Mercury as a possible link between maternal obesity and autism spectrum disorder

Medical Hypotheses

Volumn 91, Issue , 2016, Pages 90-94

  Skalny, Anatoly V ^a,b,c   Skalnaya, Margarita G ^d   Bjørklund, Geir ^e   Nikonorov, Alexandr A ^b,f   Tinkov, Alexey A ^a,b,c,f  

^a All Russia Science Research Institute of Medicinal and Aromatic Plants   (Russian Federation)

^b ORENBURG STATE UNIVERSITY   (Russian Federation)

^c YAROSLAVL STATE UNIVERSITY   (Russian Federation)

^d Russian Society of Trace Elements in Medicine   (Russian Federation)

^e Department of Research   (Norway)

^f ORENBURG STATE MEDICAL UNIVERSITY   (Russian Federation)

Author keywords

Autism; Mercury; Obesity; Overweight; Prenatal mercury exposure

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CHELATING AGENT; MERCURY;

ARTICLE; AUTISM; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; EXPOSURE; FETUS DEVELOPMENT; HAIR LEVEL; HUMAN; INCIDENCE; LEAD BLOOD LEVEL; MATERNAL OBESITY; MERCURIALISM; PLACENTAL TRANSFER; PREGNANCY; PRENATAL EXPOSURE; PROGENY; RISK REDUCTION; URINE LEVEL; CHEMICALLY INDUCED; COMPLICATION; FEMALE; HAIR; MALE; MATERNAL EXPOSURE; OBESITY;

ANTIOXIDANTS; AUTISM SPECTRUM DISORDER; CHELATING AGENTS; FEMALE; HAIR; HUMANS; MALE; MATERNAL EXPOSURE; MERCURY; OBESITY; PREGNANCY;

EID: 84963533533     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2016.04.021     Document Type: Article

References (87)

