Autoantibodies to neuronal antigens in children with focal epilepsy and no prima facie signs of encephalitis

European Journal of Paediatric Neurology

Volumn 20, Issue 4, 2016, Pages 573-579

  Borusiak, Peter ^a   Bettendorf, Ulrich ^b   Wiegand, Gert ^c   Bast, Thomas ^d   Kluger, Gerhard ^e,f   Philippi, Heike ^g   Münstermann, Dieter ^h   Bien, Christian G ⁱ  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

^b KiPraHi Neuropediatric Medical Office Hirschaid   (Germany)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^d Epilepsy Center Kork   (Germany)

^e Epilepsy Center Vogtareuth   (Germany)

^f PARACELSUS MEDICAL UNIVERSITY   (Austria)

^g Center of Developmental Neurology   (Germany)

^h Labor Krone   (Germany)

ⁱ EPILEPSY CENTER BETHEL   (Germany)

Author keywords

Autoimmune; GAD65; N methyl d aspartate receptor; Pediatrics; VGKC

Indexed keywords

ANTIBODY; AUTOANTIBODY; CELL ANTIBODY; CELL ANTIGEN; CONTACTIN ASSOCIATED PROTEIN LIKE 2 PROTEIN; GLUTAMATE DECARBOXYLASE 65 ANTIBODY; INTRACELLULAR ANTIGEN; LEUCINE RICH GLIOMA INACTIVATED 1; MEMBRANE ANTIGEN; NEURONAL AUTOANTIBODY; PROTEIN; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL COMPLEX ANTIBODY; CNTNAP2 PROTEIN, HUMAN; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 2; LGI1 PROTEIN, HUMAN; MEMBRANE PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NERVE PROTEIN; VOLTAGE GATED POTASSIUM CHANNEL;

ADOLESCENT; ANTIBODY BLOOD LEVEL; ANTIBODY SPECIFICITY; ARTICLE; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; DISEASE DURATION; DISEASE SEVERITY; ENCEPHALITIS; FEMALE; FOCAL EPILEPSY; GLIOMA; HUMAN; IMMUNOFLUORESCENCE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; COMPLICATION; EPILEPSY; HASHIMOTO DISEASE; IMMUNOLOGY; INFANT; PRESCHOOL CHILD;

ADOLESCENT; AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; ENCEPHALITIS; EPILEPSIES, PARTIAL; EPILEPSY; FEMALE; GLUTAMATE DECARBOXYLASE; HASHIMOTO DISEASE; HUMANS; INFANT; MALE; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEINS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84962013954     PISSN: 10903798     EISSN: 15322130     Source Type: Journal    
DOI: 10.1016/j.ejpn.2016.03.005     Document Type: Article

References (19)

1. S.R. Irani, C.G. Bien, and B. Lang Autoimmune epilepsies Curr Opin Neurol 24 2011 146 153
2. Y. Hacohen, S. Wright, P. Waters, and et al. Paediatric autoimmune encephalopathies: clinical features, laboratory investigations and outcomes in patients with or without antibodies to known central nervous system autoantigens J Neurol Neurosurg Psychiatry 84 2013 748 755
3. M.S. Ong, I.S. Kohane, T. Cai, and et al. Population-level evidence for an autoimmune etiology of epilepsy JAMA Neurol 71 2014 569 574
4. A. Pardo, P. González-Porque, J.M. Gobernado, and et al. Study of antiphospholipid antibodies in patients treated with antiepileptic drugs Neurologia 16 2001 7 10
5. A.N. Allen, O.O. Seminog, and M.J. Goldacre Association between multiple sclerosis and epilepsy: large population-based record-linkage studies BMC Neurol 13 2013 189 Available at: http://www.biomedcentral.com/1471-2377/13/189 [accessed 27.07.15]
6. A.T. Berg, S.F. Berkovic, M.J. Brodie, and et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009 Epilepsia 51 2010 676 685
7. A. Saiz, Y. Blanco, L. Sabater, and et al. Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association Brain 131 2008 2553 2563
8. A. Vincent, C. Buckley, J.M. Schott, and et al. Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis Brain 127 2004 701 702
9. H.M. Meinck, L. Faber, N. Morgenthaler, and et al. Antibodies against glutamic acid decarboxylase: prevalence in neurological diseases J Neurol Neurosurg Psychiatry 71 2001 100 103
10. N. Gresa-Arribas, H. Ariño, E. Martínez-Hernández, and et al. Antibodies to inhibitory synaptic proteins in neurological syndromes associated with glutamic acid decarboxylase autoimmunity PLoS One 10 2015 e0121364 Available at: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121364 [accessed 27.07.15]
11. M.R. Rosenfeld, M.J. Titulaer, and J. Dalmau Paraneoplastic syndromes and autoimmune encephalitis: five new things Neurol Clin Pract 2 2012 215 223
12. F. Leypoldt, T. Armangue, and J. Dalmau Autoimmune encephalopathies Ann N Y Acad Sci 1338 2015 94 114
13. J. Suleiman, S. Wright, D. Gill, and et al. Autoantibodies to neuronal antigens in children with new-onset seizures classified according to the revised ILAE organization of seizures and epilepsies Epilepsia 54 2013 2091 2100
14. O. Bektas, L. Jacobson, H. Tutkak, and et al. Epilepsy and autoimmunity in pediatric patients Neuropediatrics 46 2015 13 19
15. F. Graus, J.Y. Delattre, J.C. Antoine, and et al. Recommended diagnostic criteria for paraneoplastic neurological syndromes J Neurol Neurosurg Psychiatry 75 2004 1135 1140
16. Y. Hacohen, R. Singh, M. Rossi, and et al. Clinical relevance of voltage-gated potassium channel-complex antibodies in children Neurology 85 2015 967 975
17. E.G. Hughes, X. Peng, A.J. Gleichman, and et al. Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis J Neurosci 30 2010 5866 5875
18. T. Ohkawa, Y. Fukata, M. Yamasaki, and et al. Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors J Neurosci 33 2013 18161 18174
19. P. Kwan, A. Arzimanoglou, A.T. Berg, and et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on therapeutic strategies Epilepsia 51 2010 1069 1077