Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia

Pain

Volumn 154, Issue 11, 2013, Pages 2310-2316

  Oaklander, Anne Louise ^a   Herzog, Zeva Daniela ^a   Downs, Heather M ^a   Klein, Max M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Autonomic function testing; Chronic pain; Human subject research; Peripheral nerve; Peripheral neuropathy; Skin biopsy

Indexed keywords

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; FIBROMYALGIA; GLUCOSE TOLERANCE TEST; HEPATITIS C; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROLOGIC EXAMINATION; OUTCOME VARIABLE; POLYNEUROPATHY; PRIORITY JOURNAL; RATING SCALE; RHEUMATOLOGY; SAMPLE SIZE; SKIN BIOPSY; SMALL FIBER NEUROPATHY; SMALL FIBER POLYNEUROPATHY; UTAH EARLY NEUROPATHY SCALE; ADOLESCENT; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NERVE FIBER; PAIN MEASUREMENT; PATHOLOGY; POLYNEUROPATHIES; PSYCHOLOGY; QUESTIONNAIRE; REPRODUCIBILITY; SKIN; STATISTICAL ANALYSIS; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; DATA INTERPRETATION, STATISTICAL; FEMALE; FIBROMYALGIA; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NERVE FIBERS; PAIN MEASUREMENT; POLYNEUROPATHIES; QUESTIONNAIRES; REPRODUCIBILITY OF RESULTS; SAMPLE SIZE; SKIN; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84886253601     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2013.06.001     Document Type: Article

References (52)

1. Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology Assessment: clinical autonomic testing report Neurology 46 1996 873 880
2. A.M. Aalto, M. Elovainio, M. Kivimaki, A. Uutela, and S. Pirkola The Beck Depression Inventory and General Health Questionnaire as measures of depression in the general population: a validation study using the Composite International Diagnostic Interview as the gold standard Psychiatry Res 197 2012 163 171
3. N. Akkaya, S. Akkaya, N.S. Atalay, C.S. Balci, and F. Sahin Relationship between the body image and level of pain, functional status, severity of depression, and quality of life in patients with fibromyalgia syndrome Clin Rheumatol 31 2012 983 988
4. A.A. Amato, and A.L. Oaklander Case records of the Massachusetts General Hospital: case 16, 2004: a 76-year-old woman with pain and numbness in the legs and feet N Engl J Med 350 2004 2181 2189 (Pubitemid 38637999)
5. D. Califano, A. D'Alessio, G.L. Colucci-D'Amato, G. De Vita, C. Monaco, G. Santelli, P.P. Di Fiore, G. Vecchio, A. Fusco, M. Santoro, and V. de Franciscis A potential pathogenetic mechanism for multiple endocrine neoplasia type 2 syndromes involves ret-induced impairment of terminal differentiation of neuroepithelial cells Proc Natl Acad Sci 93 1996 7933 7937 (Pubitemid 26277142)
6. X.J. Caro, E.F. Winter, and A.J. Dumas A subset of fibromyalgia patients have findings suggestive of chronic inflammatory demyelinating polyneuropathy and appear to respond to IVIg Rheumatology (Oxford) 47 2008 208 211 (Pubitemid 351168234)
7. G. Devigili, V. Tugnoli, P. Penza, F. Camozzi, R. Lombardi, G. Melli, L. Broglio, E. Granieri, and G. Lauria The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology Brain 131 2008 1912 1925 (Pubitemid 351957452)
8. J.D. England, G.S. Gronseth, G. Franklin, G.T. Carter, L.J. Kinsella, J.A. Cohen, A.K. Asbury, K. Szigeti, J.R. Lupski, N. Latov, R.A. Lewis, P.A. Low, M.A. Fisher, D.N. Herrmann, J.F. Howard Jr., G. Lauria, R.G. Miller, M. Polydefkis, and A.J. Sumner Practice parameter: evaluation of distal symmetric polyneuropathy: role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review) Rep Am Acad Neurol, Am Assoc Neuromusc Electrodiagn Med, Am Acad Phys Med Rehabil, Neurology 72 2009 177 184
9. J.D. England, G.S. Gronseth, G. Franklin, G.T. Carter, L.J. Kinsella, J.A. Cohen, A.K. Asbury, K. Szigeti, J.R. Lupski, N. Latov, R.A. Lewis, P.A. Low, M.A. Fisher, D.N. Herrmann, J.F. Howard Jr., G. Lauria, R.G. Miller, M. Polydefkis, and A.J. Sumner Practice parameter: evaluation of distal symmetric polyneuropathy: role of laboratory and genetic testing (an evidence-based review) Rep Am Acad Neurol, Am Assoc Neuromusc Electrodiagn Med, Am Acad Phys Med Rehabil, Neurology 72 2009 185 192
10. C.G. Faber, J.G.J. Hoeijmakers, H.S. Ahn, X. Cheng, C. Han, J.S. Choi, M. Estacion, G. Lauria, E.K. Vanhoutte, M.M. Gerrits, S. Dib-Hajj, J.P.H. Drenth, S.G. Waxman, and I.S.J. Merkies Gain of function NaV1.7 mutations in idiopathic small-fiber neuropathy Ann Neurol 71 2012 26 39
11. E.L. Feldman, M.J. Stevens, P.K. Thomas, M.B. Brown, N. Canal, and D.A. Greene A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy Diabetes Care 17 1994 1281 1289 (Pubitemid 24324972)
12. R. Freeman, K.P. Chase, and M.R. Risk Quantitative sensory testing cannot differentiate simulated sensory loss from sensory neuropathy Neurology 60 2003 465 470 (Pubitemid 36188243)
13. R. Freeman, W. Wieling, F.B. Axelrod, D.G. Benditt, E. Benarroch, I. Biaggioni, W.P. Cheshire, T. Chelimsky, P. Cortelli, C.H. Gibbons, D.S. Goldstein, R. Hainsworth, M.J. Hilz, G. Jacob, H. Kaufmann, J. Jordan, L.A. Lipsitz, B.D. Levine, P.A. Low, C. Mathias, S.R. Raj, D. Robertson, P. Sandroni, I. Schatz, R. Schondorf, J.M. Stewart, and J.G. van Dijk Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome Clin Auton Res 21 2011 69 72
14. K. Garofalo, A. Penno, B.P. Schmidt, H.J. Lee, M.P. Frosch, E.A. von, R.H. Brown, T. Hornemann, and F.S. Eichler Oral l-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1 J Clin Invest 121 2011 4735 4745
