Serotonin Transporter Gene (SLC6A4) Methylation Associates With Neonatal Intensive Care Unit Stay and 3-Month-Old Temperament in Preterm Infants

Child Development

Volumn 87, Issue 1, 2016, Pages 38-48

  Montirosso, Rosario ^a   Provenzi, Livio ^a   Fumagalli, Monica ^b   Sirgiovanni, Ida ^b   Giorda, Roberto ^a   Pozzoli, Uberto ^a   Beri, Silvana ^a   Menozzi, Giorgia ^a   Tronick, Ed ^c   Morandi, Francesco ^d   Mosca, Fabio ^b   Borgatti, Renato ^a  

^a SCIENTIFIC INSTITUTE   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF MASSACHUSETTS   (United States)

^d Sacra Famiglia Hospital   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN;

DNA METHYLATION; FEMALE; FOLLOW UP; GENETICS; HUMAN; INFANT; MALE; MENTAL STRESS; METABOLISM; NEONATAL INTENSIVE CARE UNIT; NEWBORN; PHYSIOLOGY; PREMATURITY; TEMPERAMENT;

DNA METHYLATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT; INFANT, NEWBORN; INFANT, PREMATURE; INTENSIVE CARE UNITS, NEONATAL; MALE; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRESS, PSYCHOLOGICAL; TEMPERAMENT;

EID: 84962407413     PISSN: 00093920     EISSN: 14678624     Source Type: Journal    
DOI: 10.1111/cdev.12492     Document Type: Article

References (41)