1. James P.T., Leach R., Kalamara E., Shayeghi M. The worldwide obesity epidemic. Obes Res 2001, 9(S11):228S-233S.
2. Raine K.D. Obesity epidemics: inevitable outcome of globalization or preventable public health challenge?. Int J Public Health 2012, 57(1):35-36.
3. Ogden C.L., Carroll M.D. Prevalence of overweight, obesity, and extreme obesity among adults: United States, trends 1960-1962 through 2007-2008. NCHS 2010, 6:1-6.
4. Flegal K.M., Carroll M.D., Kit B.K., Ogden C.L. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA 2012, 307(5):491-497.
5. Imes C.C., Burke L.E. The obesity epidemic: the USA as a cautionary tale for the rest of the world. Curr Epidemiol Rep 2014, 1(2):82-88.
6. Haidar Y.M., Cosman B.C. Obesity epidemiology. Clin Colon Rectal Surg 2011, 24(4):205.
7. Roberts K.C., Shields M., de Groh M., Aziz A., Gilbert J.A. Overweight and obesity in children and adolescents: results from the 2009 to 2011 Canadian Health Measures Survey. Health Rep 2012, 23(3):37-41.
8. Suchindran C., North K.E., Popkin B.M., Gordon-Larsen P. Association of adolescent obesity with risk of severe obesity in adulthood. JAMA 2010, 304(18):2042-2047.
9. Wells J.C., Marphatia A.A., Cole T.J., McCoy D. Associations of economic and gender inequality with global obesity prevalence: understanding the female excess. Soc Sci Med 2012, 75(3):482-490.
10. Heslehurst N., Rankin J., Wilkinson J.R., Summerbell C.D. A nationally representative study of maternal obesity in England, UK: trends in incidence and demographic inequalities in 619 323 births, 1989-2007. Int J Obes 2010, 34(3):420-428.
11. Kraschnewski J.L., Sciamanna C.N., Stuckey H.L., et al. A silent response to the obesity epidemic: decline in US physician weight counseling. Med Care 2013, 51(2):186-192.
12. Horvath K., Perman J.A. Autism and gastrointestinal symptoms. Curr Gastroenterol Rep 2002, 4(3):251-258.
13. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR 2000, American Psychiatric Association, Washington, DC.
14. Diagnostic and Statistical Manual of Mental Disorders: DSM-5 2013, American Psychiatric Association Publishing, Arlington.
15. Macedoni-Lukšič M., Gosar D., Bjørklund G., et al. Levels of metals in the blood and specific porphyrins in the urine in children with autism spectrum disorders. Biol Trace Elem Res 2015, 163:2-10.
16. Essa M.M., Braidy N., Vijayan K.R., Subash S., Guillemin G.J. Excitotoxicity in the pathogenesis of autism. Neurotox Res 2013, 23:393-400. 10.1007/s12640-012-9354-3.
17. Endreffy I., Bjørklund G., Dicso F., Urbina M.A., Endreffy E. Acid glycosaminoglycan (aGAG) excretion is increased in children with autism spectrum disorder, and it can be controlled by diet. Metab Brain Dis 2015, 10.1007/s11011-015-9745-2.
18. Matelski L., Van de Water J. Risk factors in autism: thinking outside the brain. J Autoimmun 2015, 67:1-7. 10.1016/j.jaut.2015.11.003.
19. Saad K., Abdel-Rahman A.A., Elserogy Y.M., et al. Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children. Nutr Neurosci 2015, 10.1179/1476830515Y.0000000019.
20. Bertrand J., Mars A., Boyle C., Bove F., Yeargin-Allsopp M., Decoufle P. Prevalence of autism in a United States population: the Brick Township, New Jersey, investigation. Pediatrics 2001, 108(5):1155-1161.
21. Lotter V. Epidemiology of autistic conditions in young children: I. Prevalence. Soc Psychiatry 1966, 1:124-137.
22. Fombonne E. The epidemiology of autism: a review. Psychol Med 1999, 29:769-786.
23. Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveill Summ 2014, 63(2):1-21. Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators; Centers for Disease Control and Prevention (CDC).
24. Zablotsky B., Black L.I., Maenner M.J., Schieve L.A., Blumberg S.J. Estimated prevalence of autism and other developmental disabilities following questionnaire changes in the 2014 National Health Interview Survey. Natl Health Stat Rep 2015, 87:1-20.
