Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 15, 2016, Pages 4200-4205

  Blin, Sandy ^a   Soussia, Ismail Ben ^a   Kim, Eun Jin ^b   Brau, Frédéric ^a   Kang, Dawon ^b   Lesage, Florian ^a   Bichet, Delphine ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b Gyeongsang National University School of Medicine   (South Korea)

Author keywords

Electrophysiology; Heteromerization; Pharmacology; Potassium channel; Subunit assembly

Indexed keywords

ASPARTIC ACID; CYCLIC AMP DEPENDENT PROTEIN KINASE; FLUOXETINE; FORSKOLIN; HETERODIMER; HOMODIMER; ISOBUTYLMETHYLXANTHINE; ISOLEUCINE; POTASSIUM CHANNEL; PROTEIN KINASE C; TWIK RELATED ACID ARACHIDONIC ACTIVATED POTASSIUM CHANNEL; TWIK RELATED POTASSIUM CHANNEL 1; TWIK RELATED POTASSIUM CHANNEL 2; UNCLASSIFIED DRUG; POTASSIUM CHANNEL PROTEIN TREK-1; TANDEM PORE DOMAIN POTASSIUM CHANNEL;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CELL ATTACHED PATCH CLAMP; CONDUCTANCE; CONTROLLED STUDY; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEK293 CELL LINE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; TRANSLATION INITIATION; ANIMAL; CHEMISTRY; DIMERIZATION; DOG; MDCK CELL LINE; MOUSE;

ANIMALS; DIMERIZATION; DOGS; HUMANS; MADIN DARBY CANINE KIDNEY CELLS; MICE; POTASSIUM CHANNELS, TANDEM PORE DOMAIN;

EID: 84963776198     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1522748113     Document Type: Article

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