Red blood cell transfusion and immune function in critically ill children: A prospective observational study

Transfusion

Volumn 55, Issue 4, 2015, Pages 766-774

  Muszynski, Jennifer A ^a   Frazier, Elfaridah ^b   Nofziger, Ryan ^c   Nateri, Jyotsna ^a   Hanson Huber, Lisa ^a   Steele, Lisa ^a   Nicol, Kathleen ^d   Spinella, Philip C ^b   Hall, Mark W ^a  

^a NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d AKRON CHILDREN'S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; HLA DR ANTIGEN; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; PHYTOHEMAGGLUTININ; TUMOR NECROSIS FACTOR ALPHA; GAMMA INTERFERON; INTERLEUKIN DERIVATIVE;

ADAPTIVE IMMUNITY; ARTICLE; ARTIFICIAL VENTILATION; BLOOD ANALYSIS; BLOOD STORAGE; BLOOD STORAGE TIME; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CONVALESCENCE; CRITICALLY ILL PATIENT; CYTOKINE PRODUCTION; ERYTHROCYTE TRANSFUSION; EX VIVO STUDY; FEMALE; HEMOGLOBIN BLOOD LEVEL; HOSPITAL ADMISSION; HUMAN; IMMUNOMODULATION; INFANT; INFLAMMATION; INNATE IMMUNITY; IRRADIATION; MALE; MONOCYTE; OBSERVATIONAL STUDY; PILOT STUDY; PROSPECTIVE STUDY; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; BIOSYNTHESIS; BLOOD; CLINICAL TRIAL; CRITICAL ILLNESS; DRUG EFFECTS; ERYTHROCYTE LIFESPAN; LYMPHOCYTE ACTIVATION; MULTICENTER STUDY; PRESCHOOL CHILD;

ADAPTIVE IMMUNITY; BLOOD PRESERVATION; CHILD; CHILD, PRESCHOOL; CRITICAL ILLNESS; ERYTHROCYTE AGING; ERYTHROCYTE TRANSFUSION; FEMALE; HUMANS; IMMUNITY, INNATE; INFANT; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKINS; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MALE; PHYTOHEMAGGLUTININS; PILOT PROJECTS; PROSPECTIVE STUDIES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84926475067     PISSN: 00411132     EISSN: 15372995     Source Type: Journal    
DOI: 10.1111/trf.12896     Document Type: Article

References (44)

