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Volumn 120, Issue , 2014, Pages 33-42

Flavocoxid, dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, exhibits neuroprotection in rat model of ischaemic stroke

Author keywords

Cyclooxygenase; Interleukin; Lipoxygenase; Neuroprotection; Nuclear factor kappa B; Tumour necrosis factor

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; BIOGENIC AMINE; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; FLAVOCOXID; FLUOXETINE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIMBREL; NITRITE; NORADRENALIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RIVASTIGMINE; SEROTONIN; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; CATECHIN; CYTOKINE; DRUG COMBINATION; LIPOXYGENASE INHIBITOR; NEUROPROTECTIVE AGENT;

EID: 84895524306     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2014.02.006     Document Type: Article
Times cited : (43)

References (69)
  • 2
    • 2542455472 scopus 로고    scopus 로고
    • INOS-mediated nitric oxide production and its regulation
    • F. Aktan iNOS-mediated nitric oxide production and its regulation Life Sci 75 2004 639 653
    • (2004) Life Sci , vol.75 , pp. 639-653
    • Aktan, F.1
  • 3
    • 67449098178 scopus 로고    scopus 로고
    • Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages
    • D. Altavilla, F. Squadrito, A. Bitto, F. Polito, B.P. Burnett, and V. Di Stefano et al. Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages Br J Pharmacol 157 2009 1410 1418
    • (2009) Br J Pharmacol , vol.157 , pp. 1410-1418
    • Altavilla, D.1    Squadrito, F.2    Bitto, A.3    Polito, F.4    Burnett, B.P.5    Di Stefano, V.6
  • 5
    • 0022483434 scopus 로고
    • Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurologic examination
    • J.B. Bederson, L.H. Pitts, M. Tsuji, M.C. Nishimura, R.L. Davis, and H. Bartkowski Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination Stroke 17 1986 472 476
    • (1986) Stroke , vol.17 , pp. 472-476
    • Bederson, J.B.1    Pitts, L.H.2    Tsuji, M.3    Nishimura, M.C.4    Davis, R.L.5    Bartkowski, H.6
  • 6
    • 0032842038 scopus 로고    scopus 로고
    • Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: Implications for Parkinson's disease
    • S.B. Berman, and T.G. Hastings Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease J Neurochem 73 1999 1127 1137
    • (1999) J Neurochem , vol.73 , pp. 1127-1137
    • Berman, S.B.1    Hastings, T.G.2
  • 7
    • 0032983334 scopus 로고    scopus 로고
    • Beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease
    • V.D. Bianca, S. Dusi, E. Bianchini, I. Dal Pra, and F. Rossi beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease J Biol Chem 274 1999 15493 15499
    • (1999) J Biol Chem , vol.274 , pp. 15493-15499
    • Bianca, V.D.1    Dusi, S.2    Bianchini, E.3    Dal Pra, I.4    Rossi, F.5
  • 8
    • 84891719941 scopus 로고    scopus 로고
    • Rivastigmine for vascular cognitive impairment
    • 10.1002/14651858.CD004744.pub3
    • J. Birks, B. McGuinness, and D. Craig Rivastigmine for vascular cognitive impairment Cochrane Database Syst Rev 5 2013 CD004744 10.1002/14651858. CD004744.pub3
    • (2013) Cochrane Database Syst Rev , vol.5 , pp. 004744
    • Birks, J.1    McGuinness, B.2    Craig, D.3
  • 9
    • 57449110125 scopus 로고    scopus 로고
    • NADPH oxidase as a therapeutic target in Alzheimer's disease
    • M.L. Block NADPH oxidase as a therapeutic target in Alzheimer's disease BMC Neurosci 9 2008 S8
    • (2008) BMC Neurosci , vol.9 , pp. 8
    • Block, M.L.1
  • 10
    • 34848921503 scopus 로고    scopus 로고
    • A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation
