메뉴 건너뛰기




Volumn 3, Issue 1, 2015, Pages 78-84

Nonalcoholic fatty liver disease: Dyslipidemia, risk for cardiovascular complications, and treatment strategy

Author keywords

Cardiovascular disease; Dyslipidemia; Hypolipidemic agents; Nonalcoholic fatty liver disease

Indexed keywords


EID: 84962112426     PISSN: 22250719     EISSN: 23108819     Source Type: Journal    
DOI: 10.14218/JCTH.2014.00037     Document Type: Review
Times cited : (118)

References (66)
  • 1
    • 79957449923 scopus 로고    scopus 로고
    • Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008
    • Younossi ZM, Stepanova M, Afendy M, Fang Y, Younossi Y, Mir H, et al. Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008. Clin Gastroenterol Hepatol 2011;9:524–530. doi: 10.1016/j.cgh.2011.03.020.
    • (2011) Clin Gastroenterol Hepatol , vol.9 , pp. 524-530
    • Younossi, ZM1    Stepanova, M2    Afendy, M3    Fang, Y4    Younossi, Y5    Mir, H6
  • 2
    • 84874053088 scopus 로고    scopus 로고
    • The burden of liver disease in Europe. A Review of available epidemiological data
    • Blachier M, Leleu H, Peck-Radosavljevic M, Valla DC, Roudot-Thoraval F. The burden of liver disease in Europe. A Review of available epidemiological data. J Hepatol 2013;58:593–608. doi: 10.1016/j.jhep.2012.12.005.
    • (2013) J Hepatol , vol.58 , pp. 593-608
    • Blachier, M1    Leleu, H2    Peck-Radosavljevic, M3    Valla, DC4    Roudot-Thoraval, F.5
  • 3
    • 85080511749 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002;346:2121–1231.
    • (2002) N Engl J Med , vol.346 , pp. 2121-1231
    • Angulo, P.1
  • 4
    • 79952781248 scopus 로고    scopus 로고
    • accessed April 2014
    • http://dx.doi.org/10.1787/9789264183896-en, accessed April 2014.
  • 5
    • 78650486196 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepa-titis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study
    • Williams CD, Stengel J, Asike MI, Torres DM, Shaw J, Contreras M, et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepa-titis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology 2011;140:124–131. doi: 10.1053/j.gastro.2010.09.038.
    • (2011) Gastroenterology , vol.140 , pp. 124-131
    • Williams, CD1    Stengel, J2    Asike, MI3    Torres, DM4    Shaw, J5    Contreras, M6
  • 6
    • 80053581540 scopus 로고    scopus 로고
    • Frequency and outcomes of liver transplantation for nonalcoholic steatohe-patitis in the United States
    • Charlton MR, Burns JM, Pedersen RA, Watt KD, Heimbach JK, Dierkhising RA. Frequency and outcomes of liver transplantation for nonalcoholic steatohe-patitis in the United States. Gastroenterology 2011;141:1249–1253. doi: 10.1053/j.gastro.2011.06.061.
    • (2011) Gastroenterology , vol.141 , pp. 1249-1253
    • Charlton, MR1    Burns, JM2    Pedersen, RA3    Watt, KD4    Heimbach, JK5    Dierkhising, RA.6
  • 7
    • 84864090834 scopus 로고    scopus 로고
    • Mechanisms of Simple Hepatic Steatosis: Not So Simple After All
    • Scott C. Matherly, Puneet Puri. Mechanisms of Simple Hepatic Steatosis: Not So Simple After All. Clin Liver Dis 2012;16:505–524. doi: 10.1016/j.cld.2012.05.005.
    • (2012) Clin Liver Dis , vol.16 , pp. 505-524
    • Matherly, Scott C.1    Puri, Puneet2
  • 8
    • 58949094415 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: selected practical issues in their evaluation and manage-ment
    • Vuppalanchi R, Chalasani N. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: selected practical issues in their evaluation and manage-ment. Hepatology 2009;49:306–317. doi: 10.1002/hep.22603.
    • (2009) Hepatology , vol.49 , pp. 306-317
    • Vuppalanchi, R1    Chalasani, N.2
  • 9
    • 84864925003 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and the statins treatment
    • Dima A, Marinescu AG, Dima AC. Non-alcoholic fatty liver disease and the statins treatment. Rom J Intern Med 2012, 50:19–25.
