메뉴 건너뛰기




Volumn 230, Issue 2, 2013, Pages 381-389

Update on marine omega-3 fatty acids: Management of dyslipidemia and current omega-3 treatment options

Author keywords

Docosahexaenoic acid; Dyslipidemia; Eicosapentaenoic acid; Fish oil; Omega 3 fatty acid

Indexed keywords

ANTILIPEMIC AGENT; ATORVASTATIN; BILE ACID SEQUESTRANT; COLESEVELAM; COLESTIPOL; COLESTYRAMINE; DOCOSAHEXAENOIC ACID; EPANOVA; EZETIMIBE; EZETIMIBE PLUS SIMVASTATIN; FENOFIBRATE; FISH OIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ICOSAPENTAENOIC ACID; ICOSAPENTAENOIC ACID ETHYL ESTER; LAROPIPRANT PLUS NICOTINIC ACID; LOW DENSITY LIPOPROTEIN; NICOTINIC ACID; NICOTINIC ACID PLUS SIMVASTATIN; OLIVE OIL; OMEGA 3 ACID ETHYL ESTER; OMEGA 3 FATTY ACID; OMEGA 3 FREE FATTY ACID; SIMVASTATIN; UNCLASSIFIED DRUG; VEGETABLE OIL;

EID: 84884546418     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2013.07.041     Document Type: Review
Times cited : (58)

References (78)
  • 1
    • 0021350001 scopus 로고
    • The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease
    • The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease. JAm Med Assoc 1984, 251(3):351-364.
    • (1984) JAm Med Assoc , vol.251 , Issue.3 , pp. 351-364
  • 2
    • 0021349709 scopus 로고
    • The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering
    • The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAm Med Assoc 1984, 251(3):365-374.
    • (1984) JAm Med Assoc , vol.251 , Issue.3 , pp. 365-374
  • 3
    • 0025043719 scopus 로고
    • The value of lowering cholesterol after myocardial infarction
    • Rossouw J.E., Lewis B., Rifkind B.M. The value of lowering cholesterol after myocardial infarction. NEngl J Med 1990, 323(16):1112-1119.
    • (1990) NEngl J Med , vol.323 , Issue.16 , pp. 1112-1119
    • Rossouw, J.E.1    Lewis, B.2    Rifkind, B.M.3
  • 4
    • 0025376017 scopus 로고
    • Ten-year mortality from cardiovascular disease in relation to cholesterol level among men with and without preexisting cardiovascular disease
    • Pekkanen J., Linn S., Heiss G., Suchindran C.M., Leon A., Rifkind B.M., et al. Ten-year mortality from cardiovascular disease in relation to cholesterol level among men with and without preexisting cardiovascular disease. NEngl J Med 1990, 322(24):1700-1707.
    • (1990) NEngl J Med , vol.322 , Issue.24 , pp. 1700-1707
    • Pekkanen, J.1    Linn, S.2    Heiss, G.3    Suchindran, C.M.4    Leon, A.5    Rifkind, B.M.6
  • 5
    • 77956960932 scopus 로고    scopus 로고
    • 30-year trends in serum lipids among United States adults: results from the National Health and Nutrition Examination Surveys II, III, and 1999-2006
    • Cohen J.D., Cziraky M.J., Cai Q., Wallace A., Wasser T., Crouse J.R., et al. 30-year trends in serum lipids among United States adults: results from the National Health and Nutrition Examination Surveys II, III, and 1999-2006. Am J Cardiol 2010, 106(7):969-975.
    • (2010) Am J Cardiol , vol.106 , Issue.7 , pp. 969-975
    • Cohen, J.D.1    Cziraky, M.J.2    Cai, Q.3    Wallace, A.4    Wasser, T.5    Crouse, J.R.6
  • 6
    • 0037126526 scopus 로고    scopus 로고
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002, 106(25):3143-3421.
    • (2002) Circulation , vol.106 , Issue.25 , pp. 3143-3421
  • 7
    • 56249123656 scopus 로고    scopus 로고
    • The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patients
    • Fruchart J.C., Sacks F.M., Hermans M.P., Assmann G., Brown W.V., Ceska R., et al. The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patients. Diabetes Vasc Dis Res 2008, 5(4):319-335.
    • (2008) Diabetes Vasc Dis Res , vol.5 , Issue.4 , pp. 319-335
    • Fruchart, J.C.1    Sacks, F.M.2    Hermans, M.P.3    Assmann, G.4    Brown, W.V.5    Ceska, R.6
  • 8
    • 85027956925 scopus 로고    scopus 로고
    • Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association
    • Miller M., Stone N.J., Ballantyne C., Bittner V., Criqui M.H., Ginsberg H.N., et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation 2011, 123(20):2292-2333.
