Reduced epithelial Na+/H+exchange drives gut microbial dysbiosis and promotes inflammatory response in T cell-mediated murine colitis

PLoS ONE

Volumn 11, Issue 4, 2016, Pages

  Laubitz, Daniel ^a   Harrison, Christy A ^a   Midura Kiela, Monica T ^a   Ramalingam, Rajalakshmy ^a,d   Larmonier, Claire B ^a,e   Chase, John H ^b   Caporaso, J Gregory ^b   Besselsen, David G ^c   Ghishan, Fayez K ^a   Kiela, Pawel R ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b NORTHERN ARIZONA UNIVERSITY   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

^e HÔPITAL PELLEGRIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CIPROFLOXACIN; INTERLEUKIN 2 RECEPTOR ALPHA; METRONIDAZOLE; SODIUM PROTON EXCHANGE PROTEIN 3; TRANSCRIPTION FACTOR FOXP3; SODIUM PROTON EXCHANGE PROTEIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; CELL EXPANSION; COLITIS; COLON; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE EXACERBATION; DISEASE PREDISPOSITION; DYSBIOSIS; EPITHELIAL PERMEABILITY; EPITHELIUM; GENE; HEALTH STATUS; HOMEOSTASIS; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; INFANT; INFLAMMATION; INFLAMMATORY BOWEL DISEASE; INTESTINE FLORA; LYMPHOCYTE HOMING; LYMPHOCYTIC INFILTRATION; MEMBRANE PERMEABILITY; MESENTERY LYMPH NODE; MICROBIAL COMMUNITY; MICROBIOME; MOUSE; MOUSE STRAIN; MUCOSAL INFLAMMATORY TONE; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL INFLUX; NHE3-/- MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTON SODIUM EXCHANGE; RAG2-/- MOUSE; REGULATORY T LYMPHOCYTE; SLC9A3 GENE; T LYMPHOCYTE; TEMPORAL ANALYSIS; WEIGHT REDUCTION; ANIMAL; IMMUNOLOGY; INTESTINE; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY;

ANIMALS; COLITIS; INTESTINES; MICE; MICE, KNOCKOUT; SODIUM-HYDROGEN ANTIPORTER; T-LYMPHOCYTES;

EID: 84963638664     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0152044     Document Type: Article

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