A common source outbreak of severe delirium associated with exposure to the novel synthetic cannabinoid ADB-PINACA

Journal of Emergency Medicine

Volumn 48, Issue 5, 2015, Pages 573-580

  Schwartz, Michael D ^a   Trecki, Jordan ^b   Edison, Laura A ^c   Steck, Alaina R ^d   Arnold, Justin K ^d   Gerona, Roy R ^e  

^a NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

^b Drug Enforcement Administration   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^d Georgia Poison Center   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ADB PINACA; cluster; DEA scheduling; delirium; K2; outbreak; spice; synthetic cannabinoid

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BENZODIAZEPINE DERIVATIVE; CANNABINOID; CREATINE KINASE; CREATININE; HALOPERIDOL; LACTIC ACID; LORAZEPAM; N (1 AMINO 3,3 DIMETHYL 1 OXOBUTAN 2 YL) 1 PENTYL 1H INDAZOLE 3 CARBOXAMIDE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; INDAZOLE DERIVATIVE; N-(1-AMINO-3,3-DIMETHYL-1-OXOBUTAN-2-YL)-1-PENTYL-1H-INDAZOLE-3-CARBOXAMIDE;

ACIDOSIS; ADOLESCENT; ADULT; AGGRESSION; AGITATION; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANOREXIA; ANXIETY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; ASSISTED VENTILATION; BLOOD PRESSURE MEASUREMENT; BLOOD SAMPLING; BODY TEMPERATURE; BREATHING RATE; CLINICAL ARTICLE; CONFUSION; CREATININE BLOOD LEVEL; DELIRIUM; DISEASE SEVERITY; DISORIENTATION; ELECTROCARDIOGRAPHY; EMERGENCY CARE; EXTUBATION; FAMILIAL HYPERCHOLESTEROLEMIA; FEMALE; HEART ARREST; HEART CATHETERIZATION; HEART INFARCTION; HEART RATE; HOSPITALIZATION; HUMAN; HYPERGLYCEMIA; HYPERTENSION; HYPOKALEMIA; INTENSIVE CARE UNIT; IRRITABILITY; LAW ENFORCEMENT; LIVER FUNCTION TEST; MALE; MEDICAL HISTORY; NAUSEA; OXYGEN SATURATION; PARANOIA; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PNEUMONIA; PRIORITY JOURNAL; PSYCHOSIS; RESUSCITATION; RETURN OF SPONTANEOUS CIRCULATION; RHABDOMYOLYSIS; SEIZURE; SLEEP DISORDER; SMOKING; SOMNOLENCE; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; TACHYCARDIA; THORAX PAIN; TONIC CLONIC SEIZURE; VOMITING; YOUNG ADULT; CASE REPORT; CHEMICALLY INDUCED; DRUG EFFECTS; EPIDEMIC; GEORGIA; MIDDLE AGED;

ACIDOSIS; ADOLESCENT; ADULT; AGGRESSION; ANXIETY; CANNABINOIDS; DELIRIUM; DISEASE OUTBREAKS; FEMALE; GEORGIA; HUMANS; HYPERGLYCEMIA; HYPOKALEMIA; INDAZOLES; MALE; MIDDLE AGED; NAUSEA; SEIZURES; TACHYCARDIA; VOMITING; YOUNG ADULT;

EID: 84929134377     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jemermed.2014.12.038     Document Type: Article

References (26)

