Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type i Modular Polyketide Synthase Subunit

Biochemistry

Volumn 55, Issue 12, 2016, Pages 1677-1680

  Eng, Clara H ^a,d   Yuzawa, Satoshi ^c   Wang, George ^e,f   Baidoo, Edward E K ^e,f   Katz, Leonard ^c,d   Keasling, Jay D ^a,b,c,d,e,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Synthetic Biology Engineering Research Center   (United States)

^e JOINT BIOENERGY INSTITUTE   (United States)

^f LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLANTS (BOTANY); STEREOCHEMISTRY; STEREOSELECTIVITY;

ATTRACTIVE STRATEGIES; BROAD APPLICATION; DOMAIN EXCHANGE; NATURAL PRODUCTS; POLYKETIDE SYNTHASES; RETENTION OF ACTIVITIES; STEREOSPECIFICITY; SUBSTRATE DEPENDENCES;

KETONES;

HYDROXYACID; KETONE; METHYL GROUP; POLYKETIDE; POLYKETIDE SYNTHASE; BACTERIAL PROTEIN; PROTEIN SUBUNIT;

ARTICLE; DIMERIZATION; ENZYME ACTIVE SITE; MOLECULAR RECOGNITION; PRIORITY JOURNAL; STEREOCHEMISTRY; STEREOISOMERISM; CHEMISTRY; ENZYMOLOGY; METABOLISM; PHYSIOLOGY; PROTEIN SUBUNIT; PROTEIN TERTIARY STRUCTURE; STREPTOMYCES AUREOFACIENS;

BACTERIAL PROTEINS; POLYKETIDE SYNTHASES; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; STEREOISOMERISM; STREPTOMYCES AUREOFACIENS;

EID: 84962377300     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.6b00129     Document Type: Article

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