Mechanisms of Working Memory Impairment in Schizophrenia

Biological Psychiatry

Volumn 80, Issue 8, 2016, Pages 617-626

  Van Snellenberg, Jared X ^a,b,c   Girgis, Ragy R ^a,b   Horga, Guillermo ^a,b   van de Giessen, Elsmarieke ^a,b,f   Slifstein, Mark ^a,b   Ojeil, Najate ^a,b   Weinstein, Jodi J ^a,b   Moore, Holly ^a,d   Lieberman, Jeffrey A ^a,e   Shohamy, Daphna ^g   Smith, Edward E ^c,g   Abi Dargham, Anissa ^a,b  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b Dept Neurosci New York Stt P   (United States)

^c Cognitive Neuroscience ^*  (United States)

^d Roche Pharmaceutical Research and Early Development   (United States)

^e NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^f UNIVERSITY OF AMSTERDAM   (Netherlands)

^g Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Cognitive impairment; Functional magnetic resonance imaging; Inverted U; Schizophrenia; Short term memory; Working memory

Indexed keywords

ARIPIPRAZOLE; CHLORPROMAZINE; HALOPERIDOL; LURASIDONE; PALIPERIDONE; RISPERIDONE;

ADULT; ANTERIOR INSULA; ARTICLE; CONTROLLED STUDY; CUNEUS; DORSOLATERAL PREFRONTAL CORTEX; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL NEUROIMAGING; FUSIFORM GYRUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDIAL PREFRONTAL CORTEX; MEMORY DISORDER; OCCIPITAL LOBE; POSTERIOR PARIETAL CORTEX; PRIORITY JOURNAL; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SCHIZOPHRENIFORM DISORDER; SUPPLEMENTARY MOTOR AREA; VISUAL CORTEX; WORKING MEMORY; BRAIN MAPPING; CASE CONTROL STUDY; NERVE TRACT; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; PSYCHOLOGY; SHORT TERM MEMORY; YOUNG ADULT;

ADULT; BRAIN MAPPING; CASE-CONTROL STUDIES; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MEMORY DISORDERS; MEMORY, SHORT-TERM; NEURAL PATHWAYS; NEUROPSYCHOLOGICAL TESTS; OCCIPITAL LOBE; PREFRONTAL CORTEX; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; YOUNG ADULT;

EID: 84962393735     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2016.02.017     Document Type: Article

References (51)