1. Ansorge, M. S., Zhou, M., Lira, A., Hen, R., & Gingrich, J. A. (2004). Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science, 306, 879-881. doi:10.1126/science.1101678
2. Auerbach, J., Geller, V., Lezer, S., Shinwell, E., Belmaker, R. H., Levine, J., & Ebstein, R. (1999). Dopamine D4 receptor (D4DR) and serotonin transporter promoter (5-HTTLPR) polymorphisms in the determination of temperament in 2-month-old infants. Molecular Psychiatry, 4, 369-373. doi:10.1038/sj.mp.4000531
3. Banaschewski, T., Becker, K., Scherag, S., Franke, B., & Coghill, D. (2010). Molecular genetics of attention-deficit/hyperactivity disorder: An overview. European Child and Adolescence Psychiatry, 19, 237-257. doi:10.1007/s00787-010-0090-z
4. Beck, A. T., Ward, C. H., Mendelson, M., Mock, J., & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561-571.
5. Britton, J. R. (2011). Infant temperament and maternal anxiety and depressed mood in the early postpartum period. Women and Health, 51, 55-71. doi:10.1080/03630242.2011.540741
6. Brummelte, S., Grunau, R. E., Chau, V., Poskitt, K. J., Brant, R., Vinall, J., ... Miller, S. P. (2012). Procedural pain and brain development in premature newborns. Annals of Neurology, 71, 385-396. doi:10.1002/ana.22267
7. Champagne, F. A., & Curley, J. P. (2009). Epigenetic mechanisms mediating the long-term effects of maternal care on development. Neuroscience and Biobehavioral Reviews, 33, 593-600. doi:10.1002/dev.20436
8. Chau, C. M. Y., Ranger, M., Sulistyoningrum, D., Devlin, A. M., Oberlander, T. F., & Grunau, R. E. (2014). Neonatal pain and COMT Val158Met genotype in relation to serotonin transporter (SLC6A4) promoter methylation in very preterm children at school age. Frontiers in Behavioral Neuroscience, 8, 409. doi:10.3389/fnbeh.2014.00409
9. Cosentino-Rocha, L., Klein, V. C., & Linhares, M. B. (2014). Effects of preterm birth and gender on temperament and behavior in children. Infant Behavior & Development, 37, 446-456. doi:10.1016/j.infbeh.2014.04.003
10. Devlin, A. M., Brain, U., Austin, J., & Oberlander, T. F. (2010). Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth. PLoS ONE, 5, e12201. doi:10.1371/journal.pone.0012201
11. Ebstein, R. P., Levine, J., Geller, V., Auerbach, J., Gritsenko, I., & Belmaker, R. H. (1998). Dopamine D4 receptor and serotonin transporter promoter in the determination of neonatal temperament. Molecular Psychiatry, 3, 238-246. doi:10.1038/sj.mp.4000363
12. Flacking, R., Lehtonen, L., Thomson, G., Axelin, A., Ahlqvist, S., Moran, V. H., ... Dyakes, F. (2012). Closeness and separation in neonatal intensive care. Acta Paediatrica, 101, 1032-1037. doi:10.1111/j.1651-2227.2012.02787.x
13. Fox, E., Ridgewell, A., & Ashwin, C. (2009). Looking on the bright side: Biased attention and the human serotonin transporter gene. Proceedings of the Royal Society B, 276, 1747-1751. doi:10.1098/rspb.2008.1788
14. Gartstein, M. A., & Rothbart, M. K. (2003). Studying infant temperament via the Revised Infant Behavior Questionnaire. Infant Behavior & Development, 26, 64-86. doi:doi: 10.1016/j.earlhumdev.2007.01.003
15. Grunau, R. E. (2013). Neonatal pain in very preterm infants: Long-term effects on brain, neurodevelopment and pain reactivity. Rambam Maimonides Medical Journal, 4, e0025. doi:10.5041/RMMJ.10132
16. Hollingshead, A. B. (1975). Four Factor Index of Social Status. New Haven, CT: Yale University Press.
17. Hughes, M. B., Shults, J., McGrath, J., & Medoff-Cooper, B. (2002). Temperament characteristics of premature infants in the first year of life. Journal of Developmental and Behavioral Pediatrics, 23, 430-435.
18. Ivorra, J. L., Sanjuan, J., Jover, M., Carot, J. M., Frutos, R., & Molto, M. D. (2010). Gene-environment interaction of child temperament. Journal of Developmental and Behavioral Pediatrics, 31, 545-554. doi:10.1097/DBP.0b013e3181ee4072
19. Klein, V. C., Gaspardo, C. M., Martinez, F. E., Grunau, R. E., & Linhares, M. B. (2011). Pain and distress reactivity and recovery as early predictors of temperament in toddlers born preterm. Early Human Development, 85, 569-576. doi:10.1016/j.earlhumdev.2009.06.001
20. Lakatos, K., Nemoda, Z., Birkas, E., Ronai, Z., Kovacs, E., Ney, K., ... Gervai, J. (2003). Association of D4 dopamine receptor gene and serotonin transporter promoter polymorphisms with infants' response to novelty. Molecular Psychiatry, 8, 90-97. doi:10.1038/sj.mp.4001212
21. Langerock, N., van Hanswijck de Jongeb, L., Bickle Graz, M., Hüppib, P. S., Borradori Tolsa, C., & Barisnikova, K. (2013). Emotional reactivity at 12 months in very preterm infants born at <29 weeks of gestation. Infant Behavior & Development, 36, 289-297. doi:10.1016/j.infbeh.2013.02.006
22. Lesch, K. P. (2011). When the serotonin transporter gene meets adversity: The contribution of animal models to understanding epigenetic mechanisms in affective disorders and resilience. Current Topics in Behavioral Neurosciences, 7, 251-280. doi:10.1007/7854_2010_109
