Role of bile acid-regulated nuclear receptor FXR and G protein-coupled receptor TGR5 in regulation of cardiorenal syndrome (Cardiovascular Disease and Chronic Kidney Disease)

Hypertension

Volumn 67, Issue 6, 2016, Pages 1080-1084

  Levi, Moshe ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ALKALINE PHOSPHATASE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BILE ACID; CHOLESTEROL; COLLAGEN TYPE 4; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOKINE; FARNESOID X RECEPTOR; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 5; HORMONE RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LEPTIN RECEPTOR; LIPOPROTEIN RECEPTOR; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; MANGANESE SUPEROXIDE DISMUTASE; OBETICHOLIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PLASMINOGEN ACTIVATOR INHIBITOR 1; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1A; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VASCULOTROPIN; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; GPBAR1 PROTEIN, HUMAN;

ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL CALCIFICATION; CARDIORENAL SYNDROME; DIABETIC NEPHROPATHY; DIET INDUCED OBESITY; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; GLOMERULOSCLEROSIS; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; KIDNEY HYPERTROPHY; LIPID METABOLISM; LOSS OF FUNCTION MUTATION; METABOLIC SYNDROME X; MICROALBUMINURIA; MITOCHONDRIAL BIOGENESIS; OBESITY; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; AGONISTS; ANIMAL; DIABETES MELLITUS; DISEASE EXACERBATION; DRUG EFFECTS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PROGNOSIS;

ANIMALS; CARDIO-RENAL SYNDROME; DIABETES MELLITUS; DISEASE PROGRESSION; HUMANS; LIPID METABOLISM; OBESITY; PROGNOSIS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84962428833     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.115.06417     Document Type: Article

References (30)

1. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY, Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 2004 351 1296 1305. doi: 10.1056/NEJMoa041031
2. Moody WE, Ferro CJ, Edwards NC, Chue CD, Lin EL, Taylor RJ, Cockwell P, Steeds RP, Townend JN, CRIB-Donor Study Investigators Cardiovascular Effects of Unilateral Nephrectomy in Living Kidney Donors. Hypertension 2016 67 368 377. doi: 10.1161/HYPERTENSIONAHA.115.06608
3. Di Lullo L, House A, Gorini A, Santoboni A, Russo D, Ronco C, Chronic kidney disease and cardiovascular complications. Heart Fail Rev 2015 20 259 272. doi: 10.1007/s10741-014-9460-9
4. Husain-Syed F, McCullough PA, Birk HW, Renker M, Brocca A, Seeger W, Ronco C, Cardio-Pulmonary-Renal Interactions: A Multidisciplinary Approach. J Am Coll Cardiol 2015 65 2433 2448. doi: 10.1016/j.jacc.2015.04.024
5. Palazzuoli A, Lombardi C, Ruocco G, Padeletti M, Nuti R, Metra M, Ronco C, Chronic kidney disease and worsening renal function in acute heart failure: different phenotypes with similar prognostic impact [published online ahead of print June 4, 2015]? Eur Heart J Acute Cardiovasc Care. doi: 10.1177/2048872615589511. http://acc.sagepub.com/content/early/2015/05/18/2048872615589511.long. Accessed March 18, 2016
6. Clementi A, Virzì GM, Brocca A, de Cal M, Pastori S, Clementi M, Granata A, Vescovo G, Ronco C, Advances in the pathogenesis of cardiorenal syndrome type 3. Oxid Med Cell Longev 2015 2015 148082. doi: 10.1155/2015/148082
7. Sun L, Halaihel N, Zhang W, Rogers T, Levi M, Role of sterol regulatory element-binding protein 1 in regulation of renal lipid metabolism and glomerulosclerosis in diabetes mellitus. J Biol Chem 2002 277 18919 18927. doi: 10.1074/jbc.M110650200
8. Wang XX, Jiang T, Shen Y, Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model. Diabetes 2010 59 2916 2927. doi: 10.2337/db10-0019
9. Proctor G, Jiang T, Iwahashi M, Wang Z, Li J, Levi M, Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes. Diabetes 2006 55 2502 2509. doi: 10.2337/db05-0603
10. Jiang T, Wang Z, Proctor G, Moskowitz S, Liebman SE, Rogers T, Lucia MS, Li J, Levi M, Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway. J Biol Chem 2005 280 32317 32325. doi: 10.1074/jbc.M500801200
11. Wang XX, Jiang T, Shen Y, Adorini L, Pruzanski M, Gonzalez FJ, Scherzer P, Lewis L, Miyazaki-Anzai S, Levi M, The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria. Am J Physiol Renal Physiol 2009 297 F1587 F1596. doi: 10.1152/ajprenal.00404.2009
12. Wang Z, Jiang T, Li J, Proctor G, McManaman JL, Lucia S, Chua S, Levi M, Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes. Diabetes 2005 54 2328 2335
13. Jiang T, Wang XX, Scherzer P, Wilson P, Tallman J, Takahashi H, Li J, Iwahashi M, Sutherland E, Arend L, Levi M, Farnesoid X receptor modulates renal lipid metabolism, fibrosis, and diabetic nephropathy. Diabetes 2007 56 2485 2493. doi: 10.2337/db06-1642
14. Jiang T, Liebman SE, Lucia MS, Li J, Levi M, Role of altered renal lipid metabolism and the sterol regulatory element binding proteins in the pathogenesis of age-related renal disease. Kidney Int 2005 68 2608 2620. doi: 10.1111/j.1523-1755.2005.00733.x
15. Jiang T, Liebman SE, Lucia MS, Phillips CL, Levi M, Calorie restriction modulates renal expression of sterol regulatory element binding proteins, lipid accumulation, and age-related renal disease. J Am Soc Nephrol 2005 16 2385 2394. doi: 10.1681/ASN.2004080701
16. Brosius FC III, Alpers CE, Bottinger EP, Animal Models of Diabetic Complications Consortium Mouse models of diabetic nephropathy. J Am Soc Nephrol 2009 20 2503 2512. doi: 10.1681/ASN.2009070721
17. Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, Gonzalez FJ, Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 2000 102 731 744
18. Watanabe M, Houten SM, Wang L, Moschetta A, Mangelsdorf DJ, Heyman RA, Moore DD, Auwerx J, Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest 2004 113 1408 1418. doi: 10.1172/JCI21025
19. Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B, Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009 89 147 191. doi: 10.1152/physrev.00010.2008
20. Hu Z, Ren L, Wang C, Liu B, Song G, Effect of chenodeoxycholic acid on fibrosis, inflammation and oxidative stress in kidney in high-fructose-fed Wistar rats. Kidney Blood Press Res 2012 36 85 97. doi: 10.1159/000341485
21. Bae EH, Choi HS, Joo SY, Kim IJ, Kim CS, Choi JS, Ma SK, Lee J, Kim SW, Farnesoid X receptor ligand prevents cisplatin-induced kidney injury by enhancing small heterodimer partner. PLoS One 2014 9 e86553. doi: 10.1371/journal.pone.0086553
22. Gai Z, Hiller C, Chin SH, Hofstetter L, Stieger B, Konrad D, Kullak-Ublick GA, Uninephrectomy augments the effects of high fat diet induced obesity on gene expression in mouse kidney. Biochim Biophys Acta 2014 1842 1870 1878. doi: 10.1016/j.bbadis.2014.07.001
23. Gai Z, Gui T, Hiller C, Kullak-Ublick GA, Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized Obese Mice. J Biol Chem 2016 291 2397 2411. doi: 10.1074/jbc.M115.694323
24. Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y, Fujino M, A G protein-coupled receptor responsive to bile acids. J Biol Chem 2003 278 9435 9440. doi: 10.1074/jbc.M209706200
25. Katsuma S, Hirasawa A, Tsujimoto G, Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. Biochem Biophys Res Commun 2005 329 386 390. doi: 10.1016/j.bbrc.2005.01.139
26. Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J, Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 2006 439 484 489. doi: 10.1038/nature04330
27. Wang XX, Edelstein MH, Gafter U, Qiu L, Luo Y, Dobrinskikh E, Lucia S, Adorini L, D'Agati VD, Levi J, Rosenberg A, Kopp JB, Gius DR, Saleem MA, Levi M, G protein-coupled bile acid receptor tgr5 activation inhibits kidney disease in obesity and diabetes [published online ahead of print September 30, 2015]. J Am Soc Nephrol. doi: 10.1681/ASN.2014121271. http://jasn.asnjournals.org/content/early/2016/02/09/ASN.2014121271.long. Accessed March 18, 2016
28. Rizzo G, Passeri D, De Franco F, Ciaccioli G, Donadio L, Rizzo G, Orlandi S, Sadeghpour B, Wang XX, Jiang T, Levi M, Pruzanski M, Adorini L, Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist. Mol Pharmacol 2010 78 617 630. doi: 10.1124/mol.110.064501
29. Miyazaki-Anzai S, Levi M, Kratzer A, Ting TC, Lewis LB, Miyazaki M, Farnesoid X receptor activation prevents the development of vascular calcification in ApoE-/- mice with chronic kidney disease. Circ Res 2010 106 1807 1817. doi: 10.1161/CIRCRESAHA.109.212969
30. Miyazaki-Anzai S, Masuda M, Levi M, Keenan AL, Miyazaki M, Dual activation of the bile acid nuclear receptor FXR and G-protein-coupled receptor TGR5 protects mice against atherosclerosis. PLoS One 2014 9 e108270. doi: 10.1371/journal.pone.0108270