25. Russell G., Rodgers L.R., Ukoumunne O.C., Ford T. Prevalence of parent-reported ASD and ADHD in the UK: findings from the Millennium Cohort Study. J Autism Dev Disord 2014, 44(1):31-40.
26. Hertz-Picciotto I., Delwiche L. The rise in autism and the role of age at diagnosis. Epidemiology 2009, 20(1):84-90.
27. Folstein S.E., Rosen-Sheidley B. Genetics of autism: complex aetiology for a heterogeneous disorder. Nat Rev Genet 2001, 2(12):943-955.
28. Wahlgren C.M., Larsson E., Magnusson P.K., Hultgren R., Swedenborg J. Genetic and environmental contributions to abdominal aortic aneurysm development in a twin population. J Vasc Surg 2010, 51(1):3-7. discussion 7. 10.1016/j.jvs.2009.08.036.
29. James W.H. A potential explanation of some established major risk factors for autism. Dev Med Child Neurol 2012, 54(4):301-305.
30. Galliano D., Bellver J. Female obesity: short-and long-term consequences on the offspring. Gynecol Endocrinol 2013, 29(7):626-631.
31. Triunfo S., Lanzone A. Impact of overweight and obesity on obstetric outcomes. J Endocrinol Invest 2014, 37(4):323-329.
32. Craig W.Y., Palomaki G.E., Neveux L.M., Haddow J.E. Maternal body mass index during pregnancy and offspring neurocognitive development. Obstet Med 2013, 6(1):20-25.
33. Van Lieshout R.J. Role of maternal adiposity prior to and during pregnancy in cognitive and psychiatric problems in offspring. Nutr Rev 2013, 71(1):S95-S101.
34. Lyall K., Pauls D.L., Santangelo S., Spiegelman D., Ascherio A. Maternal early life factors associated with hormone levels and the risk of having a child with an autism spectrum disorder in the nurses health study II. J Autism Dev Disord 2011, 41(5):618-627.
35. Dodds L., Fell D.B., Shea S., Armson B.A., Allen A.C., Bryson S. The role of prenatal, obstetric and neonatal factors in the development of autism. J Autism Dev Disord 2011, 41(7):891-902.
36. Krakowiak P., Walker C.K., Bremer A.A., et al. Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders. Pediatrics 2012, 129(5):e1121-e1128.
37. Xiang A.H., Wang X., Martinez M.P., et al. Association of maternal diabetes with autism in offspring. JAMA 2015, 313(14):1425-1434.
38. Reynolds L.C., Inder T.E., Neil J.J., Pineda R.G., Rogers C.E. Maternal obesity and increased risk for autism and developmental delay among very preterm infants. J Perinatol 2014, 34(9):688-692.
39. Bilder D.A., Bakian A.V., Viskochil J., et al. Maternal prenatal weight gain and autism spectrum disorders. Pediatrics 2013, 132(5):e1276-e1283.
40. Stachowiak E.K., Srinivasan M., Stachowiak M.K., Patel M.S. Maternal obesity induced by a high fat diet causes altered cellular development in fetal brains suggestive of a predisposition of offspring to neurological disorders in later life. Metab Brain Dis 2013, 28(4):721-725.
41. Stachowiak E.K., Oommen S., Vasu V.T., et al. Maternal obesity affects gene expression and cellular development in fetal brains. Nutr Neurosci 2013, 16(3):96-103.
42. Edlow A.G., Vora N.L., Hui L., Wick H.C., Cowan J.M., Bianchi D.W. Maternal obesity affects fetal neurodevelopmental and metabolic gene expression: a pilot study. PLoS One 2014, 9(2).
43. Sullivan E.L., Nousen E.K., Chamlou K.A. Maternal high fat diet consumption during the perinatal period programs offspring behavior. Physiol Behav 2014, 123:236-242.
44. Cho S., Jacobs D.R., Park K. Population correlates of circulating mercury levels in Korean adults: the Korea National Health and Nutrition Examination Survey IV. BMC Public Health 2014, 14:527.
45. Kim K.N., Park S.J., Choi B., Joo N.S. Blood mercury and insulin resistance in nondiabetic Koreans (KNHANES 2008-2010). Yonsei Med J 2015, 56(4):944-950.
46. Lee S., Yoon J.H., Won J.U., et al. The association between blood mercury levels and risk for overweight in a general adult population: results from the Korean National Health and Nutrition Examination Survey. Biol Trace Elem Res 2015, 1-11.
