메뉴 건너뛰기




Volumn 64, Issue 3, 2015, Pages 696-699

Is brain insulin action relevant to the control of plasma glucose in humans?

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; ANTIDIABETIC AGENT; GLUCOSE;

EID: 84962062614     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-1666     Document Type: Note
Times cited : (16)

References (41)
  • 1
    • 84894308058 scopus 로고    scopus 로고
    • Evidence for central regulation of glucose metabolism
    • Carey M, Kehlenbrink S, Hawkins M. Evidence for central regulation of glucose metabolism. J Biol Chem 2013;288:34981-34988
    • (2013) J Biol Chem , vol.288 , pp. 34981-34988
    • Carey, M.1    Kehlenbrink, S.2    Hawkins, M.3
  • 2
    • 84871442771 scopus 로고    scopus 로고
    • Wired on sugar: The role of the CNS in the regulation of glucose homeostasis
    • Grayson BE, Seeley RJ, Sandoval DA. Wired on sugar: the role of the CNS in the regulation of glucose homeostasis. Nat Rev Neurosci 2013;14:24-37
    • (2013) Nat Rev Neurosci , vol.14 , pp. 24-37
    • Grayson, B.E.1    Seeley, R.J.2    Sandoval, D.A.3
  • 3
    • 84887347937 scopus 로고    scopus 로고
    • Cooperation between brain and islet in glucose homeostasis and diabetes
    • Schwartz MW, Seeley RJ, Tschöp MH, et al. Cooperation between brain and islet in glucose homeostasis and diabetes. Nature 2013;503:59-66
    • (2013) Nature , vol.503 , pp. 59-66
    • Schwartz, M.W.1    Seeley, R.J.2    Tschöp, M.H.3
  • 4
    • 84908555563 scopus 로고    scopus 로고
    • Control of hepatic glucose metabolism by islet and brain
    • Rojas JM, Schwartz MW. Control of hepatic glucose metabolism by islet and brain. Diabetes Obes Metab 2014;16(Suppl. 1):33-40
    • (2014) Diabetes Obes Metab , vol.16 , pp. 33-40
    • Rojas, J.M.1    Schwartz, M.W.2
  • 5
    • 84873198464 scopus 로고    scopus 로고
    • CNS insulin signaling in the control of energy homeostasis and glucose metabolism - From embryo to old age
    • Vogt MC, Brüning JC. CNS insulin signaling in the control of energy homeostasis and glucose metabolism - from embryo to old age. Trends Endocrinol Metab 2013;24:76-84
    • (2013) Trends Endocrinol Metab , vol.24 , pp. 76-84
    • Vogt, M.C.1    Brüning, J.C.2
  • 6
    • 33645579324 scopus 로고    scopus 로고
    • Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
    • Inoue H, Ogawa W, Asakawa A, et al. Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab 2006;3:267-275
    • (2006) Cell Metab , vol.3 , pp. 267-275
    • Inoue, H.1    Ogawa, W.2    Asakawa, A.3
  • 7
    • 34249651956 scopus 로고    scopus 로고
    • Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
    • Könner AC, Janoschek R, Plum L, et al. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab 2007;5:438-449
    • (2007) Cell Metab , vol.5 , pp. 438-449
    • Könner, A.C.1    Janoschek, R.2    Plum, L.3
  • 8
    • 77449144768 scopus 로고    scopus 로고
    • Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons
    • Lin HV, Plum L, Ono H, et al. Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes 2010;59:337-346
    • (2010) Diabetes , vol.59 , pp. 337-346
    • Lin, H.V.1    Plum, L.2    Ono, H.3
  • 9
    • 0036913187 scopus 로고    scopus 로고
    • Hypothalamic insulin signaling is required for inhibition of glucose production
    • Obici S, Zhang BB, Karkanias G, Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 2002;8:1376-1382
    • (2002) Nat Med , vol.8 , pp. 1376-1382
    • Obici, S.1    Zhang, B.B.2    Karkanias, G.3    Rossetti, L.4
  • 10
    • 17844379717 scopus 로고    scopus 로고
    • Hypothalamic K(ATP) channels control hepatic glucose production
    • Pocai A, Lam TK, Gutierrez-Juarez R, et al. Hypothalamic K(ATP) channels control hepatic glucose production. Nature 2005;434:1026-1031
