메뉴 건너뛰기




Volumn 28, Issue 3, 2016, Pages 267-273

Inflammation and innate immune function in critical illness

Author keywords

critical illness; immune suppression; immunoparalysis; inflammation; monocyte

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR ANTIGEN; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL MARKER; IMMUNOSUPPRESSIVE AGENT; TUMOR NECROSIS FACTOR;

EID: 84962053030     PISSN: 10408703     EISSN: 1531698X     Source Type: Journal    
DOI: 10.1097/MOP.0000000000000352     Document Type: Review
Times cited : (28)

References (48)
  • 1
    • 0029890342 scopus 로고    scopus 로고
    • Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure
    • Doughty LA, Kaplan SS, Carcillo JA. Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure. Crit Care Med. 1996; 24: 1137-1143.
    • (1996) Crit Care Med , vol.24 , pp. 1137-1143
    • Doughty, L.A.1    Kaplan, S.S.2    Carcillo, J.A.3
  • 2
    • 34548022149 scopus 로고    scopus 로고
    • Understanding the inflammatory cytokine response in pneumonia and sepsis: Results of the genetic and inflammatory markers of sepsis (genims) study
    • Kellum JA, Kong L, Fink MP, et al. Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med. 2007; 167: 1655-1663.
    • (2007) Arch Intern Med , vol.167 , pp. 1655-1663
    • Kellum, J.A.1    Kong, L.2    Fink, M.P.3
  • 3
    • 84951080610 scopus 로고    scopus 로고
    • Identifying pediatric severe sepsis and septic shock: Accuracy of diagnosis codes
    • Balamuth F, Weiss SL, Hall M, et al. Identifying pediatric severe sepsis and septic shock: accuracy of diagnosis codes. J Pediatr. 2015; 167: 1295-1300.
    • (2015) J Pediatr , vol.167 , pp. 1295-1300
    • Balamuth, F.1    Weiss, S.L.2    Hall, M.3
  • 4
    • 84872058963 scopus 로고    scopus 로고
    • Innate immune function and mortality in critically ill children with influenza: A multicenter study
    • Hall MW, Geyer SM, Guo CY, et al. Innate immune function and mortality in critically ill children with influenza: a multicenter study. Crit Care Med. 2013; 41: 224-236.
    • (2013) Crit Care Med , vol.41 , pp. 224-236
    • Hall, M.W.1    Geyer, S.M.2    Guo, C.Y.3
  • 5
    • 84914682595 scopus 로고    scopus 로고
    • Innate immune function predicts the development of nosocomial infection in critically injured children
    • Muszynski JA, Nofziger R, Greathouse K, et al. Innate immune function predicts the development of nosocomial infection in critically injured children. Shock. 2014; 42: 313-321.
    • (2014) Shock , vol.42 , pp. 313-321
    • Muszynski, J.A.1    Nofziger, R.2    Greathouse, K.3
  • 6
    • 48249148704 scopus 로고    scopus 로고
    • Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock
    • Wong HR, Cvijanovich N, Wheeler DS, et al. Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock. Am J Respir Crit Care Med. 2008; 178: 276-282.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 276-282
    • Wong, H.R.1    Cvijanovich, N.2    Wheeler, D.S.3
  • 7
    • 38549165767 scopus 로고    scopus 로고
    • The prognostic importance of serum IL-1beta, IL-6, IL-8 and TNF-Alpha levels compared to trauma scoring systems for early mortality in children with blunt trauma
    • Ozturk H, Yagmur Y, Ozturk H. The prognostic importance of serum IL-1beta, IL-6, IL-8 and TNF-Alpha levels compared to trauma scoring systems for early mortality in children with blunt trauma. Pediatr Surg Int. 2008; 24: 235-239.
    • (2008) Pediatr Surg Int , vol.24 , pp. 235-239
    • Ozturk, H.1    Yagmur, Y.2    Ozturk, H.3
  • 8
    • 84897378910 scopus 로고    scopus 로고
    • Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model
    • Wong HR, Weiss SL, Giuliano JS Jr, et al. Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model. PLoS One. 2014; 9: e86242.
