An ultra-deep targeted sequencing gene panel improves the prognostic stratification of patients with advanced oral cavity squamous cell carcinoma

Medicine (United States)

Volumn 95, Issue 8, 2016, Pages

  Liao, Chun Ta ^a   Chen, Shu Jen ^b,c   Lee, Li Yu ^a   Hsueh, Chuen ^a   Yang, Lan Yan ^d   Lin, Chien Yu ^a   Fan, Kang Hsing ^a   Wang, Hung Ming ^a   Ng, Shu Hang ^a   Lin, Chih Hung ^a   Tsao, Chung Kan ^e   Chen, I How ^a   Chang, Kai Ping ^a   Huang, Shiang Fu ^a   Kang, Chung Jan ^a   Chen, Hua Chien ^b,c   Yen, Tzu Chen ^e  

^a Head and Neck Surgery ^*  (Taiwan)

^b Georgetown Univ School of Medicine   (Taiwan)

^c Molecular Medicine Research Centre   (Taiwan)

^d Clinical Trial Center   (Taiwan)

^e CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; DISEASE FREE SURVIVAL; DISEASE SPECIFIC SURVIVAL; DISTANT METASTASIS; FEMALE; GENE SEQUENCE; GENETIC PROCEDURES; HUMAN; MAJOR CLINICAL STUDY; MALE; MOUTH SQUAMOUS CELL CARCINOMA; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSTIC ASSESSMENT; RECURRENCE FREE SURVIVAL; ULTRA DEEP TARGETED SEQUENCING GENE PANEL; CANCER STAGING; CARCINOMA, SQUAMOUS CELL; GENE EXPRESSION PROFILING; GENETICS; HIGH THROUGHPUT SEQUENCING; MIDDLE AGED; MORTALITY; MOUTH NEOPLASMS; MUTATION; ONCOGENE; PROCEDURES; PROGNOSIS; RETROSPECTIVE STUDY; RISK FACTOR; SURVIVAL ANALYSIS; SURVIVAL RATE; TUMOR SUPPRESSOR GENE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; FEMALE; GENE EXPRESSION PROFILING; GENES, TUMOR SUPPRESSOR; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; MUTATION; NEOPLASM STAGING; ONCOGENES; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL ANALYSIS; SURVIVAL RATE;

EID: 84962605896     PISSN: 00257974     EISSN: 15365964     Source Type: Journal    
DOI: 10.1097/MD.0000000000002751     Document Type: Article

References (34)

