Changes in Mucosal Homeostasis Predispose NHE3 Knockout Mice to Increased Susceptibility to DSS-Induced Epithelial Injury

Gastroenterology

Volumn 137, Issue 3, 2009, Pages

  Kiela, Pawel R ^a,b   Laubitz, Daniel ^a   Larmonier, Claire B ^a   Midura Kiela, Monica T ^a   Lipko, Maciej A ^a   Janikashvili, Nona ^a   Bai, Aiping ^a   Thurston, Robert ^a   Ghishan, Fayez K ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8ALPHA ANTIGEN; DEXTRAN SULFATE; ENDOTHELIN 1; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; SODIUM PROTON EXCHANGE PROTEIN 3;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; COLON INJURY; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; GENE EXPRESSION; HOMEOSTASIS; HYPOVOLEMIC SHOCK; IMMUNOHISTOCHEMISTRY; INTESTINAL BLEEDING; INTESTINE INJURY; LAMINA PROPRIA; LEUKOCYTOSIS; MORTALITY; MOUSE; MUCOSA CELL; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS; WILD TYPE;

EID: 69249100598     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.05.043     Document Type: Article

References (31)

1. Seidler U., Lenzen H., Cinar A., et al. Molecular mechanisms of disturbed electrolyte transport in intestinal inflammation. Ann N Y Acad Sci 1072 (2006) 262-275
2. Pardi D.S. Microscopic colitis: an update. Inflamm Bowel Dis 10 (2004) 860-870
3. Hawker P.C., McKay J.S., and Turnberg L.A. Electrolyte transport across colonic mucosa from patients with inflammatory bowel disease. Gastroenterology 79 (1980) 508-511
4. Allan R., Steinberg D.M., Dixon K., et al. Changes in the bidirectional sodium flux across the intestinal mucosa in Crohn's disease. Gut 16 (1975) 201-204
5. Sandle G.I., Hayslett J.P., and Binder H.J. Effect of glucocorticoids on rectal transport in normal subjects and patients with ulcerative colitis. Gut 27 (1986) 309-316
6. Clayburgh D.R., Musch M.W., Leitges M., et al. Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J Clin Invest 116 (2006) 2682-2694
7. Musch M.W., Clarke L.L., Mamah D., et al. T-cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase. J Clin Invest 110 (2002) 1739-1747
8. Rocha F., Musch M.W., Lishanskiy L., et al. IFN-γ down-regulates expression of Na(+)/H(+) exchangers NHE2 and NHE3 in rat intestine and human Caco-2/bbe cells. Am J Physiol Cell Physiol 280 (2001) C1224-C1232
9. Amin M.R., Malakooti J., Sandoval R., et al. IFN-γ and TNF-α regulate human NHE3 gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1. Am J Physiol Cell Physiol 291 (2006) C887-C896
10. Kiela P.R., Guner Y.S., Xu H., et al. Age- and tissue-specific induction of NHE3 by glucocorticoids in the rat small intestine. Am J Physiol Cell Physiol 278 (2000) C629-C637
11. Yun C.C., Chen Y., and Lang F. Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2. J Biol Chem 277 (2002) 7676-7683
12. Kiela P.R., Hines E.R., Collins J.F., et al. Regulation of the rat NHE3 gene promoter by sodium butyrate. Am J Physiol Gastrointest Liver Physiol 281 (2001) G947-G956
13. Siddique I., Hasan F., and Khan I. Suppression of Na(+)/H(+) exchanger isoform-3 in human inflammatory bowel disease: lack of reversal by 5′-aminosalicylate treatment. Scand J Gastroenterol 44 (2009) 56-64
14. Sullivan S., Alex P., Dassopoulos T., et al. Down-regulation of sodium transporters and NHERF proteins in IBD patients and mouse colitis models: potential contributors to IBD-associated diarrhea. Inflamm Bowel Dis 15 (2009) 261-274
15. Hayashi H., Szaszi K., Coady-Osberg N., et al. Inhibition and redistribution of NHE3, the apical Na+/H+ exchanger, by Clostridium difficile toxin B. J Gen Physiol 123 (2004) 491-504
16. Hecht G., Hodges K., Gill R.K., et al. Differential regulation of Na+/H+ exchange isoform activities by enteropathogenic E coli in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 287 (2004) G370-G378
17. Schultheis P.J., Clarke L.L., Meneton P., et al. Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger. Nat Genet 19 (1998) 282-285
18. Woo A.L., Gildea L.A., Tack L.M., et al. In vivo evidence for interferon-γ-mediated homeostatic mechanisms in small intestine of the NHE3 Na+/H+ exchanger knockout model of congenital diarrhea. J Biol Chem 277 (2002) 49036-49046
19. Laubitz D., Larmonier C.B., Bai A., et al. Colonic gene expression profile in NHE3-deficient mice: evidence for spontaneous distal colitis. Am J Physiol Gastrointest Liver Physiol 295 (2008) G63-G77
20. Kosaka A., Wakita D., Matsubara N., et al. AsialoGM1+CD8+ central memory-type T cells in unimmunized mice as novel immunomodulator of IFN-γ-dependent type 1 immunity. Int Immunol 19 (2007) 249-256
21. Collins J.F., Xu H., Kiela P.R., et al. Functional and molecular characterization of NHE3 expression during ontogeny in rat jejunal epithelium. Am J Physiol 273 (1997) C1937-C1946
22. Bruewer M., Samarin S., and Nusrat A. Inflammatory bowel disease and the apical junctional complex. Ann N Y Acad Sci 1072 (2006) 242-252
23. Chiba H., Kojima T., Osanai M., et al. The significance of interferon-γ-triggered internalization of tight-junction proteins in inflammatory bowel disease. Sci STKE 2006 (2006) pe1
24. Yu A.S., Cheng M.H., Angelow S., et al. Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site. J Gen Physiol 133 (2009) 111-127
25. Ledoussal C., Lorenz J.N., Nieman M.L., et al. Renal salt wasting in mice lacking NHE3 Na+/H+ exchanger but not in mice lacking NHE2. Am J Physiol Renal Physiol 281 (2001) F718-F727
26. Mankertz J., and Schulzke J.D. Altered permeability in inflammatory bowel disease: pathophysiology and clinical implications. Curr Opin Gastroenterol 23 (2007) 379-383
27. Hou J., Gomes A.S., Paul D.L., et al. Study of claudin function by RNA interference. J Biol Chem 281 (2006) 36117-36123
28. Weber C.R., Nalle S.C., Tretiakova M., et al. Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab Invest 88 (2008) 1110-1120
29. Okayasu I., Hatakeyama S., Yamada M., et al. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98 (1990) 694-702
30. Lim T.S., Vedula S.R., Hui S., et al. Probing effects of pH change on dynamic response of claudin-2 mediated adhesion using single molecule force spectroscopy. Exp Cell Res 314 (2008) 2643-2651
31. Amasheh S., Milatz S., Krug S.M., et al. Na+ absorption defends from paracellular back-leakage by claudin-8 up-regulation. Biochem Biophys Res Commun 378 (2009) 45-50