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Volumn 3, Issue 8, 2015, Pages 881-890

Tumoricidal effects of macrophage-activating immunotherapy in a murine model of relapsed/refractory multiple myeloma

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; INTERLEUKIN 12; N(G) NITROARGININE METHYL ESTER; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; CD40 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAP3K8 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; NFKB1 PROTEIN, MOUSE; OLIGODEOXYRIBONUCLEOTIDE; ONCOPROTEIN;

EID: 84962018269     PISSN: 23266066     EISSN: 23266074     Source Type: Journal    
DOI: 10.1158/2326-6066.CIR-15-0025-T     Document Type: Article
Times cited : (24)

References (50)
  • 3
    • 84893810104 scopus 로고    scopus 로고
    • Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms
    • Walker BA, Wardell CP, Melchor L, Brioli A, Johnson DC, Kaiser MF, et al. Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms. Leukemia 2014;28:384-90.
    • (2014) Leukemia , vol.28 , pp. 384-390
    • Walker, B.A.1    Wardell, C.P.2    Melchor, L.3    Brioli, A.4    Johnson, D.C.5    Kaiser, M.F.6
  • 4
    • 84893788363 scopus 로고    scopus 로고
    • The current status of minimal residual disease assessment in myeloma
    • Kumar SK, Rajkumar SV. The current status of minimal residual disease assessment in myeloma. Leukemia 2014;28:239-40.
    • (2014) Leukemia , vol.28 , pp. 239-240
    • Kumar, S.K.1    Rajkumar, S.V.2
  • 5
    • 84920580293 scopus 로고    scopus 로고
    • Flow cytometry detection of minimal residual disease in multiple myeloma: Lessons learned at FDA-NCI roundtable symposium
    • Landgren O, Gormley N, Turley D, Owen RG, Rawstron A, Paiva B, et al. Flow cytometry detection of minimal residual disease in multiple myeloma: lessons learned at FDA-NCI roundtable symposium. Am J Hematol 2014;89:1159-60.
    • (2014) Am J Hematol , vol.89 , pp. 1159-1160
    • Landgren, O.1    Gormley, N.2    Turley, D.3    Owen, R.G.4    Rawstron, A.5    Paiva, B.6
  • 6
  • 7
    • 84912530935 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation for multiple myeloma
    • Bensinger W. Allogeneic stem cell transplantation for multiple myeloma. Hematol Oncol Clin North Am 2014;28:891-902.
    • (2014) Hematol Oncol Clin North Am , vol.28 , pp. 891-902
    • Bensinger, W.1
  • 8
    • 84903177242 scopus 로고    scopus 로고
    • TPL2 kinase regulates the inflammatory milieu of the myeloma niche
    • Hope C, Ollar SJ, Heninger E, Hebron E, Jensen JL, Kim J, et al. TPL2 kinase regulates the inflammatory milieu of the myeloma niche. Blood 2014;123:3305-15.
    • (2014) Blood , vol.123 , pp. 3305-3315
    • Hope, C.1    Ollar, S.J.2    Heninger, E.3    Hebron, E.4    Jensen, J.L.5    Kim, J.6
  • 9
    • 70449527554 scopus 로고    scopus 로고
    • Mesenchymal stem cell-educated macrophages: A novel type of alternatively activated macrophages
    • Kim J, Hematti P. Mesenchymal stem cell-educated macrophages: a novel type of alternatively activated macrophages. Exp Hematol 2009;37:1445-53.
    • (2009) Exp Hematol , vol.37 , pp. 1445-1453
    • Kim, J.1    Hematti, P.2
  • 11
    • 33845398215 scopus 로고    scopus 로고
    • Biochemical and functional characterization of three activated macrophage populations
    • Edwards JP, Zhang X, Frauwirth KA, Mosser DM. Biochemical and functional characterization of three activated macrophage populations. J Leukoc Biol 2006;80:1298-307.
