The linkage outcomes of a large-scale, rapid transfer of HIV-infected patients from hospital-based to community-based clinics in South Africa

Open Forum Infectious Diseases

Volumn 1, Issue 2, 2014, Pages

  Cloete, Christie ^a   Regan, Susan ^b   Giddy, Janet ^a   Govender, Tessa ^a   Erlwanger, Alison ^b   Gaynes, Melanie R ^b   Freedberg, Kenneth A ^b,c,d,e   Katz, Jeffrey N ^e,f   Walensky, Rochelle P ^b,c,f   Losina, Elena ^b,c,d,f   Bassett, Ingrid V ^b,c  

^a MCCORD HOSPITAL   (South Africa)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD UNIVERSITY   (United States)

^d BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Community based clinics; Linkage to care; PEPFAR; South Africa; Transfer of HIV care

Indexed keywords

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; ELECTRONIC MEDICAL RECORD; FEMALE; HEALTH CARE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HOSPITAL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; MEDICAL RECORD; PATIENT CARE; PRIORITY JOURNAL; RISK FACTOR; SELF REPORT; SOCIAL DESIRABILITY; SOUTH AFRICA; VALIDATION PROCESS; VIRUS TRANSMISSION;

EID: 84962352119     PISSN: None     EISSN: 23288957     Source Type: Journal    
DOI: 10.1093/ofid/ofu058     Document Type: Article

References (37)

