Genetic Correlations Greatly Increase Mutational Robustness and Can Both Reduce and Enhance Evolvability

PLoS Computational Biology

Volumn 12, Issue 3, 2016, Pages

  Greenbury, Sam F ^a   Schaper, Steffen ^b,c   Ahnert, Sebastian E ^a   Louis, Ard A ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINS;

EVOLUTIONARY DYNAMICS; EVOLVABILITY; FOLDINGS; GENETIC CORRELATION; GENOTYPE MAPPING; NEIGHBOURHOOD; NON-NEUTRAL; NULL MODEL; PROTEIN TERTIARY STRUCTURES; RNA SECONDARY STRUCTURES;

MAPPING;

CONTROLLED STUDY; GENE MUTATION; GENETIC CORRELATION; GENOTYPE; HUMAN; HUMAN EXPERIMENT; INTUITION; LOSS OF FUNCTION MUTATION; MODEL; MUTATION; NEIGHBORHOOD; PHENOTYPE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; QUANTITATIVE STUDY; ANIMAL; BIOLOGICAL MODEL; COMPUTER SIMULATION; GENETICS; MOLECULAR EVOLUTION; POPULATION GENETICS; STATISTICAL MODEL;

PROTEOME;

ANIMALS; COMPUTER SIMULATION; EVOLUTION, MOLECULAR; GENETICS, POPULATION; GENOTYPE; HUMANS; MODELS, GENETIC; MODELS, STATISTICAL; MUTATION; PROTEOME;

EID: 84962090322     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004773     Document Type: Article

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