Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes

Diabetes Care

Volumn 38, Issue 10, 2015, Pages 1858-1867

  Xu, Tao ^a   Brandmaier, Stefan ^a   Messias, Ana C ^a   Herder, Christian ^b,c   Draisma, Harmen H M ^d,e,f   Demirkan, Ayse ^g,h   Yu, Zhonghao ^a   Ried, Janina S ^a   Haller, Toomas ⁱ   Heier, Margit ^a   Campillos, Monica ^a   Fobo, Gisela ^a   Stark, Renee ^j   Holzapfel, Christina ^a   Adam, Jonathan ^a   Chi, Shen ^a   Rotter, Markus ^a   Panni, Tommaso ^a   Quante, Anne S ^a,k   He, Ying ^l,m   Prehn, Cornelia ^a   Roemisch Margl, Werner ^a   Kastenmuller, Gabi ^a   Willemsen, Gonneke ^d,e   Pool, Reńe ^d,e   Kasa, Katarina ^g   Van Dijk, Ko Willems ^h   Hankemeier, Thomas ⁿ   Meisinger, Christa ^a   Thorand, Barbara ^a   Ruepp, Andreas ^a   De Angelis, Martin Hrabe ^a,j,o   Li, Yixue ^l,m   Wichmann, H E ^a,k,p   Stratmann, Bernd ^q   Strauch, Konstantin ^a,k   Metspalu, Andres ⁱ   Gieger, Christian ^a   Suhre, Karsten ^a,k,r   Adamski, Jerzy ^a,j,o   Illig, Thomas ^a,s   Rathmann, Wolfgang ^b   Roden, Michael ^b,c,t   Peters, Annette ^a,o,u   Van Duijn, Cornelia M ^f,v   Boomsma, Dorret I ^d,e   Meitinger, Thomas ^a,j   Wang Sattler, Rui ^a,j,o   more..

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

^d VU UNIVERSITY AMSTERDAM   (Netherlands)

^e UNIVERSITY OF AMSTERDAM   (Netherlands)

^f Neuroscience Campus Amsterdam ^*  (Netherlands)

^g ERASMUS MEDICAL CENTER   (Netherlands)

^h LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

ⁱ UNIVERSITY OF TARTU   (Estonia)

^j TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^k UNIVERSITY OF MUNICH   (Germany)

^l SHANGHAI CENTER FOR BIOINFORMATION TECHNOLOGY   (China)

^m Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

ⁿ LEIDEN UNIVERSITY   (Netherlands)

^o GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^p TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^q RUHR UNIVERSITY BOCHUM   (Germany)

^r WEILL CORNELL MEDICAL COLLEGE   (Qatar)

^s HANNOVER MEDICAL SCHOOL   (Germany)

^t Medical Faculty   (Germany)

^u HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^v Center of Medical Systems Biology   (Netherlands)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE 1; GLIPIZIDE; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLCHOLINE; ACYL COENZYME A DESATURASE; ANTIDIABETIC AGENT; DELTA-5 FATTY ACID DESATURASE; FADS2 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETIC PATIENT; DRUG EFFICACY; DRUG TARGETING; FADS1 GENE; FADS2 GENE; FEMALE; FOLLOW UP; GENE; GENETIC ASSOCIATION; GENOMICS; GENOTYPE; HUMAN; LIPID BLOOD LEVEL; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; METABOLITE; METABOLOMICS; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PLEIOTROPY; POPULATION RESEARCH; RISK ASSESSMENT; BLOOD; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; DIET RESTRICTION; DRUG EFFECTS; LIPID METABOLISM; METABOLISM; RISK FACTOR;

AGED; CHOLESTEROL, LDL; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; FASTING; FATTY ACID DESATURASES; FEMALE; GENOMICS; GENOTYPE; HUMANS; HYPOGLYCEMIC AGENTS; LIPID METABOLISM; MALE; METABOLOMICS; METFORMIN; MIDDLE AGED; RISK FACTORS;

EID: 84962374537     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc15-0658     Document Type: Article

References (40)