    • (2012) Rom J Intern Med , vol.50 , pp. 19-25
    • Dima, A1    Marinescu, AG2    Dima, AC.3
  • 10
    • 84908176321 scopus 로고    scopus 로고
    • Postnatal overfeeding promotes early onset and exaggeration of high-fat diet-induced nonalcoholic fatty liver disease through disordered hepatic lipid metabolism in rats
    • Ji C, Dai Y, Jiang W, Liu J, Hou M, Wang J, et al. Postnatal overfeeding promotes early onset and exaggeration of high-fat diet-induced nonalcoholic fatty liver disease through disordered hepatic lipid metabolism in rats. J Nutr Biochem 2014;25: 1108–1116. doi: 10.1016/j.jnutbio.2014.06.010.
    • (2014) J Nutr Biochem , vol.25 , pp. 1108-1116
    • Ji, C1    Dai, Y2    Jiang, W3    Liu, J4    Hou, M5    Wang, J6
  • 11
    • 77956639983 scopus 로고    scopus 로고
    • NASH Clinical Research Network. Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease
    • Neuschwander-Tetri BA, Clark JM, Bass NM, Van Natta ML, Unalp-Arida A, Tonascia J, et al. NASH Clinical Research Network. Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease. Hepatology 2010;52:913–924. doi: 10.1002/hep.23784.
    • (2010) Hepatology , vol.52 , pp. 913-924
    • Neuschwander-Tetri, BA1    Clark, JM2    Bass, NM3    Van Natta, ML4    Unalp-Arida, A5    Tonascia, J6
  • 12
    • 84880024479 scopus 로고    scopus 로고
    • Study of prevalence of nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes patients in India (SPRINT)
    • Kalra S, Vithalani M, Gulati G, Kulkarni CM, Kadam Y, Pallivathukkal J, et al. Study of prevalence of nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes patients in India (SPRINT). J Assoc Physicians India 2013;61:448– 453.
    • (2013) J Assoc Physicians India , vol.61 , pp. 448-453
    • Kalra, S1    Vithalani, M2    Gulati, G3    Kulkarni, CM4    Kadam, Y5    Pallivathukkal, J6
  • 13
    • 84905570567 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in obese children and the relationship between metabolic syndrome criteria
    • Boyraz M, Hatipoğlu N, Sarı E, Akcay A, Taskin N, Ulucan K, et al. Nonalcoholic fatty liver disease in obese children and the relationship between metabolic syndrome criteria. Obes Res Clin Pract 2014;8:e356–e363. doi: 10.1016/j.orcp.2013.08.003.
    • (2014) Obes Res Clin Pract , vol.8 , pp. e356-e363
    • Boyraz, M1    Hatipoğlu, N2    Sarı, E3    Akcay, A4    Taskin, N5    Ulucan, K6
  • 14
    • 84893649359 scopus 로고    scopus 로고
    • New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease
    • Sahebkar A, Chew GT, Watts GF. New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease. Expert Opin Pharmacother 2014;15:493– 503. doi: 10.1517/14656566.2014.876992.
    • (2014) Expert Opin Pharmacother , vol.15 , pp. 493-503
    • Sahebkar, A1    Chew, GT2    Watts, GF.3
  • 15
    • 84894234723 scopus 로고    scopus 로고
    • Risk of cardiovascular, cardiac and arrhythmic complications in patients with nonalcoholic fatty liver disease
    • Ballestri S, Lonardo A, Bonapace S, Byrne CD, Loria P, Targher G. Risk of cardiovascular, cardiac and arrhythmic complications in patients with nonalcoholic fatty liver disease. World J Gastroenterol 2014;20:1724–1745. doi: 10.3748/wjg.v20.i7.1724.
    • (2014) World J Gastroenterol , vol.20 , pp. 1724-1745
    • Ballestri, S1    Lonardo, A2    Bonapace, S3    Byrne, CD4    Loria, P5    Targher, G.6
  • 16
    • 77957375969 scopus 로고    scopus 로고
    • Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease
    • Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med 2010;363:1341–1350. doi: 10.1056/NEJMra0912063.
