The future of brown adipose tissues in the treatment of type 2 diabetes

Diabetologia

Volumn 58, Issue 8, 2015, Pages 1704-1707

  Schrauwen, Patrick ^a   van Marken Lichtenbelt, Wouter D ^a   Spiegelman, Bruce M ^b  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Brown adipose tissue; Cold induced thermogenesis; Diabetes; Energy turnover

Indexed keywords

BODY FAT; BODY WEIGHT; BROWN ADIPOSE TISSUE; EDITORIAL; ENDOCRINE FUNCTION; ENERGY EXPENDITURE; ENERGY METABOLISM; ENVIRONMENTAL TEMPERATURE; GLUCOSE HOMEOSTASIS; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHYSICAL ACTIVITY; PHYSICAL INACTIVITY; PRIORITY JOURNAL; WHITE ADIPOSE TISSUE; ANIMAL; DIABETES MELLITUS, TYPE 2; METABOLISM; OBESITY; PHYSIOLOGY; THERMOGENESIS;

ADIPOSE TISSUE, BROWN; ANIMALS; DIABETES MELLITUS, TYPE 2; ENERGY METABOLISM; HUMANS; OBESITY; THERMOGENESIS;

EID: 84937526191     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3611-y     Document Type: Editorial

References (17)

1. Gesner C (1551) Historiæ animalium lib. I. Tigvri, Apvd Christ Froschovervm (in Latin)
2. Smith RE (1961) Thermogenic activity of the hibernating gland in the cold-acclimatized rat. Physiologist 4:113
3. Nicholls DG, Bernson VS, Heaton GM (1978) The identification of the component in the inner membrane of brown adipose tissue mitochondria responsible for regulating energy dissipation. Experientia Suppl 32:89–93
4. Lowell BB, S-Susulic V, Hamann A et al (1993) Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366:740–742
5. Cypess AM, Lehman S, Williams G et al (2009) Identification and importance of brown adipose tissue in adult humans. N Engl J Med 360:1509–1517
6. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM et al (2009) Cold-activated brown adipose tissue in healthy men. N Engl J Med 360:1500–1508
7. Virtanen KA, Lidell ME, Orava J et al (2009) Functional brown adipose tissue in healthy adults. N Engl J Med 360:1518–1525
8. Saito M, Okamatsu-Ogura Y, Matsushita M et al (2009) High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58:1526–1531
9. Ravussin E, Lillioja S, Knowler WC et al (1988) Reduced rate of energy expenditure as a risk factor for body-weight gain. N Engl J Med 318:467–472
10. Vosselman MJ, van Marken Lichtenbelt WD, Schrauwen P (2013) Energy dissipation in brown adipose tissue: from mice to men. Mol Cell Endocrinol 379:43–50
11. Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI (2004) Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 350:664–671
12. Phielix E, Meex R, Ouwens DM et al (2012) High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance. Diabetes 61:2472–2478
13. Bartelt A, Bruns OT, Reimer R et al (2011) Brown adipose tissue activity controls triglyceride clearance. Nat Med 17:200–205
14. Labbè SM, Caron A, Bakan I et al (2015) In vivo measurement of energy substrate contribution to cold-induced brown adipose tissue thermogenesis. FASEB J. doi:10.1096/fj.14-266247
15. Wu J, Bostrom P, Sparks LM et al (2012) Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150:366–376
16. Cohen P, Levy JD, Zhang Y et al (2014) Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell 156:304–316
17. Lichtenbelt W, Kingma B, van der Lans A, Schellen L (2014) Cold exposure–an approach to increasing energy expenditure in humans. Trends Endocrinol Metab 25:165–167