The trifluoromethyl group as a conformational stabilizer and probe: Conformational analysis of cinchona alkaloid scaffolds

Journal of the American Chemical Society

Volumn 136, Issue 29, 2014, Pages 10418-10431

  Prakash, G K Surya ^a   Wang, Fang ^a   Rahm, Martin ^a   Zhang, Zhe ^a   Ni, Chuanfa ^a   Shen, Jingguo ^a   Olah, George A ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOIDS; NITROGEN COMPOUNDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SCAFFOLDS; SOLVATION; SOLVENTS;

ACCURATE PREDICTION; CINCHONA ALKALOID; CONFORMATIONAL ANALYSIS; CONFORMATIONAL BEHAVIOR; CONFORMATIONAL DISTRIBUTION; CONFORMATIONAL INTERCONVERSION; LINEAR FREE ENERGY RELATIONSHIPS; TRIFLUOROMETHYL GROUP;

METABOLITES;

CINCHONA ALKALOID; METHYL GROUP; QUINIDINE; SOLVENT;

ARTICLE; DRUG CONFORMATION; DRUG STABILITY; FLUORINE NUCLEAR MAGNETIC RESONANCE; MEASUREMENT ACCURACY; MOLECULAR MODEL; PREDICTION; PROTON NUCLEAR MAGNETIC RESONANCE; RELIABILITY; SOLVATION; SOLVENT EFFECT;

EID: 84961986766     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja504376u     Document Type: Article

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