    • (2006) J Leukoc Biol , vol.80 , pp. 1298-1307
    • Edwards, J.P.1    Zhang, X.2    Frauwirth, K.A.3    Mosser, D.M.4
  • 14
    • 78650956146 scopus 로고    scopus 로고
    • Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumourassociated macrophages
    • Buhtoiarov IN, Sondel PM, Wigginton JM, Buhtoiarova TN, Yanke EM, Mahvi DA, et al. Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumourassociated macrophages. Immunology 2011;132:226-39.
    • (2011) Immunology , vol.132 , pp. 226-239
    • Buhtoiarov, I.N.1    Sondel, P.M.2    Wigginton, J.M.3    Buhtoiarova, T.N.4    Yanke, E.M.5    Mahvi, D.A.6
  • 15
    • 67449138564 scopus 로고    scopus 로고
    • Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemia
    • Wu QL, Buhtoiarov IN, Sondel PM, Rakhmilevich AL, Ranheim EA. Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemia. J Immunol 2009;182:6771-8.
    • (2009) J Immunol , vol.182 , pp. 6771-6778
    • Wu, Q.L.1    Buhtoiarov, I.N.2    Sondel, P.M.3    Rakhmilevich, A.L.4    Ranheim, E.A.5
  • 16
    • 44249125542 scopus 로고    scopus 로고
    • CD40 ligation in vivo can induce T-cell independent antitumor effects even against immunogenic tumors
    • Rakhmilevich AL, Buhtoiarov IN, Malkovsky M, Sondel PM. CD40 ligation in vivo can induce T-cell independent antitumor effects even against immunogenic tumors. Cancer Immunol Immunother 2008;57:1151-60.
    • (2008) Cancer Immunol Immunother , vol.57 , pp. 1151-1160
    • Rakhmilevich, A.L.1    Buhtoiarov, I.N.2    Malkovsky, M.3    Sondel, P.M.4
  • 17
    • 33846912817 scopus 로고    scopus 로고
    • Macrophages are essential for antitumour effects against weakly immunogenic murine tumours induced by class B CpG-oligodeoxynucleotides
    • Buhtoiarov IN, Sondel PM, Eickhoff JC, Rakhmilevich AL. Macrophages are essential for antitumour effects against weakly immunogenic murine tumours induced by class B CpG-oligodeoxynucleotides. Immunology 2007;120:412-23.
    • (2007) Immunology , vol.120 , pp. 412-423
    • Buhtoiarov, I.N.1    Sondel, P.M.2    Eickhoff, J.C.3    Rakhmilevich, A.L.4
  • 18
    • 33746894598 scopus 로고    scopus 로고
    • In vivo CD40 ligation can induce T-cell-independent antitumor effects that involve macrophages
    • Lum HD, Buhtoiarov IN, Schmidt BE, Berke G, Paulnock DM, Sondel PM, et al. In vivo CD40 ligation can induce T-cell-independent antitumor effects that involve macrophages. J Leukoc Biol 2006;79:1181-92.
    • (2006) J Leukoc Biol , vol.79 , pp. 1181-1192
    • Lum, H.D.1    Buhtoiarov, I.N.2    Schmidt, B.E.3    Berke, G.4    Paulnock, D.M.5    Sondel, P.M.6
  • 19
    • 29644431786 scopus 로고    scopus 로고
    • Synergistic activation ofmacrophages viaCD40and TLR9 results in T-cell independent antitumor effects
    • Buhtoiarov IN, Lum HD, Berke G, Sondel PM, Rakhmilevich AL. Synergistic activation ofmacrophages viaCD40and TLR9 results in T-cell independent antitumor effects. J Immunol 2006;176:309-18.
    • (2006) J Immunol , vol.176 , pp. 309-318
    • Buhtoiarov, I.N.1    Lum, H.D.2    Berke, G.3    Sondel, P.M.4    Rakhmilevich, A.L.5
  • 20
    • 18644379552 scopus 로고    scopus 로고
    • CD40 ligation activates murine macrophages via an IFN-gammadependentmechanism resulting in tumor cell destruction in vitro
    • Buhtoiarov IN, Lum H, Berke G, Paulnock DM, Sondel PM, Rakhmilevich AL. CD40 ligation activates murine macrophages via an IFN-gammadependentmechanism resulting in tumor cell destruction in vitro. J Immunol 2005;174:6013-22.