    • (2005) Nature , vol.434 , pp. 1026-1031
    • Pocai, A.1    Lam, T.K.2    Gutierrez-Juarez, R.3
  • 11
    • 84908636883 scopus 로고    scopus 로고
    • Changes in glucose and fat metabolism in response to the administration of a hepato-preferential insulin analog
    • Edgerton DS, Moore MC, Winnick JJ, et al. Changes in glucose and fat metabolism in response to the administration of a hepato-preferential insulin analog. Diabetes 2014;63:3946-3954
    • (2014) Diabetes , vol.63 , pp. 3946-3954
    • Edgerton, D.S.1    Moore, M.C.2    Winnick, J.J.3
  • 12
    • 84922031936 scopus 로고    scopus 로고
    • A comparison of the physiological relevance of systemic versus portal Insulin delivery to evaluate whole body glucose flux during an insulin clamp
    • 16 December Epub ahead of print
    • Farmer TD, Jenkins EC, O'Brien TP, et al. A comparison of the physiological relevance of systemic versus portal Insulin delivery to evaluate whole body glucose flux during an insulin clamp. Am J Physiol Endocrinol Metab. 16 December 2014 [Epub ahead of print]. DOI: 10.1152/ajpendo.00406.2014
    • (2014) Am J Physiol Endocrinol Metab
    • Farmer, T.D.1    Jenkins, E.C.2    O'Brien, T.P.3
  • 13
    • 84872044062 scopus 로고    scopus 로고
    • Interaction between the central and peripheral effects of insulin in controlling hepatic glucose metabolism in the conscious dog
    • Ramnanan CJ, Kraft G, Smith MS, et al. Interaction between the central and peripheral effects of insulin in controlling hepatic glucose metabolism in the conscious dog. Diabetes 2013;62:74-84
    • (2013) Diabetes , vol.62 , pp. 74-84
    • Ramnanan, C.J.1    Kraft, G.2    Smith, M.S.3
  • 14
    • 80052345224 scopus 로고    scopus 로고
    • Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs
    • Ramnanan CJ, Saraswathi V, Smith MS, et al. Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs. J Clin Invest 2011;121:3713-3723
    • (2011) J Clin Invest , vol.121 , pp. 3713-3723
    • Ramnanan, C.J.1    Saraswathi, V.2    Smith, M.S.3
  • 15
    • 33947580628 scopus 로고    scopus 로고
    • Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver
    • Burgess SC, He T, Yan Z, et al. Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab 2007;5:313-320
    • (2007) Cell Metab , vol.5 , pp. 313-320
    • Burgess, S.C.1    He, T.2    Yan, Z.3
  • 16
    • 77953216482 scopus 로고    scopus 로고
    • Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo
    • Ramnanan CJ, Edgerton DS, Rivera N, et al. Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo. Diabetes 2010;59:1302-1311
    • (2010) Diabetes , vol.59 , pp. 1302-1311
    • Ramnanan, C.J.1    Edgerton, D.S.2    Rivera, N.3
  • 17
    • 67749142348 scopus 로고    scopus 로고
    • Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with type 2 diabetes
    • Samuel VT, Beddow SA, Iwasaki T, et al. Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with type 2 diabetes. Proc Natl Acad Sci U S A 2009;106:12121-12126
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 12121-12126
    • Samuel, V.T.1    Beddow, S.A.2    Iwasaki, T.3
  • 18
    • 84867033830 scopus 로고    scopus 로고
    • Insulin activates Erk1/2 signaling in the dorsal vagal complex to inhibit glucose production
    • Filippi BM, Yang CS, Tang C, Lam TK. Insulin activates Erk1/2 signaling in the dorsal vagal complex to inhibit glucose production. Cell Metab 2012;16:500-510
    • (2012) Cell Metab , vol.16 , pp. 500-510
    • Filippi, B.M.1    Yang, C.S.2    Tang, C.3    Lam, T.K.4
  • 19
    • 84883871864 scopus 로고    scopus 로고
    • Intranasal treatment of central nervous system dysfunction in humans
