Death associated with the use of the synthetic cannabinoid ADB-FUBINACA

Journal of Analytical Toxicology

Volumn 40, Issue 3, 2016, Pages 236-239

  Shanks, Kevin G ^a   Clark, William ^b   Behonick, George ^a  

^a AIT Laboratories   (United States)

^b East Baton Rouge Parish Coroner's Office   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID DERIVATIVE; N [1 (AMINO 3,3 DIMETHYL 1 OXOBUTAN 2 YL) 1 (4 FLUOROBENZYL) 1H INDAZOLE 3 CARBOXAMIDE; UNCLASSIFIED DRUG; ADB-FUBINACA; CANNABINOID; INDAZOLE DERIVATIVE;

ACCIDENTAL DEATH; ADULT; AGGRESSIVENESS; ARTICLE; AUTOPSY; CASE REPORT; CAUSE OF DEATH; CORONARY ARTERY THROMBOSIS; DRUG FATALITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; ISCHEMIA; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LIQUID LIQUID EXTRACTION; LUNG EDEMA; THROMBOSIS; FATALITY;

ADULT; CANNABINOIDS; FATAL OUTCOME; FEMALE; HUMANS; INDAZOLES;

EID: 84963732874     PISSN: 01464760     EISSN: 19452403     Source Type: Journal    
DOI: 10.1093/jat/bkv142     Document Type: Article

References (23)

1. Mechoulam, R., Parker, L.A. (2013) The endocannabinoid system and the brain. Annual Review of Psychology, 64, 21-47.
2. Penn, H.J., Langman, L.J., Unold, D., Shields, J., Nichols, J.H. (2011) Detection of synthetic cannabinoids in herbal incense products. Clinical Biochemistry, 44, 1163-1165.
3. Logan, B.K., Reinhold, L.E., Xu, A., Diamond, F.X. (2012) Identification of synthetic cannabinoids in herbal incense blends in the United States. Journal of Forensic Sciences, 57, 1168-1180.
4. Shanks, K.G., Dahn, T., Behonick, G., Terrell, A. (2012) Analysis of first and second generation legal highs for synthetic cannabinoids and synthetic stimulants by ultra-performance liquid chromatography and time of flight mass spectrometry. Journal of Analytical Toxicology, 36, 360-371.
5. Shanks, K.G., Behonick, G.S., Dahn, T., Terrell, A. (2013) Identification of novel third-generation synthetic cannabinoids in products by ultraperformance liquid chromatography and time of flight mass spectrometry. Journal of Analytical Toxicology, 37, 517-525.
6. Tofighi, B., Lee, J.D. (2012) Internet highs-seizures after consumption of synthetic cannabinoids purchased online. Journal of Addiction Medicine, 6, 240-241.
7. Young, A.C., Schwarz, E., Medina, G., Obafemi, A., Feng, S.Y., Kane, C. et al. (2011) Cardiotoxicity associated with the synthetic cannabinoid, K9, with laboratory confirmation. The American Journal of Emergency Medicine, 30, 1320.e5-1320.e7.
8. Lapoint, J., James, L.P., Moran, C.L., Nelson, L.S., Hoffman, R.S., Moran, J.H. (2011) Severe toxicity following synthetic cannabinoid ingestion. Clinical Toxicology, 49, 760-764.
9. Thornton, S.L., Wood, C., Friesen, M.W., Gerona, R.R. (2013) Synthetic cannabinoid use associated with acute kidney injury. Clinical Toxicology, 51, 189-190.
10. Centers for Disease Control and Prevention (CDC). (2013) Acute kidney injury associated with synthetic cannabinoid use-multiple states, 2012. MMWR Morbidity and Mortality Weekly Report, 62, 93-98.
11. Gurney, S.M.R., Scott, K.S., Kacinko, S.L., Presley, B.C., Logan, B.K. (2014) Pharmacology, toxicology, and adverse effects of synthetic cannabinoid drugs. Forensic Science Review, 26, 53-78.
12. Behonick, G., Shanks, K.G., Firchau, D.J., Mathur, G., Lynch, C.F., Nashelsky,M. et al. (2014) Four postmortem case reports with quantitative detection of the synthetic cannabinoid, 5F-PB-22. Journal of Analytical Toxicology, 38, 559-562.
13. Hasegawa, K., Wurita, A., Minakata, K., Gonmori, K., Nozawa, H., Yamagishi, I. et al. (2015) Postmortem distribution of AB-CHMINACA, 5-fluoro-AMB, and diphenidine in body fluids and solid tissues in a fatal poisoning case: usefulness of adipose tissue for detection of the drugs in unchanged forms. Forensic Toxicology, 33, 45-53.
14. Shanks, K.G., Winston, D., Heidingsfelder, J., Behonick, G. (2015) Case reports of synthetic cannabinoid XLR-11 associated fatalities. Forensic Science International, 252, e6-e9.
15. WO/2009/106982-Indazole Derivatives, Pfizer, Inc., 2/26/2009.
16. Uchiyama, N., Matsuda, S., Kawamura, M., Kikura-Hanajiri, R., Goda, Y. (2013) Two new cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products. Forensic Toxicology, 31, 223-240.
17. Gatch, M.B., Forster, M.J. (2015) Δ9-tetrahydrocannabinol-like effects of novel synthetic cannabinoids found on the gray market. Behavioural Pharmacology, 26, 460-468.
18. Takayama, T., Suzuki, M., Todoroki, K., Inoue, K., Min, J.Z., Kikura-Hanajiri, R. et al. (2014) UPLC/ESI-MS/MS-based determination of metabolism of several new illicit drugs, ADB-FUBINACA, ABFUBINACA, AB-PINACA, QUPIC, 5F-QUPIC, and α-PVT, by human liver microsome. Biomedical Chromatography, 28, 831-838.
19. Centers for Disease Control and Prevention (CDC). (2013) Notes from the field: severe illness associated with synthetic cannabinoid use-Brunswick, Georgia, 2013. MMWR Morbidity and Mortality Weekly Report, 62, 939.
20. Schwartz, M.D., Trecki, J., Edison, L.A., Stekc, A.R., Arnold, J.K., Gerona, R.R. (2015) A common source outbreak of severe delirium associated with exposure to the novel synthetic cannabinoid ADB-PINACA. Journal of Emergency Medicine, 48, 573-580.
21. Centers for Disease Control and Prevention (CDC). (2013) Notes from the field: severe illness associated with reported use of synthetic marijuana-Colorado, August-September 2013. MMWR Morbidity and Mortality Weekly Report, 62, 1016-1017.
22. Drug Enforcement Administration. (2014) Schedules of controlled substances:temporary placement of four synthetic cannabinoids into Schedule I. Final order. Federal Register, 79, 7577-7582.
23. Drug Enforcement Administration. (2015) Schedules of controlled substances:temporary placement of three synthetic cannabinoids into Schedule I. Final order. Federal Register, 80, 5042-5047.