    • (2011) Circulation , vol.123 , Issue.20 , pp. 2292-2333
    • Miller, M.1    Stone, N.J.2    Ballantyne, C.3    Bittner, V.4    Criqui, M.H.5    Ginsberg, H.N.6
  • 9
    • 63849198178 scopus 로고    scopus 로고
    • Hypertriglyceridemia and its pharmacologic treatment among US adults
    • Ford E.S., Li C., Zhao G., Pearson W.S., Mokdad A.H. Hypertriglyceridemia and its pharmacologic treatment among US adults. Arch Intern Med 2009, 169(6):572-578.
    • (2009) Arch Intern Med , vol.169 , Issue.6 , pp. 572-578
    • Ford, E.S.1    Li, C.2    Zhao, G.3    Pearson, W.S.4    Mokdad, A.H.5
  • 10
    • 77955833344 scopus 로고    scopus 로고
    • Fish oil for the treatment of cardiovascular disease
    • Weitz D., Weintraub H., Fisher E., Schwartzbard A.Z. Fish oil for the treatment of cardiovascular disease. Cardiol Rev 2010, 18(5):258-263.
    • (2010) Cardiol Rev , vol.18 , Issue.5 , pp. 258-263
    • Weitz, D.1    Weintraub, H.2    Fisher, E.3    Schwartzbard, A.Z.4
  • 11
    • 81155139591 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis
    • Wei M.Y., Jacobson T.A. Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis. Curr Atheroscler Rep 2011, 13(6):474-483.
    • (2011) Curr Atheroscler Rep , vol.13 , Issue.6 , pp. 474-483
    • Wei, M.Y.1    Jacobson, T.A.2
  • 12
    • 84856179128 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review
    • Jacobson T.A., Glickstein S.B., Rowe J.D., Soni P.N. Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review. JClin Lipidol 2012, 6(1):5-18.
    • (2012) JClin Lipidol , vol.6 , Issue.1 , pp. 5-18
    • Jacobson, T.A.1    Glickstein, S.B.2    Rowe, J.D.3    Soni, P.N.4
  • 13
    • 3142729178 scopus 로고    scopus 로고
    • Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines
    • Grundy S.M., Cleeman J.I., Merz C.N., Brewer H.B., Clark L.T., Hunninghake D.B., et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 2004, 110(2):227-239.
    • (2004) Circulation , vol.110 , Issue.2 , pp. 227-239
    • Grundy, S.M.1    Cleeman, J.I.2    Merz, C.N.3    Brewer, H.B.4    Clark, L.T.5    Hunninghake, D.B.6
  • 14
    • 84884583700 scopus 로고    scopus 로고
    • Merck & Co., Inc., Whitehouse Station, NJ
    • Zetia [package insert] 2013, Merck & Co., Inc., Whitehouse Station, NJ.
    • (2013) Zetia [package insert]
  • 15
    • 0037324442 scopus 로고    scopus 로고
    • Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association
    • Kris-Etherton P.M., Harris W.S., Appel L.J. Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association. Arterioscler Thromb Vasc Biol 2003, 23(2):151-152.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , Issue.2 , pp. 151-152
    • Kris-Etherton, P.M.1    Harris, W.S.2    Appel, L.J.3
  • 16
    • 0015369932 scopus 로고
    • Plasma lipids and lipoproteins in Greenlandic west coast Eskimos
    • Bang H.O., Dyerberg J. Plasma lipids and lipoproteins in Greenlandic west coast Eskimos. Acta Med Scand 1972, 192(1-2):85-94.
    • (1972) Acta Med Scand , vol.192 , Issue.1-2 , pp. 85-94
    • Bang, H.O.1    Dyerberg, J.2
  • 17
    • 1942532144 scopus 로고    scopus 로고
    • Meta-analysis of observational studies on fish intake and coronary heart disease
    • Whelton S.P., He J., Whelton P.K., Muntner P. Meta-analysis of observational studies on fish intake and coronary heart disease. Am J Cardiol 2004, 93(9):1119-1123.
    • (2004) Am J Cardiol , vol.93 , Issue.9 , pp. 1119-1123
    • Whelton, S.P.1    He, J.2    Whelton, P.K.3    Muntner, P.4
  • 18
    • 2942548948 scopus 로고    scopus 로고
    • Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies
    • He K., Song Y., Daviglus M.L., Liu K., Van H.L., Dyer A.R., et al. Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation 2004, 109(22):2705-2711.
    • (2004) Circulation , vol.109 , Issue.22 , pp. 2705-2711
    • He, K.1    Song, Y.2    Daviglus, M.L.3    Liu, K.4    Van, H.L.5    Dyer, A.R.6
  • 19
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
    • Rubins H.B., Robins S.J., Collins D., Fye C.L., Anderson J.W., Elam M.B., et al. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. NEngl J Med 1999, 341(6):410-418.
