Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas

Modern Pathology

Volumn 15, Issue 4, 2002, Pages 434-440

  Kahn, Harriette J ^a   Bailey, Denis ^a   Marks, Alexander ^a,b  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Kaposi's sarcoma; Lymphatic endothelium; Monoclonal antibody; Vascular lesions

Indexed keywords

CD31 ANTIGEN; FORMALDEHYDE; IMMUNOGLOBULIN G1; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY D2 40; PARAFFIN; UNCLASSIFIED DRUG;

ANGIOLIPOMA; ANGIOSARCOMA; ARTICLE; CELL DIFFERENTIATION; CONGENITAL BLOOD VESSEL MALFORMATION; CONTROLLED STUDY; DISEASE MARKER; GLOMUS TUMOR; HEMANGIOENDOTHELIOMA; HEMANGIOMA; HEMANGIOPERICYTOMA; HISTOGENESIS; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; KAPOSI SARCOMA; LYMPH VESSEL; LYMPH VESSEL ENDOTHELIUM; LYMPHANGIOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYOGENIC GRANULOMA;

ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGENS, CD31; BIOLOGICAL MARKERS; ENDOTHELIUM, LYMPHATIC; HEMANGIOSARCOMA; HUMANS; IMMUNOHISTOCHEMISTRY; SARCOMA, KAPOSI;

EID: 0036227312     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1038/modpathol.3880543     Document Type: Article

References (23)

1. Kaposi's sarcoma
2. Kaposi's sarcoma. Epidemiology, pathogenesis, histology, clinical spectrum, staging criteria and therapy
3. The enigmas of Kaposi's sarcoma
4. Origin of spindle-shaped cells in Kaposi's sarcoma
5. Evidence for the origin of Kaposi's sarcoma from lymphatic endothelium
6. Immunomorphological analysis of the role of blood vessel endothelium in the morphogenesis of cutaneous Kaposi's sarcoma: A study of 57 cases
7. QB Ind/10: A new immunostain for the routine diagnosis of Kaposi's sarcoma
8. Immunoreactivity patterns of CD31 and CD68 in 28 cases of Kaposi's sarcoma: Evidence supporting endothelial differentiation in the spindle cell compartment
9. Endothelial cell markers CD31, CD34, and BNH9 antibody to H- and Y-antigens - Evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand factor
10. Phenotype of normal cutaneous microvasculature
11. Immunoelectron microscopic characterization of human dermal lymphatic microvascular endothelial cells: Differential expression of CD31, CD34, and type IV collagen with lymphatic endothelial cells vs blood capillary endothelial cells in normal human skin, lymphangioma, and hemangioma in situ
12. Monoclonal antibody PAL-E specific for endothelium
13. Histogenesis of Kaposi's sarcoma in patients with and without acquired immune deficiency syndrome (AIDS)
14. Endemic Kaposi's sarcoma in human immunodeficiency virus type 1-seronegative persons: Demonstration of retrovirus-like particles in cutaneous lesions
15. Kaposi's sarcoma: A review of gene expression and ultrastructure of KS spindle cells in vivo
16. Expression of the vascular endothelial growth factor C receptor VEGFR-3 in lymphatic endothelium of the skin and in vascular tumors
17. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries. Podoplanin as a specific marker for lymphatic endothelium
18. Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3
19. Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells
20. Vascular endothelial growth factor receptor-3 (VEGFR-3): A marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, Kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas
21. Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor-3 in 185 vascular tumors
22. Characterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumors
23. The β-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors