메뉴 건너뛰기




Volumn 7, Issue 11, 2016, Pages 12163-12175

Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7

Author keywords

Human regulatory T cells; IL 7; Immune response; Immunity; Immunology and microbiology section; Na ve regulatory T cells; Regulatory T cell homeostasis; Thymectomy

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 7; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; FORKHEAD TRANSCRIPTION FACTOR; IL7 PROTEIN, HUMAN;

EID: 84962891343     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.7512     Document Type: Article
Times cited : (31)

References (45)
  • 2
    • 84896704750 scopus 로고    scopus 로고
    • Homeostatic control of regulatory T cell diversity
    • Liston A and Gray DH. Homeostatic control of regulatory T cell diversity. Nat Rev Immunol. 2014; 14:154-165.
    • (2014) Nat Rev Immunol. , vol.14 , pp. 154-165
    • Liston, A.1    Gray, D.H.2
  • 9
    • 67049167214 scopus 로고    scopus 로고
    • Quantifying the development of the peripheral naive CD4+ T-cell pool in humans
    • Bains I, Antia R, Callard R and Yates AJ. Quantifying the development of the peripheral naive CD4+ T-cell pool in humans. Blood. 2009; 113:5480-5487.
    • (2009) Blood. , vol.113 , pp. 5480-5487
    • Bains, I.1    Antia, R.2    Callard, R.3    Yates, A.J.4
  • 13
    • 80052741639 scopus 로고    scopus 로고
    • Immune dysregulation after cardiothoracic surgery and incidental thymectomy: maintenance of regulatory T cells despite impaired thymopoiesis
    • Halnon NJ, Cooper P, Chen DY, Boechat MI and Uittenbogaart CH. Immune dysregulation after cardiothoracic surgery and incidental thymectomy: maintenance of regulatory T cells despite impaired thymopoiesis. Clin Dev Immunol. 2011; 2011:915864.
    • (2011) Clin Dev Immunol. , vol.2011 , pp. 915864
    • Halnon, N.J.1    Cooper, P.2    Chen, D.Y.3    Boechat, M.I.4    Uittenbogaart, C.H.5
  • 16
    • 0037128660 scopus 로고    scopus 로고
    • Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood
    • Kimmig S, Przybylski GK, Schmidt CA, Laurisch K, Mowes B, Radbruch A and Thiel A. Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood. J Exp Med. 2002; 195:789-794.
    • (2002) J Exp Med. , vol.195 , pp. 789-794
    • Kimmig, S.1    Przybylski, G.K.2    Schmidt, C.A.3    Laurisch, K.4    Mowes, B.5    Radbruch, A.6    Thiel, A.7
  • 17
    • 64049104988 scopus 로고    scopus 로고
    • IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner
    • Azevedo RI, Soares MV, Barata JT, Tendeiro R, Serra-Caetano A, Victorino RM and Sousa AE. IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner. Blood. 2009; 113:2999-3007.
    • (2009) Blood. , vol.113 , pp. 2999-3007
    • Azevedo, R.I.1    Soares, M.V.2    Barata, J.T.3    Tendeiro, R.4    Serra-Caetano, A.5    Victorino, R.M.6    Sousa, A.E.7
  • 18
    • 84871152858 scopus 로고    scopus 로고
    • IL-7 abrogates suppressive activity of human CD4+CD25+FOXP3+ regulatory T cells and allows expansion of alloreactive and autoreactive T cells
    • Heninger AK, Theil A, Wilhelm C, Petzold C, Huebel N, Kretschmer K, Bonifacio E and Monti P. IL-7 abrogates suppressive activity of human CD4+CD25+FOXP3+ regulatory T cells and allows expansion of alloreactive and autoreactive T cells. J Immunol. 2012; 189:5649-5658.
    • (2012) J Immunol. , vol.189 , pp. 5649-5658
    • Heninger, A.K.1    Theil, A.2    Wilhelm, C.3    Petzold, C.4    Huebel, N.5    Kretschmer, K.6    Bonifacio, E.7    Monti, P.8
  • 24
    • 36549039484 scopus 로고    scopus 로고
    • Estimating thymic function through quantification of T-cell receptor excision circles
    • Dion ML, Sekaly RP and Cheynier R. Estimating thymic function through quantification of T-cell receptor excision circles. Methods Mol Biol. 2007; 380:197-213.
    • (2007) Methods Mol Biol. , vol.380 , pp. 197-213
    • Dion, M.L.1    Sekaly, R.P.2    Cheynier, R.3
  • 25
    • 84874232301 scopus 로고    scopus 로고
    • Helios+ and Helios-cells coexist within the natural FOXP3+ T regulatory cell subset in humans
    • Himmel ME, MacDonald KG, Garcia RV, Steiner TS and Levings MK. Helios+ and Helios-cells coexist within the natural FOXP3+ T regulatory cell subset in humans. J Immunol. 2013; 190:2001-2008.
    • (2013) J Immunol. , vol.190 , pp. 2001-2008
    • Himmel, M.E.1    MacDonald, K.G.2    Garcia, R.V.3    Steiner, T.S.4    Levings, M.K.5
  • 26
    • 84904159323 scopus 로고    scopus 로고
    • Comparative dose-responses of recombinant human IL-2 and IL-7 on STAT5 phosphorylation in CD4+FOXP3-cells versus regulatory T cells: a whole blood perspective
    • Dupont G, Demaret J, Venet F, Malergue F, Malcus C, Poitevin-Later F, Morel J and Monneret G. Comparative dose-responses of recombinant human IL-2 and IL-7 on STAT5 phosphorylation in CD4+FOXP3-cells versus regulatory T cells: a whole blood perspective. Cytokine. 2014; 69:146-149.
    • (2014) Cytokine. , vol.69 , pp. 146-149
    • Dupont, G.1    Demaret, J.2    Venet, F.3    Malergue, F.4    Malcus, C.5    Poitevin-Later, F.6    Morel, J.7    Monneret, G.8
  • 29
    • 4143085811 scopus 로고    scopus 로고
    • Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival
    • Park JH, Yu Q, Erman B, Appelbaum JS, Montoya-Durango D, Grimes HL and Singer A. Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity. 2004; 21:289-302.
    • (2004) Immunity. , vol.21 , pp. 289-302
    • Park, J.H.1    Yu, Q.2    Erman, B.3    Appelbaum, J.S.4    Montoya-Durango, D.5    Grimes, H.L.6    Singer, A.7
  • 30
    • 82255164181 scopus 로고    scopus 로고
    • Differentiation of human thymic regulatory T cells at the double positive stage
    • Nunes-Cabaco H, Caramalho I, Sepulveda N and Sousa AE. Differentiation of human thymic regulatory T cells at the double positive stage. Eur J Immunol. 2011; 41:3604-3614.
    • (2011) Eur J Immunol. , vol.41 , pp. 3604-3614
    • Nunes-Cabaco, H.1    Caramalho, I.2    Sepulveda, N.3    Sousa, A.E.4
  • 31
    • 84884280668 scopus 로고    scopus 로고
    • Interleukin-7: Fuel for the autoimmune attack
    • Dooms H. Interleukin-7: Fuel for the autoimmune attack. J Autoimmun. 2013; 45:40-48.
    • (2013) J Autoimmun. , vol.45 , pp. 40-48
    • Dooms, H.1
  • 32
    • 84908123494 scopus 로고    scopus 로고
    • Continuous requirement for the TCR in regulatory T cell function
    • Levine AG, Arvey A, Jin W and Rudensky AY. Continuous requirement for the TCR in regulatory T cell function. Nat Immunol. 2014; 15:1070-1078.
    • (2014) Nat Immunol. , vol.15 , pp. 1070-1078
    • Levine, A.G.1    Arvey, A.2    Jin, W.3    Rudensky, A.Y.4
  • 33
    • 58149191881 scopus 로고    scopus 로고
    • The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands
    • Kinter AL, Godbout EJ, McNally JP, Sereti I, Roby GA, O'Shea MA and Fauci AS. The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands. J Immunol. 2008; 181:6738-6746.
    • (2008) J Immunol. , vol.181 , pp. 6738-6746
    • Kinter, A.L.1    Godbout, E.J.2    McNally, J.P.3    Sereti, I.4    Roby, G.A.5    O'Shea, M.A.6    Fauci, A.S.7
  • 34
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: a common denominator approach to cancer therapy
    • Topalian SL, Drake CG and Pardoll DM. Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell. 2015; 27:450-461.
    • (2015) Cancer Cell. , vol.27 , pp. 450-461
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 42
    • 33847376547 scopus 로고    scopus 로고
    • Rate of increase in circulating IL-7 and loss of IL-7Ralpha expression differ in HIV-1 and HIV-2 infections: two lymphopenic diseases with similar hyperimmune activation but distinct outcomes
    • Albuquerque AS, Cortesao CS, Foxall RB, Soares RS, Victorino RM and Sousa AE. Rate of increase in circulating IL-7 and loss of IL-7Ralpha expression differ in HIV-1 and HIV-2 infections: two lymphopenic diseases with similar hyperimmune activation but distinct outcomes. J Immunol. 2007; 178:3252-3259.
    • (2007) J Immunol. , vol.178 , pp. 3252-3259
    • Albuquerque, A.S.1    Cortesao, C.S.2    Foxall, R.B.3    Soares, R.S.4    Victorino, R.M.5    Sousa, A.E.6
  • 43
    • 80054967903 scopus 로고    scopus 로고
    • Memory and naive-like regulatory CD4+ T cells expand during HIV-2 infection in direct association with CD4+ T-cell depletion irrespectively of viremia
    • Foxall RB, Albuquerque AS, Soares RS, Baptista AP, Cavaleiro R, Tendeiro R, Gomes P, Victorino RM and Sousa AE. Memory and naive-like regulatory CD4+ T cells expand during HIV-2 infection in direct association with CD4+ T-cell depletion irrespectively of viremia. AIDS. 2011; 25:1961-1970.
    • (2011) AIDS. , vol.25 , pp. 1961-1970
    • Foxall, R.B.1    Albuquerque, A.S.2    Soares, R.S.3    Baptista, A.P.4    Cavaleiro, R.5    Tendeiro, R.6    Gomes, P.7    Victorino, R.M.8    Sousa, A.E.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.