-
1
-
-
84894308058
-
Evidence for central regulation of glucose metabolism
-
Carey M, Kehlenbrink S, Hawkins M. Evidence for central regulation of glucose metabolism. J Biol Chem 2013;288:34981-34988
-
(2013)
J Biol Chem
, vol.288
, pp. 34981-34988
-
-
Carey, M.1
Kehlenbrink, S.2
Hawkins, M.3
-
2
-
-
84871442771
-
Wired on sugar: The role of the CNS in the regulation of glucose homeostasis
-
Grayson BE, Seeley RJ, Sandoval DA. Wired on sugar: the role of the CNS in the regulation of glucose homeostasis. Nat Rev Neurosci 2013;14:24-37
-
(2013)
Nat Rev Neurosci
, vol.14
, pp. 24-37
-
-
Grayson, B.E.1
Seeley, R.J.2
Sandoval, D.A.3
-
3
-
-
84887347937
-
Cooperation between brain and islet in glucose homeostasis and diabetes
-
Schwartz MW, Seeley RJ, Tschöp MH, et al. Cooperation between brain and islet in glucose homeostasis and diabetes. Nature 2013;503:59-66
-
(2013)
Nature
, vol.503
, pp. 59-66
-
-
Schwartz, M.W.1
Seeley, R.J.2
Tschöp, M.H.3
-
4
-
-
84908555563
-
Control of hepatic glucose metabolism by islet and brain
-
Rojas JM, Schwartz MW. Control of hepatic glucose metabolism by islet and brain. Diabetes Obes Metab 2014;16(Suppl. 1):33-40
-
(2014)
Diabetes Obes Metab
, vol.16
, pp. 33-40
-
-
Rojas, J.M.1
Schwartz, M.W.2
-
5
-
-
84873198464
-
CNS insulin signaling in the control of energy homeostasis and glucose metabolism - From embryo to old age
-
Vogt MC, Brüning JC. CNS insulin signaling in the control of energy homeostasis and glucose metabolism - from embryo to old age. Trends Endocrinol Metab 2013;24:76-84
-
(2013)
Trends Endocrinol Metab
, vol.24
, pp. 76-84
-
-
Vogt, M.C.1
Brüning, J.C.2
-
6
-
-
33645579324
-
Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
-
Inoue H, Ogawa W, Asakawa A, et al. Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab 2006;3:267-275
-
(2006)
Cell Metab
, vol.3
, pp. 267-275
-
-
Inoue, H.1
Ogawa, W.2
Asakawa, A.3
-
7
-
-
34249651956
-
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
-
Könner AC, Janoschek R, Plum L, et al. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab 2007;5:438-449
-
(2007)
Cell Metab
, vol.5
, pp. 438-449
-
-
Könner, A.C.1
Janoschek, R.2
Plum, L.3
-
8
-
-
77449144768
-
Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons
-
Lin HV, Plum L, Ono H, et al. Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes 2010;59:337-346
-
(2010)
Diabetes
, vol.59
, pp. 337-346
-
-
Lin, H.V.1
Plum, L.2
Ono, H.3
-
9
-
-
0036913187
-
Hypothalamic insulin signaling is required for inhibition of glucose production
-
Obici S, Zhang BB, Karkanias G, Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 2002;8:1376-1382
-
(2002)
Nat Med
, vol.8
, pp. 1376-1382
-
-
Obici, S.1
Zhang, B.B.2
Karkanias, G.3
Rossetti, L.4
-
10
-
-
17844379717
-
Hypothalamic K(ATP) channels control hepatic glucose production
-
Pocai A, Lam TK, Gutierrez-Juarez R, et al. Hypothalamic K(ATP) channels control hepatic glucose production. Nature 2005;434:1026-1031
-
(2005)
Nature
, vol.434
, pp. 1026-1031
-
-
Pocai, A.1
Lam, T.K.2
Gutierrez-Juarez, R.3
-
11
-
-
84908636883
-
Changes in glucose and fat metabolism in response to the administration of a hepato-preferential insulin analog
-
Edgerton DS, Moore MC, Winnick JJ, et al. Changes in glucose and fat metabolism in response to the administration of a hepato-preferential insulin analog. Diabetes 2014;63:3946-3954
-
(2014)
Diabetes
, vol.63
, pp. 3946-3954
-
-
Edgerton, D.S.1
Moore, M.C.2
Winnick, J.J.3
-
12
-
-
84922031936
-
A comparison of the physiological relevance of systemic versus portal Insulin delivery to evaluate whole body glucose flux during an insulin clamp
-
16 December Epub ahead of print
-
