PGC-1α coordinates mitochondrial respiratory capacity and muscular fatty acid uptake via regulation of VEGF-B

Diabetes

Volumn 65, Issue 4, 2016, Pages 861-873

  Mehlem, Annika ^a   Palombo, Isolde ^a   Wang, Xun ^a   Hagberg, Carolina E ^a   Eriksson, Ulf ^a   Falkevall, Annelie ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE MM; ESTROGEN RELATED RECEPTOR ALPHA; FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; VASCULOTROPIN B; PPARGC1A PROTEIN, MOUSE; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULAR ENDOTHELIAL GROWTH FACTOR B, MOUSE; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL; CONTROLLED STUDY; DYSLIPIDEMIA; FATTY ACID TRANSPORT; GENE; GLUCOSE INTOLERANCE; INSULIN RESISTANCE; LIPID STORAGE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATION; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; ANIMAL; CELL CULTURE; CELL RESPIRATION; CHLOROCEBUS AETHIOPS; COS CELL LINE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUSCLE MITOCHONDRION; PHYSIOLOGY; SKELETAL MUSCLE; TRANSGENIC MOUSE;

ANIMALS; CELL RESPIRATION; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; FATTY ACIDS; GENE EXPRESSION REGULATION; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR B;

EID: 84962159096     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db15-1231     Document Type: Article

References (32)

1. Hagberg CE, Falkevall A, Wang X., et al. Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature 2010; 464:917-921
2. Hagberg CE, Mehlem A, Falkevall A., et al. Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes. Nature 2012; 490:426-430
3. Aase K, von Euler G, Li X, et al Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect. Circulation 2001; 104: 358-364
4. Chan MC, Arany Z. The many roles of PGC-1α in muscle-recent developments. Metabolism 2014; 63:441-451
5. Lowell BB, Shulman GI Mitochondrial dysfunction and type 2 diabetes. Science 2005; 307:384-387
6. Lin J, Wu H, Tarr P.T., et al. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 2002; 418:797-801
7. Choi CS, Befroy DE, Codella R, et al Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc Natl Acad Sci U S A 2008; 105: 19926-19931
8. Arany Z, Foo SY, Ma Y, et al HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature 2008; 451: 1008-1012
9. Ovcharenko I, Loots GG, Giardine B.M., et al. Mulan: multiple-sequence local alignment and visualization for studying function and evolution. Genome Res 2005; 15:184-194
10. Mehlem A, Hagberg CE, Muhl L, Eriksson U., Falkevall A. Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease. Nat Protoc 2013; 8:1149-1154
11. Nygren H, Seppänen-Laakso T, Castillo S, Hyötyläinen T, Orešic M. Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues. Methods Mol Biol 2011; 708:247-257
12. Ovcharenko I, Nobrega MA, Loots G.G., Stubbs L. ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes. Nucleic Acids Res 2004; 32:W280-W286
13. Sladek R, Bader JA, Giguère V. The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene. Mol Cell Biol 1997; 17:5400-5409
14. Summermatter S, Baum O, Santos G., Hoppeler H, Handschin C. Peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway. J Biol Chem 2010; 285:32793-32800
15. Pilegaard H, Neufer PD Transcriptional regulation of pyruvate dehydrogenase kinase 4 in skeletal muscle during and after exercise. Proc Nutr Soc 2004; 63:221-226
16. Wende AR, Huss JM, Schaeffer P.J., Giguère V, Kelly DP. PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. Mol Cell Biol 2005; 25:10684-10694
17. 1H nuclear magnetic resonance spectroscopy study. J Clin Endocrinol Metab 2000; 85:748-754
18. Clerk LH, Rattigan S, Clark MG Lipid infusion impairs physiologic insulin-mediated capillary recruitment and muscle glucose uptake in vivo. Diabetes 2002; 51:1138-1145
19. Samuel VT, Petersen KF, Shulman GI Lipid-induced insulin resistance: unravelling the mechanism. Lancet 2010; 375:2267-2277
20. Majer M, Popov KM, Harris R.A., Bogardus C., Prochazka M. Insulin down-regulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects. Mol Genet Metab 1998; 65:181-186
21. Vind BF, Pehmøller C, Treebak J.T., et al. Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training. Diabetologia 2011; 54:157-167
22. Boström P., Wu J, Jedrychowski M.P., et al. A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012; 481:463-468
23. Chinsomboon J, Ruas J, Gupta R.K., et al. The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle. Proc Natl Acad Sci U S A 2009; 106:21401-21406
24. Zhang K, Lu J, Mori T., et al. Baicalin increases VEGF expression and an-giogenesis by activating the ERRalpha/PGC-1alpha pathway. Cardiovasc Res 2011; 89:426-435
25. Wallace MA, Hock MB, Hazen B.C., Kralli A., Snow RJ, Russell AP. Striated muscle activator of Rho signalling (STARS) is a PGC-1α/oestrogen-related receptor-α target gene and is upregulated in human skeletal muscle after endurance exercise. J Physiol 2011; 589:2027-2039
26. Mootha VK, Lindgren CM, Eriksson K.F., et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 2003; 34:267-273
27. Patti ME, Butte AJ, Crunkhorn S, et al Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A 2003; 100:8466-8471
28. Sun CY, Lee CC, Hsieh M.F., Chen CH, Chou KM. Clinical association of circulating VEGF-B levels with hyperlipidemia and target organ damage in type 2 diabetic patients. J Biol Regul Homeost Agents 2014; 28: 225-236
29. Cheng F, Zhao L, Wu Y., et al. Serum vascular endothelial growth factor B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment. Clin Endocrinol (Oxf) 2016; 84: 386-393
30. Gertow K, Bellanda M, Eriksson P., et al. Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome. J Clin Endocrinol Metab 2004; 89:392-399
31. Gómez-Ambrosi J., Catalán V, Rodríguez A, et al. Involvement of serum vascular endothelial growth factor family members in the development of obesity in mice and humans. J Nutr Biochem 2010; 21:774-780
32. Gómez-Ambrosi J., Catalán V, Diez-Caballero A, et al. Gene expression profile of omental adipose tissue in human obesity. FASEB J 2004; 18:215-217