    • (2010) N Engl J Med , vol.363 , pp. 1341-1350
    • Targher, G1    Day, CP2    Bonora, E.3
  • 17
    • 84859448472 scopus 로고    scopus 로고
    • Metabolic syndrome and risk factors for non-alcoholic fatty liver disease
    • Souza MR, Diniz MF, Medeiros JE, Araujo MS. Metabolic syndrome and risk factors for non-alcoholic fatty liver disease. Arq Gastroenterol 2012;49:89– 96.
    • (2012) Arq Gastroenterol , vol.49 , pp. 89-96
    • Souza, MR1    Diniz, MF2    Medeiros, JE3    Araujo, MS.4
  • 18
    • 79959685357 scopus 로고    scopus 로고
    • Circulating oxidized LDL and inflammation in extreme pediatric obesity
    • Norris AL, Steinberger J, Steffen LM, Metzig AM, Schwarzenberg SJ, Kelly AS. Circulating oxidized LDL and inflammation in extreme pediatric obesity. Obesity 2011;19:1415–1419. doi: 10.1038/oby.2011.21.
    • (2011) Obesity , vol.19 , pp. 1415-1419
    • Norris, AL1    Steinberger, J2    Steffen, LM3    Metzig, AM4    Schwarzenberg, SJ5    Kelly, AS.6
  • 19
    • 84893649359 scopus 로고    scopus 로고
    • New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease
    • 1
    • Sahebkar A1, Chew GT, Watts GF. New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease. Expert Opin Pharmacother 2014, 15:493– 503. doi: 10.1517/14656566.2014.876992.
    • (2014) Expert Opin Pharmacother , vol.15 , pp. 493-503
    • Sahebkar, A1    Chew, GT2    Watts, GF.3
  • 20
    • 77957332990 scopus 로고    scopus 로고
    • Non-Alcoholic Fatty Liver Disease (NAFLD): new challenge for general practitioners and important burden for health authorities?
    • Ahmed MH, Abu EO, Byrne CD. Non-Alcoholic Fatty Liver Disease (NAFLD): new challenge for general practitioners and important burden for health authorities? Prim Care Diabetes 2010;4:129–137. doi: 10.1016/j.pcd.2010. 02.004.
    • (2010) Prim Care Diabetes , vol.4 , pp. 129-137
    • Ahmed, MH1    Abu, EO2    Byrne, CD.3
  • 21
    • 78650690095 scopus 로고    scopus 로고
    • Hepatic gene networks in morbidly obese patients with nonalcoholic fatty liver disease
    • Gawrieh S, Baye TM, Carless M, Wallace J, Komorowski R, Kleiner DE, et al. Hepatic gene networks in morbidly obese patients with nonalcoholic fatty liver disease. Obes Surg 2010;20:1698–1709. doi: 10.1007/s11695-010-0171-6.
    • (2010) Obes Surg , vol.20 , pp. 1698-1709
    • Gawrieh, S1    Baye, TM2    Carless, M3    Wallace, J4    Komorowski, R5    Kleiner, DE6
  • 22
    • 84939166142 scopus 로고    scopus 로고
    • Non-high-density lipoprotein cholesterol (non-HDL-C) levels in children with nonalcoholic fatty liver disease (NAFLD)
    • Alkhouri N, Eng K, Lopez R, Nobili V. Non-high-density lipoprotein cholesterol (non-HDL-C) levels in children with nonalcoholic fatty liver disease (NAFLD). Springerplus 2014;3:407. doi: 10.1186/2193-1801-3-407.
    • (2014) Springerplus , vol.3 , pp. 407
    • Alkhouri, N1    Eng, K2    Lopez, R3    Nobili, V.4
  • 23
    • 84891782428 scopus 로고    scopus 로고
    • Cytokeratin 18, alanine aminotransferase, platelets and triglycerides predict the presence of nonalcoholic steatohepa-titis
    • Cao W, Zhao C, Shen C, Wang Y. Cytokeratin 18, alanine aminotransferase, platelets and triglycerides predict the presence of nonalcoholic steatohepa-titis. PLOS One 2013;8:e82092. doi: 10.1371/journal.pone.0082092.
    • (2013) PLOS One , vol.8 , pp. e82092
    • Cao, W1    Zhao, C2    Shen, C3    Wang, Y.4
  • 24
    • 84908481540 scopus 로고    scopus 로고
    • Western diet in ApoE-LDLR double-deficient mouse model of atherosclerosis leads to hepatic steatosis, fibrosis, and tumorigenesis
    • Kampschulte M, Stockl C, Langheinrich AC, Althohn U, Bohle RM, Krombach GA, et al. Western diet in ApoE-LDLR double-deficient mouse model of atherosclerosis leads to hepatic steatosis, fibrosis, and tumorigenesis. Lab Invest 2014;94:1273–1282. doi: 10.1038/labinvest.2014.112.