1. K.A. Seely, J. Lapoint, J.H. Moran, and L. Fattore Spice drugs are more than harmless herbal blends: a review of the pharmacology and toxicology of synthetic cannabinoids Prog Neuropsychopharmacol Biol Psychiatry 39 2012 234 243
2. M.B. Forrester, K. Kleinschmidt, E. Schwarz, and A. Young Synthetic cannabinoid and marijuana exposures reported to poison centers Hum Exp Toxicol 31 2012 1006 1011
3. C.O. Hoyte, J. Jacob, A.A. Monte, M. Al-Jumaan, A.C. Bronstein, and K.J. Heard A characterization of synthetic cannabinoid exposures reported to the National Poison Data System in 2010 Ann Emerg Med 60 2012 435 438
4. J. Simmons, L. Cookman, C. Kang, and C. Skinner Three cases of spice exposure Clin Toxicol (Phila) 49 2011 431 433
5. J. Lapoint, L.P. James, C.L. Moran, L.S. Nelson, R.S. Hoffman, and J.H. Moran Severe toxicity following synthetic cannabinoid ingestion Clin Toxicol (Phila) 49 2011 760 764
6. A.B. Schneir, and T. Baumbacher Convulsions associated with the use of a synthetic cannabinoid product J Med Toxicol 8 2012 62 64
7. C.R. Harris, and A. Brown Synthetic cannabinoid intoxication: a case series and review J Emerg Med 44 2013 360 366
8. B. Tofighi, and J.D. Lee Internet highs - seizures after consumption of synthetic cannabinoids purchased online J Addict Med 6 2012 240 241
9. S. Pant, A. Deshmukh, and B. Dholaria Spicy seizure Am J Med Sci 344 2012 67 68
10. D. McQuade, S. Hudson, P.I. Dargan, and D.M. Wood First European case of convulsions related to analytically confirmed use of the synthetic cannabinoid receptor agonist AM-2201 Eur J Clin Pharmacol 69 2013 373 376
11. A. Mir, A. Obafemi, A. Young, and C. Kane Myocardial infarction associated with use of the synthetic cannabinoid K2 Pediatrics 128 2011 e1622 e1627
12. A.C. Young, E. Schwarz, and G. Medina Cardiotoxicity associated with the synthetic cannabinoid, K9, with laboratory confirmation Am J Emerg Med 30 2012 1320
13. Centers for Disease Control and Prevention (CDC) Acute kidney injury associated with synthetic cannabinoid use - multiple states, 2012 MMWR Morb Mortal Wkly Rep 62 2013 93 98
14. A.A. Monte, A.C. Bronstein, and D.J. Cao An outbreak of exposure to a novel synthetic cannabinoid N Engl J Med 370 2014 389 390
15. Centers for Disease Control and Prevention (CDC) Notes from the field: Severe illness associated with synthetic cannabinoid use - Brunswick, Georgia, 2013 MMWR Morb Mortal Wkly Rep 62 2013 939
16. Centers for Disease Control and Prevention (CDC) Notes from the field: severe illness associated with reported use of synthetic marijuana - Colorado, August-September 2013 MMWR Morb Mortal Wkly Rep 62 2013 1016 1017
17. A.L. Patton, K.C. Chimalakonda, and C.L. Moran K2 toxicity: fatal case of psychiatric complications following AM2201 exposure J Forensic Sci 58 2013 1676 1680
18. Georgia Bureau of Investigation. Herbal Incense Seized in Glynn County Determined to be Schedule I Substance. Available at: http://gbi.georgia.gov/press-releases/2013-09-12/herbal-incense-seized-glynn-county-determined-be-schedule-i-substance. Accessed January 28, 2014.
19. A. Wintermeyer, I. Möller, and M. Thevis In vitro phase I metabolism of the synthetic cannabimimetic JWH-018 Anal Bioanal Chem 398 2010 2141 2153
20. S.L. Kacinko, A. Xu, J.W. Homan, M.M. McMullin, D.M. Warrington, and B.K. Logan Development and validation of a liquid chromatography-tandem mass spectrometry method for the identification and quantification of JWH-018, JWH-073, JWH-019, and JWH-250 in human whole blood J Anal Toxicol 35 2011 386 393
21. S. Dresen, S. Kneisel, W. Weinmann, R. Zimmermann, and V. Auwarter Development and validation of a liquid chromatography-tandem mass spectrometry method for the quantitation of synthetic cannabinoids of the aminoalkylindole type and methanandamide in serum and its application to forensic samples J Mass Spectrom 46 2011 163 171
22. Hutter M, B. Moosmann, S. Kneisel, and V. Auwärter Characteristics of the designer drug and synthetic cannabinoid receptor agonist AM-2201 regarding its chemistry and metabolism J Mass Spectrom 48 2013 885 894
23. M. Hutter, S. Broecker, S. Kneisel, and V. Auwärter Identification of the major urinary metabolites in man of seven synthetic cannabinoids of the aminoalkylindole type present as adulterants in 'herbal mixtures' using LC-MS/MS techniques J Mass Spectrom 47 2012 54 65
24. G.K. Bhanushali, G. Jain, H. Fatima, L.J. Leisch, and D. Thornley-Brown AKI associated with synthetic cannabinoids: a case series Clin J Am Soc Nephrol 8 2013 523 526
25. nd Annual Epidemiologic Intelligence Service Conference, April 25, 2013, Atlanta, GA.
26. Drug Enforcement Administration (DEA). Schedules of Controlled Substances: Temporary Placement of Three Synthetic Cannabinoids Into Schedule I. May 16, 2013. (78 FR 28735).