    • (2014) PLoS One , vol.9 , pp. e86242
    • Wong, H.R.1    Weiss, S.L.2    Giuliano, J.S.3
  • 9
    • 9344246862 scopus 로고    scopus 로고
    • Assessment of the safety and efficacy of the monoclonal antitumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: A multicenter, randomized, placebo-controlled, dose-ranging study
    • Reinhart K, Wiegand-Lohnert C, Grimminger F, et al. Assessment of the safety and efficacy of the monoclonal antitumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: a multicenter, randomized, placebo-controlled, dose-ranging study. Crit Care Med. 1996; 24: 733-742.
    • (1996) Crit Care Med , vol.24 , pp. 733-742
    • Reinhart, K.1    Wiegand-Lohnert, C.2    Grimminger, F.3
  • 10
    • 0035046049 scopus 로고    scopus 로고
    • Randomized, placebo-controlled trial of the antitumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES Study
    • Reinhart K, Menges T, Gardlund B, et al. Randomized, placebo-controlled trial of the antitumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: the RAMSES Study. Crit Care Med. 2001; 29: 765-769.
    • (2001) Crit Care Med , vol.29 , pp. 765-769
    • Reinhart, K.1    Menges, T.2    Gardlund, B.3
  • 11
    • 8544262221 scopus 로고    scopus 로고
    • Efficacy and safety of the monoclonal antitumor necrosis factor antibody F(ab)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels
    • Panacek EA, Marshall JC, Albertson TE, et al. Efficacy and safety of the monoclonal antitumor necrosis factor antibody F(ab)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med. 2004; 32: 2173-2182.
    • (2004) Crit Care Med , vol.32 , pp. 2173-2182
    • Panacek, E.A.1    Marshall, J.C.2    Albertson, T.E.3
  • 13
    • 4544231442 scopus 로고    scopus 로고
    • The anti-inflammatory response dominates after septic shock: Association of low monocyte HLA-DR expression and high interleukin-10 concentration
    • Monneret G, Finck ME, Venet F, et al. The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration. Immunol Lett. 2004; 95: 193-198.
    • (2004) Immunol Lett , vol.95 , pp. 193-198
    • Monneret, G.1    Finck, M.E.2    Venet, F.3
  • 14
    • 33748766617 scopus 로고    scopus 로고
    • Interleukin-10 and its role in clinical immunoparalysis following pediatric cardiac surgery
    • Allen ML, Hoschtitzky JA, Peters MJ, et al. Interleukin-10 and its role in clinical immunoparalysis following pediatric cardiac surgery. Crit Care Med. 2006; 34: 2658-2665.
    • (2006) Crit Care Med , vol.34 , pp. 2658-2665
    • Allen, M.L.1    Hoschtitzky, J.A.2    Peters, M.J.3
  • 15
    • 38849151194 scopus 로고    scopus 로고
    • Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome
    • Hall MW, Gavrilin MA, Knatz NL, et al. Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome. Pediatr Res. 2007; 62: 597-603.
    • (2007) Pediatr Res , vol.62 , pp. 597-603
    • Hall, M.W.1    Gavrilin, M.A.2    Knatz, N.L.3
  • 16
    • 0036892751 scopus 로고    scopus 로고
    • Role of interleukin-10 in the intracellular sequestration of human leukocyte antigen-DR in monocytes during septic shock
    • Fumeaux T, Pugin J. Role of interleukin-10 in the intracellular sequestration of human leukocyte antigen-DR in monocytes during septic shock. Am J Respir Crit Care Med. 2002; 166: 1475-1482.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 1475-1482
    • Fumeaux, T.1    Pugin, J.2
  • 17
    • 0029823055 scopus 로고    scopus 로고
    • Monocyte deactivation: Rationale for a new therapeutic strategy in sepsis
    • Volk HD, Reinke P, Krausch D, et al. Monocyte deactivation: rationale for a new therapeutic strategy in sepsis. Intensive Care Med. 1996; 22: (Suppl 4): S474-481.