    • B.P. Burnett, Q. Jia, Y. Zhao, and R.M. Levy A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation J Med Food 10 2007 442 451
    • (2007) J Med Food , vol.10 , pp. 442-451
    • Burnett, B.P.1    Jia, Q.2    Zhao, Y.3    Levy, R.M.4
  • 11
    • 34848928838 scopus 로고    scopus 로고
    • Safety evaluation of a combination, defined extract of Scutellaria baicalensis and Acacia catechu
    • B.P. Burnett, S. Silva, M.H. Mesches, S. Wilson, and Q.I. Jia Safety evaluation of a combination, defined extract of Scutellaria baicalensis and Acacia catechu J Food Biochem 31 2007 797 825
    • (2007) J Food Biochem , vol.31 , pp. 797-825
    • Burnett, B.P.1    Silva, S.2    Mesches, M.H.3    Wilson, S.4    Jia, Q.I.5
  • 12
    • 80052376967 scopus 로고    scopus 로고
    • Flavocoxid inhibits phospholipase A2, peroxidase moieties of the cyclooxygenases (COX), and 5-lipoxygenase, modifies COX-2 gene expression, and acts as an antioxidant
    • 10.1155/2011/385780
    • B.P. Burnett, A. Bitto, D. Altavilla, F. Squadrito, R.M. Levy, and L. Pillai Flavocoxid inhibits phospholipase A2, peroxidase moieties of the cyclooxygenases (COX), and 5-lipoxygenase, modifies COX-2 gene expression, and acts as an antioxidant Mediators Inflamm 2011 385780 10.1155/2011/385780
    • (2011) Mediators Inflamm , pp. 385780
    • Burnett, B.P.1    Bitto, A.2    Altavilla, D.3    Squadrito, F.4    Levy, R.M.5    Pillai, L.6
  • 13
    • 84862734518 scopus 로고    scopus 로고
    • Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: A case series
    • N. Chalasani, R. Vuppalanchi, V. Navarro, R. Fontana, H. Bonkovsky, and H. Barnhart et al. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series Ann Intern Med 156 2012 857 860
    • (2012) Ann Intern Med , vol.156 , pp. 857-860
    • Chalasani, N.1    Vuppalanchi, R.2    Navarro, V.3    Fontana, R.4    Bonkovsky, H.5    Barnhart, H.6
  • 14
    • 78751580257 scopus 로고    scopus 로고
    • Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): A randomised placebo-controlled trial
    • F. Chollet, J. Tardy, J.F. Albucher, C. Thalamas, E. Berard, and C. Lamy et al. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial Lancet Neurol 10 2011 123 130
    • (2011) Lancet Neurol , vol.10 , pp. 123-130
    • Chollet, F.1    Tardy, J.2    Albucher, J.F.3    Thalamas, C.4    Berard, E.5    Lamy, C.6
  • 16
    • 13344283416 scopus 로고    scopus 로고
    • Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke
    • E.S. Connolly Jr., C.J. Winfree, T.A. Springer, Y. Naka, H. Liao, and S.D. Yan et al. Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke J Clin Invest. 97 1996 209 216
    • (1996) J Clin Invest. , vol.97 , pp. 209-216
    • Connolly, Jr.E.S.1    Winfree, C.J.2    Springer, T.A.3    Naka, Y.4    Liao, H.5    Yan, S.D.6
  • 17
    • 39749100656 scopus 로고    scopus 로고
    • Tiagabine, a GABA uptake inhibitor, attenuates 3-nitropropionic acid-induced alterations in various behavioral and biochemical parameters in rats
    • A. Dhir, K.K. Akula, and S.K. Kulkarni Tiagabine, a GABA uptake inhibitor, attenuates 3-nitropropionic acid-induced alterations in various behavioral and biochemical parameters in rats Prog Neuropsychopharmacol Biol Psychiatry 32 2008 835 843
    • (2008) Prog Neuropsychopharmacol Biol Psychiatry , vol.32 , pp. 835-843
    • Dhir, A.1    Akula, K.K.2    Kulkarni, S.K.3
  • 18
    • 60049091968 scopus 로고    scopus 로고
    • Penumbral selection of patients for trials of acute stroke therapy
    • G.A. Donnan, J.C. Baron, H. Ma, and S.M. Davis Penumbral selection of patients for trials of acute stroke therapy Lancet Neurol 8 2009 261 269
    • (2009) Lancet Neurol , vol.8 , pp. 261-269
    • Donnan, G.A.1    Baron, J.C.2    Ma, H.3    Davis, S.M.4
  • 19
    • 3042934967 scopus 로고
    • Tissue sulfhydryl groups
    • G.L. Ellman Tissue sulfhydryl groups Arch Biochem Biophys 82 1959 70 77
    • (1959) Arch Biochem Biophys , vol.82 , pp. 70-77
    • Ellman, G.L.1
  • 21
    • 0142009034 scopus 로고    scopus 로고
    • The protective effects of tea catechins on the injury of cerebral ischemia and reperfusion in rats
    • F. Fang, Y.J. Han, and Z.Q. Cui The protective effects of tea catechins on the injury of cerebral ischemia and reperfusion in rats Zhongguo Zhong Yao Za Zhi 26 2001 777 780
    • (2001) Zhongguo Zhong Yao Za Zhi , vol.26 , pp. 777-780
    • Fang, F.1    Han, Y.J.2    Cui, Z.Q.3
  • 22
    • 84870826919 scopus 로고    scopus 로고
    • Penetration of verapamil across blood brain barrier following cerebral ischemia depending on both paracellular pathway and P-glycoprotein transportation
    • W. Fang, P. Lv, X. Geng, E. Shang, Q. Yang, and L. Sha et al. Penetration of verapamil across blood brain barrier following cerebral ischemia depending on both paracellular pathway and P-glycoprotein transportation Neurochem Int 62 2013 23 30
    • (2013) Neurochem Int , vol.62 , pp. 23-30
    • Fang, W.1    Lv, P.2    Geng, X.3    Shang, E.4    Yang, Q.5    Sha, L.6
  • 23
    • 67651099137 scopus 로고    scopus 로고
    • Protective effect of naringin against ischemic reperfusion cerebral injury: Possible neurobehavioral, biochemical and cellular alterations in rat brain
    • V. Gaur, A. Aggarwal, and A. Kumar Protective effect of naringin against ischemic reperfusion cerebral injury: possible neurobehavioral, biochemical and cellular alterations in rat brain Eur J Pharmacol 616 2009 147 154
    • (2009) Eur J Pharmacol , vol.616 , pp. 147-154
    • Gaur, V.1    Aggarwal, A.2    Kumar, A.3
  • 25
    • 0025367735 scopus 로고
    • Cerebral ischemia model with conscious mice. Involvement of NMDA receptor activation and derangement of learning and memory ability
    • N. Himori, H. Watanabe, N. Akaike, M. Kurasawa, J. Itoh, and Y. Tanaka Cerebral ischemia model with conscious mice. Involvement of NMDA receptor activation and derangement of learning and memory ability J Pharmacol Methods 23 1990 311 327
    • (1990) J Pharmacol Methods , vol.23 , pp. 311-327
    • Himori, N.1    Watanabe, H.2    Akaike, N.3    Kurasawa, M.4    Itoh, J.5    Tanaka, Y.6
  • 27
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: From mechanisms to translation
    • C. Iadecola, and J. Anrather The immunology of stroke: from mechanisms to translation Nat Med 17 2011 796 808
    • (2011) Nat Med , vol.17 , pp. 796-808
    • Iadecola, C.1    Anrather, J.2
  • 28
    • 77957029010 scopus 로고    scopus 로고
    • Generating and screening a natural product library for cyclooxygenase and lipoxygenase dual inhibitors
    • R. Atta ur, Elsevier
    • Q. Jia Generating and screening a natural product library for cyclooxygenase and lipoxygenase dual inhibitors R. Atta ur, Studies in natural products chemistry 2003 Elsevier 643 718
    • (2003) Studies in Natural Products Chemistry , pp. 643-718
    • Jia, Q.1
  • 29
    • 78149464408 scopus 로고    scopus 로고
    • The effect of stress on stroke recovery in a photothrombotic stroke animal model
    • Z. Jin, J. Wu, S.Y. Oh, K.W. Kim, and B.S. Shin The effect of stress on stroke recovery in a photothrombotic stroke animal model Brain Res 1363 2010 191 197
    • (2010) Brain Res , vol.1363 , pp. 191-197
    • Jin, Z.1    Wu, J.2    Oh, S.Y.3    Kim, K.W.4    Shin, B.S.5
  • 30
    • 0033497149 scopus 로고    scopus 로고