    • (1999) NEngl J Med , vol.341 , Issue.6 , pp. 410-418
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3    Fye, C.L.4    Anderson, J.W.5    Elam, M.B.6
  • 20
    • 0037049366 scopus 로고    scopus 로고
    • Diabetes, plasma insulin, and cardiovascular disease: subgroup analysis from the Department of Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT)
    • Rubins H.B., Robins S.J., Collins D., Nelson D.B., Elam M.B., Schaefer E.J., et al. Diabetes, plasma insulin, and cardiovascular disease: subgroup analysis from the Department of Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT). Arch Intern Med 2002, 162(22):2597-2604.
    • (2002) Arch Intern Med , vol.162 , Issue.22 , pp. 2597-2604
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3    Nelson, D.B.4    Elam, M.B.5    Schaefer, E.J.6
  • 21
    • 28044452217 scopus 로고    scopus 로고
    • Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial
    • Keech A., Simes R.J., Barter P., Best J., Scott R., Taskinen M.R., et al. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 2005, 366(9500):1849-1861.
    • (2005) Lancet , vol.366 , Issue.9500 , pp. 1849-1861
    • Keech, A.1    Simes, R.J.2    Barter, P.3    Best, J.4    Scott, R.5    Taskinen, M.R.6
  • 23
    • 79960700766 scopus 로고    scopus 로고
    • Efficacy of fibrates for cardiovascular risk reduction in persons with atherogenic dyslipidemia: a meta-analysis
    • Lee M., Saver J.L., Towfighi A., Chow J., Ovbiagele B. Efficacy of fibrates for cardiovascular risk reduction in persons with atherogenic dyslipidemia: a meta-analysis. Atherosclerosis 2011, 217(2):492-498.
    • (2011) Atherosclerosis , vol.217 , Issue.2 , pp. 492-498
    • Lee, M.1    Saver, J.L.2    Towfighi, A.3    Chow, J.4    Ovbiagele, B.5
  • 27
    • 0035313336 scopus 로고    scopus 로고
    • Efficacy and safety of combination simvastatin and colesevelam in patients with primary hypercholesterolemia
    • Knapp H.H., Schrott H., Ma P., Knopp R., Chin B., Gaziano J.M., et al. Efficacy and safety of combination simvastatin and colesevelam in patients with primary hypercholesterolemia. Am J Med 2001, 110(5):352-360.
    • (2001) Am J Med , vol.110 , Issue.5 , pp. 352-360
    • Knapp, H.H.1    Schrott, H.2    Ma, P.3    Knopp, R.4    Chin, B.5    Gaziano, J.M.6
  • 28
    • 0025273073 scopus 로고
    • Bile acid sequestrants
    • Ast M., Frishman W.H. Bile acid sequestrants. JClin Pharmacol 1990, 30(2):99-106.
    • (1990) JClin Pharmacol , vol.30 , Issue.2 , pp. 99-106
    • Ast, M.1    Frishman, W.H.2
  • 29
    • 84884558008 scopus 로고    scopus 로고
    • Daiichi Sankyo Inc., Parsippany, NJ
    • Welchol [package insert] 2012, Daiichi Sankyo Inc., Parsippany, NJ.
    • (2012) Welchol [package insert]
  • 31
    • 84884551889 scopus 로고    scopus 로고
    • IMPROVE-IT: Examining outcomes in subjects with acute coronary syndrome: Vytorin (ezetimibe/simvastatin) vs simvastatin (P04103 AM5) NCT00202878. ClinicalTrials.gov. Available from: , [accessed 06.05.13].
    • IMPROVE-IT: Examining outcomes in subjects with acute coronary syndrome: Vytorin (ezetimibe/simvastatin) vs simvastatin (P04103 AM5) NCT00202878. ClinicalTrials.gov. Available from: , [accessed 06.05.13]. http://clinicaltrials.gov/show/NCT00202878.
  • 32
    • 0036075998 scopus 로고    scopus 로고
    • The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans
    • Nestel P., Shige H., Pomeroy S., Cehun M., Abbey M., Raederstorff D. The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. Am J Clin Nutr 2002, 76(2):326-330.
    • (2002) Am J Clin Nutr , vol.76 , Issue.2 , pp. 326-330
    • Nestel, P.1    Shige, H.2    Pomeroy, S.3    Cehun, M.4    Abbey, M.5    Raederstorff, D.6
  • 33
    • 0032861520 scopus 로고    scopus 로고
    • Eicosapentanoic acid reduces plasma levels of remnant lipoproteins and prevents invivo peroxidation of LDL in dialysis patients
    • Ando M., Sanaka T., Nihei H. Eicosapentanoic acid reduces plasma levels of remnant lipoproteins and prevents invivo peroxidation of LDL in dialysis patients. JAm Soc Nephrol 1999, 10(10):2177-2184.