Farmer TD, Jenkins EC, O'Brien TP, et al. A comparison of the physiological relevance of systemic versus portal Insulin delivery to evaluate whole body glucose flux during an insulin clamp. Am J Physiol Endocrinol Metab. 16 December 2014 [Epub ahead of print]. DOI: 10.1152/ajpendo.00406.2014
-
(2014)
Am J Physiol Endocrinol Metab
-
-
Farmer, T.D.1
Jenkins, E.C.2
O'Brien, T.P.3
-
13
-
-
84872044062
-
Interaction between the central and peripheral effects of insulin in controlling hepatic glucose metabolism in the conscious dog
-
Ramnanan CJ, Kraft G, Smith MS, et al. Interaction between the central and peripheral effects of insulin in controlling hepatic glucose metabolism in the conscious dog. Diabetes 2013;62:74-84
-
(2013)
Diabetes
, vol.62
, pp. 74-84
-
-
Ramnanan, C.J.1
Kraft, G.2
Smith, M.S.3
-
14
-
-
80052345224
-
Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs
-
Ramnanan CJ, Saraswathi V, Smith MS, et al. Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs. J Clin Invest 2011;121:3713-3723
-
(2011)
J Clin Invest
, vol.121
, pp. 3713-3723
-
-
Ramnanan, C.J.1
Saraswathi, V.2
Smith, M.S.3
-
15
-
-
33947580628
-
Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver
-
Burgess SC, He T, Yan Z, et al. Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab 2007;5:313-320
-
(2007)
Cell Metab
, vol.5
, pp. 313-320
-
-
Burgess, S.C.1
He, T.2
Yan, Z.3
-
16
-
-
77953216482
-
Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo
-
Ramnanan CJ, Edgerton DS, Rivera N, et al. Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo. Diabetes 2010;59:1302-1311
-
(2010)
Diabetes
, vol.59
, pp. 1302-1311
-
-
Ramnanan, C.J.1
Edgerton, D.S.2
Rivera, N.3
-
17
-
-
67749142348
-
Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with type 2 diabetes
-
Samuel VT, Beddow SA, Iwasaki T, et al. Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with type 2 diabetes. Proc Natl Acad Sci U S A 2009;106:12121-12126
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 12121-12126
-
-
Samuel, V.T.1
Beddow, S.A.2
Iwasaki, T.3
-
18
-
-
84867033830
-
Insulin activates Erk1/2 signaling in the dorsal vagal complex to inhibit glucose production
-
Filippi BM, Yang CS, Tang C, Lam TK. Insulin activates Erk1/2 signaling in the dorsal vagal complex to inhibit glucose production. Cell Metab 2012;16:500-510
-
(2012)
Cell Metab
, vol.16
, pp. 500-510
-
-
Filippi, B.M.1
Yang, C.S.2
Tang, C.3
Lam, T.K.4
-
19
-
-
84883871864
-
Intranasal treatment of central nervous system dysfunction in humans
-
Chapman CD, Frey WH 2nd, Craft S, et al. Intranasal treatment of central nervous system dysfunction in humans. Pharm Res 2013;30:2475-2484
-
(2013)
Pharm Res
, vol.30
, pp. 2475-2484
-
-
Chapman, C.D.1
Frey, W.H.2
Craft, S.3
-
20
-
-
84928209333
-
Intranasal insulin suppresses endogenous glucose production in humans compared with placebo in the presence of similar venous insulin concentrations
-
Dash S, Xiao C, Morgantini C, Koulajian K, Lewis GF. Intranasal insulin suppresses endogenous glucose production in humans compared with placebo in the presence of similar venous insulin concentrations. Diabetes 2015;64:766-774
-
(2015)
Diabetes
, vol.64
, pp. 766-774
-
-
Dash, S.1
Xiao, C.2
Morgantini, C.3
Koulajian, K.4
Lewis, G.F.5
-
21
-
-
84928211042
-
Central nervous insulin administration does not potentiate the acute glucoregulatory impact of concurrent mild hyperinsulinemia
-
Ott V, Lehnert H, Staub J, Wönne K, Born J, Hallschmid M. Central nervous insulin administration does not potentiate the acute glucoregulatory impact of concurrent mild hyperinsulinemia. Diabetes 2015;64:760-765
-
(2015)
Diabetes
, vol.64
, pp. 760-765
-
-
Ott, V.1
Lehnert, H.2
Staub, J.3