    • Changes in cerebral blood flow and blood brain barrier in the gerbil hippocampal CA1 region following repeated brief cerebral ischemia
    • J. Jingtao, S. Sato, and N. Yamanaka Changes in cerebral blood flow and blood brain barrier in the gerbil hippocampal CA1 region following repeated brief cerebral ischemia Med Electron Microsc 32 1999 175 183
    • (1999) Med Electron Microsc , vol.32 , pp. 175-183
    • Jingtao, J.1    Sato, S.2    Yamanaka, N.3
  • 31
    • 0032825712 scopus 로고    scopus 로고
    • Poststroke depression correlates with cognitive impairment and neurological deficits
    • M. Kauhanen, J.T. Korpelainen, P. Hiltunen, E. Brusin, H. Mononen, and R. Maatta et al. Poststroke depression correlates with cognitive impairment and neurological deficits Stroke 30 1999 1875 1880
    • (1999) Stroke , vol.30 , pp. 1875-1880
    • Kauhanen, M.1    Korpelainen, J.T.2    Hiltunen, P.3    Brusin, E.4    Mononen, H.5    Maatta, R.6
  • 32
    • 77956987911 scopus 로고
    • [58] Preparation of succinate dehydrogenase and reconstitution of succinate oxidase
    • Ronald W. Estabrook, MEP Academic Press
    • T.E. King [58] Preparation of succinate dehydrogenase and reconstitution of succinate oxidase Ronald W. Estabrook, MEP Methods in enzymology 1967 Academic Press 322 331
    • (1967) Methods in Enzymology , pp. 322-331
    • King, T.E.1
  • 33
    • 77956999492 scopus 로고
    • Preparations and properties of soluble NADH dehydrogenases from cardiac muscle
    • Ronald W. Estabrook, MEP Academic Press
    • T.E. King, and R.L. Howard Preparations and properties of soluble NADH dehydrogenases from cardiac muscle Ronald W. Estabrook, MEP Methods in enzymology 1967 Academic Press 275 294
    • (1967) Methods in Enzymology , pp. 275-294
    • King, T.E.1    Howard, R.L.2
  • 34
    • 0036753450 scopus 로고    scopus 로고
    • Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity
    • A. Klegeris, and P.L. McGeer Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity Neurobiol Aging 23 2002 787 794
    • (2002) Neurobiol Aging , vol.23 , pp. 787-794
    • Klegeris, A.1    McGeer, P.L.2
  • 35
    • 0017804313 scopus 로고
    • Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase
    • Y. Kono Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase Arch Biochem Biophys 186 1978 189 195
    • (1978) Arch Biochem Biophys , vol.186 , pp. 189-195
    • Kono, Y.1
  • 36
    • 67449086585 scopus 로고    scopus 로고
    • Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: A short-term randomized, double-blind pilot study
    • R.M. Levy, R. Saikovsky, E. Shmidt, A. Khokhlov, and B.P. Burnett Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study Nutr Res 29 2009 298 304
    • (2009) Nutr Res , vol.29 , pp. 298-304
    • Levy, R.M.1    Saikovsky, R.2    Shmidt, E.3    Khokhlov, A.4    Burnett, B.P.5
  • 37
    • 80052682050 scopus 로고    scopus 로고
    • Nutritional benefits of flavocoxid in patients with osteoarthritis: Efficacy and safety
    • R.M. Levy, L. Pillai, and B.P. Burnett Nutritional benefits of flavocoxid in patients with osteoarthritis: efficacy and safety Nutr Diet Suppl 2010 2 2010 27 38
    • (2010) Nutr Diet Suppl , vol.2010 , Issue.2 , pp. 27-38
    • Levy, R.M.1    Pillai, L.2    Burnett, B.P.3
  • 38
    • 0038147318 scopus 로고    scopus 로고
    • Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs
    • J. Martel-Pelletier, D. Lajeunesse, P. Reboul, and J.P. Pelletier Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs Ann Rheum Dis 62 2003 501 509
    • (2003) Ann Rheum Dis , vol.62 , pp. 501-509
    • Martel-Pelletier, J.1    Lajeunesse, D.2    Reboul, P.3    Pelletier, J.P.4
  • 39
    • 71549162551 scopus 로고    scopus 로고
