T cell infiltration is associated with kidney injury in patients with anti-glomerular basement membrane disease

Science China Life Sciences

Volumn 59, Issue 12, 2016, Pages 1282-1289

  Hu, Shui Yi ^a,c   Jia, Xiao Yu ^a   Li, Jian Nan ^a   Zheng, Xin ^a   Ao, Jie ^a   Liu, Gang ^a   Cui, Zhao ^a   Zhao, Ming Hui ^a,b  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b Tsinghua University   (China)

^c TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

anti GBM disease; CD8; IL 17; kidney injury; T cell

Indexed keywords

ANTIGLOMERULAR BASEMENT MEMBRANE ANTIBODY; AUTOANTIBODY; CD3 ANTIGEN; CD68 ANTIGEN, HUMAN; DIFFERENTIATION ANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IMMUNOGLOBULIN G; INTERLEUKIN 17; LEUKOCYTE ANTIGEN;

ADOLESCENT; ADULT; AUTOIMMUNITY; CD8+ T LYMPHOCYTE; CHRONIC KIDNEY FAILURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLOMERULONEPHRITIS; GLOMERULUS; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; KIDNEY; MACROPHAGE; MALE; METABOLISM; PATHOLOGY; T LYMPHOCYTE; YOUNG ADULT;

ADOLESCENT; ADULT; ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE; ANTIGENS, CD; ANTIGENS, CD3; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; AUTOANTIBODIES; AUTOIMMUNITY; CD8-POSITIVE T-LYMPHOCYTES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-17; KIDNEY; KIDNEY FAILURE, CHRONIC; KIDNEY GLOMERULUS; MACROPHAGES; MALE; T-LYMPHOCYTES; YOUNG ADULT;

EID: 84963732152     PISSN: 16747305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11427-016-5030-9     Document Type: Article

References (32)

