Human Umbilical Vein Endothelial Cells foster conversion of CD4+ CD25- Foxp3- T cells into CD4+ Foxp3+ Regulatory T Cells via Transforming Growth Factor-β

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Oettel, Anika ^a   Lorenz, Mario ^b,c   Stangl, Verena ^b,c   Costa, Serban Dan ^a   Zenclussen, Ana Claudia ^a   Schumacher, Anne ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

ADULT; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; COCULTURE; CYTOLOGY; FEMALE; GENE EXPRESSION REGULATION; HUMAN; MALE; METABOLISM; PREGNANCY; PROCEDURES; REGULATORY T LYMPHOCYTE; UMBILICAL VEIN ENDOTHELIAL CELL;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; PREGNANCY; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 84962548148     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep23278     Document Type: Article

References (39)

1. Lapaire, O., Holzgreve, W., Oosterwijk, J. C., Brinkhaus, R., Bianchi, D. W. Georg Schmorl on trophoblasts in the maternal circulation, Placenta 28, 1-5 (2007).
2. Walknowska, J., Conte, F. A., Grumbach, M. M. Practical and theoretical implications of fetal-maternal lymphocyte transfer. Lancet 1, 1119-1122 (1969).
3. Schroder, J., La Chapelle, A. de. Fetal lymphocytes in the maternal blood. Blood 39, 153-162 (1972).
4. Gotherstrom, C., Johnsson, A. M., Mattsson, J., Papadogiannakis, N., Westgren, M. Identification of maternal hematopoietic cells in a 2nd-trimester fetus. Fetal. Diagn. Ther. 20, 355-358 (2005).
5. Srivatsa, B., Srivatsa, S., Johnson, K. L., Bianchi, D. W. Maternal cell microchimerism in newborn tissues. J. Pediatr. 142, 31-35 (2003).
6. Loubiere, L. S. et al. Maternal microchimerism in healthy adults in lymphocytes, monocyte/macrophages and NK cells. Lab. Invest. 86, 1185-1192 (2006).
7. Stevens, A. M., Hermes, H. M., Rutledge, J. C., Buyon, J. P., Nelson, J. L. Myocardial-tissue-specific phenotype of maternal microchimerism in neonatal lupus congenital heart block. Lancet 362, 1617-1623 (2003).
8. Artlett, C. M. et al. Chimeric cells of maternal origin in juvenile idiopathic inflammatory myopathies. Childhood Myositis Heterogeneity Collaborative Group. Lancet 356, 2155-2156 (2000).
9. Reed, A. M., Picornell, Y. J., Harwood, A., Kredich, D. W. Chimerism in children with juvenile dermatomyositis. Lancet 356, 2156-2157 (2000).
10. Suskind, D. L. et al. Maternal microchimerism in the livers of patients with biliary atresia. BMC Gastroenterol. 4, 14 (2004).
11. Kobayashi, H. et al. Maternal microchimerism in biliary atresia. J. Pediatr. Surg. 42, 987-91; discussion 991 (2007).
12. Quinello, C. et al. Phenotypic Differences in Leucocyte Populations among Healthy Preterm and Full-Term Newborns. Scand. J. Immunol. 80, 57-70 (2014).
13. Fu, B., Tian, Z., Wei, H. Subsets of human natural killer cells and their regulatory effects. Immunology 141, 483-489 (2014).
14. Hall, J. M. et al. Detection of maternal cells in human umbilical cord blood using fluorescence in situ hybridization. Blood 86, 2829-2832 (1995).
15. Mold, J. E. et al. Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero. Science 322, 1562-1565 (2008).
16. Rodig, N. et al. Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis. Eur. J. Immunol. 33, 3117-3126 (2003).
17. Patel, K. D. Mechanisms of selective leukocyte recruitment from whole blood on cytokine-activated endothelial cells under flow conditions. J. Immunol. 162, 6209-6216 (1999).
18. Mestas, J., Hughes, C. C. Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involves lipid raft aggregation. J. Immunol. 167, 4378-4385 (2001).
19. Schumacher, A., Zenclussen, A. C. Regulatory T Cells: Regulators of Life. Am. J. Reprod. Immunol. 72, 158-170 (2014).
20. Yagi, H. et al. Crucial role of FOXP3 in the development and function of human CD25+ CD4+ regulatory T cells. Int. Immunol. 16, 1643-1656 (2004).
21. Groux, H. et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389, 737-742 (1997).
22. Chen, W. et al. Conversion of peripheral CD4+ CD25? naive T cells to CD4+ CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886 (2003).
23. Adams, P. W., Lee, H. S., Ferguson, R. M., Orosz, C. G. Alloantigenicity of human endothelial cells. II. Analysis of interleukin 2 production and proliferation by T cells after contact with allogeneic endothelia, Transplantation 57, 115-122 (1994).
24. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases, J. Immunol. 155, 1151-1164 (1995).
25. Fritzsching, B. et al. Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death. Blood 108, 3371-3378 (2006).
26. Li, L. CD4+ CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy. Blood 106, 3068-3073 (2005).
27. Tang, J., Li, B.-q., Ruan, J., Zhang, L.-j. [Expression of Foxp3 in CD4+ CD25 high Treg cells of neonatal cord blood], Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24, 365-367 (2008).
28. Godfrey, W. R. et al. Cord blood CD4(+ )CD25(+ )-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood 105, 750-758 (2005).
29. Fan, H. et al. Comparative study of regulatory T cells expanded ex vivo from cord blood and adult peripheral blood. Immunology 136, 218-230 (2012).
30. Fu, S. et al. TGF-beta induces Foxp3+ T-regulatory cells from CD4+ CD25? precursors. Am. J. Transplant. 4, 1614-1627 (2004).
31. Fantini, M. C. et al. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+ CD25? T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. (Baltimore, Md. : 1950) 172, 5149-5153 (2004).
32. Peng, Y., Laouar, Y., Li, M. O., Green, E. A., Flavell, R. A. TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+ CD25+ regulatory T cells responsible for protection against diabetes. PNAS 101, 4572-4577 (2004).
33. Huber, S. et al. Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+ CD25+ T cells. J. Immunol. (Baltimore, Md. : 1950) 173, 6526-6531 (2004).
34. Carambia, A. et al. TGF-?-dependent induction of CD4+ CD25+ Foxp3+ Tregs by liver sinusoidal endothelial cells. J. Hepatol. 61, 594-599 (2014).
35. Lorenz, M. et al. Does cellular sex matter? Dimorphic transcriptional differences between female and male endothelial cells. Atherosclerosis 240, 61-72 (2015).
36. Muenchhoff, M., Goulder, P. J. R. Sex differences in pediatric infectious diseases. J. Infect. Dis. 209 Suppl 3, S120-6 (2014).
37. Ku, C. C. Kappler, J., Marrack, P. The growth of the very large CD8+ T cell clones in older mice is controlled by cytokines. J. Immunol. 166, 2186-2193 (2001).
38. van der Vliet, H. J. J. et al. Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells, J. Immunol. (Baltimore, Md. : 1950) 180, 7287-7293 (2008).
39. Zenclussen, A. C. et al. Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+ CD25+ T regulatory cells prevents fetal rejection in a murine abortion model. Am. J. Pathol. 166, 811-822 (2005).