    • Flavocoxid counteracts muscle necrosis and improves functional properties in mdx mice: A comparison study with methylprednisolone
    • S. Messina, A. Bitto, M. Aguennouz, A. Mazzeo, A. Migliorato, and F. Polito et al. Flavocoxid counteracts muscle necrosis and improves functional properties in mdx mice: a comparison study with methylprednisolone Exp Neurol 220 2009 349 358
    • (2009) Exp Neurol , vol.220 , pp. 349-358
    • Messina, S.1    Bitto, A.2    Aguennouz, M.3    Mazzeo, A.4    Migliorato, A.5    Polito, F.6
  • 40
    • 34547557661 scopus 로고    scopus 로고
    • Role of COX-2 in inflammatory and degenerative brain diseases
    • L. Minghetti Role of COX-2 in inflammatory and degenerative brain diseases Subcell Biochem 42 2007 127 141
    • (2007) Subcell Biochem , vol.42 , pp. 127-141
    • Minghetti, L.1
  • 41
    • 0019957779 scopus 로고
    • Place navigation impaired in rats with hippocampal lesions
    • R.G. Morris, P. Garrud, J.N. Rawlins, and J. O'Keefe Place navigation impaired in rats with hippocampal lesions Nature 297 1982 681 683
    • (1982) Nature , vol.297 , pp. 681-683
    • Morris, R.G.1    Garrud, P.2    Rawlins, J.N.3    O'Keefe, J.4
  • 42
    • 0033782950 scopus 로고    scopus 로고
    • Does cognitive impairment cause post-stroke depression?
    • Y. Murata, M. Kimura, and R.G. Robinson Does cognitive impairment cause post-stroke depression? Am J Geriatr Psychiatry 8 2000 310 317
    • (2000) Am J Geriatr Psychiatry , vol.8 , pp. 310-317
    • Murata, Y.1    Kimura, M.2    Robinson, R.G.3
  • 43
    • 77749279917 scopus 로고    scopus 로고
    • A randomized controlled trial of rivastigmine in patients with cognitive impairment no dementia because of cerebrovascular disease
    • K. Narasimhalu, S. Effendy, C.H. Sim, J.M. Lee, I. Chen, and S.B. Hia et al. A randomized controlled trial of rivastigmine in patients with cognitive impairment no dementia because of cerebrovascular disease Acta Neurol Scand 121 2010 217 224
    • (2010) Acta Neurol Scand , vol.121 , pp. 217-224
    • Narasimhalu, K.1    Effendy, S.2    Sim, C.H.3    Lee, J.M.4    Chen, I.5    Hia, S.B.6
  • 44
    • 0030909616 scopus 로고    scopus 로고
    • Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage
    • S. Nogawa, F. Zhang, M.E. Ross, and C. Iadecola Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage J Neurosci 17 1997 2746 2755
    • (1997) J Neurosci , vol.17 , pp. 2746-2755
    • Nogawa, S.1    Zhang, F.2    Ross, M.E.3    Iadecola, C.4
  • 45
    • 79952811938 scopus 로고    scopus 로고
    • An open-label pilot study of the use of rivastigmine to promote functional recovery in patients with unilateral spatial neglect due to first ischemic stroke
    • S. Paolucci, I. Bureca, M. Multari, U. Nocentini, and A. Matano An open-label pilot study of the use of rivastigmine to promote functional recovery in patients with unilateral spatial neglect due to first ischemic stroke Funct Neurol 25 2010 195 200
    • (2010) Funct Neurol , vol.25 , pp. 195-200
    • Paolucci, S.1    Bureca, I.2    Multari, M.3    Nocentini, U.4    Matano, A.5
  • 46
    • 14844331038 scopus 로고    scopus 로고
    • Simple and rapid determination of serotonin and catecholamines in biological tissue using high-performance liquid chromatography with electrochemical detection
    • B.A. Patel, M. Arundell, K.H. Parker, M.S. Yeoman, and D. O'Hare Simple and rapid determination of serotonin and catecholamines in biological tissue using high-performance liquid chromatography with electrochemical detection J Chromatogr B Analyt Technol Biomed Life Sci 818 2005 269 276
    • (2005) J Chromatogr B Analyt Technol Biomed Life Sci , vol.818 , pp. 269-276
