A comparative study of linear, Y-shaped and linear-dendritic methoxy poly(ethylene glycol)-block-polyamidoamine-block-poly(L-glutamic acid) block copolymers for doxorubicin delivery in vitro and in vivo

Acta Biomaterialia

Volumn 40, Issue , 2016, Pages 243-253

  Zhang, Yu ^a   Xiao, Chunsheng ^a   Ding, Jianxun ^a   Li, Mingqiang ^a   Chen, Xin ^a,b   Tang, Zhaohui ^a   Zhuang, Xiuli ^a   Chen, Xuesi ^a  

^a CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Block copolymer; Cancer therapy; Controlled release; Drug delivery; Macromolecular architecture

Indexed keywords

AMINO ACIDS; BIOCOMPATIBILITY; BLOCK COPOLYMERS; CARDIOVASCULAR SYSTEM; CONTROLLED DRUG DELIVERY; CYTOTOXICITY; DENDRIMERS; ETHYLENE GLYCOL; POLYETHYLENE GLYCOLS; POLYOLS; SELF ASSEMBLY; TARGETED DRUG DELIVERY; TUMORS;

BLOCK CO POLYMERS; CANCER THERAPY; COMPARATIVES STUDIES; CONTROLLED RELEASE; DOXORUBICIN HYDROCHLORIDE; IN-VITRO; LINEAR DENDRITIC; MACROMOLECULAR ARCHITECTURE; VITRO AND IN VIVO; Y-SHAPED;

MACROMOLECULES;

COPOLYMER; DOXORUBICIN; MACROGOL; POLYAMIDOAMINE; POLYGLUTAMIC ACID; MACROGOL DERIVATIVE; POLYETHYLENE GLYCOL 1000;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CIRCULATION; CIRCULATION TIME; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG RELEASE; DRUG SYNTHESIS; EX VIVO STUDY; FEMALE; FLUORESCENCE IMAGING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STATIC ELECTRICITY; TUNEL ASSAY; ANIMAL; CHEMISTRY; DRUG SCREENING; HELA CELL LINE; HUMAN; MCF-7 CELL LINE; PROCEDURES; WISTAR RAT;

ANIMALS; DOXORUBICIN; DRUG DELIVERY SYSTEMS; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; MCF-7 CELLS; POLYETHYLENE GLYCOLS; POLYGLUTAMIC ACID; RATS, WISTAR;

EID: 84963574971     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2016.04.007     Document Type: Article

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