, C. et al. Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors. Mol Cancer. 8, 105 (2009).
42. Zachariah, R. R. et al. Levels of circulating cell-free nuclear and mitochondrial DNA in benign and malignant ovarian tumors. Obstet Gynecol. 112, 843-850 (2008).
43. Dimmock, D., Tang, L. Y., Schmitt, E. S. & Wong, L. J. Quantitative evaluation of the mitochondrial DNA depletion syndrome. Clin Chem. 56, 1119-1127 (2010).