Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens

Immunity

Volumn 43, Issue 6, 2015, Pages 1087-1100

  Alloatti, Andrés ^a   Kotsias, Fiorella ^a,b   Pauwels, Anne Marie ^c,d   Carpier, Jean Marie ^a   Jouve, Mabel ^e   Timmerman, Evy ^c,d   Pace, Luigia ^a   Vargas, Pablo ^a,f   Maurin, Mathieu ^a   Gehrmann, Ulf ^a   Joannas, Leonel ^a   Vivar, Omar I ^a   Lennon Duménil, Ana Maria ^a   Savina, Ariel ^a,g   Gevaert, Kris ^c,d   Beyaert, Rudi ^c,d   Hoffmann, Eik ^a,c,d   Amigorena, Sebastian ^a  

^a PSL RESEARCH UNIVERSITY   (France)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^d GHENT UNIVERSITY   (Belgium)

^e INSTITUT CURIE   (France)

^f INSTITUT CURIE   (France)

^g Roche   (France)

Author keywords

Antigen presentation; Cross presentation; Dendritic cell; GTPase Rab34; Phagocytosis; Phagosome maturation; Toll like receptor 4

Indexed keywords

CATHEPSIN B; CATHEPSIN D; CD69 ANTIGEN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 2 RECEPTOR ALPHA; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; RAB PROTEIN; RAB34 PROTEIN; RAB7 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; ANTIGEN; RAB34 PROTEIN, MOUSE; SMALL INTERFERING RNA; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN ANTIBODY COMPLEX; ANTIGEN SPECIFICITY; ARTICLE; BONE MARROW DERIVED DENDRITIC CELL; CD8+ T LYMPHOCYTE; CELL MATURATION; CELL MIGRATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CROSS PRESENTATION; CYTOSOL; EMBRYO; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LYSOSOME; MICROTUBULE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PHAGOLYSOSOME; PHAGOSOME; PINOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; ANIMAL; ANTIGEN PRESENTATION; C57BL MOUSE; CYTOTOXICITY; DENDRITIC CELL; FLOW CYTOMETRY; GENETIC TRANSFECTION; IMMUNOLOGY; TRANSGENIC MOUSE;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; CROSS-PRIMING; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; LYSOSOMES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHAGOSOMES; RAB GTP-BINDING PROTEINS; RNA, SMALL INTERFERING; TOLL-LIKE RECEPTOR 4; TRANSFECTION;

EID: 84963612047     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2015.11.006     Document Type: Article

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