    • (2005) J Immunol , vol.174 , pp. 6013-6022
    • Buhtoiarov, I.N.1    Lum, H.2    Berke, G.3    Paulnock, D.M.4    Sondel, P.M.5    Rakhmilevich, A.L.6
  • 21
    • 79953154967 scopus 로고    scopus 로고
    • CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • Beatty GL, Chiorean EG, Fishman MP, Saboury B, Teitelbaum UR, Sun W, et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 2011;331:1612-6.
    • (2011) Science , vol.331 , pp. 1612-1616
    • Beatty, G.L.1    Chiorean, E.G.2    Fishman, M.P.3    Saboury, B.4    Teitelbaum, U.R.5    Sun, W.6
  • 22
    • 67649700427 scopus 로고    scopus 로고
    • Tumorassociated macrophages infiltrate plasmacytomas and can serve as cell carriers for oncolytic measles virotherapy of disseminated myeloma
    • Peng KW, Dogan A, Vrana J, Liu C, Ong HT, Kumar S, et al. Tumorassociated macrophages infiltrate plasmacytomas and can serve as cell carriers for oncolytic measles virotherapy of disseminated myeloma. Am J Hematol 2009;84:401-7.
    • (2009) Am J Hematol , vol.84 , pp. 401-407
    • Peng, K.W.1    Dogan, A.2    Vrana, J.3    Liu, C.4    Ong, H.T.5    Kumar, S.6
  • 23
    • 84874705979 scopus 로고    scopus 로고
    • MAP3K8 kinase regulates myeloma growth by cell-autonomous and non-autonomous mechanisms involving myeloma-associated monocytes/macrophages
    • Hebron E, Hope C, Kim J, Jensen JL, Flanagan C, Bhatia N, et al. MAP3K8 kinase regulates myeloma growth by cell-autonomous and non-autonomous mechanisms involving myeloma-associated monocytes/macrophages. Br J Haematol 2013;160:779-84.
    • (2013) Br J Haematol , vol.160 , pp. 779-784
    • Hebron, E.1    Hope, C.2    Kim, J.3    Jensen, J.L.4    Flanagan, C.5    Bhatia, N.6
  • 25
    • 79957553362 scopus 로고    scopus 로고
    • Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression
    • Lopez-Pelaez M, Soria-Castro I, Bosca L, Fernandez M, Alemany S. Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: implications for NO synthase 2 expression. Eur J Immunol 2011;41:1733-41.
    • (2011) Eur J Immunol , vol.41 , pp. 1733-1741
    • Lopez-Pelaez, M.1    Soria-Castro, I.2    Bosca, L.3    Fernandez, M.4    Alemany, S.5
  • 26
    • 9644301015 scopus 로고    scopus 로고
    • A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation
    • Sugimoto K, Ohata M, Miyoshi J, Ishizaki H, Tsuboi N, Masuda A, et al. A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation. J Clin Invest 2004;114:857-66.
    • (2004) J Clin Invest , vol.114 , pp. 857-866
    • Sugimoto, K.1    Ohata, M.2    Miyoshi, J.3    Ishizaki, H.4    Tsuboi, N.5    Masuda, A.6
  • 27
    • 69549129472 scopus 로고    scopus 로고
    • TPL-2 negatively regulates interferon-beta production inmacrophages and myeloid dendritic cells
    • Kaiser F, Cook D, Papoutsopoulou S, Rajsbaum R, Wu X, Yang HT, et al. TPL-2 negatively regulates interferon-beta production inmacrophages and myeloid dendritic cells. J Exp Med 2009;206:1863-71.
    • (2009) J Exp Med , vol.206 , pp. 1863-1871
    • Kaiser, F.1    Cook, D.2    Papoutsopoulou, S.3    Rajsbaum, R.4    Wu, X.5    Yang, H.T.6
  • 29
    • 84864040412 scopus 로고    scopus 로고
    • Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy
    • Chesi M, Matthews GM, Garbitt VM, Palmer SE, Shortt J, Lefebure M, et al. Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy. Blood 2012;120:376-85.
