Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors

Journal of Neuroscience

Volumn 33, Issue 46, 2013, Pages 18161-18174

  Ohkawa, Toshika ^a,b   Fukata, Yuko ^a,b   Yamasaki, Miwako ^c   Miyazaki, Taisuke ^c   Yokoi, Norihiko ^a,b   Takashima, Hiroshi ^d   Watanabe, Masahiko ^c,e   Watanabe, Osamu ^d   Fukata, Masaki ^a,b  

^a NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^b GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^c HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d KAGOSHIMA UNIVERSITY   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM PROTEIN; ADAM22 PROTEIN; ADAM23 PROTEIN; AMPA RECEPTOR; AUTOANTIBODY; DELETED IN COLORECTAL CARCINOMA ANTIBODY; DIPEPTIDYL PEPTIDASE 10 ANTIBODY; GLUTAMATE DECARBOXYLASE 67; LGI1 AUTOANTIBODY; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ANIMAL CELL; ANIMAL TISSUE; ANTIBODY SCREENING; ARTICLE; BINDING ASSAY; CHILD; CONTROLLED STUDY; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; EPILEPSY; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; MYOKYMIA; NONHUMAN; NUCLEOTIDE SEQUENCE; PARANEOPLASTIC NEUROPATHY; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROTEIN INTERACTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNAPTIC TRANSMISSION;

ADAM PROTEINS; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; AUTOANTIBODIES; CERCOPITHECUS AETHIOPS; CHILD; CHILD, PRESCHOOL; COS CELLS; EPILEPSY; FEMALE; HEK293 CELLS; HUMANS; INFANT; LIMBIC ENCEPHALITIS; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; NERVE TISSUE PROTEINS; PROTEIN BINDING; PROTEINS; RATS; RECEPTORS, AMPA; YOUNG ADULT;

EID: 84887328315     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3506-13.2013     Document Type: Article

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