    • Chapman CD, Frey WH 2nd, Craft S, et al. Intranasal treatment of central nervous system dysfunction in humans. Pharm Res 2013;30:2475-2484
    • (2013) Pharm Res , vol.30 , pp. 2475-2484
    • Chapman, C.D.1    Frey, W.H.2    Craft, S.3
  • 20
    • 84928209333 scopus 로고    scopus 로고
    • Intranasal insulin suppresses endogenous glucose production in humans compared with placebo in the presence of similar venous insulin concentrations
    • Dash S, Xiao C, Morgantini C, Koulajian K, Lewis GF. Intranasal insulin suppresses endogenous glucose production in humans compared with placebo in the presence of similar venous insulin concentrations. Diabetes 2015;64:766-774
    • (2015) Diabetes , vol.64 , pp. 766-774
    • Dash, S.1    Xiao, C.2    Morgantini, C.3    Koulajian, K.4    Lewis, G.F.5
  • 21
    • 84928211042 scopus 로고    scopus 로고
    • Central nervous insulin administration does not potentiate the acute glucoregulatory impact of concurrent mild hyperinsulinemia
    • Ott V, Lehnert H, Staub J, Wönne K, Born J, Hallschmid M. Central nervous insulin administration does not potentiate the acute glucoregulatory impact of concurrent mild hyperinsulinemia. Diabetes 2015;64:760-765
    • (2015) Diabetes , vol.64 , pp. 760-765
    • Ott, V.1    Lehnert, H.2    Staub, J.3    Wönne, K.4    Born, J.5    Hallschmid, M.6
  • 22
    • 0029969117 scopus 로고    scopus 로고
    • A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog
    • Sindelar DK, Balcom JH, Chu CA, Neal DW, Cherrington AD. A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes 1996;45:1594-1604
    • (1996) Diabetes , vol.45 , pp. 1594-1604
    • Sindelar, D.K.1    Balcom, J.H.2    Chu, C.A.3    Neal, D.W.4    Cherrington, A.D.5
  • 23
    • 84911916822 scopus 로고    scopus 로고
    • Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men
    • Heni M, Wagner R, Kullmann S, et al. Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men. Diabetes 2014;63:4083-4088
    • (2014) Diabetes , vol.63 , pp. 4083-4088
    • Heni, M.1    Wagner, R.2    Kullmann, S.3
  • 24
    • 84055184949 scopus 로고    scopus 로고
    • Activation of K(ATP) channels suppresses glucose production in humans
    • Kishore P, Boucai L, Zhang K, et al. Activation of K(ATP) channels suppresses glucose production in humans. J Clin Invest 2011;121:4916-4920
    • (2011) J Clin Invest , vol.121 , pp. 4916-4920
    • Kishore, P.1    Boucai, L.2    Zhang, K.3
  • 25
    • 18244384200 scopus 로고    scopus 로고
    • Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action
    • Okamoto H, Obici S, Accili D, Rossetti L. Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action. J Clin Invest 2005; 115:1314-1322
    • (2005) J Clin Invest , vol.115 , pp. 1314-1322
    • Okamoto, H.1    Obici, S.2    Accili, D.3    Rossetti, L.4
  • 26
    • 18244395309 scopus 로고    scopus 로고
    • Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice
    • Buettner C, Patel R, Muse ED, et al. Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice. J Clin Invest 2005; 115:1306-1313
    • (2005) J Clin Invest , vol.115 , pp. 1306-1313
    • Buettner, C.1    Patel, R.2    Muse, E.D.3
  • 27
    • 56249148830 scopus 로고    scopus 로고
    • Intranasal insulin attenuates the hypothalamic-pituitary-adrenal axis response to psychosocial stress
    • Bohringer A, Schwabe L, Richter S, Schachinger H. Intranasal insulin attenuates the hypothalamic-pituitary-adrenal axis response to psychosocial stress. Psychoneuroendocrinology 2008;33:1394-1400
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 1394-1400
    • Bohringer, A.1    Schwabe, L.2    Richter, S.3    Schachinger, H.4
  • 29
    • 84865522894 scopus 로고    scopus 로고
    • Intranasal insulin suppresses food intake via enhancement of brain energy levels in humans
