Intervention of death-associated protein kinase 1-p53 interaction exerts the therapeutic effects against stroke

Stroke

Volumn 45, Issue 10, 2014, Pages 3089-3091

  Wang, Xiaoxi ^a,c   Pei, Lei ^a,c   Yan, Honglin ^a,c   Wang, Zhongping ^b,c   Wei, Na ^a,c   Wang, Shan ^a,c   Yang, Xin ^a,c   Tian, Qing ^a   Lu, Youming ^a,c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b JIUJIANG UNIVERSITY   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

death associated protein kinases; stroke

Indexed keywords

DEATH ASSOCIATED PROTEIN KINASE; DEATH ASSOCIATED PROTEIN KINASE 1; PROTEIN P53; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; DAPK1 PROTEIN, MOUSE; HYBRID PROTEIN; NEUROPROTECTIVE AGENT; PEPTIDE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CELL; CEREBROVASCULAR ACCIDENT; EXPERIMENTAL MODEL; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; THERAPY EFFECT; TUMOR SUPPRESSOR GENE; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; METABOLISM; PROTEIN DOMAIN; SYNTHESIS;

ANIMALS; DEATH-ASSOCIATED PROTEIN KINASES; DISEASE MODELS, ANIMAL; MICE; NEUROPROTECTIVE AGENTS; PEPTIDES; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECOMBINANT FUSION PROTEINS; STROKE; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84919744877     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.114.006348     Document Type: Article

References (7)

1. Bialik S, Kimchi A. The death-associated protein kinases: structure, function, and beyond. Annu Rev Biochem. 2006;75:189-210.
2. Tu W, Xu X, Peng L, Zhong X, Zhang W, Soundarapandian MM, et al. DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell. 2010;140:222-234.
3. Pei L, Shang Y, Jin H, Wang S, Wei N, Yan H, et al. DAPK1-p53 interaction converges necrotic and apoptotic pathways of ischemic neuronal death. J Neurosci. 2014;34:6546-6556.
4. Vaseva AV, Marchenko ND, Ji K, Tsirka SE, Holzmann S, Moll UM. p53 opens the mitochondrial permeability transition pore to trigger necrosis. Cell. 2012;149:1536-1548.
5. Maiuri MC, Tasdemir E, Criollo A, Morselli E, Vicencio JM, Carnuccio R, et al. Control of autophagy by oncogenes and tumor suppressor genes. Cell Death Differ. 2009;16:87-93.
6. Green DR, Kroemer G. Cytoplasmic functions of the tumour suppressor p53. Nature. 2009;458:1127-1130.
7. Copani A, Uberti D, Sortino MA, Bruno V, Nicoletti F, Memo M. Activation of cell-cycle-associated proteins in neuronal death: A mandatory or dispensable path? Trends Neurosci. 2001;24:25-31.