23. Montirosso, R., Cozzi, P., Putnam, S. P., Gartstein, M. A., & Borgatti, R. (2011). Studying cross-cultural differences in temperament in the first year of life: United States and Italy. International Journal of Behavioral Development, 35, 27-37. doi:10.1177/0165025410368944
24. Montirosso, R., Cozzi, P., Trojan, S., Bellù, R., Zanini, R., & Borgatti, R. (2005). Temperamental style in preterms and fullterms aged 6-12 months of age. Italian Journal of Pediatrics, 31, 108-115.
25. Montirosso, R., Del Prete, A., Bellù, R., Tronick, E., Borgatti, R., & Neonatal Adequate Care for Quality of Life (NEO-ACQUA) Study Group. (2012). Level of NICU quality of developmental care and neurobehavioral performance in very preterm infants. Pediatrics, 129, e1129-e1137. doi:10.1542/peds.2011-0813
26. Montirosso, R., & Provenzi, L. (2015). Implications of epigenetics and stress regulation on research and developmental care of preterm infants. Journal of Obstetric, Gynecologic & Neonatal Nursing, 44, 174-182. doi:10.1111/1552-6909.12559
27. Montirosso, R., Provenzi, L., Tavian, D., Morandi, F., Bonanomi, A., Missaglia, S., ... Borgatti, R. (2015). Social stress regulation in 4-month-old infants: Contribution of maternal social engagement and infants' 5-HTTLPR genotype. Early Human Development, 91, 173-179. doi:10.1016/j.earlhumdev.2015.01.010
28. Nygaard, E., Smith, L., & Torgersen, A. M. (2002). Temperament in children with Down syndrome and in prematurely born children. Scandinavian Journal of Psychology, 43, 61-71. doi:10.1111/1467-9450.00269
29. Oberlander, T. F., Weinberg, J., Papsdorf, M., Grunau, R., Misri, S., & Devlin, A. M. (2008). Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics, 3, 97-106. doi:10.4161/epi.3.2.6034
30. Philibert, R., Madan, A., Andersen, A., Cadoret, R., Packer, H., & Sandhu, H. (2007). Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. American Journal of Medical Genetics, 144B, 101-105. doi:10.1002/ajmg.b.30414
31. Philibert, R. A., Sandhu, H., Hollenbeck, N., Gunter, T., Adams, W., & Madan, A. (2008). The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. American Journal of Medical Genetics, 147B, 543-549. doi:10.1002/ajmg.b.30657
32. Provenzi, L., & Barello, S. (2015). Behavioral epigenetics of family-centered care in the Neonatal Intensive Care Unit. JAMA Pediatrics, 169, 697-698. doi:10.1001/jamapediatrics.2015.0367
33. Provenzi, L., Fumagalli, M., Sirgiovanni, I., Giorda, R., Pozzoli, U., Morandi, F., ... Montirosso, R. (2015). Pain-related stress during the Neonatal Intensive Care Unit stay and SLC6A4 methylation in very preterm infants. Frontiers in Behavioral Neuroscience, 9, 99. doi:10.3389/fnbeh.2015.00099
34. Provenzi, L., & Montirosso, R. (2015). "Epigen-Ethics" in the Neonatal Intensive Care Unit: Conveying complexity in health care for preterm children. JAMA Pediatrics, 169, 617-618. doi:10.1001/jamapediatrics.2015.43
35. Schwartz, C. E., Kunwar, P. S., Greve, D. N., Moran, L. R., Viner, J. C., Covino, J. M., ... Wallace, S. R. (2010). Structural differences in adult orbital and ventromedial prefrontal cortex predicted by infant temperament at 4 months of age. Archives of General Psychiatry, 67, 78-84. doi:10.1001/archgenpsychiatry.2009.171
36. Smith, G. C., Gutovich, J., Smyser, C., Pineda, R., Newnham, C., Tjoeng, T. H., ... Inder, T. (2011). Neonatal Intensive Care Unit stress is associated with brain development in preterm infants. Annals of Neurology, 70, 541-549. doi:10.1002/ana.22545
37. Spielberger, C. D. (1985). Assessment of state and trait anxiety: Conceptual and methodological issues. Southern Psychologist, 2, 6-16.
38. Tabano, S., Colapietro, P., Cetin, I., Grati, F. R., Zanutto, S., Mando, C., ... Miozzo, M. (2010). Epigenetic modulation of the IGF2/H19 imprinted domain in human embryonic and extra-embryonic compartments and its possible role in fetal growth restriction. Epigenetics, 5, 313-324. doi:10.4161/epi.5.4.11637
39. van IJzendoorn, M. H., Caspers, K., Bakermans-Kranenburg, M. J., Beach, S. R., & Philibert, R. (2010). Methylation matters: Interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma. Biological Psychiatry, 68, 405-407. doi:10.1016/j.biopsych.2010.05.008
40. Vijayendran, M., Beach, S. R., Plume, J. M., Brody, G. H., & Philibert, R. A. (2012). Effects of genotype and child abuse on DNA methylation and gene expression at the serotonin transporter. Frontiers in Psychiatry, 3, 55. doi:10.3389/fpsyt.2012.00055
41. Walker, S. M., Franck, L. S., Fitzgerald, M., Myles, J., Stocks, J., & Marlow, N. (2009). Long-term impact of neonatal intensive care and surgery on somatosensory perception in children born extremely preterm. Pain, 141, 79-87. doi:10.1016/j.pain.2008.10.012