Clinical relevance of voltage-gated potassium channel-complex antibodies in children

Neurology

Volumn 85, Issue 11, 2015, Pages 967-975

  Hacohen, Yael ^a   Singh, Rahul ^b   Rossi, Meghan ^a   Lang, Bethan ^a   Hemingway, Cheryl ^c   Lim, Ming ^a,b   Vincent, Angela ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c GREAT ORMOND STREET HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CONTACTIN ASSOCIATED PROTEIN 2 ANTIBODY; LEUCINE RICH GLIOMA INACTIVATED 1 PROTEIN ANTIBODY; N METHYL DEXTRO ASPARTIC ACID RECEPTOR ANTIBODY; PROTEIN ANTIBODY; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL COMPLEX ANTIBODY; ANTIBODY; AUTOANTIBODY; LGI1 PROTEIN, HUMAN; NERVE PROTEIN; POSTSYNAPTIC DENSITY PROTEINS; PROTEIN; VOLTAGE GATED POTASSIUM CHANNEL;

ADOLESCENT; ADULT; ARTICLE; BRAIN DISEASE; CHILD; CHOREA MINOR; CLINICAL ARTICLE; DEMYELINATING DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EATON LAMBERT SYNDROME; FEMALE; GUILLAIN BARRE SYNDROME; HEADACHE; HEMIPLEGIA; HUMAN; HUMAN CELL; INFANT; INFLAMMATION; INFLAMMATORY DISEASE; MALE; MEDICAL RECORD REVIEW; NEUROMUSCULAR DISEASE; OPSOCLONUS MYOCLONUS SYNDROME; PAIN; POSTSYNAPTIC DENSITY; PREDICTIVE VALUE; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD; SEIZURE; TIC; BLOOD; IMMUNOLOGY; LIMBIC ENCEPHALITIS; METABOLISM; NERVE CELL; NERVOUS SYSTEM DISEASES;

ADOLESCENT; ANTIBODIES; AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; LIMBIC ENCEPHALITIS; MALE; NERVE TISSUE PROTEINS; NERVOUS SYSTEM DISEASES; NEURONS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEINS; RETROSPECTIVE STUDIES;

EID: 84947249483     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0000000000001922     Document Type: Article

References (25)

1. Ogawa Y, Oses-Prieto J, Kim MY, et al. ADAM22, a Kv1 channel-interacting protein, recruits membrane-Associated guanylate kinases to juxtaparanodes of myelinated axons. J Neurosci 2010;30:1038-1048.
2. Lai M, Huijbers MG, Lancaster E, et al. Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol 2010;9:776-785.
3. Irani SR, Alexander S, Waters P, et al. Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-Associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. Brain 2010;133:2734-2748.
4. Lancaster E, Huijbers MG, Bar V, et al. Investigations of Caspr2, an autoantigen of encephalitis and neuromyotonia. Ann Neurol 2011;69:303-311.
5. Irani SR, Pettingill P, Kleopa KA, et al. Morvan syndrome: clinical and serological observations in 29 cases. Ann Neurol 2012;72:241-255.
6. Paterson RW, Zandi MS, Armstrong R, Vincent A, Schott JM. Clinical relevance of positive voltage-gated potassium channel (VGKC)-complex antibodies: experience from a tertiary referral centre. J Neurol Neurosurg Psychiatry 2014;85:625-630.
7. Armangue T, Petit-Pedrol M, Dalmau J. Autoimmune encephalitis in children. J Child Neurol 2012;27:1460-1469.
8. Hacohen Y, Wright S, Waters P, et al. Paediatric autoimmune encephalopathies: clinical features, laboratory investigations and outcomes in patients with or without antibodies to known central nervous system autoantigens. J Neurol Neurosurg Psychiatry 2013;84:748-755.
9. Suleiman J, Wright S, Gill D, et al. Autoantibodies to neuronal antigens in children with new-onset seizures classified according to the revised ILAE organization of seizures and epilepsies. Epilepsia 2013;54:2091-2100.
10. Hacohen Y, Absoud M, Woodhall M, et al. Autoantibody biomarkers in childhood-Acquired demyelinating syndromes: results from a national surveillance cohort. J Neurol Neurosurg Psychiatry 2014;85:456-461.
11. Vincent A, Buckley C, Schott JM, et al. Potassium channel antibody-Associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. Brain 2004;127:701-712.
12. Kleopa KA, Elman LB, Lang B, Vincent A, Scherer SS. Neuromyotonia and limbic encephalitis sera target mature Shaker-Dype K1 channels: subunit specificity correlates with clinical manifestations. Brain 2006;129:1570-1584.
13. Benarroch EE. ADAM proteins, their ligands, and clinical implications. Neurology 2012;78:914-920.
14. Irani SR, Bera K, Waters P, et al. N-methyl-D-Aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly nonparaneoplastic disorder of both sexes. Brain 2010;133: 1655-1667.
15. Rosch RE, Bamford A, Hacohen Y, et al. Guillain-Barré syndrome associated with CASPR2 antibodies: two paediatric cases. J Peripher Nerv Syst 2014;19:246-249.
16. Huda S, Wong SH, Pettingill P, O'Connell D, Vincent A, Steiger M. An 11-year retrospective experience of antibodies against the voltage-gated potassium channel (VGKC) complex from a tertiary neurological centre. J Neurol 2015;262:418-424.
17. Klein CJ, Lennon VA, Aston PA, et al. Insights from LGI1 and CASPR2 potassium channel complex autoantibody subtyping. JAMA Neurol 2013;70:229-234.
18. Dhamija R, Renaud DL, Pittock SJ, et al. Neuronal voltage-gated potassium channel complex autoimmunity in children. Pediatr Neurol 2011;44:275-281.
19. Dhaunchak AS, Becker C, Schulman H, et al. Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis. Ann Neurol 2012;71:601-613.
20. Meeusen JW, Klein CJ, Pirko I, et al. Potassium channel complex autoimmunity induced by inhaled brain tissue aerosol. Ann Neurol 2012;71:417-426.
21. Suleiman J, Brenner T, Gill D, et al. VGKC antibodies in pediatric encephalitis presenting with status epilepticus. Neurology 2011;76:1252-1255.
22. Illingworth MA, Hanrahan D, Anderson CE, et al. Elevated VGKC-complex antibodies in a boy with feverinduced refractory epileptic encephalopathy in school-Age children (FIRES). Dev Med Child Neurol 2011;53: 1053-1057.
23. Hacohen Y, Wright S, Siddiqui A, et al. A clinicoradiological phenotype of voltage-gated potassium channel complex antibody-mediated disorder presenting with seizures and basal ganglia changes. Dev Med Child Neurol 2012;54:1157-1159.
24. Lim M. Treating inflammation in childhood neurodegenerative disorders. Dev Med Child Neurol 2011;53: 298-304.
25. Haberlandt E, Bast T, Ebner A, et al. Limbic encephalitis in children and adolescents. Arch Dis Child 2011;96: 186-191.