Neuropathological signs of inflammation correlate with mitochondrial DNA deletions in mesial temporal lobe epilepsy

Acta Neuropathologica

Volumn 132, Issue 2, 2016, Pages 277-288

  Volmering, Elisa ^a   Niehusmann, Pitt ^a,b   Peeva, Viktoriya ^c   Grote, Alexander ^a   Zsurka, Gábor ^c   Altmüller, Janine ^d,e   Nürnberg, Peter ^d   Becker, Albert J ^a   Schoch, Susanne ^a   Elger, Christian E ^c   Kunz, Wolfram S ^c  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF BONN   (Germany)

^d UNIVERSITY OF COLOGNE   (Germany)

^e UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Hippocampal sclerosis neuropathology; Inflammation; Mitochondria; mtDNA deletions; Temporal lobe epilepsy

Indexed keywords

CD20 ANTIGEN; CD3 ANTIGEN; CD68 ANTIGEN; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

ARTICLE; B LYMPHOCYTE; BRAIN MITOCHONDRION; BRAIN REGION; BRAIN TISSUE; CD3+ T LYMPHOCYTE; CELL LOSS; CHRONIC INFLAMMATION; CONTROLLED STUDY; DENTATE HILUS; DNA SEQUENCE; EPILEPTOGENESIS; GENE DELETION; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA2 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPAL SCLEROSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INFLAMMATORY INFILTRATE; MAJOR CLINICAL STUDY; MESIAL TEMPORAL LOBE EPILEPSY; MULTIPLEX POLYMERASE CHAIN REACTION; MUTAGENESIS; NERVOUS SYSTEM INFLAMMATION; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; T LYMPHOCYTE; ADULT; FEMALE; GENETICS; HIGH THROUGHPUT SEQUENCING; HIPPOCAMPUS; INFLAMMATION; MALE; METABOLISM; MIDDLE AGED; NERVE CELL; PATHOLOGY; PROCEDURES; SCLEROSIS; TEMPORAL LOBE EPILEPSY;

ADULT; DNA, MITOCHONDRIAL; EPILEPSY, TEMPORAL LOBE; FEMALE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HIPPOCAMPUS; HUMANS; INFLAMMATION; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEURONS; SCLEROSIS;

EID: 84962558331     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-016-1561-1     Document Type: Article

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