    • (1999) JAm Soc Nephrol , vol.10 , Issue.10 , pp. 2177-2184
    • Ando, M.1    Sanaka, T.2    Nihei, H.3
  • 34
    • 0033833730 scopus 로고    scopus 로고
    • Eicosapentaenoic acid effect on hyperlipidemia in menopausal Japanese women. The Niigata Epadel Study Group
    • Kurabayashi T., Okada M., Tanaka K. Eicosapentaenoic acid effect on hyperlipidemia in menopausal Japanese women. The Niigata Epadel Study Group. Obstet Gynecol 2000, 96(4):521-528.
    • (2000) Obstet Gynecol , vol.96 , Issue.4 , pp. 521-528
    • Kurabayashi, T.1    Okada, M.2    Tanaka, K.3
  • 35
    • 33846046854 scopus 로고    scopus 로고
    • Purified eicosapentaenoic acid reduces small dense LDL, remnant lipoprotein particles, and C-reactive protein in metabolic syndrome
    • Satoh N., Shimatsu A., Kotani K., Sakane N., Yamada K., Suganami T., et al. Purified eicosapentaenoic acid reduces small dense LDL, remnant lipoprotein particles, and C-reactive protein in metabolic syndrome. Diabetes Care 2007, 30(1):144-146.
    • (2007) Diabetes Care , vol.30 , Issue.1 , pp. 144-146
    • Satoh, N.1    Shimatsu, A.2    Kotani, K.3    Sakane, N.4    Yamada, K.5    Suganami, T.6
  • 36
    • 84878567066 scopus 로고    scopus 로고
    • Efficacy and safety of TAK-085 compared with eicosapentaenoic acid in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized double-blind (ORD) study
    • Tatsuno I., Saito Y., Kudou K., Ootake J. Efficacy and safety of TAK-085 compared with eicosapentaenoic acid in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized double-blind (ORD) study. JClin Lipidol 2013, 7(3):199-207.
    • (2013) JClin Lipidol , vol.7 , Issue.3 , pp. 199-207
    • Tatsuno, I.1    Saito, Y.2    Kudou, K.3    Ootake, J.4
  • 37
    • 84884536323 scopus 로고    scopus 로고
    • GlaxoSmithKline, Research Triangle Park, NC
    • Lovaza [package insert] 2012, GlaxoSmithKline, Research Triangle Park, NC.
    • (2012) Lovaza [package insert]
  • 38
    • 84884583116 scopus 로고    scopus 로고
    • Mochida Pharmaceutical Co., Ltd, Tokyo, Japan
    • Epadel [package insert] 2007, Mochida Pharmaceutical Co., Ltd, Tokyo, Japan.
    • (2007) Epadel [package insert]
  • 40
    • 0032917836 scopus 로고    scopus 로고
    • Correlation of serum triglyceride and its reduction by omega-3 fatty acids with lipid transfer activity and the neutral lipid compositions of high-density and low-density lipoproteins
    • Pownall H.J., Brauchi D., Kilinc C., Osmundsen K., Pao Q., Payton-Ross C., et al. Correlation of serum triglyceride and its reduction by omega-3 fatty acids with lipid transfer activity and the neutral lipid compositions of high-density and low-density lipoproteins. Atherosclerosis 1999, 143(2):285-297.
    • (1999) Atherosclerosis , vol.143 , Issue.2 , pp. 285-297
    • Pownall, H.J.1    Brauchi, D.2    Kilinc, C.3    Osmundsen, K.4    Pao, Q.5    Payton-Ross, C.6
  • 41
    • 34548319692 scopus 로고    scopus 로고
    • Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study
    • Davidson M.H., Stein E.A., Bays H.E., Maki K.C., Doyle R.T., Shalwitz R.A., et al. Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study. Clin Ther 2007, 29(7):1354-1367.
    • (2007) Clin Ther , vol.29 , Issue.7 , pp. 1354-1367
    • Davidson, M.H.1    Stein, E.A.2    Bays, H.E.3    Maki, K.C.4    Doyle, R.T.5    Shalwitz, R.A.6
  • 42
    • 75749115919 scopus 로고    scopus 로고
    • Effects of prescription omega-3-acid ethyl esters on non-high-density lipoprotein cholesterol when coadministered with escalating doses of atorvastatin
    • Bays H.E., McKenney J., Maki K.C., Doyle R.T., Carter R.N., Stein E. Effects of prescription omega-3-acid ethyl esters on non-high-density lipoprotein cholesterol when coadministered with escalating doses of atorvastatin. Mayo Clin Proc 2010, 85(2):122-128.