1. UNAIDS. Getting to zero: HIV in eastern and southern Africa. Available at: http://www.sanac.org.za/resources/doc_download/50-unaidsreport-2013. Accessed May 9, 2014.
2. United States President's Emergency Plan for AIDS Relief. 10 years of PEPFAR: the power of partnership. Available at: http://southafrica. usembassy.gov/pepfar.html. Accessed May 9, 2014.
3. Lawn SD, Myer L, Bekker LG, et al. Burden of tuberculosis in an antiretroviral treatment programme in sub-Saharan Africa: Impact on treatment outcomes and implications for tuberculosis control. AIDS. 2006; 20:1605-12.
4. Partnership framework in support of South Africa's National HIV & AIDS and TB Response 2012/13-2016/17 between the Government of the Republic of South Africa and the Government of the United States of America. Available at: http://www.pepfar.gov/documents/ organization/196651.pdf. Accessed May 9, 2014.
5. Institute of Medicine. Evaluation of PEPFAR. Available at: http://www. iom.edu/~/media/Files/Report%20Files/2013/PEPFAR/PEPFAR_RB. pdf. Accessed May 9, 2014.
6. Collins C, Beyrer C. Country ownership and the turning point for HIV/ AIDS. Lancet Global Health. 2013; 1:e319-20.
7. Organisation for Economic Co-operation and Development. The Paris declaration on aid effectiveness. http://www.oecd.org/development/ effectiveness/34428351.pdf. Accessed May 13, 2014.
8. UNAIDS. Country ownership for a sustainable AIDS response: From principles to practice. Available at: http://www.unaids.org/en/media/ unaids/contentassets/documents/unaidspublication/2012/20120717_ JC2134_UNAIDS_Country_Ownership_Discussion_Paper.pdf. Accessed May 13, 2014.
9. Katz IT, Bassett IV, Wright AA. PEPFAR in transition-implications for HIV care in South Africa. N Engl J Med. 2013; 369:1385-7.
10. Larson E, O'Bra H, Brown JW, et al. Supporting the massive scale-up of antiretroviral therapy: The evolution of PEPFAR-supported treatment facilities in South Africa, 2005-2009. BMC Public Health. 2012; 12:173.
11. SANAC. South Africa National Department of Health clinical guidelines for the management of HIV & AIDS in adults and adolescents. Available at: http://www.who.int/hiv/pub/guidelines/south_africa_art. pdf. Accessed May 9, 2014.
12. Lawn SD, Myer L, Edwards D, et al. Short-term and long-term risk of tuberculosis associated with CD4 cell recovery during antiretroviral therapy in South Africa. AIDS. 2009; 23:1717-25.
13. Fairall L, Bachmann MO, Lombard C, et al. Task shifting of antiretroviral treatment from doctors to primary-care nurses in South Africa (STRETCH): a pragmatic, parallel, cluster-randomised trial. Lancet. 2012; 380:889-98.
14. Humphreys CP, Wright J, Walley J, et al. Nurse led, primary care based antiretroviral treatment versus hospital care: A controlled prospective study in Swaziland. BMC Health Serv Res. 2010; 10:229.
15. Sanne I, Orrell C, Fox MP, et al. Nurse versus doctor management of HIV-infected patients receiving antiretroviral therapy (CIPRA-SA): A randomised non-inferiority trial. Lancet. 2010; 376:33-40.
16. Long L, Brennan A, Fox MP, et al. Treatment outcomes and costeffectiveness of shifting management of stable ART patients to nurses in South Africa: An observational cohort. PLoS Med. 2011; 8:e1001055.
17. Brennan AT, Long L, Maskew M, et al. Outcomes of stable HIV-positive patients down-referred from a doctor-managed antiretroviral therapy clinic to a nurse-managed primary health clinic for monitoring and treatment. AIDS. 2011; 25:2027-36.
18. O'Connor C, Osih R, Jaffer A. Loss to follow-up of stable antiretroviral therapy patients in a decentralized down-referral model of care in Johannesburg, South Africa. J Acquir Immune Defic Syndr. 2011; 58:429-32.
19. McGuire M, Ben Farhat J, Pedrono G, et al. Task-sharing of HIV care and ART initiation: evaluation of a mixed-care non-physician provider model for ART delivery in rural Malawi. PLoS One. 2013; 8: e74090.
20. Bemelmans M, van den Akker T, Ford N, et al. Providing universal access to antiretroviral therapy in Thyolo, Malawi through task shifting and decentralization of HIV/AIDS care. Trop Med Int Health. 2010; 15:1413-20.
21. Massaquoi M, Zachariah R, Manzi M, et al. Patient retention and attrition on antiretroviral treatment at district level in rural Malawi. Trans R Soc Trop Med Hyg. 2009; 103:594-600.
22. Sturm G, Zangerle R, for the AHIVCOS Group. Mortality in the combination antiretroviral therapy era: Will switching to another treatment centre become a risk factor? In: 7th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Kuala Lumpur, Malaysia, 2013.
23. South Africa Department of Health. Standard treatment guidelines and essential medicines list for South Africa. Available at: www.kznhealth. gov.za/pharmacy/edladult_2012.pdf. Accessed May 9, 2014.
24. Johnson LF, Mossong J, Dorrington RE, et al. Life expectancies of South African adults starting antiretroviral treatment: Collaborative analysis of cohort studies. PLoS Med. 2013; 10:e1001418.
25. Mukora R, Charalambous S, Dahab M, et al. A study of patient attitudes towards decentralisation of HIV care in an urban clinic in South Africa. BMC Health Serv Res. 2011; 11:205.
26. Cook PA, Downing J, Wheater CP, et al. Influence of sociodemographic factors on distances travelled to access HIV services: enhanced surveillance of HIV patients in northwest England. BMC Public Health. 2009; 9:78.
27. Ware NC, Wyatt MA, Geng EH, et al. Toward an understanding of disengagement from HIV treatment and care in sub-Saharan Africa: A qualitative study. PLoS Med. 2013; 10:e1001369.
28. Tuller DM, Bangsberg DR, Senkungu J, et al. Transportation costs impede sustained adherence and access to HAART in a clinic population in southwestern Uganda: A qualitative study. AIDS Behav. 2010; 14:778-84.
29. Tweya H, Feldacker C, Estill J, et al. Are they really lost? "True" status and reasons for treatment discontinuation among HIV infected patients on antiretroviral therapy considered lost to follow up in urban Malawi. PLoS One. 2013; 8:e75761.
30. Wolfe WR,Weiser SD, Bangsberg DR, et al. Effects of HIV-related stigma among an early sample of patients receiving antiretroviral therapy in Botswana. AIDS Care. 2006; 18:931-3.
31. Nachega JB, Stein DM, Lehman DA, et al. Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South Africa. AIDS Res Hum Retroviruses. 2004; 20:1053-6.
32. Talam NC, Gatongi P, Rotich J, Kimaiyo S. Factors affecting antiretroviral drug adherence among HIV/AIDS adult patients attending HIV/ AIDS clinic at Moi Teaching and Referral Hospital, Eldoret, Kenya. East Afr J Public Health. 2008; 5:74-8.
33. Katz IT, Ryu AE, Onuegbu AG, et al. Impact of HIV-related stigma on treatment adherence: Systematic review and meta-synthesis. J Int AIDS Soc. 2013; 16:18640.
34. UNAIDS. Developing and using individual identifiers for the provision of health services including HIV: Proceedings from a workshop, 24-26 February 2009, Montreux, Switzerland. Available at: http://www.unaids.org/en/media/unaids/contentassets/documents/ dataanalysis/20110520_Unique_Identifiers_Meeting_Report_Mon treux.pdf. Accessed May 13, 2014.
35. Brinkhof MW, Pujades-Rodriguez M, Egger M. Mortality of patients lost to follow-up in antiretroviral treatment programmes in resourcelimited settings: Systematic review and meta-analysis. PLoS One. 2009; 4:e5790.
36. Dalal RP, Macphail C, Mqhayi M, et al. Characteristics and outcomes of adult patients lost to follow-up at an antiretroviral treatment clinic in Johannesburg, South Africa. J Acquir Immune Defic Syndr. 2008; 47:101-7.
37. Maskew M, MacPhail P, Menezes C, Rubel D. Lost to follow up: Contributing factors and challenges in South African patients on antiretroviral therapy. S Afr Med J. 2007; 97:853-7.