47. Chang J.W., Chen H.L., Su H.J., Liao P.C., Guo H.R., Lee C.C. Simultaneous exposure of non-diabetics to high levels of dioxins and mercury increases their risk of insulin resistance. J Hazard Mater 2011, 185(2-3):749-755.
48. Kang D., Lee K. The relationships between blood Mercury concentration and body composition measures using 2010 Korean National Health and Nutrition Examination Survey. Korean J Obes 2013, 22(4):237-242.
49. You C.H., Kim B.G., Kim J.M., et al. Relationship between blood mercury concentration and waist-to-hip ratio in elderly Korean individuals living in coastal areas. J Prev Med Public Health 2011, 44(5):218-225.
50. Skalnaya M.G., Tinkov A.A., Demidov V.A., Serebryansky E.P., Nikonorov A.A., Skalny A.V. Hair toxic element content in adult men and women in relation to body mass index. Biol Trace Elem Res 2014, 161(1):13-19.
51. Skalnaya M.G., Demidov V.A. Hair trace element contents in women with obesity and type 2 diabetes. J Trace Elem Med Biol 2007, 21(s1):59-61.
52. Wright D.L., Afeiche M.C., Ehrlich S., et al. Hair mercury concentrations and in vitro fertilization (IVF) outcomes among women from a fertility clinic. Reprod Toxicol 2015, 51:125-132.
53. Rothenberg S.E., Korrick S.A., Fayad R. The influence of obesity on blood mercury levels for US non-pregnant adults and children: NHANES 2007-2010. Environ Res 2015, 138:173-180.
54. Jeon J.Y., Ha K.H., Kim D.J. New risk factors for obesity and diabetes: environmental chemicals. J Diab Invest 2015, 6(2):109-111.
55. Tinkov A.A., Ajsuvakova O.P., Skalnaya M.G., et al. Mercury and metabolic syndrome: a review of experimental and clinical observations. Biometals 2015, 28(2):231-254.
56. Rice K.M., Walker E.M., Wu M., Gillette C., Blough E.R. Environmental mercury and its toxic effects. J Prev Med Public Health 2014, 47(2):74-83.
57. Kim B.M., Lee B.E., Hong Y.C., et al. Mercury levels in maternal and cord blood and attained weight through the 24 months of life. Sci Total Environ 2011, 410:26-33.
58. Dennis C.A.R., Fehr F. The relationship between mercury levels in maternal and cord blood. Sci Total Environ 1975, 3(3):275-277.
59. Pitkin R.M., Bahns J.A., Filer L.J., Reynolds W.A. Mercury in human maternal and cord blood, placenta, and milk. Exp Biol Med 1976, 151(3):565-567.
60. Unuvar E., Ahmadov H., Kiziler A.R., et al. Mercury levels in cord blood and meconium of healthy newborns and venous blood of their mothers: clinical, prospective cohort study. Sci Total Environ 2007, 374(1):60-70.
61. Al-Saleh I., Shinwari N., Mashhour A., Mohamed G.E.D., Rabah A. Heavy metals (lead, cadmium and mercury) in maternal, cord blood and placenta of healthy women. Int J Hyg Environ Health 2011, 214(2):79-101.
62. Walker J.B., Houseman J., Seddon L., et al. Maternal and umbilical cord blood levels of mercury, lead, cadmium, and essential trace elements in Arctic Canada. Environ Res 2006, 100(3):295-318.
63. Vahter M., Åkesson A., Lind B., Björs U., Schütz A., Berglund M. Longitudinal study of methylmercury and inorganic mercury in blood and urine of pregnant and lactating women, as well as in umbilical cord blood. Environ Res 2000, 84(2):186-194.
64. Rudge C.V., Röllin H.B., Nogueira C.M., Thomassen Y., Rudge M.C., Odland J.Ø. The placenta as a barrier for toxic and essential elements in paired maternal and cord blood samples of South African delivering women. J Environ Monit 2009, 11(7):1322-1330.
65. Marques R.C., Dórea J.G., Bastos W.R., de Freitas Rebelo M., de Freitas Fonseca M., Malm O. Maternal mercury exposure and neuro-motor development in breastfed infants from Porto Velho (Amazon), Brazil. Int J Hyg Environ Health 2007, 210(1):51-60.