    • (2010) Mayo Clin Proc , vol.85 , Issue.2 , pp. 122-128
    • Bays, H.E.1    McKenney, J.2    Maki, K.C.3    Doyle, R.T.4    Carter, R.N.5    Stein, E.6
  • 43
    • 84884556688 scopus 로고    scopus 로고
    • Abbott Laboratories, North Chicago, IL
    • Tricor [package insert] 2010, Abbott Laboratories, North Chicago, IL.
    • (2010) Tricor [package insert]
  • 44
    • 79951643956 scopus 로고    scopus 로고
    • Abbott Laboratories, North Chicago, IL
    • Niaspan [package insert] 2010, Abbott Laboratories, North Chicago, IL.
    • (2010) Niaspan [package insert]
  • 45
    • 80051784104 scopus 로고    scopus 로고
    • Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial)
    • Bays H.E., Ballantyne C.M., Kastelein J.J., Isaacsohn J.L., Braeckman R.A., Soni P.N. Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial). Am J Cardiol 2011, 108(5):682-690.
    • (2011) Am J Cardiol , vol.108 , Issue.5 , pp. 682-690
    • Bays, H.E.1    Ballantyne, C.M.2    Kastelein, J.J.3    Isaacsohn, J.L.4    Braeckman, R.A.5    Soni, P.N.6
  • 46
    • 84866124338 scopus 로고    scopus 로고
    • Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin-treated patients with persistent high triglycerides (from the ANCHOR study)
    • Ballantyne C.M., Bays H.E., Kastelein J.J., Stein E., Isaacsohn J.L., Braeckman R.A., et al. Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin-treated patients with persistent high triglycerides (from the ANCHOR study). Am J Cardiol 2012, 110(7):984-992.
    • (2012) Am J Cardiol , vol.110 , Issue.7 , pp. 984-992
    • Ballantyne, C.M.1    Bays, H.E.2    Kastelein, J.J.3    Stein, E.4    Isaacsohn, J.L.5    Braeckman, R.A.6
  • 47
    • 81855194044 scopus 로고    scopus 로고
    • Novel developments in omega-3 fatty acid-based strategies
    • Davidson M.H., Kling D., Maki K.C. Novel developments in omega-3 fatty acid-based strategies. Curr Opin Lipidol 2011, 22(6):437-444.
    • (2011) Curr Opin Lipidol , vol.22 , Issue.6 , pp. 437-444
    • Davidson, M.H.1    Kling, D.2    Maki, K.C.3
  • 48
    • 84870302077 scopus 로고    scopus 로고
    • Anovel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3-acid ethyl esters: the ECLIPSE (Epanova compared to Lovaza in a pharmacokinetic single-dose evaluation) study
    • Davidson M.H., Johnson J., Rooney M.W., Kyle M.L., Kling D.F. Anovel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3-acid ethyl esters: the ECLIPSE (Epanova compared to Lovaza in a pharmacokinetic single-dose evaluation) study. JClin Lipidol 2012, 6(6):573-584.
    • (2012) JClin Lipidol , vol.6 , Issue.6 , pp. 573-584
    • Davidson, M.H.1    Johnson, J.2    Rooney, M.W.3    Kyle, M.L.4    Kling, D.F.5
  • 49
    • 84884573934 scopus 로고    scopus 로고
    • Omthera Pharmaceuticals announces positive top-line results from phase 3 EVOLVE study. Omthera Pharmaceuticals. Available from: , [accessed 06.05.13].
    • Omthera Pharmaceuticals announces positive top-line results from phase 3 EVOLVE study. Omthera Pharmaceuticals. Available from: , [accessed 06.05.13]. http://www.omthera.com/pdf/EVOLVE_Data_Final.pdf.
  • 50
    • 84885469821 scopus 로고    scopus 로고
    • Dose response of a novel free-fatty acid formulation of omega-3 for the management of dyslipidemia in patients with severe hypertriglyceridemia - EpanoVa fOr Lowering Very High TriglycErides (the EVOLVE trial) [abstract 16374]
    • Kastelein J.J., Maki K.C., Susekov A., Ezhov M., Nordestgaard B.G., Kling D., et al. Dose response of a novel free-fatty acid formulation of omega-3 for the management of dyslipidemia in patients with severe hypertriglyceridemia - EpanoVa fOr Lowering Very High TriglycErides (the EVOLVE trial) [abstract 16374]. Circulation 2012, 126:A16374.