    • (2012) Blood , vol.120 , pp. 376-385
    • Chesi, M.1    Matthews, G.M.2    Garbitt, V.M.3    Palmer, S.E.4    Shortt, J.5    Lefebure, M.6
  • 30
    • 84859842179 scopus 로고    scopus 로고
    • Compartment-specific bioluminescence imaging platform for the high-throughput evaluation of antitumor immune function
    • McMillin DW, Delmore J, Negri JM, Vanneman M, Koyama S, Schlossman RL, et al. Compartment-Specific Bioluminescence Imaging platform for the high-throughput evaluation of antitumor immune function. Blood 2012;119:e131-8.
    • (2012) Blood , vol.119 , pp. e131-e138
    • McMillin, D.W.1    Delmore, J.2    Negri, J.M.3    Vanneman, M.4    Koyama, S.5    Schlossman, R.L.6
  • 31
    • 84875229708 scopus 로고    scopus 로고
    • PSGL-1/selectin and ICAM-1/CD18 interactions are involved in macrophage-induced drug resistance in myeloma
    • Zheng Y, Yang J, Qian J, Qiu P, Hanabuchi S, Lu Y, et al. PSGL-1/selectin and ICAM-1/CD18 interactions are involved in macrophage-induced drug resistance in myeloma. Leukemia 2013;27:702-10.
    • (2013) Leukemia , vol.27 , pp. 702-710
    • Zheng, Y.1    Yang, J.2    Qian, J.3    Qiu, P.4    Hanabuchi, S.5    Lu, Y.6
  • 32
    • 84871182464 scopus 로고    scopus 로고
    • Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells
    • Kim D, Wang J, Willingham SB, Martin R, Wernig G, Weissman IL. Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells. Leukemia 2012;26:2538-45.
    • (2012) Leukemia , vol.26 , pp. 2538-2545
    • Kim, D.1    Wang, J.2    Willingham, S.B.3    Martin, R.4    Wernig, G.5    Weissman, I.L.6
  • 33
    • 78650887845 scopus 로고    scopus 로고
    • Regulation and function of TPL-2, an IkappaB kinase-regulated MAP kinase kinase kinase
    • Gantke T, Sriskantharajah S, Ley SC. Regulation and function of TPL-2, an IkappaB kinase-regulated MAP kinase kinase kinase. Cell Res 2011;21:131-45.
    • (2011) Cell Res , vol.21 , pp. 131-145
    • Gantke, T.1    Sriskantharajah, S.2    Ley, S.C.3
  • 34
    • 20144376830 scopus 로고    scopus 로고
    • Clonal plasma cells from monoclonal gammopathy of undetermined significance, multiple myeloma and plasma cell leukemia show different expression profiles of molecules involved in the interaction with the immunological bone marrow microenvironment
    • Perez-Andres M, Almeida J, Martin-Ayuso M, Moro MJ, Martin-Nunez G, Galende J, et al. Clonal plasma cells from monoclonal gammopathy of undetermined significance, multiple myeloma and plasma cell leukemia show different expression profiles of molecules involved in the interaction with the immunological bone marrow microenvironment. Leukemia 2005;19:449-55.
    • (2005) Leukemia , vol.19 , pp. 449-455
    • Perez-Andres, M.1    Almeida, J.2    Martin-Ayuso, M.3    Moro, M.J.4    Martin-Nunez, G.5    Galende, J.6
  • 35
    • 0018372542 scopus 로고
    • The beige mutation in the mouse selectively impairs natural killer cell function
    • Roder J, Duwe A. The beige mutation in the mouse selectively impairs natural killer cell function. Nature 1979;278:451-3.
    • (1979) Nature , vol.278 , pp. 451-453
    • Roder, J.1    Duwe, A.2
  • 36
    • 84858794257 scopus 로고    scopus 로고
    • A novel Ly6C/Ly6G-based strategy to analyze the mouse splenic myeloid compartment
    • Rose S, Misharin A, Perlman H. A novel Ly6C/Ly6G-based strategy to analyze the mouse splenic myeloid compartment. Cytometry A 2012;81:343-50.