1. 1 Lee, J., Park, S., Working memory impairments in schizophrenia: A meta-analysis. J Abnorm Psychol 114 (2005), 599–611.
2. 2 Green, M.F., What are the functional consequences of neurocognitive deficits in schizophrenia?. Am J Psychiatry 153 (1996), 321–330.
3. 3 Green, M.F., Schizophrenia From a Neurocognitive Perspective: Probing the Impenetrable Darkness. 1998, Allyn & Bacon, Boston, MA.
4. 4 Slifstein, M., van de Geissen, E., Van Snellenberg, J., Thompson, J.L., Narendran, R., Gil, R., et al. Deficits in prefrontal cortical and extra-striatal dopamine release in schizophrenia: A positron emission tomographic functional magnetic resonance imaging study. JAMA Psychiatry 72 (2015), 316–324.
5. 5 Abi-Dargham, A., Mawlawi, O., Lombardo, I., Gil, R., Martinez, D., Huang, Y., et al. Prefrontal dopamine D1 receptors and working memory in schizophrenia. J Neurosci 22 (2002), 3708–3719.
6. 6 Cools, R., D'Esposito, M., Inverted-U-shaped dopamine actions on human working memory and cognitive control. Biol Psychiatry 69 (2011), e113–e125.
7. 7 Egan, M.F., Goldberg, T.E., Kolachana, B.S., Callicott, J.H., Mazzanti, C.M., Straub, R.E., et al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A 98 (2001), 6917–6922.
8. 8 Arnsten, A.F., Wang, M.J., Paspalas, C.D., Neuromodulation of thought: Flexibilities and vulnerabilities in prefrontal cortical network synapses. Neuron 76 (2012), 223–239.
9. 9 Abi-Dargham, A., Gil, R., Krystal, J., Baldwin, R.M., Seibyl, J.P., Bowers, M., et al. Increased striatal dopamine transmission in schizophrenia: Confirmation in a second cohort. Am J Psychiatry 155 (1998), 761–767.
10. 10 Kegeles, L.S., Abi-Dargham, A., Frankle, W.G., Gil, R., Cooper, T.B., Slifstein, M., et al. Increased synaptic dopamine function in associative regions of the striatum in schizophrenia. Arch Gen Psychiatry 67 (2010), 231–239.
11. 11 Laruelle, M., Abi-Dargham, A., van Dyck, C.H., Gil, R., D'Souza, C.D., Erdos, J., et al. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proc Natl Acad Sci U S A 93 (1996), 9235–9240.
12. 12 Goff, D.C., Coyle, J.T., The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. Am J Psychiatry 158 (2001), 1367–1377.
13. 13 Javitt, D.C., Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions. Int Rev Neurobiol 78 (2007), 69–108.
14. 14 Gonzalez-Burgos, G., Lewis, D.A., GABA neurons and the mechanisms of network oscillations: Implications for understanding cortical dysfunction in schizophrenia. Schizophr Bull 34 (2008), 944–961.
15. 15 Hashimoto, T., Volk, D.W., Eggan, S.M., Mirnics, K., Pierri, J.N., Sun, Z., et al. Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia. J Neurosci 23 (2003), 6315–6326.
16. 16 Callicott, J.H., Ramsey, N.F., Tallen, K., Bertolino, A., Knable, M.B., Coppola, R., et al. Functional magnetic resonance imaging brain mapping in psychiatry: Methodological issues illustrated in a study of working memory in schizophrenia. Neuropsychopharmacology 18 (1998), 186–196.
17. 17 Carter, C.S., Perlstein, W., Ganguli, R., Brar, J., Mintun, M., Cohen, J.D., Functional hypofrontality and working memory dysfunction in schizophrenia. Am J Psychiatry 155 (1998), 1285–1287.
18. 18 Stevens, A.A., Goldman-Rakic, P.S., Gore, J.C., Fulbright, R.K., Wexler, B.E., Cortical dysfunction in schizophrenia during auditory word and tone working memory demonstrated by functional magnetic resonance imaging. Arch Gen Psychiatry 55 (1998), 1097–1103.
19. 19 Perlstein, W.M., Carter, C.S., Noll, D.C., Cohen, J.D., Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia. Am J Psychiatry 158 (2001), 1105–1113.
20. 20 Sawaguchi, T., Goldman-Rakic, P.S., D1 dopamine receptors in prefrontal cortex: Involvement in working memory. Science 251 (1991), 947–950.
21. 21 Williams, G.V., Goldman-Rakic, P.S., Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature 376 (1995), 572–575.
22. 22 Callicott, J.H., Bertolino, A., Mattay, V.S., Langheim, F.J., Duyn, J., Coppola, R., et al. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cerebral Cortex 10 (2000), 1078–1092.
23. 23 Manoach, D.S., Gollub, R.L., Benson, E.S., Searl, M.M., Goff, D.C., Halpern, E., et al. Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biol Psychiatry 48 (2000), 99–109.
24. 24 Manoach, D.S., Press, D.Z., Thangaraj, V., Searl, M.M., Goff, D.C., Halpern, E., et al. Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biol Psychiatry 45 (1999), 1128–1137.
25. 25 Van Snellenberg, J.X., Torres, I.J., Thornton, A.E., Functional neuroimaging of working memory in schizophrenia: Task performance as a moderating variable. Neuropsychology 20 (2006), 497–510.
26. 26 Manoach, D.S., Functional neuroimaging investigations of working memory deficits in schizophrenia: Reconciling discrepant findings. Lenzenweger, M.F., Hooley, J.M., (eds.) Principles of Experimental Psychopathology: Essays in Honor of Brendan A Maher, 2002, American Psychological Association, Washington, DC, 119–134.