    • (2012) Circulation , vol.126
    • Kastelein, J.J.1    Maki, K.C.2    Susekov, A.3    Ezhov, M.4    Nordestgaard, B.G.5    Kling, D.6
  • 51
    • 84884566424 scopus 로고    scopus 로고
    • Efficacy and safety of add-on Epanova® to statin in subjects with persistent hypertriglyceridemia and high risk for cardiovascular disease (ESPRIT). NCT01408303. ClinicalTrials.gov. Available from: , [accessed 06.05.13].
    • Efficacy and safety of add-on Epanova® to statin in subjects with persistent hypertriglyceridemia and high risk for cardiovascular disease (ESPRIT). NCT01408303. ClinicalTrials.gov. Available from: , [accessed 06.05.13]. http://www.clinicaltrials.gov/ct2/show/NCT01408303?term=nct01408303%26rank=1.
  • 52
    • 84885478544 scopus 로고    scopus 로고
    • Ahighly bioavailable omega-3 free-fatty acid reduces non-high density lipoprotein cholesterol in high-risk patients treated with a statin and residual hypertriglycerigemia (ESPRIT trial) [abstract]
    • Maki K.C., Orloff D., Nicholls S., Dunbar R., Roth E., Curcio D.L., et al. Ahighly bioavailable omega-3 free-fatty acid reduces non-high density lipoprotein cholesterol in high-risk patients treated with a statin and residual hypertriglycerigemia (ESPRIT trial) [abstract]. JAm Coll Cardiol 2013, 61(10 Suppl.):E1468.
    • (2013) JAm Coll Cardiol , vol.61 , Issue.10 SUPPL.
    • Maki, K.C.1    Orloff, D.2    Nicholls, S.3    Dunbar, R.4    Roth, E.5    Curcio, D.L.6
  • 53
    • 11244306637 scopus 로고    scopus 로고
    • Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia
    • Bunea R., El Farrah K., Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004, 9(4):420-428.
    • (2004) Altern Med Rev , vol.9 , Issue.4 , pp. 420-428
    • Bunea, R.1    El, F.K.2    Deutsch, L.3
  • 54
    • 84884580272 scopus 로고    scopus 로고
    • TRIal For Efficacy of Capre on hyperTriglyceridemiA (TRIFECTA). NCT01455844. Available from: , [accessed 06.05.13].
    • TRIal For Efficacy of Capre on hyperTriglyceridemiA (TRIFECTA). NCT01455844. Available from: , [accessed 06.05.13]. http://clinicaltrials.gov/ct2/show/NCT01455844?term=%2528TRIFECTA%2529.%26rank=1.
  • 55
    • 84884578192 scopus 로고    scopus 로고
    • Study to investigate the effects of krill oil on fasting serum triglycerides. NCT01415388. ClinicalTrials.gov. Available from: , [accessed 06.05.13].
    • Study to investigate the effects of krill oil on fasting serum triglycerides. NCT01415388. ClinicalTrials.gov. Available from: , [accessed 06.05.13]. http://www.clinicaltrials.gov/ct2/show/NCT01415388?term=NCT01415388%26rank=1.
  • 56
    • 2142817149 scopus 로고    scopus 로고
    • Biotechnological production and applications of the omega-3 polyunsaturated fatty acid docosahexaenoic acid
    • Sijtsma L., de Swaaf M.E. Biotechnological production and applications of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. Appl Microbiol Biotechnol 2004, 64(2):146-153.
    • (2004) Appl Microbiol Biotechnol , vol.64 , Issue.2 , pp. 146-153
    • Sijtsma, L.1    de Swaaf, M.E.2
  • 57
    • 84855565346 scopus 로고    scopus 로고
    • Ameta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease
    • Bernstein A.M., Ding E.L., Willett W.C., Rimm E.B. Ameta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. JNutr 2012, 142(1):99-104.
    • (2012) JNutr , vol.142 , Issue.1 , pp. 99-104
    • Bernstein, A.M.1    Ding, E.L.2    Willett, W.C.3    Rimm, E.B.4
  • 58
    • 84861130202 scopus 로고    scopus 로고
    • Dietary sources of omega 3 fatty acids: public health risks and benefits
    • Tur J.A., Bibiloni M.M., Sureda A., Pons A. Dietary sources of omega 3 fatty acids: public health risks and benefits. Br J Nutr 2012, 107(Suppl.2):S23-S52.
    • (2012) Br J Nutr , vol.107 , Issue.SUPPL.2
    • Tur, J.A.1    Bibiloni, M.M.2    Sureda, A.3    Pons, A.4
  • 59
    • 84869768090 scopus 로고    scopus 로고
    • Alpha-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis
    • Pan A., Chen M., Chowdhury R., Wu J.H., Sun Q., Campos H., et al. alpha-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis. Am J Clin Nutr 2012, 96(6):1262-1273.