1. Foretz M, Guigas B, Bertrand L, Pollak M, Viollet B. Metformin: from mechanisms of action to therapies. Cell Metab 2014;20:953-966.
2. ADA. Executive summary: Standards of medical care in diabetes-2013. Diabetes Care 2013; 36(Suppl.1):S4-S10.
3. Madiraju AK, Erion DM, Rahimi Y, et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature 2014;510:542-546.
4. Law V, Knox C, Djoumbou Y, et al. DrugBank 4.0: shedding new light on drug metabolism. Nucleic Acids Res 2014;42:D1091-D1097.
5. Decensi A, Puntoni M, Goodwin P, et al. Metformin and cancer risk in diabetic patients: A systematic review and meta-analysis. Cancer Prev Res (Phila) 2010;3:1451-1461.
6. Norwood DK, Chilipko AA, Amin SM, Macharia D, Still KL. Evaluating the potential benefits ofmetformin in patients with cardiovascular disease and heart failure. Consult Pharm 2013;28:579-583.
7. Glueck CJ, Fontaine RN, Wang P, et al. Metformin reducesweight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30. Metabolism 2001; 50:856-861.
8. Wulffeĺe MG, Kooy A, de Zeeuw D, Stehouwer CD, Gansevoort RT. The effect of metformin on blood pressure, plasma cholesterol and triglycerides in type 2 diabetes mellitus: A systematic review. J Intern Med 2004;256:1-14.
9. Wang-Sattler R, Yu Z, Herder C, et al. Novel biomarkers for pre-diabetes identified by metabolomics. Mol Syst Biol 2012;8:615.
10. Wang TJ, Larson MG, Vasan RS, et al. Metabolite profiles and the risk of developing diabetes. Nat Med 2011;17:448-453.
11. Floegel A, Stefan N, Yu Z, et al. Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. Diabetes 2013;62:639-648.
12. Newgard CB, An J, Bain JR, et al. A branchedchain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 2009;9: 311-326.
13. Yu Z, Zhai G, Singmann P, et al. Human serum metabolic profiles are age dependent. Aging Cell 2012;11:960-967.
14. Mittelstrass K, Ried JS, Yu Z, et al. Discovery of sexual dimorphisms in metabolic and genetic biomarkers. PLoS Genet 2011;7:e1002215.
15. Xu T, Holzapfel C, Dong X, et al. Effects of smoking and smoking cessation on human serum metabolite profile: Results from the KORA cohort study. BMC Med 2013;11:60.
16. Jaremek M, Yu Z, Mangino M, et al. Alcoholinduced metabolomic differences in humans. Transl Psychiatry 2013;3:e276.
17. Marchetti P, Masiello P, Benzi L, et al. Effects of metformin therapy on plasma amino acid pattern in patients with maturity-onset diabetes. Drugs Exp Clin Res 1989;15:565-570.
18. Cai S, Huo T, Li N, Xiong Z, Li F. Lysophosphatidylcholine- biomarker of Metformin action: studied using UPLC/MS/MS. Biomed Chromatogr 2009;23:782-786.
19. Huo T, Cai S, Lu X, Sha Y, Yu M, Li F. Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride. J Pharm Biomed Anal 2009;49:976-982.
20. Asagami T, Abbasi F, Stuelinger M, et al. Metformin treatment lowers asymmetric dimethylarginine concentrations in patients with type 2 diabetes. Metabolism 2002;51:843-846.
21. Zhang Y, Hu C, Hong J, et al. Lipid profiling reveals different therapeutic effects of metformin and glipizide in patients with type 2 diabetes and coronary artery disease. Diabetes Care 2014;37:2804-2812.
22. Gieger C, Geistlinger L, Altmaier E, et al. Genetics meets metabolomics: A genome-wide association study of metabolite profiles in human serum. PLoS Genet 2008;4:e1000282.
23. Illig T, Gieger C, Zhai G, et al. A genomewide perspective of genetic variation in human metabolism. Nat Genet 2010;42:137-141.
24. Suhre K, Shin SY, Petersen AK, et al.; CARDIoGRAM. Human metabolic individuality in biomedical and pharmaceutical research. Nature 2011;477:54-60.
25. Ried JS, Doring A, Oexle K, et al. PSEA: Phenotype Set Enrichment Analysis-a new method for analysis of multiple phenotypes. Genet Epidemiol 2012;36:244-252.
26. Rathmann W, Kowall B, Heier M, et al. Prediction models for incident type 2 diabetes mellitusin the older population: KORA S4/F4 cohort study. Diabet Med 2010;27:1116- 1123.
27. Jourdan C, Petersen AK, Gieger C, et al. Body fat free mass is associated with the serum metabolite profile in a population-based study. PLoS One 2012;7:e40009.
28. Aulchenko YS, Heutink P, Mackay I, et al. Linkage disequilibrium in young genetically isolated Dutch population. Eur J Hum Genet 2004; 12:527-534.
29. Boomsma DI, de Geus EJ, Vink JM, et al. Netherlands Twin Register: from twins to twin families. Twin Res 2006;9:849-857.
30. Kuhn M, Szklarczyk D, Pletscher-Frankild S, et al. STITCH 4: integration of protein-chemical interactions with user data. Nucleic Acids Res 2014;42:D401-D407.
31. Lechner M, Hohn V, Brauner B, et al. CIDeR: multifactorial interaction networks in human diseases. Genome Biol 2012;13:R62.
32. Willemsen G, de Geus EJ, Bartels M, et al. The Netherlands Twin Register biobank: A resource for genetic epidemiological studies. Twin Res 2010;13:231-245.
33. Bauer DJ, Preacher KJ, Gil KM. Conceptualizing and testing random indirect effects and moderated mediation in multilevel models: new procedures and recommendations. Psychol Methods 2006;11:142-163.
34. Lim CT, Kola B, Korbonits M. AMPK as a mediator of hormonal signalling. J Mol Endocrinol 2010;44:87-97.
35. Sone Y, Kido T, Ainuki T, et al. Genetic variants of the fatty acid desaturase gene cluster are associated with plasma LDL cholesterol levels in Japanese males. J Nutr Sci Vitaminol (Tokyo) 2013;59:325-335.
36. Global Lipids Genetics Consortium, Willer CJ, Schmidt EM, Sengupta S, et al. Discovery and refinement of loci associated with lipid levels. Nat Genet 2013;45:1274-1283.
37. Lee JM, Lee YK, Mamrosh JL, et al. Anuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature 2011; 474:506-510.
38. Pernicova I, Korbonits M. Metformin-mode of action and clinical implications for diabetes and cancer. Nat Rev Endocrinol 2014;10:143-156.
39. Liu L, Zhou C, Zhou L, et al. Functional FEN1 genetic variants contribute to risk of hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer. Carcinogenesis 2012;33:119-123.
40. Meissner B, Bartram T, Eckert C, et al. Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia. Hum Mol Genet 2014;23:590-601.