Meta-analysis Reveals Genome-Wide Significance at 15q13 for Nonsyndromic Clefting of Both the Lip and the Palate, and Functional Analyses Implicate GREM1 As a Plausible Causative Gene

PLoS Genetics

Volumn 12, Issue 3, 2016, Pages

  Ludwig, Kerstin U ^a   Ahmed, Syeda Tasnim ^b   Böhmer, Anne C ^a   Sangani, Nasim Bahram ^b   Varghese, Sheryil ^b   Klamt, Johanna ^a   Schuenke, Hannah ^a   Gültepe, Pinar ^a   Hofmann, Andrea ^a   Rubini, Michele ^c   Aldhorae, Khalid Ahmed ^d   Steegers Theunissen, Regine P ^e,f   Rojas Martinez, Augusto ^g   Reiter, Rudolf ^h   Borck, Guntram ^h   Knapp, Michael ^a   Nakatomi, Mitsushiro ⁱ   Graf, Daniel ^j,k   Mangold, Elisabeth ^a   Peters, Heiko ^b  

^a UNIVERSITY OF BONN   (Germany)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF FERRARA   (Italy)

^d THAMAR UNIVERSITY   (Yemen)

^e ERASMUS MEDICAL CENTER   (Netherlands)

^f RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^g UNIVERSIDAD AUTÓNOMA DE NUEVO LEÓN   (Mexico)

^h UNIVERSITY OF ULM   (Germany)

ⁱ KYUSHU DENTAL COLLEGE   (Japan)

^j UNIVERSITY OF ZURICH   (Switzerland)

^k UNIVERSITY OF ALBERTA   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 15Q; CLEFT LIP PALATE; CRANIOFACIAL DEVELOPMENT; EMBRYO DEVELOPMENT; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE PHENOTYPE CORRELATION; GREMLIN 1 GENE; HARD PALATE; HUMAN; LIP; NONHUMAN; SOFT PALATE; ABNORMALITIES; ALLELE; ANIMAL; BRAIN; CAUCASIAN; CHROMOSOME 15; CLEFT LIP; CLEFT PALATE; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; META ANALYSIS; MOUSE; PATHOLOGY;

GREM1 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ALLELES; ANIMALS; BRAIN; CHROMOSOMES, HUMAN, PAIR 15; CLEFT LIP; CLEFT PALATE; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE;

EID: 84962446651     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005914     Document Type: Article

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