    • (2012) Cytometry A , vol.81 , pp. 343-350
    • Rose, S.1    Misharin, A.2    Perlman, H.3
  • 38
    • 84904509138 scopus 로고    scopus 로고
    • The future of autologous stem cell transplantation in myeloma
    • Van Rhee F, Giralt S, Barlogie B. The future of autologous stem cell transplantation in myeloma. Blood 2014;124:328-33.
    • (2014) Blood , vol.124 , pp. 328-333
    • Van Rhee, F.1    Giralt, S.2    Barlogie, B.3
  • 41
    • 84855416310 scopus 로고    scopus 로고
    • Autologous stem cell transplantation and multiple myeloma cancer stem cells
    • Matsui W, Borrello I, Mitsiades C. Autologous stem cell transplantation and multiple myeloma cancer stem cells. Biol Blood Marrow Transplant 2012;18(Suppl 1):S27-32.
    • (2012) Biol Blood Marrow Transplant , vol.18 , pp. S27-S32
    • Matsui, W.1    Borrello, I.2    Mitsiades, C.3
  • 42
    • 84871238560 scopus 로고    scopus 로고
    • CD19 (+) CD45 (low/+) CD38 (high)/CD138 (+) plasma cells enrich for human tumorigenic myeloma cells
    • Kim D, Park CY, Medeiros BC, Weissman IL. CD19 (+) CD45 (low/+) CD38 (high)/CD138 (+) plasma cells enrich for human tumorigenic myeloma cells. Leukemia 2012;26:2530-7.
    • (2012) Leukemia , vol.26 , pp. 2530-2537
    • Kim, D.1    Park, C.Y.2    Medeiros, B.C.3    Weissman, I.L.4
  • 43
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell 2010;141:39-51.
    • (2010) Cell , vol.141 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 45
    • 38549131395 scopus 로고    scopus 로고
    • AIDdependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies
    • Chesi M, Robbiani DF, Sebag M, Chng WJ, Affer M, Tiedemann R, et al. AIDdependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies. Cancer Cell 2008;13:167-80.
    • (2008) Cancer Cell , vol.13 , pp. 167-180
    • Chesi, M.1    Robbiani, D.F.2    Sebag, M.3    Chng, W.J.4    Affer, M.5    Tiedemann, R.6
  • 46
    • 77952315198 scopus 로고    scopus 로고
    • A phase I multidose study of dacetuzumab (SGN-40; humanized anti-CD40 monoclonal antibody) in patients with multiple myeloma
    • Hussein M, Berenson JR, Niesvizky R, Munshi N, Matous J, Sobecks R, et al. A phase I multidose study of dacetuzumab (SGN-40; humanized anti-CD40 monoclonal antibody) in patients with multiple myeloma. Haematologica 2010;95:845-8.
    • (2010) Haematologica , vol.95 , pp. 845-848
    • Hussein, M.1    Berenson, J.R.2    Niesvizky, R.3    Munshi, N.4    Matous, J.5    Sobecks, R.6
  • 47
    • 84874845333 scopus 로고    scopus 로고
    • Agonistic CD40 antibodies and cancer therapy
    • Vonderheide RH, Glennie MJ. Agonistic CD40 antibodies and cancer therapy. Clin Cancer Res 2013;19:1035-43.
    • (2013) Clin Cancer Res , vol.19 , pp. 1035-1043
    • Vonderheide, R.H.1    Glennie, M.J.2
  • 48
    • 0042525945 scopus 로고    scopus 로고
    • Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40
    • Eliopoulos AG, Wang CC, Dumitru CD, Tsichlis PN. Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40. EMBO J 2003;22:3855-64.
    • (2003) EMBO J , vol.22 , pp. 3855-3864
    • Eliopoulos, A.G.1    Wang, C.C.2    Dumitru, C.D.3    Tsichlis, P.N.4
  • 49
    • 36348968386 scopus 로고    scopus 로고
    • Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood
    • Hall JP, Kurdi Y, Hsu S, Cuozzo J, Liu J, Telliez JB, et al. Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. J Biol Chem 2007;282:33295-304.
    • (2007) J Biol Chem , vol.282 , pp. 33295-33304
    • Hall, J.P.1    Kurdi, Y.2    Hsu, S.3    Cuozzo, J.4    Liu, J.5    Telliez, J.B.6


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