    • Patel, B.A.1    Arundell, M.2    Parker, K.H.3    Yeoman, M.S.4    O'Hare, D.5
  • 47
    • 33747885659 scopus 로고    scopus 로고
    • Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: Their role and involvement in neurological disorders
    • J.W. Phillis, L.A. Horrocks, and A.A. Farooqui Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders Brain Res Rev 52 2006 201 243
    • (2006) Brain Res Rev , vol.52 , pp. 201-243
    • Phillis, J.W.1    Horrocks, L.A.2    Farooqui, A.A.3
  • 48
    • 77951031884 scopus 로고    scopus 로고
    • GOAL: Multicenter, open-label, post-marketing study of flavocoxid, a novel dual pathway inhibitor anti-inflammatory agent of botanical origin
    • L. Pillai, B.P. Burnett, and R.M. Levy GOAL: multicenter, open-label, post-marketing study of flavocoxid, a novel dual pathway inhibitor anti-inflammatory agent of botanical origin Curr Med Res Opin 26 2010 1055 1063
    • (2010) Curr Med Res Opin , vol.26 , pp. 1055-1063
    • Pillai, L.1    Burnett, B.P.2    Levy, R.M.3
  • 49
    • 77958536786 scopus 로고    scopus 로고
    • Flavocoxid, a dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, reduces pancreatic damage in an experimental model of acute pancreatitis
    • F. Polito, A. Bitto, N. Irrera, F. Squadrito, C. Fazzari, and L. Minutoli et al. Flavocoxid, a dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, reduces pancreatic damage in an experimental model of acute pancreatitis Br J Pharmacol 161 2010 1002 1011
    • (2010) Br J Pharmacol , vol.161 , pp. 1002-1011
    • Polito, F.1    Bitto, A.2    Irrera, N.3    Squadrito, F.4    Fazzari, C.5    Minutoli, L.6
  • 50
    • 0017618768 scopus 로고
    • Depression: A new animal model sensitive to antidepressant treatments
    • R.D. Porsolt, M. Le Pichon, and M. Jalfre Depression: a new animal model sensitive to antidepressant treatments Nature 266 1977 730 732
    • (1977) Nature , vol.266 , pp. 730-732
    • Porsolt, R.D.1    Le Pichon, M.2    Jalfre, M.3
  • 51
    • 0037169236 scopus 로고    scopus 로고
    • Aging has a complex effect on a rat model of ischemic stroke
    • S. Shapira, M. Sapir, A. Wengier, E. Grauer, and T. Kadar Aging has a complex effect on a rat model of ischemic stroke Brain Res 925 2002 148 158
    • (2002) Brain Res , vol.925 , pp. 148-158
    • Shapira, S.1    Sapir, M.2    Wengier, A.3    Grauer, E.4    Kadar, T.5
  • 52
    • 79959846261 scopus 로고    scopus 로고
    • Dual inhibition of 5-LOX and COX-2 suppresses esophageal squamous cell carcinoma
    • H.Y. Shi, F.J. Lv, S.T. Zhu, Q.G. Wang, and S.T. Zhang Dual inhibition of 5-LOX and COX-2 suppresses esophageal squamous cell carcinoma Cancer Lett 309 2011 19 26
    • (2011) Cancer Lett , vol.309 , pp. 19-26
    • Shi, H.Y.1    Lv, F.J.2    Zhu, S.T.3    Wang, Q.G.4    Zhang, S.T.5
  • 53
    • 84890128058 scopus 로고    scopus 로고
    • Verapamil augments the neuroprotectant action of berberine in rat model of transient global cerebral ischemia
    • D.P. Singh, and K. Chopra Verapamil augments the neuroprotectant action of berberine in rat model of transient global cerebral ischemia Eur J Pharmacol 720 2013 98 106
    • (2013) Eur J Pharmacol , vol.720 , pp. 98-106
    • Singh, D.P.1    Chopra, K.2
  • 54
    • 0014059118 scopus 로고
    • An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study
    • G.L. Sottocasa, B. Kuylenstierna, L. Ernster, and A. Bergstrand An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study J Cell Biol 32 1967 415 438
    • (1967) J Cell Biol , vol.32 , pp. 415-438
    • Sottocasa, G.L.1    Kuylenstierna, B.2    Ernster, L.3    Bergstrand, A.4
  • 55
    • 33750321709 scopus 로고    scopus 로고