    • (1996) Intensive Care Med , vol.22 , pp. S474-S481
    • Volk, H.D.1    Reinke, P.2    Krausch, D.3
  • 18
    • 79953819133 scopus 로고    scopus 로고
    • Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome
    • Hall MW, Knatz NL, Vetterly C, et al. Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome. Intensive Care Med. 2011; 37: 525-532.
    • (2011) Intensive Care Med , vol.37 , pp. 525-532
    • Hall, M.W.1    Knatz, N.L.2    Vetterly, C.3
  • 19
    • 33747156889 scopus 로고    scopus 로고
    • Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock
    • Monneret G, Lepape A, Voirin N, et al. Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock. Intensive Care Med. 2006; 32: 1175-1183.
    • (2006) Intensive Care Med , vol.32 , pp. 1175-1183
    • Monneret, G.1    Lepape, A.2    Voirin, N.3
  • 20
    • 0026720270 scopus 로고
    • Prophylactic intravenous administration of standard immune globulin as compared with core-lipopolysaccharide immune globulin in patients at high risk of postsurgical infection
    • The Intravenous Immunoglobulin Collaborative Study Group
    • Prophylactic intravenous administration of standard immune globulin as compared with core-lipopolysaccharide immune globulin in patients at high risk of postsurgical infection. The Intravenous Immunoglobulin Collaborative Study Group. N Engl J Med. 1992; 327: 234-240.
    • (1992) N Engl J Med , vol.327 , pp. 234-240
  • 21
    • 33646568479 scopus 로고    scopus 로고
    • A strong association between downregulation of HLA-DR expression and the late mortality in patients with severe acute pancreatitis
    • Ho YP, Sheen IS, Chiu CT, et al. A strong association between downregulation of HLA-DR expression and the late mortality in patients with severe acute pancreatitis. Am J Gastroenterol. 2006; 101: 1117-1124.
    • (2006) Am J Gastroenterol , vol.101 , pp. 1117-1124
    • Ho, Y.P.1    Sheen, I.S.2    Chiu, C.T.3
  • 22
    • 34547697348 scopus 로고    scopus 로고
    • Decreased monocyte human leukocyte antigen-DR expression after severe burn injury: Correlation with severity and secondary septic shock
    • Venet F, Tissot S, Debard AL, et al. Decreased monocyte human leukocyte antigen-DR expression after severe burn injury: Correlation with severity and secondary septic shock. Crit Care Med. 2007; 35: 1910-1917.
    • (2007) Crit Care Med , vol.35 , pp. 1910-1917
    • Venet, F.1    Tissot, S.2    Debard, A.L.3
  • 23
    • 28044470484 scopus 로고    scopus 로고
    • Monitoring temporary immunodepression by flow cytometric measurement of monocytic HLA-DR expression: A multicenter standardized study
    • Docke WD, Hoflich C, Davis KA, et al. Monitoring temporary immunodepression by flow cytometric measurement of monocytic HLA-DR expression: a multicenter standardized study. Clin Chem. 2005; 51: 2341-2347.
    • (2005) Clin Chem , vol.51 , pp. 2341-2347
    • Docke, W.D.1    Hoflich, C.2    Davis, K.A.3
  • 24
    • 84906940700 scopus 로고    scopus 로고
    • Candida in the respiratory tract secretions of critically ill patients and the impact of antifungal treatment: A randomized placebo controlled pilot trial (CANTREAT study
    • Albert M, Williamson D, Muscedere J, et al. Candida in the respiratory tract secretions of critically ill patients and the impact of antifungal treatment: a randomized placebo controlled pilot trial (CANTREAT study). Intensive Care Med. 2014; 40: 1313-1322.
