Elevated Leukocyte Azurophilic Enzymes in Human Diabetic Ketoacidosis Plasma Degrade Cerebrovascular Endothelial Junctional Proteins∗

Critical Care Medicine

Volumn 44, Issue 9, 2016, Pages e846-e853

  Woo, Martin M H ^a,b   Patterson, Eric K ^c   Clarson, Cheril ^a,d   Cepinskas, Gediminas ^b,c   Bani Yaghoub, Mahmud ^d,e   Stanimirovic, Danica B ^d,e   Fraser, Douglas D ^a,b,c  

^a CHILDREN S HEALTH RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^d NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^e UNIVERSITY OF OTTAWA   (Canada)

Author keywords

blood brain barrier; children; diabetic ketoacidosis; leukocytes; proteinase 3; vasogenic cerebral edema

Indexed keywords

ELASTASE; GLUCOSE; HEMOGLOBIN A1C; HUMAN LEUKOCYTE ELASTASE; MYELOBLASTIN; MYELOPEROXIDASE; OCCLUDIN; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; CATHEPSIN G; LEUKOCYTE ELASTASE; PEROXIDASE;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY ENDOTHELIAL CELL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC KETOACIDOSIS; DIABETIC PATIENT; DISEASE SEVERITY; ENZYME BLOOD LEVEL; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; LEUKOCYTE ACTIVATION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN DEGRADATION; REAL TIME POLYMERASE CHAIN REACTION; BLOOD; BRAIN EDEMA; CASE CONTROL STUDY; CELL CULTURE TECHNIQUE; COMPLICATION; ENDOTHELIUM CELL; ENZYMOLOGY; METABOLISM; PHYSIOLOGY;

BLOOD-BRAIN BARRIER; BRAIN EDEMA; CASE-CONTROL STUDIES; CATHEPSIN G; CELL CULTURE TECHNIQUES; CHILD; DIABETES MELLITUS, TYPE 1; DIABETIC KETOACIDOSIS; ENDOTHELIAL CELLS; FEMALE; HUMANS; LEUKOCYTE ELASTASE; MALE; MYELOBLASTIN; PEROXIDASE;

EID: 84963700680     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000001720     Document Type: Article

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