    • The etiology of poststroke depression: A review of the literature and a new hypothesis involving inflammatory cytokines
    • G. Spalletta, P. Bossu, A. Ciaramella, P. Bria, C. Caltagirone, and R.G. Robinson The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines Mol Psychiatry 11 2006 984 991
    • (2006) Mol Psychiatry , vol.11 , pp. 984-991
    • Spalletta, G.1    Bossu, P.2    Ciaramella, A.3    Bria, P.4    Caltagirone, C.5    Robinson, R.G.6
  • 56
    • 0030048911 scopus 로고    scopus 로고
    • Therapy of post-stroke depression with fluoxetine. A pilot project
    • M. Stamenkovic, S. Schindler, and S. Kasper Therapy of post-stroke depression with fluoxetine. A pilot project Nervenarzt 67 1996 62 67
    • (1996) Nervenarzt , vol.67 , pp. 62-67
    • Stamenkovic, M.1    Schindler, S.2    Kasper, S.3
  • 57
    • 78149409947 scopus 로고    scopus 로고
    • Riluzole rapidly attenuates hyperemotional responses in olfactory bulbectomized rats, an animal model of depression
    • K. Takahashi, H. Murasawa, K. Yamaguchi, M. Yamada, A. Nakatani, and M. Yoshida et al. Riluzole rapidly attenuates hyperemotional responses in olfactory bulbectomized rats, an animal model of depression Behav Brain Res 216 2011 46 52
    • (2011) Behav Brain Res , vol.216 , pp. 46-52
    • Takahashi, K.1    Murasawa, H.2    Yamaguchi, K.3    Yamada, M.4    Nakatani, A.5    Yoshida, M.6
  • 58
    • 84857526959 scopus 로고    scopus 로고
    • Post-stroke emotional adjustment: A modified social cognitive transition model
    • G.H. Taylor, J. Todman, and N.M. Broomfield Post-stroke emotional adjustment: a modified social cognitive transition model Neuropsychol Rehabil 21 2011 808 824
    • (2011) Neuropsychol Rehabil , vol.21 , pp. 808-824
    • Taylor, G.H.1    Todman, J.2    Broomfield, N.M.3
  • 59
    • 56049123856 scopus 로고    scopus 로고
    • Time course of caspase activation in selectively vulnerable brain areas following global cerebral ischemia due to cardiac arrest in rats
    • P. Teschendorf, S.A. Padosch, F. Spohr, M. Albertsmeier, A. Schneider, and P. Vogel et al. Time course of caspase activation in selectively vulnerable brain areas following global cerebral ischemia due to cardiac arrest in rats Neurosci Lett 448 2008 194 199
    • (2008) Neurosci Lett , vol.448 , pp. 194-199
    • Teschendorf, P.1    Padosch, S.A.2    Spohr, F.3    Albertsmeier, M.4    Schneider, A.5    Vogel, P.6
  • 60
    • 84875069192 scopus 로고    scopus 로고
    • Resveratrol abrogates alcohol-induced cognitive deficits by attenuating oxidative-nitrosative stress and inflammatory cascade in the adult rat brain
    • V. Tiwari, and K. Chopra Resveratrol abrogates alcohol-induced cognitive deficits by attenuating oxidative-nitrosative stress and inflammatory cascade in the adult rat brain Neurochem Int 62 2013 861 869
    • (2013) Neurochem Int , vol.62 , pp. 861-869
    • Tiwari, V.1    Chopra, K.2
  • 61
    • 33646161716 scopus 로고    scopus 로고
    • Effect of melatonin and vitamin e on diabetes-induced learning and memory impairment in rats
    • M. Tuzcu, and G. Baydas Effect of melatonin and vitamin E on diabetes-induced learning and memory impairment in rats Eur J Pharmacol 537 2006 106 110
    • (2006) Eur J Pharmacol , vol.537 , pp. 106-110
    • Tuzcu, M.1    Baydas, G.2
  • 63
    • 33744816479 scopus 로고    scopus 로고
    • Influence of baicalin on the expression of receptor activator of nuclear factor-kappaB ligand in cultured human periodontal ligament cells
    • G.F. Wang, Z.F. Wu, L. Wan, Q.T. Wang, and F.M. Chen Influence of baicalin on the expression of receptor activator of nuclear factor-kappaB ligand in cultured human periodontal ligament cells Pharmacology 77 2006 71 77