15. C.H. Gibbons, N. Wang, and R. Freeman Capsaicin induces degeneration of cutaneous autonomic nerve fibers Ann Neurol 68 2010 888 898
16. K.C. Gorson, D.N. Herrmann, R. Thiagarajan, T. Brannagan, R.L. Chin, L.J. Kinsella, and A.H. Ropper Non-length-dependent small fiber neuropathy small neuropathy/ganglionopathy J Neurol Neurosurg Psychiatr 79 2007 163 169
17. R.H. Gracely, F. Petzke, J.M. Wolf, and D.J. Clauw Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia Arthritis Rheum 46 2002 1333 1343 (Pubitemid 34525843)
18. P.A. Harris, R. Taylor, R. Thielke, J. Payne, N. Gonzalez, and J.G. Conde Research electronic data capture (REDCap): a metadata-driven methodology and workflow process for providing translational research informatics support J Biomed Inform 42 2009 377 381
19. D.L. Hoffman, and E.M. Dukes The health status burden of people with fibromyalgia: a review of studies that assessed health status with the SF-36 or the SF-12 Int J Clin Pract 62 2008 115 126 (Pubitemid 350294025)
20. P. Holzer Efferent-like roles of afferent neurons in the gut: blood flow regulation and tissue protection Auton Neurosci 125 2006 70 75
21. M.C. Hsu, R.E. Harris, P.C. Sundgren, R.C. Welsh, C.R. Fernandes, D.J. Clauw, and D.A. Williams No consistent difference in gray matter volume between individuals with fibromyalgia and age-matched healthy subjects when controlling for affective disorder PAIN® 143 2009 262 267
22. K.B. Jensen, E. Kosek, F. Petzke, S. Carville, P. Fransson, H. Marcus, S.C.R. Williams, E. Choy, T. Giesecke, Y. Mainguy, R. Gracely, and M. Ingvar Evidence of dysfunctional pain inhibition in fibromyalgia reflected in rACC during provoked pain PAIN® 144 2009 95 100
23. K.B. Jensen, F. Petzke, S. Carville, P. Fransson, H. Marcus, S.C. Williams, E. Choy, Y. Mainguy, R. Gracely, M. Ingvar, and E. Kosek Anxiety and depressive symptoms in fibromyalgia are related to poor perception of health but not to pain sensitivity or cerebral processing of pain Arthritis Rheum 62 2010 3488 3495
24. R.S. Katz, F. Wolfe, and K. Michaud Fibromyalgia diagnosis: a comparison of clinical, survey, and American College of Rheumatology criteria Arthritis Rheum 54 2006 169 176 (Pubitemid 43122199)
25. M.M. Klein, H. Downs, and A.L. Oaklander Normal innervation in distal-leg skin biopsies: evidence of superabundance in youth, subsequent axonal pruning, plus new diagnostic recommendations Ann Neurol 68 2010 S68
26. J. Koroschetz, S.E. Rehm, U. Gockel, M. Brosz, R. Freynhagen, T.R. Tolle, and R. Baron Fibromyalgia and neuropathic pain: differences and similarities:a comparison of 3057 patients with diabetic painful neuropathy and fibromyalgia BMC Neurol 11 2011 55
27. G. Lauria, D.R. Cornblath, O. Johansson, J.C. McArthur, S.I. Mellgren, M. Nolano, N. Rosenberg, and C. Sommer EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy Eur J Neurol 12 2005 747 758 (Pubitemid 41495131)
28. G. Lauria, S.T. Hsieh, O. Johansson, W.R. Kennedy, J.M. Leger, S.I. Mellgren, M. Nolano, I.S. Merkies, M. Polydefkis, A.G. Smith, C. Sommer, and J. Valls-Sole European Federation of Neurological Societies/Peripheral Nerve Society Guidelines on the use of skin biopsy in the diagnosis of small fiber neuropathy Eur J Neurol 17 2010 903 909
29. L. Lindell, S. Bergman, I.F. Petersson, L.T. Jacobsson, and P. Herrstrom Prevalence of fibromyalgia and chronic widespread pain Scand J Prim Health Care 18 2000 149 153
30. P.A. Low Composite autonomic scoring scale for laboratory quantification of generalized autonomic failure Mayo Clin Proc 68 1993 748 752 (Pubitemid 23222298)
31. P.A. Low Prevalence of orthostatic hypotension Clin Auton Res 18 2008 8 13 (Pubitemid 351667197)
32. P.A. Low, J.C. Denq, T.L. Opfer-Gehrking, P.J. Dyck, P.C. O'Brien, and J.M. Slezak Effect of age and gender on sudomotor and cardiovagal function and blood pressure response to tilt in normal subjects Muscle Nerve 20 1997 1561 1568 (Pubitemid 27512345)
33. P.A. Low, and D.M. Sletten Laboratory evaluation of autonomic failure P.A. Low, E.E. Benarroch, Clinical autonomic disorders 2008 Lippincott Williams & Wilkins Baltimore 130 163