66. Marques R.C., Dórea J.G., Bastos W.R., Malm O. Changes in children hair-Hg concentrations during the first 5 years: maternal, environmental and iatrogenic modifying factors. Regul Toxicol Pharmacol 2007, 49(1):17-24.
67. Kim S.A., Jeon C.K., Paek D.M. Hair mercury concentrations of children and mothers in Korea: implication for exposure and evaluation. Sci Total Environ 2008, 402(1):36-42.
68. Santos E.O., Jesus I.M.D., Câmara V.D.M., et al. Correlation between blood mercury levels in mothers and newborns in Itaituba, Pará State, Brazil. Cadernos de saúde pública 2007, 23:S622-S629.
69. Dorea J.G., Donangelo C.M. Early (in uterus and infant) exposure to mercury and lead. Clin Nutr 2006, 25(3):369-376.
70. Bernard S., Enayati A., Binstock T., Roger H., Redwood L., McGinnis W. Autism: A Unique Type of Mercury Poisoning 2000, ARC Research, Cranford, NJ.
71. Kern J.K., Geier D.A., Audhya T., King P.G., Sykes L.K., Geier M.R. Evidence of parallels between mercury intoxication and the brain pathology in autism. Acta Neurobiol Exp 2012, 72:113-153.
72. Geier D.A., Kern J.K., Geier M.R. A prospective study of prenatal mercury exposure from maternal dental amalgams and autism severity. Acta Neurobiol Exp (Warsz) 2009, 69:189-197.
73. Drasch G., Schupp I., Hofl H., Reinke R., Roider G. Mercury burden of human fetal and infant tissues. Eur J Pediatr 1994, 153(8):607-610.
74. Mutter J., Naumann J., Guethlin C. Comments on the article "The toxicology of mercury and its chemical compounds" by Clarkson and Magos (2006). Crit Rev Toxicol 2007, 47:537-549.
75. Palkovicova L., Ursinyova M., Masanova V., Yu Z., Hertz Picciotto I. Maternal amalgam dental fillings as the source of mercury exposure in developing fetus and newborn. J Expo Sci Environ Epidemiol 2008, 18:326-331.
76. Oskarsson A., Schultz A., Skerfving S., Hallen I.P., Ohlin B., Lagerkvist B.J. Total and inorganic mercury in breast milk in relation to fish consumption and amalgam in lactating women. Arch Environ Health 1996, 51(3):234-241.
77. Bjørklund G. The role of zinc and copper in autism spectrum disorders. Acta Neurobiol Exp 2013, 73:225-236.
78. von Mühlendahl K.E. Feer's disease (in German). Monatsschr Kinderheilkd 1991, 139(4):224-227.
79. Yeates K.O., Mortensen M.E. Acute and chronic neuropsychological consequences of mercury vapor poisoning in two early adolescents. J Clin Exp Neuropsychol 1994, 16(2):209-222.
80. Geier D.A., King P.G., Sykes L.K., Geier M.R. A comprehensive review of mercury provoked autism. Indian J Med Res 2008, 128:383-411.
81. Geier D.A., Kern J.K., Geier M.R. The biological basis of autism spectrum disorders: understanding causation and treatment by clinical geneticists. Acta Neurobiol Exp (Wars) 2010, 70:209-226.
82. Mostafa G.A., Bjørklund G., Urbina M.A., Al-Ayadhi L.Y. The levels of blood mercury and inflammatory-related neuropeptides in the serum are correlated in children with autism spectrum disorder. Metab Brain Dis 2016, 1-7. 10.1007/s11011-015-9784-8.
83. Davis L.E., Kornfeld M., Mooney H.S., et al. Methylmercury poisoning: long-term clinical, radiological, toxicological, and pathological studies of an affected family. Ann Neurol 1994, 35(6):680-688.
84. Marlowe M., Cossairt A., Moon C., et al. Main and interaction effects of metallic toxins on classroom behavior. J Abnorm Child Psychol 1985, 13(2):185-198.
85. Palmer R.F., Blanchard S., Stein Z., Mandell D., Miller C. Environmental mercury release, special education rates, and autism disorder: an ecological study of Texas. Health Place 2006, 12:203-209.
86. Chrysochoou C., Rutishauser C., Rauber-Luthy C., Neuhaus T., Boltshauser E., Superti-Furga A. An 11-monthold boy with psychomotor regression and auto-aggressive behavior. Eur J Pediatr 2003, 162:559-561.
87. Geier D.A., Geier M.R. A case series of children with apparent mercury toxic encephalopathies manifesting with clinical symptoms of regressive autistic disorders. J Toxicol Environ Health A 2007, 70:837-851.