Wönne, K.4
Born, J.5
Hallschmid, M.6
-
22
-
-
0029969117
-
A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog
-
Sindelar DK, Balcom JH, Chu CA, Neal DW, Cherrington AD. A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes 1996;45:1594-1604
-
(1996)
Diabetes
, vol.45
, pp. 1594-1604
-
-
Sindelar, D.K.1
Balcom, J.H.2
Chu, C.A.3
Neal, D.W.4
Cherrington, A.D.5
-
23
-
-
84911916822
-
Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men
-
Heni M, Wagner R, Kullmann S, et al. Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men. Diabetes 2014;63:4083-4088
-
(2014)
Diabetes
, vol.63
, pp. 4083-4088
-
-
Heni, M.1
Wagner, R.2
Kullmann, S.3
-
24
-
-
84055184949
-
Activation of K(ATP) channels suppresses glucose production in humans
-
Kishore P, Boucai L, Zhang K, et al. Activation of K(ATP) channels suppresses glucose production in humans. J Clin Invest 2011;121:4916-4920
-
(2011)
J Clin Invest
, vol.121
, pp. 4916-4920
-
-
Kishore, P.1
Boucai, L.2
Zhang, K.3
-
25
-
-
18244384200
-
Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action
-
Okamoto H, Obici S, Accili D, Rossetti L. Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action. J Clin Invest 2005; 115:1314-1322
-
(2005)
J Clin Invest
, vol.115
, pp. 1314-1322
-
-
Okamoto, H.1
Obici, S.2
Accili, D.3
Rossetti, L.4
-
26
-
-
18244395309
-
Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice
-
Buettner C, Patel R, Muse ED, et al. Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice. J Clin Invest 2005; 115:1306-1313
-
(2005)
J Clin Invest
, vol.115
, pp. 1306-1313
-
-
Buettner, C.1
Patel, R.2
Muse, E.D.3
-
27
-
-
56249148830
-
Intranasal insulin attenuates the hypothalamic-pituitary-adrenal axis response to psychosocial stress
-
Bohringer A, Schwabe L, Richter S, Schachinger H. Intranasal insulin attenuates the hypothalamic-pituitary-adrenal axis response to psychosocial stress. Psychoneuroendocrinology 2008;33:1394-1400
-
(2008)
Psychoneuroendocrinology
, vol.33
, pp. 1394-1400
-
-
Bohringer, A.1
Schwabe, L.2
Richter, S.3
Schachinger, H.4
-
28
-
-
85047698627
-
Sniffing neuropeptides: A transnasal approach to the human brain
-
Born J, Lange T, Kern W, McGregor GP, Bickel U, Fehm HL. Sniffing neuropeptides: a transnasal approach to the human brain. Nat Neurosci 2002; 5:514-516
-
(2002)
Nat Neurosci
, vol.5
, pp. 514-516
-
-
Born, J.1
Lange, T.2
Kern, W.3
McGregor, G.P.4
Bickel, U.5
Fehm, H.L.6
-
29
-
-
84865522894
-
Intranasal insulin suppresses food intake via enhancement of brain energy levels in humans
-
Jauch-Chara K, Friedrich A, Rezmer M, et al. Intranasal insulin suppresses food intake via enhancement of brain energy levels in humans. Diabetes 2012; 61:2261-2268
-
(2012)
Diabetes
, vol.61
, pp. 2261-2268
-
-
Jauch-Chara, K.1
Friedrich, A.2
Rezmer, M.3
-
30
-
-
78650054323
-
Comparable sensitivity of postmenopausal and young women to the effects of intranasal insulin on food intake and working memory
-
Krug R, Benedict C, Born J, Hallschmid M. Comparable sensitivity of postmenopausal and young women to the effects of intranasal insulin on food intake and working memory. J Clin Endocrinol Metab 2010;95:E468-E472
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. E468-E472
-
-
Krug, R.1
Benedict, C.2
Born, J.3
Hallschmid, M.4
-
31
-
-
78751485383
-
Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men
-
Benedict C, Brede S, Schiöth HB, et al. Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men. Diabetes 2011;60:114-118
-
(2011)
Diabetes
, vol.60
, pp. 114-118
-
-
Benedict, C.1
Brede, S.2
Schiöth, H.B.3
-
32
-
-
84865434170
-
Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and rewardrelated human brain regions
