Study of the bioactive conformation of novel 5-HT4 receptor ligands: Influence of an intramolecular hydrogen bond

Tetrahedron

Volumn 57, Issue 31, 2001, Pages 6745-6749

  López Rodríguez, María L ^a   Benhamú, Bellinda ^a   Viso, Alma ^a   Murcia, Marta ^a   Pardo, Leonardo ^b  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

5 HT4 receptor; Benzimidazoles; Hydrogen bonding; Tautomerism

Indexed keywords

(1 BUTYL 4 PIPERIDYL)METHYL 5 CHLORO 1 METHYLBENZIMIDAZOLE 7 CARBOXYLATE; AMIDE; BENZIMIDAZOLE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; LIGAND; N [(1 BUTYL 4 PIPERIDYL)METHYL]BENZIMIDAZOLE 5 CARBOXAMIDE; N [(1 ISOBUTYL 4 PIPERIDYL)METHYL] 1 BENZYL 6 CHLOROBENZIMIDAZOLE 4 CARBOXAMIDE; N [(1 ISOBUTYL 4 PIPERIDYL)METHYL] 6 CHLORO 1 METHYLBENZIMIDAZOLE 4 CARBOXAMIDE; SEROTONIN 4 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING SITE; DRUG ACTIVITY; DRUG CONFORMATION; DRUG STRUCTURE; HYDROGEN BOND; LIGAND BINDING; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TECHNIQUE;

EID: 84961974889     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(01)00621-4     Document Type: Article

References (20)