    • (2014) Lab Invest , vol.94 , pp. 1273-1282
    • Kampschulte, M1    Stockl, C2    Langheinrich, AC3    Althohn, U4    Bohle, RM5    Krombach, GA6
  • 25
    • 84908029914 scopus 로고    scopus 로고
    • Obesity and the liver: nonalcoholic fatty liver disease
    • Koppe SW. Obesity and the liver: nonalcoholic fatty liver disease. Transl Res 2014, 164:312–322. doi: 10.1016/j.trsl.2014.06.008.
    • (2014) Transl Res , vol.164 , pp. 312-322
    • Koppe, SW.1
  • 26
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002;346:1221– 1231.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 27
    • 77952680758 scopus 로고    scopus 로고
    • Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham Heart Study
    • Speliotes EK, Massaro JM, Hoffmann U, Vasan RS, Meigs JB, Sahani DV, et al. Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham Heart Study. Hepatology 2010;51:1979–1987. doi: 10.1002/hep.23593.
    • (2010) Hepatology , vol.51 , pp. 1979-1987
    • Speliotes, EK1    Massaro, JM2    Hoffmann, U3    Vasan, RS4    Meigs, JB5    Sahani, DV6
  • 28
    • 75449088414 scopus 로고    scopus 로고
    • Decreased survival of subjects with elevated liver function tests during a 28-year follow-up
    • Söderberg C, Stål P, Askling J, Glaumann H, Lindberg G, Marmur J, et al. Decreased survival of subjects with elevated liver function tests during a 28-year follow-up. Hepatology 2010;51:595–602. doi: 10.1002/hep.23314.
    • (2010) Hepatology , vol.51 , pp. 595-602
    • Söderberg, C1    Stål, P2    Askling, J3    Glaumann, H4    Lindberg, G5    Marmur, J6
  • 29
    • 33750606061 scopus 로고    scopus 로고
    • Long-term follow-up of patients with NAFLD and elevated liver enzymes
    • Ekstedt M, Franzén LE, Mathiesen UL, Thorelius L, Holmqvist M, Bodemar G, et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006;44:865–873. doi: 10.1002/hep.21327.
    • (2006) Hepatology , vol.44 , pp. 865-873
    • Ekstedt, M1    Franzén, LE2    Mathiesen, UL3    Thorelius, L4    Holmqvist, M5    Bodemar, G6
  • 30
    • 0033038672 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity
    • Matteoni CA, Younossi ZM, Gramlich T, Boparai N, Liu YC, McCullough AJ. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999;116:1413–1419. doi: 10.1016/S0016-5085(99)70506-8.
    • (1999) Gastroenterology , vol.116 , pp. 1413-1419
    • Matteoni, CA1    Younossi, ZM2    Gramlich, T3    Boparai, N4    Liu, YC5    McCullough, AJ.6
  • 32
    • 84904390832 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and cardiovascular disease
    • Liu H, Lu HY. Nonalcoholic fatty liver disease and cardiovascular disease. World J Gastroenterol 2014;20:8407–8415. doi: 10.3748/wjg.v20.i26.8407.
    • (2014) World J Gastroenterol , vol.20 , pp. 8407-8415
    • Liu, H1    Lu, HY.2
  • 33
    • 84877854022 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease
    • Gaggini M, Morelli M, Buzzigoli E, DeFronzo RA, Bugianesi E, Gastaldelli A. Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease. Nutrients 2013;5:1544–1560. doi: 10.3390/nu5051544.
    • (2013) Nutrients , vol.5 , pp. 1544-1560
    • Gaggini, M1    Morelli, M2    Buzzigoli, E3    DeFronzo, RA4    Bugianesi, E5    Gastaldelli, A.6
  • 34
    • 70350360003 scopus 로고    scopus 로고
    • Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult-2009 recommendations
    • Genest J, McPherson R, Frohlich J, Anderson T, Campbell N, Carpentier A, et al. Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult-2009 recommendations. Can J Cardiol 2009;25:567–579.