-
Heni M, Kullmann S, Ketterer C, et al. Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and rewardrelated human brain regions. Diabetologia 2012;55:1773-1782
-
(2012)
Diabetologia
, vol.55
, pp. 1773-1782
-
-
Heni, M.1
Kullmann, S.2
Ketterer, C.3
-
33
-
-
7044241101
-
Intranasal insulin reduces body fat in men but not in women
-
Hallschmid M, Benedict C, Schultes B, Fehm HL, Born J, Kern W. Intranasal insulin reduces body fat in men but not in women. Diabetes 2004;53:3024-3029
-
(2004)
Diabetes
, vol.53
, pp. 3024-3029
-
-
Hallschmid, M.1
Benedict, C.2
Schultes, B.3
Fehm, H.L.4
Born, J.5
Kern, W.6
-
34
-
-
0031034472
-
Metabolic effects of liver transplantation in cirrhotic patients
-
Luzi L, Perseghin G, Regalia E, et al. Metabolic effects of liver transplantation in cirrhotic patients. J Clin Invest 1997;99:692-700
-
(1997)
J Clin Invest
, vol.99
, pp. 692-700
-
-
Luzi, L.1
Perseghin, G.2
Regalia, E.3
-
35
-
-
0030865881
-
Regulation of glucose homeostasis in humans with denervated livers
-
Perseghin G, Regalia E, Battezzati A, et al. Regulation of glucose homeostasis in humans with denervated livers. J Clin Invest 1997;100:931-941
-
(1997)
J Clin Invest
, vol.100
, pp. 931-941
-
-
Perseghin, G.1
Regalia, E.2
Battezzati, A.3
-
36
-
-
0034653587
-
Postprandial hepatic glycogen synthesis in liver transplant recipients
-
Schneiter P, Gillet M, Chioléro R, Wauters JP, Berger M, Tappy L. Postprandial hepatic glycogen synthesis in liver transplant recipients. Transplantation 2000;69:978-981
-
(2000)
Transplantation
, vol.69
, pp. 978-981
-
-
Schneiter, P.1
Gillet, M.2
Chioléro, R.3
Wauters, J.P.4
Berger, M.5
Tappy, L.6
-
37
-
-
0023918674
-
Hormonal regulation of hepatic gluconeogenesis and glycolysis
-
Pilkis SJ, el-Maghrabi MR, Claus TH. Hormonal regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Biochem 1988;57:755-783
-
(1988)
Annu Rev Biochem
, vol.57
, pp. 755-783
-
-
Pilkis, S.J.1
El-Maghrabi, M.R.2
Claus, T.H.3
-
38
-
-
33644784867
-
Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR
-
Hausler N, Browning J, Merritt M, et al. Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR. Biochem J 2006;394:465-473
-
(2006)
Biochem J
, vol.394
, pp. 465-473
-
-
Hausler, N.1
Browning, J.2
Merritt, M.3
-
39
-
-
32444434587
-
Insulin's direct effects on the liver dominate the control of hepatic glucose production
-
Edgerton DS, Lautz M, Scott M, et al. Insulin's direct effects on the liver dominate the control of hepatic glucose production. J Clin Invest 2006;116: 521-527
-
(2006)
J Clin Invest
, vol.116
, pp. 521-527
-
-
Edgerton, D.S.1
Lautz, M.2
Scott, M.3
-
40
-
-
0009805718
-
Control of Glucose Production in vivo by insulin and glucagon
-
Jefferson LSC, Cherrington A.D., Eds. New York, Oxford University Press
-
Cherrington AD. Control of Glucose Production in vivo by insulin and glucagon. In Handbook of Physiology: A Critical, Comprehensive Presentation of Physiological Knowledge and Concepts: Section 7: The Endocrine System, Volume 2: The Endocrine Pancreas and Regulation of Metabolism. Jefferson LSC, Cherrington A.D., Eds. New York, Oxford University Press, 2001, p. 759-785
-
(2001)
Handbook of Physiology: A Critical, Comprehensive Presentation of Physiological Knowledge and Concepts: Section 7: The Endocrine System, Volume 2: The Endocrine Pancreas and Regulation of Metabolism
, pp. 759-785
-
-
Cherrington, A.D.1
-
41
-
-
0023546855
-
Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects
-
Prager R, Wallace P, Olefsky JM. Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects. Diabetes 1987;36:607-611
-
(1987)
Diabetes
, vol.36
, pp. 607-611
-
-
Prager, R.1
Wallace, P.2
Olefsky, J.M.3
|