Treatment outcomes and cost-effectiveness of shifting management of stable ART patients to nurses in South Africa: An observational cohort

PLoS Medicine

Volumn 8, Issue 7, 2011, Pages

  Long, Lawrence ^a,b   Brennan, Alana ^a,b,c   Fox, Matthew P ^a,b,c   Ndibongo, Buyiswa ^a,b   Jaffray, Imogen ^c   Sanne, Ian ^a,b,c   Rosen, Sydney ^a,b,c  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; EFAVIRENZ PLUS LAMIVUDINE PLUS STAVUDINE; EFAVIRENZ PLUS LAMIVUDINE PLUS ZIDOVUDINE; UNCLASSIFIED DRUG;

ADULT; ANTIVIRAL THERAPY; ARTICLE; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; CONTROLLED STUDY; COST CONTROL; COST EFFECTIVENESS ANALYSIS; DRUG EFFICACY; FEMALE; HEALTH CARE COST; HEALTH STATUS; HOSPITAL CARE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; MEDICAL CARE; NURSING CARE; OBSERVATIONAL STUDY; OPPORTUNISTIC INFECTION; PATIENT REFERRAL; PRIMARY HEALTH CARE; RISK BENEFIT ANALYSIS; SOUTH AFRICA; TREATMENT DURATION; TREATMENT OUTCOME; VIRUS LOAD; WEIGHT REDUCTION; ADOLESCENT; COST BENEFIT ANALYSIS; ECONOMICS; METHODOLOGY; MIDDLE AGED; NURSING; OUTCOME ASSESSMENT;

ADOLESCENT; ADULT; ANTI-RETROVIRAL AGENTS; COHORT STUDIES; COST-BENEFIT ANALYSIS; FEMALE; HEALTH CARE COSTS; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; NURSING; OUTCOME ASSESSMENT (HEALTH CARE); SOUTH AFRICA; TREATMENT OUTCOME;

EID: 79960925910     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1001055     Document Type: Article

References (18)

1. World Health Organization (2008) Task shifting: rational redistribution of tasks among health workforce teams: global recommendations and guidelines Geneva World Health Organization Available: http://www.who.int/healthsystems/TTR-TaskShifting.pdf. Accessed 2 November 2010.
2. Callaghan M, Ford N, Schneider H, (2010) A systematic review of task- shifting for HIV treatment and care in Africa. Hum Resour Health 8: 8 doi:10.1186/1478-4491-8-8.
3. Bedelu M, Ford N, Hilderbrand K, Reuter H, (2007) Implementing antiretroviral therapy in rural communities: the Lusikisiki model of decentralized HIV/AIDS care. J Infect Dis 196 (Suppl): S464-S468.
4. Fatti G, Grimwood A, Bock P, (2010) Better antiretroviral therapy outcomes at primary healthcare facilities: an evaluation of three tiers of ART services in four South African provinces. PLoS ONE 5: e12888 doi:10.1371/journal.pone.0012888.
5. Humphreys CP, Wright J, Walley J, Mamvura CT, Bailey KA, et al. (2010) Nurse led, primary care based antiretroviral treatment versus hospital care: a controlled prospective study in Swaziland. BMC Health Serv Res 10: 229.
6. Bemelmans M, Van Den Akker T, Ford N, Philips M, Zachariah R, et al. (2010) Providing universal access to antiretroviral therapy in Thyolo, Malawi through task shifting and decentralization of HIV/AIDS care. Trop Med Int Health 15: 1413-1420 doi:10.1111/j.1365-3156.2010.02649.x.
7. Selke HM, Kimaiyo S, Sidle JE, Vedanthan R, Tierney WM, et al. (2010) Task-shifting of antiretroviral delivery from health care workers to persons living with HIV/AIDS: clinical outcomes of a community-based program in Kenya. J Acquir Immune Defic Syndr 55: 483-490 doi:10.1097/QAI.0b013e3181eb5edb.
8. Sanne IM, Orrell C, Fox MP, Conradie F, Ive P, et al. (2010) Nurse versus doctor management of HIV-infected patients receiving antiretroviral therapy (CIPRA-SA): a randomised non-inferiority trial. Lancet 376: 33-40.
9. Sanne IM, Westreich D, Macphail AP, Rubel D, Majuba P, et al. (2009) Long term outcomes of antiretroviral therapy in a large HIV/AIDS care clinic in urban South Africa: a prospective cohort study. J Int AIDS Soc 12: 38 doi:10.1186/1758-2652-12-38.
10. Rosenbaum PR, Rubin DB, (1983) The central role of the propensity score in observational studies for causal effects. Biometrika 70: 41-55 doi:10.1093/biomet/70.1.41.
11. Kosanke JL, Bergstralh EJ, (2010) Dist [SAS macro] Rochester (Minnesota) Division of Biomedical Statistics and Informatics, Mayo Clinic, 2010 Available: http://mayoresearch.mayo.edu/biostat/sasmacros.cfm. Accessed 9 June 2011.
12. Rosen S, Long L, Sanne IM, (2008) The outcomes and outpatient costs of different models of antiretroviral treatment delivery in South Africa. Trop Med Int Health 13: 1005-1015 doi:10.1111/j.1365-3156.2008.02114.x.
13. Efron B, Tibshirani RJ, (1993) An introduction to the bootstrap Boca Raton (Florida) Chapman and Hall/CRC.
14. Joint United Nations Programme on HIV/AIDS (2010) Outlook report 2010 Geneva Joint United Nations Programme on HIV/AIDS Available: http://data.unaids.org/pub/Outlook/2010/20100713_outlook_report_web_en.pdf. Accessed 3 October 2010.
15. South African National AIDS Council (2010) National strategic plan 2007-2011: mid term review 2010 Pretoria South African National AIDS Council Available: http://www.irinnews.org/pdf/Mid_Term_Review_of_the_NSP_(preliminary_report).pdf. Accessed 7 April 2011.
16. Drummond M, Sculpher M, Torrance G, O'Brien B, Stoddart G, (2005) Methods for the economic evaluation of health care programmes, 3rd edition Oxford Oxford University Press.
17. Geng EH, Nash D, Kambugu A, Zhang Y, Braitstein P, et al. (2010) Retention in care among HIV-infected patients in resource-limited settings: emerging insights and new directions. Curr HIV/AIDS Rep 7: 234-244 doi:10.1007/s11904-010-0061-5.
18. World Health Organization (2007) Task shifting to tackle health worker shortages Geneva World Health Organization Available: http://www.who.int/healthsystems/task_shifting_booklet.pdf. Accessed 12 January 2011.