    • (2006) Pharmacology , vol.77 , pp. 71-77
    • Wang, G.F.1    Wu, Z.F.2    Wan, L.3    Wang, Q.T.4    Chen, F.M.5
  • 64
    • 0000055268 scopus 로고
    • Mechanisms of lipid peroxide formation in tissues. Role of metals and haematin proteins in the catalysis of the oxidation unsaturated fatty acids
    • E.D. Wills Mechanisms of lipid peroxide formation in tissues. Role of metals and haematin proteins in the catalysis of the oxidation unsaturated fatty acids Biochim Biophys Acta 98 1965 238 251
    • (1965) Biochim Biophys Acta , vol.98 , pp. 238-251
    • Wills, E.D.1
  • 65
    • 34447293701 scopus 로고    scopus 로고
    • Quetiapine attenuates the depressive and anxiolytic-like behavioural changes induced by global cerebral ischemia in mice
    • B. Yan, J. He, H. Xu, Y. Zhang, X. Bi, and S. Thakur et al. Quetiapine attenuates the depressive and anxiolytic-like behavioural changes induced by global cerebral ischemia in mice Behav Brain Res 182 2007 36 41
    • (2007) Behav Brain Res , vol.182 , pp. 36-41
    • Yan, B.1    He, J.2    Xu, H.3    Zhang, Y.4    Bi, X.5    Thakur, S.6
  • 66
    • 77953913463 scopus 로고    scopus 로고
    • Escin attenuates cognitive deficits and hippocampal injury after transient global cerebral ischemia in mice via regulating certain inflammatory genes
    • L. Zhang, F. Fu, X. Zhang, M. Zhu, T. Wang, and H. Fan Escin attenuates cognitive deficits and hippocampal injury after transient global cerebral ischemia in mice via regulating certain inflammatory genes Neurochem Int 57 2010 119 127
    • (2010) Neurochem Int , vol.57 , pp. 119-127
    • Zhang, L.1    Fu, F.2    Zhang, X.3    Zhu, M.4    Wang, T.5    Fan, H.6
  • 67
    • 84863504689 scopus 로고    scopus 로고
    • Optimal dosages of fluoxetine in the treatment of hypoxic brain injury induced by 3-nitropropionic acid: Implications for the adjunctive treatment of patients after acute ischemic stroke
    • B.G. Zhu, Y. Sun, Z.Q. Sun, G. Yang, C.H. Zhou, and R.S. Zhu Optimal dosages of fluoxetine in the treatment of hypoxic brain injury induced by 3-nitropropionic acid: implications for the adjunctive treatment of patients after acute ischemic stroke CNS Neurosci Ther 18 2012 530 535
    • (2012) CNS Neurosci Ther , vol.18 , pp. 530-535
    • Zhu, B.G.1    Sun, Y.2    Sun, Z.Q.3    Yang, G.4    Zhou, C.H.5    Zhu, R.S.6
  • 68
    • 84861200987 scopus 로고    scopus 로고
    • Baicalin reduces the permeability of the blood-brain barrier during hypoxia in vitro by increasing the expression of tight junction proteins in brain microvascular endothelial cells
    • H. Zhu, Z. Wang, Y. Xing, Y. Gao, T. Ma, and L. Lou et al. Baicalin reduces the permeability of the blood-brain barrier during hypoxia in vitro by increasing the expression of tight junction proteins in brain microvascular endothelial cells J Ethnopharmacol 141 2012 714 720
    • (2012) J Ethnopharmacol , vol.141 , pp. 714-720
    • Zhu, H.1    Wang, Z.2    Xing, Y.3    Gao, Y.4    Ma, T.5    Lou, L.6
  • 69
    • 84862143575 scopus 로고    scopus 로고
    • The sensorimotor and cognitive deficits in rats following 90- and 120-min transient occlusion of the middle cerebral artery
    • L. Zvejniece, B. Svalbe, E. Liepinsh, E. Pulks, and M. Dambrova The sensorimotor and cognitive deficits in rats following 90- and 120-min transient occlusion of the middle cerebral artery J Neurosci Methods 208 2012 197 204
    • (2012) J Neurosci Methods , vol.208 , pp. 197-204
    • Zvejniece, L.1    Svalbe, B.2    Liepinsh, E.3    Pulks, E.4    Dambrova, M.5


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