    • (2014) Intensive Care Med , vol.40 , pp. 1313-1322
    • Albert, M.1    Williamson, D.2    Muscedere, J.3
  • 25
    • 84876094420 scopus 로고    scopus 로고
    • Innate immune dysfunction is associated with enhanced disease severity in infants with severe respiratory syncytial virus bronchiolitis
    • Mella C, Suarez-Arrabal MC, Lopez S, et al. Innate immune dysfunction is associated with enhanced disease severity in infants with severe respiratory syncytial virus bronchiolitis. J Infect Dis. 2013; 207: 564-573.
    • (2013) J Infect Dis , vol.207 , pp. 564-573
    • Mella, C.1    Suarez-Arrabal, M.C.2    Lopez, S.3
  • 26
    • 84859751165 scopus 로고    scopus 로고
    • Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass
    • Cornell TT, Sun L, Hall MW, et al. Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2012; 143: 1160-1166.
    • (2012) J Thorac Cardiovasc Surg , vol.143 , pp. 1160-1166
    • Cornell, T.T.1    Sun, L.2    Hall, M.W.3
  • 27
    • 0023769976 scopus 로고
    • Depressed interferon gamma production and monocyte HLA-DR expression after severe injury
    • Livingston DH, Appel SH, Wellhausen SR, et al. Depressed interferon gamma production and monocyte HLA-DR expression after severe injury. Arch Surg. 1988; 123: 1309-1312.
    • (1988) Arch Surg , vol.123 , pp. 1309-1312
    • Livingston, D.H.1    Appel, S.H.2    Wellhausen, S.R.3
  • 28
    • 0033505573 scopus 로고    scopus 로고
    • HLA-DR expression and soluble HLA-DR levels in septic patients after trauma
    • Ditschkowski M, Kreuzfelder E, Rebmann V, et al. HLA-DR expression and soluble HLA-DR levels in septic patients after trauma. Ann Surg. 1999; 229: 246-254.
    • (1999) Ann Surg , vol.229 , pp. 246-254
    • Ditschkowski, M.1    Kreuzfelder, E.2    Rebmann, V.3
  • 29
    • 0025100823 scopus 로고
    • Monocyte HLA-DR antigen expression characterizes clinical outcome in the trauma patient
    • Hershman MJ, Cheadle WG, Wellhausen SR, et al. Monocyte HLA-DR antigen expression characterizes clinical outcome in the trauma patient. Br J Surg. 1990; 77: 204-207.
    • (1990) Br J Surg , vol.77 , pp. 204-207
    • Hershman, M.J.1    Cheadle, W.G.2    Wellhausen, S.R.3
  • 30
    • 33646778526 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced tumor necrosis factor alpha production and not monocyte human leukocyte antigen-DR expression is correlated with survival in septic trauma patients
    • Ploder M, Pelinka L, Schmuckenschlager C, et al. Lipopolysaccharide-induced tumor necrosis factor alpha production and not monocyte human leukocyte antigen-DR expression is correlated with survival in septic trauma patients. Shock. 2006; 25: 129-134.
    • (2006) Shock , vol.25 , pp. 129-134
    • Ploder, M.1    Pelinka, L.2    Schmuckenschlager, C.3
  • 31
    • 0027477817 scopus 로고
    • Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery
    • Wakefield CH, Carey PD, Foulds S, et al. Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery. Br J Surg. 1993; 80: 205-209.
    • (1993) Br J Surg , vol.80 , pp. 205-209
    • Wakefield, C.H.1    Carey, P.D.2    Foulds, S.3
  • 32
    • 0026075133 scopus 로고
    • HLA-DR antigen expression on peripheral blood monocytes correlates with surgical infection
    • Cheadle WG, Hershman MJ, Wellhausen SR, et al. HLA-DR antigen expression on peripheral blood monocytes correlates with surgical infection. Am J Surg. 1991; 161: 639-645.
    • (1991) Am J Surg , vol.161 , pp. 639-645
    • Cheadle, W.G.1    Hershman, M.J.2    Wellhausen, S.R.3
  • 33
    • 0029586138 scopus 로고
    • Immunodepression following neurosurgical procedures
    • Asadullah K, Woiciechowsky C, Docke WD, et al. Immunodepression following neurosurgical procedures. Crit Care Med. 1995; 23: 1976-1983.