    • (2012) Am J Clin Nutr , vol.96 , Issue.6 , pp. 1262-1273
    • Pan, A.1    Chen, M.2    Chowdhury, R.3    Wu, J.H.4    Sun, Q.5    Campos, H.6
  • 60
    • 84873688136 scopus 로고    scopus 로고
    • Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis
    • Ramsden C.E., Zamora D., Leelarthaepin B., Majchrzak-Hong S.F., Faurot K.R., Suchindran C.M., et al. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. Br Med J 2013, 346:e8707.
    • (2013) Br Med J , vol.346
    • Ramsden, C.E.1    Zamora, D.2    Leelarthaepin, B.3    Majchrzak-Hong, S.F.4    Faurot, K.R.5    Suchindran, C.M.6
  • 61
    • 33947583493 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
    • Yokoyama M., Origasa H., Matsuzaki M., Matsuzawa Y., Saito Y., Ishikawa Y., et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 2007, 369(9567):1090-1098.
    • (2007) Lancet , vol.369 , Issue.9567 , pp. 1090-1098
    • Yokoyama, M.1    Origasa, H.2    Matsuzaki, M.3    Matsuzawa, Y.4    Saito, Y.5    Ishikawa, Y.6
  • 62
    • 49749128376 scopus 로고    scopus 로고
    • Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from theJapan EPA Lipid Intervention Study (JELIS)
    • Saito Y., Yokoyama M., Origasa H., Matsuzaki M., Matsuzawa Y., Ishikawa Y., et al. Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from theJapan EPA Lipid Intervention Study (JELIS). Atherosclerosis 2008, 200(1):135-140.
    • (2008) Atherosclerosis , vol.200 , Issue.1 , pp. 135-140
    • Saito, Y.1    Yokoyama, M.2    Origasa, H.3    Matsuzaki, M.4    Matsuzawa, Y.5    Ishikawa, Y.6
  • 63
    • 0345109256 scopus 로고    scopus 로고
    • Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico
    • GISSI Prevenzione Investigators
    • GISSI Prevenzione Investigators Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet 1999, 354(9177):447-455.
    • (1999) Lancet , vol.354 , Issue.9177 , pp. 447-455
  • 64
    • 53049110571 scopus 로고    scopus 로고
    • Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial
    • GISSI-HF Investigators
    • GISSI-HF Investigators Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet 2008, 372(9645):1223-1230.
    • (2008) Lancet , vol.372 , Issue.9645 , pp. 1223-1230
  • 65
    • 78549233384 scopus 로고    scopus 로고
    • N-3 fatty acids and cardiovascular events after myocardial infarction
    • Kromhout D., Giltay E.J., Geleijnse J.M. n-3 fatty acids and cardiovascular events after myocardial infarction. NEngl J Med 2010, 363(21):2015-2026.
    • (2010) NEngl J Med , vol.363 , Issue.21 , pp. 2015-2026
    • Kromhout, D.1    Giltay, E.J.2    Geleijnse, J.M.3
  • 66
    • 78650169331 scopus 로고    scopus 로고
    • OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction
    • Rauch B., Schiele R., Schneider S., Diller F., Victor N., Gohlke H., et al. OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction. Circulation 2010, 122(21):2152-2159.
    • (2010) Circulation , vol.122 , Issue.21 , pp. 2152-2159
    • Rauch, B.1    Schiele, R.2    Schneider, S.3    Diller, F.4    Victor, N.5    Gohlke, H.6
  • 67
    • 84864219466 scopus 로고    scopus 로고
    • N-3 fatty acids and cardiovascular outcomes in patients with dysglycemia
    • ORIGIN Trial Investigators
    • ORIGIN Trial Investigators n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia. NEngl J Med 2012, 367(4):309-318.
    • (2012) NEngl J Med , vol.367 , Issue.4 , pp. 309-318
  • 68
    • 84869170925 scopus 로고    scopus 로고
    • Fish oil and postoperative atrial fibrillation: the Omega-3 Fatty Acids for Prevention of Post-operative AtrialFibrillation (OPERA) randomized trial
    • Mozaffarian D., Marchioli R., Macchia A., Silletta M.G., Ferrazzi P., Gardner T.J., et al. Fish oil and postoperative atrial fibrillation: the Omega-3 Fatty Acids for Prevention of Post-operative AtrialFibrillation (OPERA) randomized trial. JAm Med Assoc 2012, 308(19):2001-2011.
    • (2012) JAm Med Assoc , vol.308 , Issue.19 , pp. 2001-2011
    • Mozaffarian, D.1    Marchioli, R.2    Macchia, A.3    Silletta, M.G.4    Ferrazzi, P.5    Gardner, T.J.6
  • 69
    • 84875802805 scopus 로고    scopus 로고
    • Long-chain omega-3 polyunsaturated fatty acids and risk of stroke: a meta-analysis
    • Larsson S.C., Orsini N., Wolk A. Long-chain omega-3 polyunsaturated fatty acids and risk of stroke: a meta-analysis. Eur J Epidemiol 2012, 27(12):895-901.
