Evaluation of the RBC Pig-a assay and the PIGRET assay using benzo[a]pyrene in rats

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 811, Issue , 2016, Pages 86-90

  Kikuzuki, Ryuta ^a   Sato, Haruka ^a   Fujiwara, Ai ^a   Takahashi, Tomoko ^a   Ogiwara, Yosuke ^a   Sugiura, Mihoko ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Benzo a pyrene; PIGRET assay; RBC Pig a assay

Indexed keywords

BENZO[A]PYRENE; MEMBRANE PROTEIN; MUTAGENIC AGENT; PHOSPHATIDYLINOSITOL GLYCAN-CLASS A PROTEIN;

ARTICLE; ASSAY; BLOOD SAMPLING; CONTROLLED STUDY; IN VIVO STUDY; MALE; MORTALITY; MUTAGENICITY; NONHUMAN; PIG A ASSAY WITH RETICULOCYTE ASSAY; PRIORITY JOURNAL; RAT; RED BLOOD CELL PIG A ASSAY; WEIGHT CHANGE; ANIMAL; BODY WEIGHT; DRUG EFFECTS; ERYTHROCYTE; EVALUATION STUDY; GENETICS; MUTAGEN TESTING; PROCEDURES; RETICULOCYTE; SPRAGUE DAWLEY RAT;

ANIMALS; BENZO(A)PYRENE; BODY WEIGHT; ERYTHROCYTES; MALE; MEMBRANE PROTEINS; MUTAGENICITY TESTS; MUTAGENS; RATS; RATS, SPRAGUE-DAWLEY; RETICULOCYTES;

EID: 84962110900     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2016.03.010     Document Type: Article

References (25)