    • (2009) Can J Cardiol , vol.25 , pp. 567-579
    • Genest, J1    McPherson, R2    Frohlich, J3    Anderson, T4    Campbell, N5    Carpentier, A6
  • 35
    • 77956637403 scopus 로고    scopus 로고
    • Managing your dyslipidemia with TLC: Therapeutic Lifestyle Changes
    • Managing your dyslipidemia with TLC: Therapeutic Lifestyle Changes. J Am Osteopath Assoc 2010, 110:eS17–eS18.
    • (2010) J Am Osteopath Assoc , vol.110 , pp. eS17-eS18
  • 36
    • 77953444310 scopus 로고    scopus 로고
    • Treatment options for nonalcoholic fatty liver disease
    • Lam B, Younossi ZM. Treatment options for nonalcoholic fatty liver disease. Therap Adv Gastroenterol 2010;3:121–137. doi: 10.1177/1756283X09359964.
    • (2010) Therap Adv Gastroenterol , vol.3 , pp. 121-137
    • Lam, B1    Younossi, ZM.2
  • 37
    • 84897597946 scopus 로고    scopus 로고
    • Diet and exercise in management of obesity and overweight
    • (Suppl)
    • Fock KM, Khoo J. Diet and exercise in management of obesity and overweight. J Gastroenterol Hepatol 2013;28(Suppl):59–63. doi: 10.1111/jgh.12407.
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 59-63
    • Fock, KM1    Khoo, J.2
  • 38
    • 67651146947 scopus 로고    scopus 로고
    • The independent effects of physical activity in patients with non-alcoholic fatty liver disease
    • St George A, Bauman A, Johnston A, Farrell G, Chey T, Georgr J. The independent effects of physical activity in patients with non-alcoholic fatty liver disease. Hepatology 2009;50:68–76. doi: 10.1002/hep.22940.
    • (2009) Hepatology , vol.50 , pp. 68-76
    • St George, A1    Bauman, A2    Johnston, A3    Farrell, G4    Chey, T5    Georgr, J.6
  • 39
    • 63049120544 scopus 로고    scopus 로고
    • Effect of lifestyle intervention in patients with abnormal liver enzymes and metabolic risk factors
    • St George A, Bauman A, Johnston A, Farrell G, Chey T, George J. Effect of lifestyle intervention in patients with abnormal liver enzymes and metabolic risk factors. J Gastroenterol Hepatol 2009;24:399–407. doi: 10.1111/j.1440-1746.2008.05694.x
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 399-407
    • St George, A1    Bauman, A2    Johnston, A3    Farrell, G4    Chey, T5    George, J.6
  • 40
    • 19144372447 scopus 로고    scopus 로고
    • One-year intense nutritional counseling results in histological improvement in patients with nonalcoholic steatohepatitis: a pilot study
    • Huang MA, Greenson JK, Chao C, Anderson L, Peterman D, Jacobson J, et al. One-year intense nutritional counseling results in histological improvement in patients with nonalcoholic steatohepatitis: a pilot study. Am J Gastroenterol 2005;100:1072–1081. doi: 10.1111/j.1572-0241.2005.41334.x.
    • (2005) Am J Gastroenterol , vol.100 , pp. 1072-1081
    • Huang, MA1    Greenson, JK2    Chao, C3    Anderson, L4    Peterman, D5    Jacobson, J6
  • 41
    • 84907681143 scopus 로고    scopus 로고
    • Effect of lifestyle changes and atorvastatin administration on dyslipidemia in hemodialysis patients: a prospective study
    • Grzegorzewska AE, Niepolski L, Sikora J, Jankow M, Jagodzinski PP, Sowinska A. Effect of lifestyle changes and atorvastatin administration on dyslipidemia in hemodialysis patients: a prospective study. Pol Arch Med Wewn 2014;124: 443–451.
    • (2014) Pol Arch Med Wewn , vol.124 , pp. 443-451
    • Grzegorzewska, AE1    Niepolski, L2    Sikora, J3    Jankow, M4    Jagodzinski, PP5    Sowinska, A.6
  • 42
    • 78649890465 scopus 로고    scopus 로고
    • Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis
    • Athyros VG, Tziomalos K, Gossios TD, Griva T, Anagnostis P, Kargiotis K, et al. Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis. Lancet 2010;376:1916–1922. doi: 10.1016/S0140-6736(10)61272-X.