    • (1995) Crit Care Med , vol.23 , pp. 1976-1983
    • Asadullah, K.1    Woiciechowsky, C.2    Docke, W.D.3
  • 34
    • 0242576267 scopus 로고    scopus 로고
    • Immune suppression and isolated severe head injury: A significant clinical problem
    • Boddie DE, Currie DG, Eremin O, et al. Immune suppression and isolated severe head injury: a significant clinical problem. Br J Neurosurg. 2003; 17: 405-417.
    • (2003) Br J Neurosurg , vol.17 , pp. 405-417
    • Boddie, D.E.1    Currie, D.G.2    Eremin, O.3
  • 35
    • 0033372942 scopus 로고    scopus 로고
    • Mechanisms of brainmediated systemic anti-inflammatory syndrome causing immunodepression
    • Woiciechowsky C, Schoning B, Lanksch WR, et al. Mechanisms of brainmediated systemic anti-inflammatory syndrome causing immunodepression. J Mol Med. 1999; 77: 769-780.
    • (1999) J Mol Med , vol.77 , pp. 769-780
    • Woiciechowsky, C.1    Schoning, B.2    Lanksch, W.R.3
  • 36
    • 43049085950 scopus 로고    scopus 로고
    • Up-regulation of interleukin-10 mRNA expression in peripheral leukocytes predicts poor outcome and diminished human leukocyte antigen-DR expression on monocytes in septic patients
    • Abe R, Hirasawa H, Oda S, et al. Up-regulation of interleukin-10 mRNA expression in peripheral leukocytes predicts poor outcome and diminished human leukocyte antigen-DR expression on monocytes in septic patients. J Surg Res. 2008; 147: 1-8.
    • (2008) J Surg Res , vol.147 , pp. 1-8
    • Abe, R.1    Hirasawa, H.2    Oda, S.3
  • 37
    • 0036245945 scopus 로고    scopus 로고
    • Early postoperative monocyte deactivation predicts systemic inflammation and prolonged stay in pediatric cardiac intensive care
    • Allen ML, Peters MJ, Goldman A, et al. Early postoperative monocyte deactivation predicts systemic inflammation and prolonged stay in pediatric cardiac intensive care. Crit Care Med. 2002; 30: 1140-1145.
    • (2002) Crit Care Med , vol.30 , pp. 1140-1145
    • Allen, M.L.1    Peters, M.J.2    Goldman, A.3
  • 38
    • 84859751165 scopus 로고    scopus 로고
    • Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass
    • Cornell TT, Sun L, Hall MW, et al. Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2012; 143: 1160-1166.
    • (2012) J Thorac Cardiovasc Surg , vol.143 , pp. 1160-1166
    • Cornell, T.T.1    Sun, L.2    Hall, M.W.3
  • 39
    • 0030957998 scopus 로고    scopus 로고
    • Genetic influence on cytokine production in meningococcal disease
    • Westendorp RG, Langermans JA, Huizinga TW, et al. Genetic influence on cytokine production in meningococcal disease. Lancet. 1997; 349: 1912-1913.
    • (1997) Lancet , vol.349 , pp. 1912-1913
    • Westendorp, R.G.1    Langermans, J.A.2    Huizinga, T.W.3
  • 40
    • 0026784290 scopus 로고
    • Diagnostic and predictive value of an immune monitoring program for complications after kidney transplantation
    • Reinke P, Volk HD. Diagnostic and predictive value of an immune monitoring program for complications after kidney transplantation. Urol Int. 1992; 49: 69-75.
    • (1992) Urol Int , vol.49 , pp. 69-75
    • Reinke, P.1    Volk, H.D.2
  • 41
    • 0033188567 scopus 로고    scopus 로고
    • Low HLA-DR expression on peripheral blood monocytes predicts bacterial sepsis after liver transplantation: Relation with prednisolone intake
    • Haveman JW, van den Berg AP, van den Berk JM, et al. Low HLA-DR expression on peripheral blood monocytes predicts bacterial sepsis after liver transplantation: relation with prednisolone intake. Transpl Infect Dis. 1999; 1: 146-152.