1. [1] Kimoto, T., Horibata, K., Chikura, S., Hashimoto, K., Itoh, S., Sanada, H., Muto, S., Uno, Y., Yamada, M., Honma, M., Interlaboratory trial of the rat Pig-a mutation assay using an erythroid marker HIS49 antibody. Mutat. Res. 755 (2013), 126–134.
2. [2] Kimoto, T., Introduction to a special issue on the Pig-a gene mutation assay. Genes Environ. 36 (2014), 167–168.
3. [3] Miura, D., The in vivo Pig-a gene mutation assay. Genes Environ. 36 (2014), 169–173.
4. [4] Itoh, S., Nagata, M., Hattori, C., Takasaki, W., In vivo mutagenicity of ethyl methanesulfonate detected by Pig-a and PIGRET assays. Genes Environ. 36 (2014), 174–178.
5. [5] Sanada, H., Okamoto, M., Ohsumi, T., Nakamura, T., Evaluation for a mutagenicity of 4,4′-methylenedianiline on hematopoietic cells by a Pig-a gene mutation assay in rats. Genes Environ. 36 (2014), 179–185.
6. [6] Muto, S., Yamada, K., Kato, T., Iwase, Y., Uno, Y., Pig-a gene mutation and micronucleus induction in rat peripheral blood by methyl methanesulfonate. Genes Environ. 36 (2014), 186–190.
7. [7] Kimoto, T., Chikura, S., Suzuki-Okada, K., Kobayashi, X., Itano, Y., Miura, D., Kasahara, Y., The rat pig-a mutation assay in single and 28 day-repeated dose study of cyclophosphamide: the PIGRET assay can detect the in vivo mutagenicity earlier than the RBC Pig-a assay. Genes Environ. 36 (2014), 191–198.
8. [8] Horibata, K., Ukai, A., Honma, M., Evaluation of rats’ in vivo genotoxicity induced by N-ethyl-N-nitrosourea in the RBC Pig-a, PIGRET, and gpt assays. Genes Environ. 36 (2014), 199–202.
9. [9] Gollapudi, B.B., Lynch, A.M., Heflich, R.H., Dertinger, S.D., Dobrovolsky, V.N., Froetschl, R., Horibata, K., Kenyon, M.O., Kimoto, T., Lovell, D.P., Stankowski, L.F. Jr., White, P.A., Witt, K.L., Tanir, J.Y., The in vivo pig-a assay: a report of the international workshop on genotoxicity testing (IWGT) workgroup. Mutat. Res. 783 (2015), 23–35.
10. [10] Horibata, K., Ukai, A., Kimoto, T., Suzuki, T., Kamoshita, N., Masumura, K., Nohmi, T., Honma, M., Evaluation of in vivo genotoxicity induced by N-ethyl-N-nitrosourea benzo[a]pyrene, and 4-nitroquinoline-1-oxide in the Pig-a and gpt assays. Environ. Mol. Mutagen. 54 (2013), 747–754.
11. [11] Torous, D.K., Phonethepswath, S., Avlasevich, S.L., Mereness, J., Bryce, S.M., Bemis, J.C., Weller, P., Bell, S., Gleason, C., Custer, L.L., MacGregor, J.T., Dertinger, S.D., In vivo flow cytometric Pig-a and micronucleus assays: highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo[a]pyrene and pyrene using acute and repeated-dose designs. Environ. Mol. Mutagen. 53 (2012), 420–428.
12. [12] Pashin, Y.V., Bakhitova, L.M., Mutagenic and carcinogenic properties of polycyclic aromatic hydrocarbons. Environ. Health Perspect. 30 (1979), 185–189.
13. [13] Gupta, R.S., Singh, B., Mutagenic responses of five independent genetic loci in CHO cells to a variety of mutagens. Development and characteristics of a mutagen screening system based on selection for multiple drug-resistant markers. Mutat. Res. 94 (1982), 449–466.
14. [14] Kliesch, U., Roupova, I., Adler, I.D., Induction of chromosome damage in mouse bone marrow by benzo[a]pyrene. Mutat. Res. 102 (1982), 265–273.
15. [15] International Agency for Research on Cancer, Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures, IARC Monogr. Eval. Carcinog. Risks Hum. 92 (2010), 1–853.
16. [16] Rosenkranz, H.S., Poirier, L.A., Evaluation of the mutagenicity and DNA-modifying activity of carcinogens and noncarcinogens in microbial systems. J. Natl. Cancer Inst. 62 (1979), 873–892.
17. [17] Kaden, D.A., Hites, R.A., Thilly, W.G., Mutagenicity of soot and associated polycyclic aromatic hydrocarbons to Salmonella typhimurium. Cancer Res. 39 (1979), 4152–4159.
18. [18] Dunkel, V.C., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H.S., Simmon, V.F., Reproducibility of microbial mutagenicity assay: 1. Test with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6:Suppl. 2 (1984), 1–254.
19. [19] Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., Salmonella mutagenicity tests: v. Results from the testing of 311 chemicals. Environ. Mol. Mutagen. 19:Suppl. 21 (1992), 2–141.
20. [20] Arce, G.T., Allen, J.W., Doerr, C.L., Elmore, E., Hatch, G.G., Moore, M.M., Sharief, Y., Grunberger, D., Nesnow, S., Relationships between benzo[a]pyrene-DNA adduct levels and genotoxic effects in mammalian cells. Cancer Res. 47 (1987), 3388–3395.
21. [21] Amacher, D.E., Paillet, S.C., Hamster hepatocyte-mediated activation of procarcinogens to mutagens in the L5178Y/TK mutation assay. Mutat. Res. 106 (1982), 305–316.
22. [22] Hashimoto, A.H., Amanuma, K., Hiyoshi, K., Takano, H., Masumura, K., Nohmi, T., Aoki, Y., In vivo mutagenesis induced by benzo[a]pyrene instilled into the lung of gpt delta transgenic mice. Environ. Mol. Mutagen. 45 (2005), 365–373.
23. [23] Kimoto, T., et al. The PIGRET assay, a method for measuring Pig-a gene mutation in reticulocytes, is reliable as a short-term in vivo genotoxicity test: summary of the MMS/JEMS-collaborative study across 16 laboratoriesusing 24 chemicals. Mutat. Res. 811 (2016), 3–15.
24. [24] Jiang, H., Gelhaus, S.L., Mangal, D., Harvey, R.G., Blair, I.A., Penning, T.M., Metabolism of benzo[a]pyrene in human bronchoalveolar H358 cells using liquid chromatography-mass spectrometry. Chem. Res. Toxicol. 20 (2007), 1331–1341.
25. [25] Miura, D., Dobrovolsky, V.N., Kimoto, T., Kasahara, Y., Heflich, R.H., Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea. Mutat. Res. 677 (2009), 86–89.