    • (2010) Lancet , vol.376 , pp. 1916-1922
    • Athyros, VG1    Tziomalos, K2    Gossios, TD3    Griva, T4    Anagnostis, P5    Kargiotis, K6
  • 43
    • 74949102941 scopus 로고    scopus 로고
    • A pilot study using simvastatin in the treatment of nonalcoholic steatohepatitis: A randomized placebo-controlled trial
    • Nelson A, Torres DM, Morgan AE, Fincke C, Harrison SA. A pilot study using simvastatin in the treatment of nonalcoholic steatohepatitis: A randomized placebo-controlled trial. J Clin Gastroenterol 2009;43:990–994. doi: 10.1097/MCG.0b013e31819c392e.
    • (2009) J Clin Gastroenterol , vol.43 , pp. 990-994
    • Nelson, A1    Torres, DM2    Morgan, AE3    Fincke, C4    Harrison, SA.5
  • 44
    • 28344436469 scopus 로고    scopus 로고
    • Rosuvastatin as a novel treatment of non-alcoholic fatty liver disease in hyperlipidemic patients
    • Antonopoulos S, Mikros S, Mylonopoulou M, Kokkoris S, Giannoulis G. Rosuvastatin as a novel treatment of non-alcoholic fatty liver disease in hyperlipidemic patients. Atherosclerosis 2006;184:233–234. doi: 10.1016/j.atherosclerosis.2005.08.021.
    • (2006) Atherosclerosis , vol.184 , pp. 233-234
    • Antonopoulos, S1    Mikros, S2    Mylonopoulou, M3    Kokkoris, S4    Giannoulis, G.5
  • 45
    • 2342456307 scopus 로고    scopus 로고
    • Pravastatin in patients with nonalcoholic steatohepatitis: results of a pilot study
    • Rallidis LS, Drakoulis CK, Parasi AS. Pravastatin in patients with nonalcoholic steatohepatitis: results of a pilot study. Atherosclerosis 2004;174:193–196. doi: 10.1016/j.atherosclerosis.2004.01.008.
    • (2004) Atherosclerosis , vol.174 , pp. 193-196
    • Rallidis, LS1    Drakoulis, CK2    Parasi, AS.3
  • 47
    • 0032776856 scopus 로고    scopus 로고
    • A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis
    • Basaranoglu M, Acbay O, Sonsuz A. A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis. J Hepatol 1999;31: 384. doi: 10.1016/S0168-8278(99)80243-8.
    • (1999) J Hepatol , vol.31 , pp. 384
    • Basaranoglu, M1    Acbay, O2    Sonsuz, A.3
  • 48
    • 33745046866 scopus 로고    scopus 로고
    • Effect of multifactorial treatment on non-alcoholic fatty liver disease in metabolic syndrome: a randomized study
    • Athyros VG, Mikhailidis DP, Didangelos TP, Giouleme OI, Liberopoulos EN, Karagiannis A, et al. Effect of multifactorial treatment on non-alcoholic fatty liver disease in metabolic syndrome: a randomized study. Curr Med Res Opin 2006;22:873–883. doi: 10.1185/030079906X104696.
    • (2006) Curr Med Res Opin , vol.22 , pp. 873-883
    • Athyros, VG1    Mikhailidis, DP2    Didangelos, TP3    Giouleme, OI4    Liberopoulos, EN5    Karagiannis, A6
  • 50
    • 2342595828 scopus 로고    scopus 로고
    • Ezetimibe: a novel option for lowering cholesterol
    • Davidson HM. Ezetimibe: a novel option for lowering cholesterol. Expert Rev Cardiovasc Ther 2003;1:11–21. doi: 10.1586/14779072.1.1.11.
    • (2003) Expert Rev Cardiovasc Ther , vol.1 , pp. 11-21
    • Davidson, HM.1
  • 51
    • 84884546418 scopus 로고    scopus 로고
    • Update on marine omega-3 fatty acids: management of dyslipidemia and current omega-3 treatment options
    • Weintraub H. Update on marine omega-3 fatty acids: management of dyslipidemia and current omega-3 treatment options. Atherosclerosis 2013; 230:381–389. doi: 10.1016/j.atherosclerosis.2013.07.041.
