Maternal obesity affects gene expression and cellular development in fetal brains

Nutritional Neuroscience

Volumn 16, Issue 3, 2013, Pages 96-103

  Stachowiak, Ewa K ^a   Oommen, Saji ^b   Vasu, Vihas T ^b   Srinivasan, Malathi ^a   Stachowiak, Michal ^a   Gohil, Kishorchandra ^b   Patel, Mulchand S ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Fetal hyperinsulinemia and hyperleptinemia; Global gene expression; Maternal obesity; Neurogenesis; Neuronal maturation

Indexed keywords

CARBOHYDRATE; RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; BRAIN REGION; BRAIN SLICE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FETUS; GENE CLUSTER; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; HYPERINSULINEMIA; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MATERNAL OBESITY; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; CELL PROLIFERATION; DIETARY CARBOHYDRATES; FEMALE; FETAL DEVELOPMENT; GENE EXPRESSION; GENE EXPRESSION PROFILING; HYPERINSULINISM; HYPOTHALAMUS; INSULIN; LEPTIN; MALE; OBESITY; PHENOTYPE; PREGNANCY; RATS;

RATTUS;

EID: 84876074901     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/1476830512Y.0000000035     Document Type: Article

References (35)

1. Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults 1999-2008. JAMA 2010;303: 235-41.
2. Barker DJ. Intrauterine programming of adult disease. Mol Med Today 1995;1:418-23.
3. Fernandez-Twinn DS, Ozanne SE. Early life nutrition and metabolic programming. Ann New York Acad Sci 2010;1212: 78-96.
4. Li M, Sloboda DM, Vickers MH. Maternal obesity and developmental programming of metabolic disorders in offspring: evidence from animal models. Exp Diabetes Res 2011;2011: 592408.
5. Grove KL, Allen S, Grayson BE, Smith MS. Postnatal development of the hypothalamic neuropeptide Y system. Neuroscience 2003;116:393-406.
6. Bouret SG. Early life origins of obesity: role of hypothalamic programming. J Pediatr Gastroenterol Nutr 2009;48(Suppl. 1): S31-8.
7. Patel MS, Srinivasan M. Metabolic programming in the immediate postnatal life. Ann Nutr Metab 2011;58(Suppl. 2):18-28
8. Srinivasan M, Dodds C, Ghanim H, Gao T, Ross PJ, Browne RW, et al. Maternal obesity and fetal programming: effects of a high-carbohydrate nutritional modification in the immediate postnatal life of female rats. Am J Physiol Endocrinol Metab 2008;295:E895-903.
9. Chang GQ, Gaysinskaya V, Karatayev O, Leibowitz SF. Maternal high-fat diet and fetal programming: increased proliferation of hypothalamic peptide-producing neurons that increase risk for overeating and obesity. J Neurosci 2008;28: 12107-19.
10. Tozuka Y, Wada E, Wada K. 'Bio-communication' between mother and offspring: lessons from animals and new perspectives for brain science. J Pharmacol Sci 2009;110:127-32
11. Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009;4:44-57.
12. Stachowiak EK, Roy I, Lee YW, Capacchietti M, Aletta JM, Prasad PN, et al. Targeting novel integrative nuclear FGFR1 signaling by nanoparticle-mediated gene transfer stimulates neurogenesis in the adult brain. Integr Biol: Quant Biosci from Nano to Macro. 2009;1:394-403.
13. Vadlamudi S, Kalhan SC, Patel MS. Persistence of metabolic consequences in the progeny of rats fed a HC formula in their early postnatal life. Am J Physiol Endocrinol Metab 1999;269: E731-8.
14. Gordon MN, Kumar S, Espinosa de los Monteros A, Scully S, Zhang MS, Huber J, et al. Developmental regulation of myelin-associated genes in the normal and the myelin deficient mutant rat. Adv Exp Med Biol 1990;265:11-22.
15. Coman I, Aigrot MS, Seilhean D, Reynolds R, Girault JA, Zalc B, et al. Nodal, paranodal and juxtaparanodal axonal proteins during demyelination and remyelination in multiple sclerosis. Brain 2006;129:3186-95.
16. Helgeson SC, Schmutz SM. Genetic variation in the pro-melanin-concentrating hormone gene affects carcass traits in Bos taurus cattle. Anim Genet 2008;39:310-5.
17. Remaury A, Vita N, Gendreau S, Jung M, Arnone M, Poncelet M, et al. Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia. Brain Res 2002;953:63-72.
18. Reue K, Zhang P. The lipin protein family: dual roles in lipid biosynthesis and gene expression. FEBS Lett 2008;582:90-6
19. Li M, Ren D, Iseki M, Takaki S, Rui L. Differential role of SH2-B and APS in regulating energy and glucose homeostasis. Endocrinology 2006;147:2163-70.
20. Carroll K, Gomez C, Shapiro L. Tubby proteins: the plot thickens. Nat Rev 2004;5:55-63.
21. Fine R, Lehman W, Head J, Blitz A. Troponin C in brain. Nature 1975;258:260-7.
22. Kimura N, Nakashima K, Ueno M, Kiyama H, Taga T. A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain. Brain Res: Dev Brain Res 1999;115: 183-93.
23. Adhihetty PJ, Beal MF. Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases. Neuromol Med 2008;10:275-90.
24. Tozuka Y, Kumon M, Wada E, Onodera M, Mochizuki H, Wada K. Maternal obesity impairs hippocampal BDNF production and spatial learning performance in young mouse offspring. Neurochem Int 2010;57:235-47.
25. Niculescu MD, Lupu DS. High fat diet-induced maternal obesity alters fetal hippocampal development. Int J Dev Neurosci 2009;27:627-33.
26. Chiu SL, Cline HT. Insulin receptor signaling in the development of neuronal structure and function. Neural Dev 2010;5:7
27. Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, et al. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease-is this type 3 diabetes? J Alzheimers Dis 2005;7:63-80.
28. Wertheimer E, Lu SP, Backeljauw PF, Davenport ML, Taylor SI. Homozygous deletion of the human insulin receptor gene results in leprechaunism. Nat Gen 1993;5:71-3.
29. LaFever L, Drummond-Barbosa D. Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila. Science 2005;309:1071-3.
30. Desai M, Li T, Ross MG. Hypothalamic neurosphere progenitor cells in low birth-weight rat newborns: neurotrophic effects of leptin and insulin. Brain Res 2011;1378:29-42.
31. Plagemann A, Harder T, Rake A, Voits M, Fink H, Rohde W, et al. Perinatal elevation of hypothalamic insulin, acquired malformation of hypothalamic galaninergic neurons, and syndrome x-like alterations in adulthood of neonatally overfed rats. Brain Res 1999;836:146-55.
32. Udagawa J, Hatta T, Hashimoto R, Otani H. Roles of leptin in prenatal and perinatal brain development. Congenit Anom (Kyoto) 2007;47:77-83.
33. Bouret SG, Draper SJ, Simerly RB. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 2004;304: 108-10.
34. Krakowiak P, Walker CK, Bremer AA, Baker AS, Ozonoff S, Hansen RL, et al. Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders. Pediatrics 2012;129:e1121-8.
35. Rodriguez JS, Rodriguez-Gonzalez GL, Reyes-Castro LA, Ibanez C, Ramirez A, Chavira R, et al. Maternal obesity in the rat programs male offspring exploratory, learning and motivation behavior: prevention by dietary intervention pregestation or in gestation. Int J Dev Neurosci 2012;30:75-81.