27. 27 Manoach, D.S., Prefrontal cortex dysfunction during working memory performance in schizophrenia: Reconciling discrepant findings. Schizophr Res 60 (2003), 285–298.
28. 28 Callicott, J.H., Mattay, V.S., Verchinski, B.A., Marenco, S., Egan, M.F., Weinberger, D.R., Complexity of prefrontal cortical dysfunction in schizophrenia: More than up or down. Am J Psychiatry 160 (2003), 2209–2215.
29. 29 Jansma, J.M., Ramsey, N.F., van der Wee, N.J., Kahn, R.S., Working memory capacity in schizophrenia: A parametric fMRI study. Schizophr Res 68 (2004), 159–171.
30. 30 Johnson, M.R., Morris, N.A., Astur, R.S., Calhoun, V.D., Mathalon, D.H., Kiehl, K.A., et al. A functional magnetic resonance imaging study of working memory abnormalities in schizophrenia. Biol Psychiatry 60 (2006), 11–21.
31. 31 Karlsgodt, K.H., Glahn, D.C., van Erp, T.G.M., Therman, S., Huttunen, M., Manninen, M., et al. The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects. Schizophr Res 89 (2007), 191–197.
32. 32 Potkin, S.G., Turner, J.A., Brown, G.G., McCarthy, G., Greve, D.N., Glover, G.H., et al. Working memory and DLPFC inefficiency in schizophrenia: The FBIRN study. Schizophr Bull 35 (2009), 19–31.
33. 33 Schneider, F., Habel, U., Reske, M., Kellermann, T., Stocker, T., Shah, N.J., et al. Neural correlates of working memory dysfunction in first-episode schizophrenia patients: An fMRI multi-center study. Schizophr Res 89 (2007), 198–210.
34. 34 Petrides, M., Milner, B., Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man. Neuropsychologia 20 (1982), 249–262.
35. 35 Van Snellenberg, J.X., Conway, A.R., Spicer, J., Read, C., Smith, E.E., Capacity estimates in working memory: Reliability and interrelationships among tasks. Cogn Affect Behav Neurosci 14 (2014), 106–116.
36. 36 Van Snellenberg, J.X., Slifstein, M., Read, C., Weber, J., Thompson, J.L., Wager, T.D., et al. Dynamic shifts in brain network activation during supracapacity working memory task performance. Hum Brain Mapp 36 (2015), 1245–1264.
37. 37 Karlsgodt, K.H., Sanz, J., van Erp, T.G., Bearden, C.E., Nuechterlein, K.H., Cannon, T.D., Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia. Schizophr Res 108 (2009), 143–150.
38. 38 Wager, T.D., Keller, M.C., Lacey, S.C., Jonides, J., Increased sensitivity in neuroimaging analyses using robust regression. Neuroimage 26 (2005), 99–113.
39. 39 Anticevic, A., Cole, M.W., Murray, J.D., Corlett, P.R., Wang, X.J., Krystal, J.H., The role of default network deactivation in cognition and disease. Trends Cogn Sci 16 (2012), 584–592.
40. 40 Kim, D.I., Manoach, D.S., Mathalon, D.H., Turner, J.A., Mannell, M., Brown, G.G., et al. Dysregulation of working memory and default-mode networks in schizophrenia using independent component analysis, an fBIRN and MCIC study. Hum Brain Mapp 30 (2009), 3795–3811.
41. 41 Metzak, P.D., Riley, J.D., Wang, L., Whitman, J.C., Ngan, E.T.C., Woodward, T.S., Decreased efficiency of task-positive and task-negative networks during working memory in schizophrenia. Schizophr Bull 38 (2012), 803–813.
42. 42 Pomarol-Clotet, E., Salvador, R., Sarro, S., Gomar, J., Vila, F., Martinez, A., et al. Failure to deactivate in the prefrontal cortex in schizophrenia: Dysfunction of the default mode network?. Psychol Med 38 (2008), 1185–1193.
43. 43 Anticevic, A., Repovs, G., Shulman, G.L., Barch, D.M., When less is more: TPJ and default network deactivation during encoding predicts working memory performance. Neuroimage 49 (2010), 2638–2648.
44. 44 Gusnard, D.A., Akbudak, E., Shulman, G.L., Raichle, M.E., Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function. Proc Natl Acad Sci U S A 98 (2001), 4259–4264.
45. 45 Macrae, C.N., Moran, J.M., Heatherton, T.F., Banfield, J.F., Kelley, W.M., Medial prefrontal activity predicts memory for self. Cereb Cortex 14 (2004), 647–654.
46. 46 Mitchell, J.P., Banaji, M.R., Macrae, C.N., The link between social cognition and self-referential thought in the medial prefrontal cortex. J Cogn Neurosci 17 (2005), 1306–1315.
47. 47 Addis, D.R., Wong, A.T., Schacter, D.L., Remembering the past and imagining the future: Common and distinct neural substrates during event construction and elaboration. Neuropsychologia 45 (2007), 1363–1377.
48. 48 Maddock, R.J., Garrett, A.S., Buonocore, M.H., Remembering familiar people: The posterior cingulate cortex and autobiographical memory retrieval. Neuroscience 104 (2001), 667–676.
49. 49 Steinvorth, S., Corkin, S., Halgren, E., Ecphory of autobiographical memories: An fMRI study on recent and remote memory retrieval. Neuroimage 30 (2006), 285–298.
50. 50 Wagner, A.D., Shannon, B.J., Kahn, I., Buckner, R.L., Parietal lobe contributions to episodic memory retrieval. Trends Cogn Sci 9 (2005), 445–453.
51. 51 Woods, S.W., Chlorpromazine equivalent doses for the newer atypical antipsychotics. J Clin Psychiatry 64 (2003), 663–667.