    • (2013) Atherosclerosis , vol.230 , pp. 381-389
    • Weintraub, H.1
  • 52
    • 34247885908 scopus 로고    scopus 로고
    • Role of prescription omega-3 fatty acids in the treatment of hypertriglyceridemia
    • McKenney JM, Sica D. Role of prescription omega-3 fatty acids in the treatment of hypertriglyceridemia. Pharmacotherapy 2007;27:715–728. doi: 10.1592/phco.27.5.715.
    • (2007) Pharmacotherapy , vol.27 , pp. 715-728
    • McKenney, JM1    Sica, D.2
  • 53
    • 33646882162 scopus 로고    scopus 로고
    • Prolonged omega-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study
    • Capanni M, Calella F, Biagini MR, Genise S, Raimondi L, Bedogni G, et al. Prolonged omega-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study. Aliment Pharmacol Ther 2006;23:1143–1151. doi: 10.1111/j.1365-2036.2006.02885.x.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1143-1151
    • Capanni, M1    Calella, F2    Biagini, MR3    Genise, S4    Raimondi, L5    Bedogni, G6
  • 54
    • 38749115791 scopus 로고    scopus 로고
    • Effects of omega-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease
    • Spadaro L, Magliocco O, Spampinato D, Piro S, Oliveri C, Alagona C, et al. Effects of omega-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease. Dig Liver Dis 2008;40:194–199. doi: 10.1016/j.dld.2007.10.003.
    • (2008) Dig Liver Dis , vol.40 , pp. 194-199
    • Spadaro, L1    Magliocco, O2    Spampinato, D3    Piro, S4    Oliveri, C5    Alagona, C6
  • 55
    • 41349102802 scopus 로고    scopus 로고
    • Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohe-patitis
    • Tanaka N, Sano K, Horiuchi A, Tanaka E, Kiyosawa K, Aoyama T. Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohe-patitis. J Clin Gastroenterol 2008;42:413–418. doi: 10.1097/MCG.0b013 e31815591aa.
    • (2008) J Clin Gastroenterol , vol.42 , pp. 413-418
    • Tanaka, N1    Sano, K2    Horiuchi, A3    Tanaka, E4    Kiyosawa, K5    Aoyama, T.6
  • 56
    • 49149084590 scopus 로고    scopus 로고
    • Effects of N-3 fatty acids on hepatic triglyceride content in humans
    • Vega GL, Chandalia M, Szczepaniak LS, Grundy SM. Effects of N-3 fatty acids on hepatic triglyceride content in humans. J Investig Med 2008;56:780–785. doi: 10.231/JIM.0b013e318177024d.
    • (2008) J Investig Med , vol.56 , pp. 780-785
    • Vega, GL1    Chandalia, M2    Szczepaniak, LS3    Grundy, SM.4
  • 57
    • 34548274430 scopus 로고    scopus 로고
    • Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects
    • Itoh M, Suganami T, Satoh N, Tanimoto-Koyama K, Yuan X, Tanaka M, et al. Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects. Arterioscler Thromb Vasc Biol 2007;27:1918–1925. doi: 10.1161/ATVBAHA.106.136853.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1918-1925
    • Itoh, M1    Suganami, T2    Satoh, N3    Tanimoto-Koyama, K4    Yuan, X5    Tanaka, M6
  • 58
    • 78650971903 scopus 로고    scopus 로고
    • Atorvastatin and antioxidants for the treatment of nonalcoholic fatty liver disease: the St Francis Heart Study randomized clinical trial
    • Foster T, Budoff MJ, Saab S, Ahmadi N, Gordon C, Guerci AD. Atorvastatin and antioxidants for the treatment of nonalcoholic fatty liver disease: the St Francis Heart Study randomized clinical trial. Am J Gastroenterol 2011;106: 71–77. doi: 10.1038/ajg.2010.299.
    • (2011) Am J Gastroenterol , vol.106 , pp. 71-77
    • Foster, T1    Budoff, MJ2    Saab, S3    Ahmadi, N4    Gordon, C5    Guerci, AD.6
  • 59
    • 36348987648 scopus 로고    scopus 로고
    • Efficacy and safety of high-dose pravastatin in hypercholesterolemic patients with well-compensated chronic liver disease: Results of a prospective, randomized, double-blind, placebo-controlled, multicenter trial
    • Lewis JH, Mortensen ME, Zweig S, Fusco MJ, Medoff JR, Belder R. Efficacy and safety of high-dose pravastatin in hypercholesterolemic patients with well-compensated chronic liver disease: Results of a prospective, randomized, double-blind, placebo-controlled, multicenter trial. Hepatology 2007;46: 1453–1463. doi: 10.1002/hep.21848.