1. Appel, D., Kershaw, D.B., Smeets, B., Yuan, G., Fuss, A., Frye, B., Elger, M., Kriz, W., Floege, J., and Moeller, M.J. (2009). Recruitment of podocytes from glomerular parietal epithelial cells. J Am Soc Nephrol 20, 333–343.
2. Bolton, W.K., Innes, D.J., Sturgill, B.C., and Kaiser, D.L. (1987). T-cells and macrophages in rapidly progressive glomerulonephritis: clinicopathologic correlations. Kidney Int 32, 869–876.
3. Boucher, A., Droz, D., Adafer, E., and Noël, L.H. (1987). Relationship between the integrity of Bowman’s capsule and the composition of cellular crescents in human crescentic glomerulonephritis. Lab Invest 56, 526–533.
4. Couzi, L., Merville, P., Deminière, C., Moreau, J.F., Combe, C., Pellegrin, J.L., Viallard, J.F., and Blanco, P. (2007). Predominance of CD8+ T lymphocytes among periglomerular infiltrating cells and link to the prognosis of class III and class IV lupus nephritis. Arthritis Rheum 56, 2362–2370.
5. Cui, Z., Zhao, M.H., Xin, G., and Wang, H.Y. (2005). Characteristics and prognosis of Chinese patients with anti-glomerular basement membrane disease. Nephron Clin Pract 99, c49–c55.
6. Goldwich, A., Burkard, M., Olke, M., Daniel, C., Amann, K., Hugo, C., Kurts, C., Steinkasserer, A., and Gessner, A. (2013). Podocytes are nonhematopoietic professional antigen-presenting cells. J Am Soc Nephrol 24, 906–916.
7. Kalluri, R., Wilson, C.B., Weber, M., Gunwar, S., Chonko, A.M., Neilson, E.G., and Hudson, B.G. (1995). Identification of the alpha 3 chain of type IV collagen as the common autoantigen in antibasement membrane disease and Goodpasture syndrome. J Am Soc Nephrol 6, 1178–1185.
8. Kawasaki, K., Yaoita, E., Yamamoto, T., and Kihara, I. (1992). Depletion of CD8 positive cells in nephrotoxic serum nephritis of WKY rats. Kidney Int 41, 1517–1526.
9. Kitching, A.R., and Holdsworth, S.R. (2011). The emergence of TH17 cells as effectors of renal injury. J Am Soc Nephrol 22, 235–238.
10. Krüger, T., Benke, D., Eitner, F., Lang, A., Wirtz, M., Hamilton-Williams, E.E., Engel, D., Giese, B., Müller-Newen, G., Floege, J., and Kurts, C. (2004). Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis. J Am Soc Nephrol 15, 613–621.
11. Li, X.Z., and He, J. C. (2015). An update: the role of Nephrin inside and outside the kidney. Sci China Life Sci 58, 649–657.
12. Macconi, D., Chiabrando, C., Schiarea, S., Aiello, S., Cassis, L., Gagliardini, E., Noris, M., Buelli, S., Zoja, C., Corna, D., Mele, C., Fanelli, R., Remuzzi, G., and Benigni, A. (2009). Proteasomal processing of albumin by renal dendritic cells generates antigenic peptides. J Am Soc Nephrol 20, 123–130.
13. Miossec, P., Korn, T., and Kuchroo, V.K. (2009). Interleukin-17 and type 17 helper T cells. N Engl J Med 361, 888–898.
14. Ooi, J.D., Phoon, R.K., Holdsworth, S.R., and Kitching, A.R. (2009). IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen. J Am Soc Nephrol 20, 980–989.
15. Ooi, J.D., Snelgrove, S.L., Engel, D.R., Hochheiser, K., Ludwig-Portugall, I., Nozaki, Y., O’Sullivan, K.M., Hickey, M.J., Holdsworth, S.R., Kurts, C., and Kitching, A.R. (2011). Endogenous foxp3+ T-regulatory cells suppress anti-glomerular basement membrane nephritis. Kidney Int 79, 977–986.
16. Paust, H.J., Turner, J.E., Riedel, J.H., Disteldorf, E., Peters, A., Schmidt, T., Krebs, C., Velden, J., Mittrücker, H.W., Steinmetz, O.M., Stahl, R.A., and Panzer, U. (2012). Chemokines play a critical role in the cross-regulation of Th1 and Th17 immune responses in murine crescentic glomerulonephritis. Kidney Int 82, 72–83.
17. Phelps, R.G., and Rees, A.J. (1999). The HLA complex in Goodpasture’s disease: a model for analyzing susceptibility to autoimmunity. Kidney Int 56, 1638–1653.
18. Reynolds, J., Khan, S.B., Allen, A.R., Benjamin, C.D., and Pusey, C.D. (2004). Blockade of the CD154-CD40 costimulatory pathway prevents the development of experimental autoimmune glomerulonephritis. Kidney Int 66, 1444–1452.
19. Reynolds, J., Norgan, V.A., Bhambra, U., Smith, J., Cook, H.T., and Pusey, C.D. (2002). Anti-CD8 monoclonal antibody therapy is effective in the prevention and treatment of experimental autoimmune glomerulonephritis. J Am Soc Nephrol 13, 359–369.
20. Reynolds, J., Tam, F.W., Chandraker, A., Smith J., Karkar, A.M., Cross, J., Peach, R., Sayegh, M.H., and Pusey, C.D. (2000). CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis. J Clin Invest 105, 643–651.
21. Rutgers, A., Slot, M., van, Paassen, P., van, Breda, Vriesman, P., Heeringa, P., and Tervaert, J.W. (2005). Coexistence of anti-glomerular basement membrane antibodies and myeloperoxidase-ANCAs in crescentic glomerulonephritis. Am J Kidney Dis 46, 253–262.
22. Sado, Y., Naito, I., and Okigaki, T. (1989). Transfer of anti-glomerular basement membrane antibody-induced glomerulonephritis in inbred rats with isologous antibodies from the urine of nephritic rats. J Pathol 158, 325–332.
23. Sheerin, N.S., Springall, T., Abe, K., and Sacks, S.H. (2001). Protection and injury: the differing roles of complement in the development of glomerular injury. Eur J Immunol 31, 1255–1260.
24. Tan, D.S., Gan, P.Y., O'Sullivan, K.M., Hammett, M.V., Summers, S.A., Ooi, J.D., Lundgren, B.A., Boyd, R.L., Scott, H.S., Kitching, A.R., Chidgey, A.P., and Holdsworth, S.R. (2013). Thymic deletion and regulatory T cells prevent antimyeloperoxidase GN. J Am Soc Nephrol 24, 573–585.
25. Tipping, P.G., Huang, X.R., Qi, M., Van, G.Y., and Tang, W.W. (1998). Crescentic glomerulonephritis in CD4- and CD8-deficient mice. Requirement for CD4 but not CD8 cells. Am J Pathol 152, 1541–1548.
26. Turner, J.E., Krebs, C., Tittel, A.P., Paust, H.J., Meyer-Schwesinger, C., Bennstein, S.B., Steinmetz, O.M., Prinz, I., Magnus, T., Korn, T., Stahl, R.A., Kurts, C., and Panzer, U. (2012). IL-17A production by renal T cells promotes kidney injury in crescentic GN. J Am Soc Nephrol 23, 1486–1495.
27. Velden, J., Paust, H.J., Hoxha, E., Turner, J.E., Steinmetz, O.M., Wolf, G., Jabs, W.J., Özcan, F., Beige, J., Heering, P.J., Schröder, S., Kneißler, U., Disteldorf, E., Mittrücker, H.W., Stahl, R.A., Helmchen, U., and Panzer, U. (2012). Renal IL-17 expression in human ANCA-associated glomerulonephritis. Am J Physiol Renal Physiol 302, 1663–1673.
28. Wilde, B., van, Paassen, P., Damoiseaux, J., Heerings-Rewinkel, P., van, Rie, H., Witzke, O., and Tervaert, J.W. (2009). Dendritic cells in renal biopsies of patients with ANCA-associated vasculitis. Nephrol Dial Transplant 24, 2151–2156.
29. Wilson, C.B., and Dixon, F.J. (1973). Anti-glomerular basement membrane antibody-induced glomerulonephritis. Kidney Int 3, 74–89.
30. Wolf, D., Hochegger, K., Wolf, A.M., Rumpold, H.F., Gastl, G., Tilg, H., Mayer, G., Gunsilius, E., and Rosenkranz, A.R. (2005). CD4+CD25+ regulatory T cells inhibit experimental anti-glomerular basement membrane glomerulonephritis in mice. J Am Soc Nephrol 16, 1360–1370.
31. Wu, J., Hicks, J., Borillo, J., Glass, W.F. II., and Lou, Y.H. (2002). CD4+ T cells specific to a glomerular basement membrane antigen mediate glomerulonephritis. J Clin Invest 109, 517–524.
32. Wu, J., Hicks, J., Ou, C., Singleton, D., Borillo, J., and Lou, Y.H. (2001). Glomerulonephritis induced by recombinant collagen IV alpha 3 chain noncollagen domain 1 is not associated with glomerular basement membrane antibody: a potential T cell-mediated mechanism. J Immunol 167, 2388–2395.