1. Acker SN, Partrick DA, Ross JT, et al. Blood component transfusion increases the risk of death in children with traumatic brain injury. J Trauma Acute Care Surg 2014; 76: 1082-1087; discussion 1087-8.
2. Claridge JA, Sawyer RG, Schulman AM, et al. Blood transfusions correlate with infections in trauma patients in a dose-dependent manner. Am Surg 2002; 68: 566-572.
3. Malone DL, Dunne J, Tracy JK, et al. Blood transfusion, independent of shock severity, is associated with worse outcome in trauma. J Trauma 2003; 54: 898-905; discussion 905-7.
4. Paone G, Likosky DS, Brewer R, et al. Transfusion of 1 and 2 units of red blood cells is associated with increased morbidity and mortality. Ann Thorac Surg 2014; 97: 87-93; discussion 93-4.
5. Rachoin JS, Daher R, Schorr C, et al. Microbiology, time course and clinical characteristics of infection in critically ill patients receiving packed red blood cell transfusion. Vox Sang 2009; 97: 294-302.
6. Rohde JM, Dimcheff DE, Blumberg N, et al. Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. JAMA 2014; 311: 1317-1326.
7. Shorr AF, Jackson WL, Kelly KM, et al. Transfusion practice and blood stream infections in critically ill patients. Chest 2005; 127: 1722-1728.
8. Cornell TT, Sun L, Hall MW, et al. Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass. J Thorac Cardiovasc Surg 2012; 143: 1160-1161.
9. Felmet KA, Hall MW, Clark RS, et al. Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure. J Immunol 2005; 174: 3765-3772.
10. Hall MW, Geyer SM, Guo CY, et al. Innate immune function and mortality in critically ill children with influenza: a multicenter study. Crit Care Med 2013; 41: 224-236.
11. Hall MW, Knatz NL, Vetterly C, et al. Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome. Intensive Care Med 2011; 37: 525-532.
12. Hotchkiss RS, Tinsley KW, Swanson PE, et al. Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J Immunol 2001; 166: 6952-6963.
13. Muszynski JA, Nofziger R, Greathouse K, et al. Innate immune function predicts the development of nosocomial infection in critically injured children. Shock 2014; 42: 313-321.
14. Boomer JS, To K, Chang KC, et al. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 2011; 306: 2594-2605.
15. Muszynski JA, Nofziger R, Greathouse K, et al. Early adaptive immune suppression in children with septic shock: a prospective observational study. Crit Care 2014; 18: R145.
16. Hotchkiss RS, Monneret G, Payen D,. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 2013; 13: 862-874.
17. Volk HD, Reinke P, Docke WD,. Clinical aspects: from systemic inflammation to "immunoparalysis." Chem Immunol 2000; 74: 162-177.
18. Koch CG, Li L, Sessler DI, et al. Duration of red-cell storage and complications after cardiac surgery. N Engl J Med 2008; 358: 1229-1239.
19. Manlhiot C, McCrindle BW, Menjak IB, et al. Longer blood storage is associated with suboptimal outcomes in high-risk pediatric cardiac surgery. Ann Thorac Surg 2012; 93: 1563-1569.
20. Offner PJ, Moore EE, Biffl WL, et al. Increased rate of infection associated with transfusion of old blood after severe injury. Arch Surg 2002; 137: 711-716; discussion 716-7.
21. Ranucci M, Carlucci C, Isgro G, et al. Duration of red blood cell storage and outcomes in pediatric cardiac surgery: an association found for pump prime blood. Crit Care 2009; 13: R207.
22. Weinberg JA, McGwin G, Jr, Vandromme MJ, et al. Duration of red cell storage influences mortality after trauma. J Trauma 2010; 69: 1427-1431; discussion 1431-2.
23. Biedler AE, Schneider SO, Seyfert U, et al. Impact of alloantigens and storage-associated factors on stimulated cytokine response in an in vitro model of blood transfusion. Anesthesiology 2002; 97: 1102-1109.
24. Karam O, Tucci M, Toledano BJ, et al. Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells. Transfusion 2009; 49: 2326-2334.
25. Muszynski J, Nateri J, Nicol K, et al. Immunosuppressive effects of red blood cells on monocytes are related to both storage time and storage solution. Transfusion 2012; 52: 794-802.
26. Mynster T,. Effects of red cell storage and lysis on in vitro cytokine release. Transfus Apher Sci 2001; 25: 17-23.
27. Leteurtre S, Martinot A, Duhamel A, et al. Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study. Lancet 2003; 362: 192-197.
28. Pollack MM, Patel KM, Ruttimann UE,. PRISM III: an updated Pediatric Risk of Mortality score. Crit Care Med 1996; 24: 743-752.
29. van de Watering L,. Pitfalls in the current published observational literature on the effects of red blood cell storage. Transfusion 2011; 51: 1847-1854.
30. Gauvin F, Spinella PC, Lacroix J, et al. Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients. Transfusion 2010; 50: 1902-1913.
31. Spinella PC, Carroll CL, Staff I, et al. Duration of red blood cell storage is associated with increased incidence of deep vein thrombosis and in hospital mortality in patients with traumatic injuries. Crit Care 2009; 13: R151.
32. Zallen G, Offner PJ, Moore EE, et al. Age of transfused blood is an independent risk factor for postinjury multiple organ failure. Am J Surg 1999; 178: 570-572.
33. Karam O, Tucci M, Bateman ST, et al. Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study. Crit Care 2010; 14: R57.
34. Hall MW, Gavrilin MA, Knatz NL, et al. Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome. Pediatr Res 2007; 62: 597-603.
35. Mella C, Suarez-Arrabal MC, Lopez S, et al. Innate immune dysfunction is associated with enhanced disease severity in infants with severe respiratory syncytial virus bronchiolitis. J Infect Dis 2013; 207: 564-573.
36. Docke WD, Randow F, Syrbe U, et al. Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 1997; 3: 678-681.
37. Monneret G, Lepape A, Voirin N, et al. Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock. Intensive Care Med 2006; 32: 1175-1183.
38. Volk HD, Reinke P, Krausch D, et al. Monocyte deactivation-rationale for a new therapeutic strategy in sepsis. Intensive Care Med 1996; 22 (Suppl 4): S474-481.
39. Keir AK, McPhee AJ, Andersen CC, et al. Plasma cytokines and markers of endothelial activation increase after packed red blood cell transfusion in the preterm infant. Pediatr Res 2013; 73: 75-79.
40. Kor DJ, Kashyap R, Weiskopf RB, et al. Fresh red blood cell transfusion and short-term pulmonary, immunologic, and coagulation status: a randomized clinical trial. Am J Respir Crit Care Med 2012; 185: 842-850.
41. Lebiedz P, Glasmeyer S, Hilker E, et al. Influence of red blood cell storage time on clinical course and cytokine profile in septic shock patients. Transfus Med Hemother 2012; 39: 271-276.
42. Bernard A, Meier C, Ward M, et al. Packed red blood cells suppress T-cell proliferation through a process involving cell-cell contact. J Trauma 2010; 69: 320-329.
43. Danesh A, Inglis HC, Jackman RP, et al. Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro. Blood 2014; 123: 687-696.
44. Long K, Meier C, Ward M, et al. Immunologic profiles of red blood cells using in vitro models of transfusion. J Surg Res 2013; 184: 567-571.