    • (2012) Eur J Epidemiol , vol.27 , Issue.12 , pp. 895-901
    • Larsson, S.C.1    Orsini, N.2    Wolk, A.3
  • 70
    • 84884540818 scopus 로고    scopus 로고
    • A study of AMR101 to evaluate its ability to reduce cardiovascular eventsinhigh risk patients with hypertriglyceridemia and on statin (REDUCE-IT). Available from: , [accessed 06.05.13].
    • A study of AMR101 to evaluate its ability to reduce cardiovascular eventsinhigh risk patients with hypertriglyceridemia and on statin (REDUCE-IT). Available from: , [accessed 06.05.13]. http://clinicaltrials.gov/show/NCT01492361.
  • 71
    • 84861137053 scopus 로고    scopus 로고
    • Omega-3 fatty acids and incident type 2 diabetes: a systematic review and meta-analysis
    • Wu J.H., Micha R., Imamura F., Pan A., Biggs M.L., Ajaz O., et al. Omega-3 fatty acids and incident type 2 diabetes: a systematic review and meta-analysis. Br J Nutr 2012, 107(Suppl.2):S214-S227.
    • (2012) Br J Nutr , vol.107 , Issue.SUPPL.2
    • Wu, J.H.1    Micha, R.2    Imamura, F.3    Pan, A.4    Biggs, M.L.5    Ajaz, O.6
  • 72
    • 55349135709 scopus 로고    scopus 로고
    • Differences between dietary supplement and prescription drug omega-3 fatty acid formulations: a legislative and regulatory perspective
    • Collins N., Tighe A.P., Brunton S.A., Kris-Etherton P.M. Differences between dietary supplement and prescription drug omega-3 fatty acid formulations: a legislative and regulatory perspective. JAm Coll Nutr 2008, 27(6):659-666.
    • (2008) JAm Coll Nutr , vol.27 , Issue.6 , pp. 659-666
    • Collins, N.1    Tighe, A.P.2    Brunton, S.A.3    Kris-Etherton, P.M.4
  • 73
    • 84884579972 scopus 로고    scopus 로고
    • Food and Drug Administration. Dietary supplements. Food and Drug Administration; Available from: , [accessed 06.05.13].
    • Food and Drug Administration. Dietary supplements. Food and Drug Administration; Available from: , [accessed 06.05.13]. http://www.fda.gov/Food/DietarySupplements/UsingDietarySupplements/ucm109760.htm.
  • 74
    • 84884571516 scopus 로고    scopus 로고
    • Fish oil and omega-3 fatty acid supplements (EPA and DHA from fish, algae, and krill). Consumer Lab; Available from: , [accessed 06.05.13].
    • Fish oil and omega-3 fatty acid supplements (EPA and DHA from fish, algae, and krill). Consumer Lab; Available from: , [accessed 06.05.13]. http://www.consumerlab.com/reviews/fish_oil_supplements_review/omega3.
  • 75
    • 84884575551 scopus 로고    scopus 로고
    • Amarin Pharma Inc., Bedminster, NJ
    • Vascepa [package insert] 2012, Amarin Pharma Inc., Bedminster, NJ.
    • (2012) Vascepa [package insert]
  • 76
    • 84874729635 scopus 로고    scopus 로고
    • ® and hypertriglyceridemia: pharmacological mechanisms and clinical efficacy
    • ® and hypertriglyceridemia: pharmacological mechanisms and clinical efficacy. Future Cardiol 2013, 9(2):177-186.
    • (2013) Future Cardiol , vol.9 , Issue.2 , pp. 177-186
    • Kataoka, Y.1    Uno, K.2    Puri, R.3    Nicholls, S.J.4
  • 77
    • 79960814823 scopus 로고    scopus 로고
    • Long chain omega-3 dietary supplements: a review of the National Library of Medicine Herbal Supplement Database
    • Zargar A., Ito M.K. Long chain omega-3 dietary supplements: a review of the National Library of Medicine Herbal Supplement Database. Metab Syndr Relat Disord 2011, 9(4):255-271.
    • (2011) Metab Syndr Relat Disord , vol.9 , Issue.4 , pp. 255-271
    • Zargar, A.1    Ito, M.K.2
  • 78
    • 77952522075 scopus 로고    scopus 로고
    • Krill oil. Monograph
    • Krill oil. Monograph. Altern Med Rev 2010, 15(1):84-86.
    • (2010) Altern Med Rev , vol.15 , Issue.1 , pp. 84-86


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.