Cornea nerve fiber quantification and construction of phenotypes in patients with fibromyalgia

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Oudejans, Linda ^a   He, Xuan ^a   Niesters, Marieke ^a   Dahan, Albert ^a   Brines, Michael ^b   Van Velzen, Monique ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ARAIM PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; CONFOCAL MICROSCOPY; CORNEA; DIAGNOSTIC IMAGING; FEMALE; FIBROMYALGIA; HUMAN; INNERVATION; MALE; MIDDLE AGED; NERVE FIBER; PATHOLOGY; YOUNG ADULT;

ADULT; CORNEA; FEMALE; FIBROMYALGIA; HUMANS; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; NERVE FIBERS; YOUNG ADULT;

EID: 84962276388     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep23573     Document Type: Article

References (45)

1. Clauw, D. J. Fibromyalgia: A clinical review. Jama 311, 1547-1555, doi: 10.1001/jama.2014.3266 (2014).
2. Schmidt-Wilcke, T. & Clauw, D. J. Fibromyalgia: From pathophysiology to therapy. Nature reviews. Rheumatology 7, 518-527, doi: 10.1038/nrrheum.2011.98 (2011).
3. Jensen, K. B. et al. Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked pain. Pain 144, 95-100, doi: 10.1016/j.pain.2009.03.018 (2009).
4. Lautenbacher, S. & Rollman, G. B. Possible deficiencies of pain modulation in fibromyalgia. The Clinical journal of pain 13, 189-196 (1997).
5. Caro, X. J. & Winter, E. F. Evidence of abnormal epidermal nerve fiber density in fibromyalgia: Clinical and immunologic implications. Arthritis Rheumatol 66, 1945-1954, doi: 10.1002/art.38662 (2014).
6. Doppler, K., Rittner, H. L., Deckart, M. & Sommer, C. Reduced dermal nerve fiber diameter in skin biopsies of patients with fibromyalgia. Pain 156, 2319-2325, doi: 10.1097/j.pain.0000000000000285 (2015).
7. Giannoccaro, M. P., Donadio, V., Incensi, A., Avoni, P. & Liguori, R. Small nerve fiber involvement in patients referred for fibromyalgia. Muscle & nerve 49, 757-759, doi: 10.1002/mus.24156 (2014).
8. Oaklander, A. L., Herzog, Z. D., Downs, H. M. & Klein, M. M. Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia. Pain 154, 2310-2316, doi: 10.1016/j.pain.2013.06.001 (2013).
9. Ramirez, M. et al. Small fiber neuropathy in women with fibromyalgia. An in vivo assessment using corneal confocal biomicroscopy. Seminars in arthritis and rheumatism 45, 214-219, doi: 10.1016/j.semarthrit.2015.03.003 (2015).
10. Uceyler, N. et al. Small fibre pathology in patients with fibromyalgia syndrome. Brain : A journal of neurology 136, 1857-1867, doi: 10.1093/brain/awt053 (2013).
11. Serra, J. et al. Hyperexcitable C nociceptors in fibromyalgia. Annals of neurology 75, 196-208, doi: 10.1002/ana.24065 (2014).
12. Clauw, D. J. What is the meaning of "small fiber neuropathy" in fibromyalgia? Pain 156, 2115-2116, doi: 10.1097/j. pain.0000000000000311 (2015).
13. Uceyler, N. & Sommer, C. Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia. Pain 154, 2569, doi: 10.1016/j.pain.2013.06.037 (2013).
14. Wopking, S. et al. Significant difference between three observers in the assessment of intraepidermal nerve fiber density in skin biopsy. BMC Neurol 9, 13, doi: 10.1186/1471-2377-9-13 (2009).
15. Petropoulos, I. N. et al. Corneal nerve loss detected with corneal confocal microscopy is symmetrical and related to the severity of diabetic polyneuropathy. Diabetes Care 36, 3646-3651, doi: 10.2337/dc13-0193 (2013).
16. Tavakoli, M. et al. Corneal confocal microscopy: A novel noninvasive test to diagnose and stratify the severity of human diabetic neuropathy. Diabetes Care 33, 1792-1797, doi: 10.2337/dc10-0253 (2010).
17. Brines, M. et al. Corneal nerve quantification predicts the severity of symptoms in sarcoidosis patients with painful neuropathy. Technology 1, 1-7 (2013).
18. Ziegler, D. et al. Early detection of nerve fiber loss by corneal confocal microscopy and skin biopsy in recently diagnosed type 2 diabetes. Diabetes 63, 2454-2463, doi: 10.2337/db13-1819 (2014).
19. Tavakoli, M. et al. Normative values for corneal nerve morphology assessed using corneal confocal microscopy: A multinational normative data set. Diabetes Care 38, 838-843, doi: 10.2337/dc14-2311 (2015).
20. Arendt-Nielsen, L. & Yarnitsky, D. Experimental and clinical applications of quantitative sensory testing applied to skin, muscles and viscera. The journal of pain: Official journal of the American Pain Society 10, 556-572, doi: 10.1016/j.jpain.2009.02.002 (2009).
21. Woolf, C. J. Central sensitization: Implications for the diagnosis and treatment of pain. Pain 152, S2-15, doi: 10.1016/j. pain.2010.09.030 (2011).