    • (2007) Hepatology , vol.46 , pp. 1453-1463
    • Lewis, JH1    Mortensen, ME2    Zweig, S3    Fusco, MJ4    Medoff, JR5    Belder, R.6
  • 60
    • 2142768218 scopus 로고    scopus 로고
    • Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity
    • Chalasani N, Aljadhey H, Kesterson J, Murray MD, Hall SD. Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity. Gastroenterology 2004;126:1287–1292. doi: 10.1053/j.gastro.2004. 02.015.
    • (2004) Gastroenterology , vol.126 , pp. 1287-1292
    • Chalasani, N1    Aljadhey, H2    Kesterson, J3    Murray, MD4    Hall, SD.5
  • 61
    • 0037150209 scopus 로고    scopus 로고
    • Safety and tolerability of pravastatin in long-term clinical trials: prospective Pravastatin Pooling (PPP) Project
    • Pfeffer MA, Keech A, Sacks FM, Cobbe SM, Tonkin A, Byington RP, et al. Safety and tolerability of pravastatin in long-term clinical trials: prospective Pravastatin Pooling (PPP) Project. Circulation 2002;105:2341–2346. doi: 10.1161/01.CIR.0000017634.00171.24.
    • (2002) Circulation , vol.105 , pp. 2341-2346
    • Pfeffer, MA1    Keech, A2    Sacks, FM3    Cobbe, SM4    Tonkin, A5    Byington, RP6
  • 62
    • 84880042692 scopus 로고    scopus 로고
    • Hypertension prevalence and Framingham risk score stratification in a large HIV-positive cohort in Uganda
    • Mateen FJ, Kanters S, Kalyesubula R, Mukasa B, Kawuma E, Kengne AP, et al. Hypertension prevalence and Framingham risk score stratification in a large HIV-positive cohort in Uganda. J Hypertens 2013;31:1372–1378. doi: 10.1097/HJH.0b013e328360de1c.
    • (2013) J Hypertens , vol.31 , pp. 1372-1378
    • Mateen, FJ1    Kanters, S2    Kalyesubula, R3    Mukasa, B4    Kawuma, E5    Kengne, AP6
  • 63
    • 79955446251 scopus 로고    scopus 로고
    • Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial
    • Lavine JE, Schwimmer JB, Natta ML, Molleston JP, Murray KF, Rosenthal P. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. JAMA 2011;305:1659–1668. doi: 10.1001/jama.2011.520.
    • (2011) JAMA , vol.305 , pp. 1659-1668
    • Lavine, JE1    Schwimmer, JB2    Natta, ML3    Molleston, JP4    Murray, KF5    Rosenthal, P.6
  • 64
    • 77952529040 scopus 로고    scopus 로고
    • A position statement on NAFLD/NASH based on the EASL 2009 special conference
    • Ratziu V, Bellentani S, Cortez-Pinto H, Day C, Marchesini G. A position statement on NAFLD/NASH based on the EASL 2009 special conference. J Hepatol 2010;53:372–384. doi: 10.1016/j.jhep.2010.04.008.
    • (2010) J Hepatol , vol.53 , pp. 372-384
    • Ratziu, V1    Bellentani, S2    Cortez-Pinto, H3    Day, C4    Marchesini, G.5
  • 65
    • 0035120396 scopus 로고    scopus 로고
    • A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohe-patitis
    • Caldwell SH, Hespenheide EE, Redick JA, Iezzoni JC, Battle EH, Sheppard BL. A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohe-patitis. Am J Gastroenterol 2001;96:519–525. doi: 10.1111/j.1572-0241.2001.03553.x.
    • (2001) Am J Gastroenterol , vol.96 , pp. 519-525
    • Caldwell, SH1    Hespenheide, EE2    Redick, JA3    Iezzoni, JC4    Battle, EH5    Sheppard, BL.6
  • 66
    • 84862517200 scopus 로고    scopus 로고
    • Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials
    • Musso G, Cassader G, Rosina F, Gambino F. Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials. Diabetologia 2012;55:885–904. doi: 10.1007/s00125-011-2446-4.
    • (2012) Diabetologia , vol.55 , pp. 885-904
    • Musso, G1    Cassader, G2    Rosina, F3    Gambino, F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.