Cytokine profile and lymphocyte subsets in type 2 diabetes

Brazilian Journal of Medical and Biological Research

Volumn 49, Issue 4, 2016, Pages

  Francisco, C O ^a   Catai, A M ^a   Moura Tonello, S C G ^a   Arruda, L C M ^b,c   Lopes, S L B ^a   Benze, B G ^a   Del Vale, A M ^a   Malmegrim, K C R ^c   Leal, A M O ^a  

^a FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^b Centro de Terapia Celular   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cytokines; Inflammation; Lymphocytes; Type 2 diabetes mellitus

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; GAMMA INTERFERON; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE;

ADULT; ARTICLE; BLOOD ANALYSIS; BODY MASS; CASE CONTROL STUDY; CD3+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLOW CYTOMETRY; HUMAN; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; T LYMPHOCYTE; BLOOD; CELLULAR IMMUNITY; CYTOLOGY; IMMUNOLOGY; LYMPHOCYTE COUNT; METABOLISM; NONPARAMETRIC TEST; REFERENCE VALUE; T LYMPHOCYTE SUBPOPULATION;

ADULT; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; CYTOKINES; DIABETES MELLITUS, TYPE 2; FLOW CYTOMETRY; HUMANS; IMMUNITY, CELLULAR; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; REFERENCE VALUES; STATISTICS, NONPARAMETRIC; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 84962494004     PISSN: None     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/1414-431X20155062     Document Type: Article

References (15)

1. Nikolajczyk BS, Jagannathan-Bogdan M, Shin H, Gyurko R. State of the union between metabolism and the immune system in type 2 diabetes. Genes Immun 2011; 12: 239–250, doi: 10.1038/gene.2011.14.
2. Snyder-Cappione JE, Nikolajczyk BS. When diet and exercise are not enough, think immunomodulation. Mol Aspects Med 2013; 34: 30–38, doi: 10.1016/j.mam.2012.10.003.
3. Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 2011; 11: 98–107, doi: 10.1038/nri2925.
4. Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 2009; 15: 930–939, doi: 10.1038/nm.2002.
5. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003; 26 (Suppl1): S5–S20.
6. Francisco CO, Catai AM, Moura-Tonello SC, Lopes SL, Benze BG, Del Vale AM, et al. Cardiorespiratory fitness, pulmonary function and C-reactive protein levels in nonsmoking individuals with diabetes. Braz J Med Biol Res 2014; 47: 426–431, doi: 10.1590/1414-431X20143370.
7. Jagannathan-Bogdan M, McDonnell ME, Shin H, Rehman Q, Hasturk H, Apovian CM, et al. Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes. J Immunol 2011; 186: 1162–1172.
8. Sumarac-Dumanovic M, Jeremic D, Pantovic A, Janjetovic K, Stamenkovic-Pejkovic D, Cvijovic G, et al. Therapeutic improvement of glucoregulation in newly diagnosed type 2 diabetes patients is associated with a reduction of IL-17 levels. Immunobiology 2013; 218: 1113–1118, doi: 10.1016/j.imbio.2013.03.002.
9. Zhao R, Tang D, Yi S, Li W, Wu C, Lu Y, et al. Elevated peripheral frequencies of Th22 cells: a novel potent participant in obesity and type 2 diabetes. PLoS One 2014; 9: e85770, doi: 10.1371/journal.pone.0085770.
10. Mocellin S, Marincola F, Rossi CR, Nitti D, Lise M. The multifaceted relationship between IL-10 and adaptive immunity: putting together the pieces of a puzzle. Cytokine Growth Factor Rev 2004; 15: 61–76, doi: 10.1016/j.cytogfr.2003.11.001.
11. McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, et al. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by Tcells and restrain T(H)-17 cell-mediated pathology. Nat Immunol 2007; 8: 1390–1397, doi: 10.1038/ni1539.
12. Martin-Orozco N, Chung Y, Chang SH, Wang YH, Dong C. Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur J Immunol 2009; 39: 216–224, doi: 10.1002/eji.200838475.
13. Utsal L, Tillmann V, Zilmer M, Maestu J, Purge P, Jurimae J, et al. Elevated serum IL-6, IL-8, MCP-1, CRP, and IFNgamma levels in 10- to 11-year-old boys with increased BMI. Horm Res Paediatr 2012; 78: 31–39, doi: 10.1159/000339831.
14. Zeng C, Shi X, Zhang B, Liu H, Zhang L, Ding W, et al. The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications. J Mol Med 2012; 90: 175–186, doi: 10.1007/s00109-011-0816-5.
15. Evia-Viscarra ML, Rodea-Montero ER, Apolinar-Jimenez E, Munoz-Noriega N, Garcia-Morales LM, Leanos-Perez C, et al. The effects of metformin on inflammatory mediators in obese adolescents with insulin resistance: controlled randomized clinical trial. J Pediatr Endocrinol Metab 2012; 25: 41–49, doi: 10.1515/jpem-2011-0469.