    • Jauch-Chara K, Friedrich A, Rezmer M, et al. Intranasal insulin suppresses food intake via enhancement of brain energy levels in humans. Diabetes 2012; 61:2261-2268
    • (2012) Diabetes , vol.61 , pp. 2261-2268
    • Jauch-Chara, K.1    Friedrich, A.2    Rezmer, M.3
  • 30
    • 78650054323 scopus 로고    scopus 로고
    • Comparable sensitivity of postmenopausal and young women to the effects of intranasal insulin on food intake and working memory
    • Krug R, Benedict C, Born J, Hallschmid M. Comparable sensitivity of postmenopausal and young women to the effects of intranasal insulin on food intake and working memory. J Clin Endocrinol Metab 2010;95:E468-E472
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. E468-E472
    • Krug, R.1    Benedict, C.2    Born, J.3    Hallschmid, M.4
  • 31
    • 78751485383 scopus 로고    scopus 로고
    • Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men
    • Benedict C, Brede S, Schiöth HB, et al. Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men. Diabetes 2011;60:114-118
    • (2011) Diabetes , vol.60 , pp. 114-118
    • Benedict, C.1    Brede, S.2    Schiöth, H.B.3
  • 32
    • 84865434170 scopus 로고    scopus 로고
    • Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and rewardrelated human brain regions
    • Heni M, Kullmann S, Ketterer C, et al. Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and rewardrelated human brain regions. Diabetologia 2012;55:1773-1782
    • (2012) Diabetologia , vol.55 , pp. 1773-1782
    • Heni, M.1    Kullmann, S.2    Ketterer, C.3
  • 34
    • 0031034472 scopus 로고    scopus 로고
    • Metabolic effects of liver transplantation in cirrhotic patients
    • Luzi L, Perseghin G, Regalia E, et al. Metabolic effects of liver transplantation in cirrhotic patients. J Clin Invest 1997;99:692-700
    • (1997) J Clin Invest , vol.99 , pp. 692-700
    • Luzi, L.1    Perseghin, G.2    Regalia, E.3
  • 35
    • 0030865881 scopus 로고    scopus 로고
    • Regulation of glucose homeostasis in humans with denervated livers
    • Perseghin G, Regalia E, Battezzati A, et al. Regulation of glucose homeostasis in humans with denervated livers. J Clin Invest 1997;100:931-941
    • (1997) J Clin Invest , vol.100 , pp. 931-941
    • Perseghin, G.1    Regalia, E.2    Battezzati, A.3
  • 37
    • 0023918674 scopus 로고
    • Hormonal regulation of hepatic gluconeogenesis and glycolysis
    • Pilkis SJ, el-Maghrabi MR, Claus TH. Hormonal regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Biochem 1988;57:755-783
    • (1988) Annu Rev Biochem , vol.57 , pp. 755-783
    • Pilkis, S.J.1    El-Maghrabi, M.R.2    Claus, T.H.3
  • 38
    • 33644784867 scopus 로고    scopus 로고
    • Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR
    • Hausler N, Browning J, Merritt M, et al. Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR. Biochem J 2006;394:465-473
    • (2006) Biochem J , vol.394 , pp. 465-473
    • Hausler, N.1    Browning, J.2    Merritt, M.3
  • 39
    • 32444434587 scopus 로고    scopus 로고
    • Insulin's direct effects on the liver dominate the control of hepatic glucose production
    • Edgerton DS, Lautz M, Scott M, et al. Insulin's direct effects on the liver dominate the control of hepatic glucose production. J Clin Invest 2006;116: 521-527
    • (2006) J Clin Invest , vol.116 , pp. 521-527
    • Edgerton, D.S.1    Lautz, M.2    Scott, M.3
  • 41
    • 0023546855 scopus 로고
    • Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects
    • Prager R, Wallace P, Olefsky JM. Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects. Diabetes 1987;36:607-611
    • (1987) Diabetes , vol.36 , pp. 607-611
    • Prager, R.1    Wallace, P.2    Olefsky, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.