34. A. Moghtaderi, A. Bakhshipour, and H. Rashidi Validation of Michigan neuropathy screening instrument for diabetic peripheral neuropathy Clin Neurol Neurosurg 108 2006 477 481 (Pubitemid 43729483)
35. P. Novak Assessment of sympathetic index from the Valsalva maneuver Neurology 76 2011 2010 2016
36. P. Novak Quantitative autonomic testing. J Vis Exp 53 2011 e2502
37. A.L. Oaklander, and M.M. Klein Evidence of small-fiber polyneuropathy in unexplained, juvenile-onset, widespread pain syndromes Pediatrics 131 2013 e1091 e1100
38. J. Paticoff, A. Valovska, S.S. Nedeljkovic, and A.L. Oaklander Defining a treatable cause of erythromelalgia: acute adolescent autoimmune small-fiber axonopathy Anesth Analg 104 2007 438 441 (Pubitemid 46146756)
39. C. Reed, H.G. Birnbaum, J.I. Ivanova, M. Schiller, T. Waldman, R.E. Mullen, and R. Swindle Real-world role of tricyclic antidepressants in the treatment of fibromyalgia Pain Pract 12 2012 533 540
40. R. Ruscheweyh, M. Deppe, H. Lohmann, C. Stehling, A. Flöel, E.B. Ringelstein, and S. Knecht Pain is associated with regional grey matter reduction in the general, population PAIN® 152 2011 904 911
41. Shtein R, Hussain M, Hamid M, Raval N, Williams DA, Clauw DJ. In vivo corneal confocal microscopy and clinical correlations in fibromyalgia (FM). In: Meeting of the International Association for the Study of Pain; 2012.
42. D.A. Simone, M. Nolano, T. Johnson, G. Wendelschafer-Crabb, and W.R. Kennedy Intradermal injection of capsaicin in humans produces degeneration and subsequent reinnervation of epidermal nerve fibers: correlation with sensory function J Neurosci 18 1998 8947 8959 (Pubitemid 28491759)
43. J.R. Singleton, B. Bixby, J.W. Russell, E.L. Feldman, A. Peltier, J. Goldstein, J. Howard, and A.G. Smith The Utah Early Neuropathy Scale: a sensitive clinical scale for early sensory predominant neuropathy J Peripher Nerv Syst 13 2008 218 227
44. Solà R, Collado A, Antonelli F, Quiles C, Serra J. Is fibromyalgia a special type of small fiber neuropathy? A microneurography study. In: Meeting of the International Association for the Study of Pain; 2012.
45. Üçeyler N, Kahn A-K, Zeller D, Kewenig S, Kittel-Schneider S, Reiners K, Sommer C. Functional and morphological impairment of small nerve fibers in fibromyalgia syndrome. In: Meeting of the International Association for the Study of Pain; 2012.
46. G. Vargas-Alarcon, E. Alvarez-Leon, J.M. Fragoso, A. Vargas, A. Martinez, M. Vallejo, and M. Martinez-Lavin An SCN9A gene-encoded dorsal root ganglia sodium channel polymorphism associated with severe fibromyalgia BMC Musculoskelet Disord 13 2012 23 28
47. K. Vincent, C. Warnaby, C.J. Stagg, J. Moore, S. Kennedy, and I. Tracey Dysmenorrhoea is associated with central changes in otherwise healthy women PAIN® 152 2011 1966 1975
48. L. Wang, M. Hilliges, T. Jernberg, D. Wiegleb-Edstrom, and O. Johansson Protein gene product 9.5-immunoreactive nerve fibres and cells in human skin Cell Tissue Res 261 1990 25 33 (Pubitemid 20205948)
49. K.P. White, M. Speechley, M. Harth, and T. Ostbye The London Fibromyalgia Epidemiology Study: direct health care costs of fibromyalgia syndrome in London, Canada J Rheumatol 26 1999 885 889 (Pubitemid 29195677)
50. K.P. White, M. Speechley, M. Harth, and T. Ostbye The London Fibromyalgia Epidemiology Study: the prevalence of fibromyalgia syndrome in London, Ontario J Rheumatol 26 1999 1570 1576 (Pubitemid 29317882)
51. F. Wolfe, D.J. Clauw, M.A. Fitzcharles, D.L. Goldenberg, R.S. Katz, P. Mease, A.S. Russell, I.J. Russell, J.B. Winfield, and M.B. Yunus The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity Arthritis Care Res (Hoboken) 62 2010 600 610
52. F. Wolfe, H.A. Smythe, M.B. Yunus, R.M. Bennett, C. Bombardier, D.L. Goldenberg, P. Tugwell, S.M. Campbell, M. Abeles, and P. Clark The American College of Rheumatology 1990 criteria for the classification of fibromyalgia: report of the multicenter criteria committee Arthritis Rheum 33 1990 160 172 (Pubitemid 20098653)