1. Cancer registry annual report, 2011 Taiwan. Available from: http://www.bhp.doh.gov.tw/. Accessed October 20, 2015.
2. Liao CT, Wallace CG, Lee LY, et al. Clinical evidence of field cancerization in patients with oral cavity cancer in a betel quid chewing area. Oral Oncol. 2014;50:721-731.
3. Liao CT, Wang HM, Ng SH, et al. Good tumor control and survivals of squamous cell carcinoma of buccal mucosa treated with radical surgery with or without neck dissection in Taiwan. Oral Oncol. 2006;42:800-809.
4. Shah JP, Candela FC, Poddar AK. The patterns of cervical lymph node metastases from squamous carcinoma of the oral cavity. Cancer. 1990;66:109-113.
5. Woolgar JA. Histopathological prognosticators in oral and oropharyngeal squamous cell carcinoma. Oral Oncol. 2006;42:229-239.
6. Bernier J, Cooper JS, Pajak TF, et al. Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (#9501). Head Neck. 2005;27:843-850.
7. Liao CT, Hsueh C, Lee LY, et al. Neck dissection field and lymph nodes density predict prognosis in patients with oral cavity cancer and pathological node metastases treated by adjuvant therapy. Oral Oncol. 2012;48:329-336.
8. Liao CT, Huang SF, Chen IH, et al. Outcome analysis of patients with pN2 oral cavity cancer. Ann Surg Oncol. 2010;17:1118-1126.
9. Patel SG, Amit M, Yen TC, et al. Lymph node density in oral cavity cancer: results of the International Consortium for Outcomes Research. Br J Cancer. 2013;109:2087-2095.
10. Chen SJ, Liu H, Liao CT, et al. Ultra-deep targeted sequencing of advanced oral squamous cell carcinoma identifies a mutation-based prognostic gene signature. Oncotarget. 2015;6:18066-18080.
11. Peng CH, Liao CT, Ng KP, et al. Somatic copy number alterations detected by ultra-deep targeted sequencing predict prognosis in oral cavity squamous cell carcinoma. Oncotarget. 2015;6:19891-19906.
12. National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology, Head and Neck Cancers, V.I.2015. Available from: http://www.nccn.org/. Accessed October 22, 2015.
13. Wang HM, Wang CS, Chen JS, et al. Cisplatin, tegafur, and leucovorin: a moderately effective and minimally toxic outpatient neoadjuvant chemotherapy for locally advanced squamous cell carcinoma of the head and neck. Cancer. 2002;94:2989-2995.
14. Tsan DL, Lin CY, Kang CJ, et al. The comparison between weekly and three-weekly cisplatin delivered concurrently with radiotherapy for patients with postoperative high-risk squamous cell carcinoma of the oral cavity. Radiat Oncol. 2012;7:215.
15. Harrell FE Jr, Lee KL, Mark DB. Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med. 1996;15:361-387.
16. cBioPortal for Cancer Genomics. Available from: http://www.cbioportal.org/. Accessed December 7, 2015.
17. Méndez E, Houck JR, Doody DR, et al. A genetic expression profile associated with oral cancer identifies a group of patients at high risk of poor survival. Clin Cancer Res. 2009;15:1353-1361.
18. Kassouf W, Agarwal PK, Herr HW, et al. Lymph node density is superior to TNM nodal status in predicting disease-specific survival after radical cystectomy for bladder cancer: analysis of pooled data from MDACC and MSKCC. J Clin Oncol. 2008;26:121-126.
19. Liao CT, Lee LY, Huang SF, et al. Outcome analysis of patients with oral cavity cancer and extracapsular spread in neck lymph nodes. Int J Radiat Oncol Biol Phys. 2011;81:930-937.
20. Kijima T, Maulik G, Ma PC, et al. Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells. Cancer Res. 2002;62:6304-6311.
21. Vila L, Liu H, Al-Quran SZ, et al. Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland. Mod Pathol. 2009;22:1296-1302.
22. Webster MK, Donoghue DJ. Enhanced signaling and morphological transformation by a membrane-localized derivative of the fibroblast growth factor receptor 3 kinase domain. Mol Cell Biol. 1997;17:5739-5747.
23. Morrison DK, Cutler RE. The complexity of Raf-1 regulation. Curr Opin Cell Biol. 1997;9:174-179.
24. Koumaki D, Kostakis G, Koumaki V, et al. Novel mutations of the HRAS gene and absence of hotspot mutations of the BRAF genes in oral squamous cell carcinoma in a Greek population. Oncol Rep. 2012;27:1555-1560.
25. Montagut C, Settleman J. Targeting the RAF-MEK-ERK pathway in cancer therapy. Cancer Lett. 2009;283:125-134.
26. Freudlsperger C, Burnett JR, Friedman JA, et al. EGFR-PI3K-AKTmTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy. Expert Opin Ther Targets. 2011;15:63-74.
27. Hemmings BA. Akt signaling: linking membrane events to life and death decisions. Science. 1997;275:628-630.
28. Pezzolesi MG, Zbuk KM, Waite KA, et al. Comparative genomic and functional analyses reveal a novel cis-acting PTEN regulatory element as a highly conserved functional E-box motif deleted in Cowden syndrome. Hum Mol Genet. 2007;16:1058-1071.
29. Snietura M, Jaworska M, Mlynarczyk-Liszka J, et al. PTEN as a prognostic and predictive marker in postoperative radiotherapy for squamous cell cancer of the head and neck. PLoS ONE. 2012;7:e33396.
30. Ohashi S, Natsuizaka M, Yashiro-Ohtani Y, et al. NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network. Gastroenterology. 2010;139:2113-2123.
31. Zhou S, Buckhaults P, Zawel L, et al. Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells. Proc Natl Acad Sci USA. 1998;95:2412-2416.
32. MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell. 2009;17:9-26.
33. Sakamoto K, Fujii T, Kawachi H, et al. Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. Lab Invest. 2012;92:688-702.
34. Yoshida R, Nagata M, Nakayama H, et al. The pathological significance of Notch1 in oral squamous cell carcinoma. Lab Invest. 2013;93:1068-1081.