Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53

Neuropharmacology

Volumn 107, Issue , 2016, Pages 68-78

  Shan, Han ^a   Bian, Yaqi ^a   Shu, Zhaoma ^a   Zhang, Linxia ^a   Zhu, Jialei ^a   Ding, Jianhua ^a   Lu, Ming ^a   Xiao, Ming ^a   Hu, Gang ^a,b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Apoptosis; Fluoxetine; Interleukin 1 ; Neuroinflammation; p53; Stroke

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANISOMYCIN; FLUOXETINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; BCL2 PROTEIN, MOUSE; ENZYME INHIBITOR; IL1B PROTEIN, MOUSE; IMIDAZOLE DERIVATIVE; NEUROPROTECTIVE AGENT; PYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN ISCHEMIA; CONTROLLED STUDY; DOWN REGULATION; IN VITRO STUDY; IN VIVO STUDY; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROBLASTOMA CELL LINE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION; IMMUNOMODULATION; METABOLISM; NERVE CELL; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; STROKE; TUMOR CELL LINE;

ANIMALS; ANISOMYCIN; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRAIN ISCHEMIA; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FLUOXETINE; GENE EXPRESSION; IMIDAZOLES; INTERLEUKIN-1BETA; MAP KINASE SIGNALING SYSTEM; MICE, INBRED C57BL; NEUROIMMUNOMODULATION; NEURONS; NEUROPROTECTIVE AGENTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRIDINES; STROKE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84962324668     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2016.03.019     Document Type: Article

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