    • (1999) Transpl Infect Dis , vol.1 , pp. 146-152
    • Haveman, J.W.1    Van Den Berg, A.P.2    Van Den Berk, J.M.3
  • 42
    • 17144379985 scopus 로고    scopus 로고
    • Human leukocyte antigen-DR expression on peripheral blood monocytes and the risk of pneumonia in pediatric lung transplant recipients
    • Hoffman JA, Weinberg KI, Azen CG, et al. Human leukocyte antigen-DR expression on peripheral blood monocytes and the risk of pneumonia in pediatric lung transplant recipients. Transpl Infect Dis. 2004; 6: 147-155.
    • (2004) Transpl Infect Dis , vol.6 , pp. 147-155
    • Hoffman, J.A.1    Weinberg, K.I.2    Azen, C.G.3
  • 43
    • 84903796935 scopus 로고    scopus 로고
    • Early adaptive immune suppression in children with septic shock: A prospective observational study
    • Muszynski JA, Nofziger R, Greathouse K, et al. Early adaptive immune suppression in children with septic shock: a prospective observational study. Crit Care. 2014; 18: R145.
    • (2014) Crit Care , vol.18 , pp. R145
    • Muszynski, J.A.1    Nofziger, R.2    Greathouse, K.3
  • 44
    • 84926475067 scopus 로고    scopus 로고
    • Red blood cell transfusion and immune function in critically ill children: A prospective observational study
    • Muszynski JA, Frazier E, Nofziger R, et al. Red blood cell transfusion and immune function in critically ill children: a prospective observational study. Transfusion. 2015; 55: 766-774.
    • (2015) Transfusion , vol.55 , pp. 766-774
    • Muszynski, J.A.1    Frazier, E.2    Nofziger, R.3
  • 45
    • 0030917203 scopus 로고    scopus 로고
    • Monocyte deactivation in septic patients: Restoration by IFN-gamma treatment
    • Docke WD, Randow F, Syrbe U, et al. Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med. 1997; 3: 678-681.
    • (1997) Nat Med , vol.3 , pp. 678-681
    • Docke, W.D.1    Randow, F.2    Syrbe, U.3
  • 46
    • 0036310152 scopus 로고    scopus 로고
    • Immunoparalysis in patients with severe trauma and the effect of inhaled interferon-gamma
    • Nakos G, Malamou-Mitsi VD, Lachana A, et al. Immunoparalysis in patients with severe trauma and the effect of inhaled interferon-gamma. Crit Care Med. 2002; 30: 1488-1494.
    • (2002) Crit Care Med , vol.30 , pp. 1488-1494
    • Nakos, G.1    Malamou-Mitsi, V.D.2    Lachana, A.3
  • 47
    • 21844453227 scopus 로고    scopus 로고
    • Effect of granulocyte-monocyte colony-stimulating factor therapy on leukocyte function and clearance of serious infection in nonneutropenic patients
    • Rosenbloom AJ, Linden PK, Dorrance A, et al. Effect of granulocyte-monocyte colony-stimulating factor therapy on leukocyte function and clearance of serious infection in nonneutropenic patients. Chest. 2005; 127: 2139-2150.
    • (2005) Chest , vol.127 , pp. 2139-2150
    • Rosenbloom, A.J.1    Linden, P.K.2    Dorrance, A.3
  • 48
    • 70349469854 scopus 로고    scopus 로고
    • Granulocyte-macrophage colonystimulating factor to reverse sepsis-Associated immunosuppression: A double-blind, randomized, placebo-controlled multicenter trial
    • Meisel C, Schefold JC, Pschowski R, et al. Granulocyte-macrophage colonystimulating factor to reverse sepsis-Associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med. 2009; 180: 640-648.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 640-648
    • Meisel, C.1    Schefold, J.C.2    Pschowski, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.