22. Malik, R. A. et al. Corneal confocal microscopy: A non-invasive surrogate of nerve fibre damage and repair in diabetic patients. Diabetologia 46, 683-688, doi: 10.1007/s00125-003-1086-8 (2003).
23. Tavakoli, M. & Malik, R. A. Corneal confocal microscopy: A novel non-invasive technique to quantify small fibre pathology in peripheral neuropathies. J Vis Exp, doi: 10.3791/2194 (2011).
24. Tavakoli, M. et al. Corneal confocal microscopy: A novel noninvasive means to diagnose neuropathy in patients with Fabry disease. Muscle & nerve 40, 976-984, doi: 10.1002/mus.21383 (2009).
25. Kosmidis, M. L. et al. Reduction of Intraepidermal Nerve Fiber Density (IENFD) in the skin biopsies of patients with fibromyalgia: A controlled study. J Neurol Sci 347, 143-147, doi: 10.1016/j.jns.2014.09.035 (2014).
26. Klauenberg, S. et al. Depression and changed pain perception: Hints for a central disinhibition mechanism. Pain 140, 332-343, doi: 10.1016/j.pain.2008.09.003 (2008).
27. Blumenstiel, K. et al. Quantitative sensory testing profiles in chronic back pain are distinct from those in fibromyalgia. The Clinical journal of pain 27, 682-690, doi: 10.1097/AJP.0b013e3182177654 (2011).
28. Rolke, R. et al. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Standardized protocol and reference values. Pain 123, 231-243, doi: 10.1016/j.pain.2006.01.041 (2006).
29. Lang, P. M. et al. Sensory neuropathy and signs of central sensitization in patients with peripheral arterial disease. Pain 124, 190-200, doi: 10.1016/j.pain.2006.04.011 (2006).
30. Wolfe, F. et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis care & research 62, 600-610, doi: 10.1002/acr.20140 (2010).
31. Desmeules, J. A. et al. Neurophysiologic evidence for a central sensitization in patients with fibromyalgia. Arthritis and rheumatism 48, 1420-1429, doi: 10.1002/art.10893 (2003).
32. Fayed, N. et al. Localized 1H-NMR spectroscopy in patients with fibromyalgia: A controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate. Arthritis research & therapy 12, R134, doi: 10.1186/ar3072 (2010).
33. Harris, R. E. et al. Elevated insular glutamate in fibromyalgia is associated with experimental pain. Arthritis and rheumatism 60, 3146-3152, doi: 10.1002/art.24849 (2009).
34. Gracely, R. H. & Ambrose, K. R. Neuroimaging of fibromyalgia. Best practice & research. Clinical rheumatology 25, 271-284, doi: 10.1016/j.berh.2011.02.003 (2011).
35. Jensen, K. B. et al. Patients with fibromyalgia display less functional connectivity in the brain's pain inhibitory network. Molecular pain 8, 32, doi: 10.1186/1744-8069-8-32 (2012).
36. Napadow, V. & Harris, R. E. What has functional connectivity and chemical neuroimaging in fibromyalgia taught us about the mechanisms and management of 'centralized' pain? Arthritis research & therapy 16, 425 (2014).
37. Clauw, D. J. Diagnosing and treating chronic musculoskeletal pain based on the underlying mechanism(s). Best Pract Res Cl Rh 29, 6-19, doi: 10.1016/j.berh.2015.04.024 (2015).
38. Ablin, J. N. & Buskila, D. Update on the genetics of the fibromyalgia syndrome. Best practice & research. Clinical rheumatology 29, 20-28, doi: 10.1016/j.berh.2015.04.018 (2015).
39. Desmeules, J. et al. Central pain sensitization, COMT Val158Met polymorphism, and emotional factors in fibromyalgia. The journal of pain : Official journal of the American Pain Society 15, 129-135, doi: 10.1016/j.jpain.2013.10.004 (2014).
40. Heij, L. et al. Safety and efficacy of ARA 290 in sarcoidosis patients with symptoms of small fiber neuropathy: A randomized, doubleblind pilot study. Mol Med 18, 1430-1436, doi: 10.2119/molmed.2012.00332 (2012).
41. Wolfe, F. et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheumatol 33, 160-172 (1990).
42. Chen, X. et al. Small Nerve Fiber Quantification in the Diagnosis of Diabetic Sensorimotor Polyneuropathy: Comparing Corneal Confocal Microscopy With Intraepidermal Nerve Fiber Density. Diabetes Care, doi: 10.2337/dc14-2422 (2015).
43. Petropoulos, I. N. et al. Rapid automated diagnosis of diabetic peripheral neuropathy with in vivo corneal confocal microscopy. Investigative ophthalmology & visual science 55, 2071-2078, doi: 10.1167/iovs.13-13787 (2014).
44. Hoitsma, E., De Vries, J. & Drent, M. The small fiber neuropathy screening list: Construction and cross-validation in sarcoidosis. Respiratory medicine 105, 95-100, doi: 10.1016/j.rmed.2010.09.014 (2011).
45. Magerl, W. et al. Reference data for quantitative sensory testing (QST): Refined stratification for age and a novel method for statistical comparison of group data. Pain 151, 598-605, doi: 10.1016/j.pain.2010.07.026 (2010).