Abscopal benefits of localized radiotherapy depend on activated T-cell trafficking and distribution between metastatic lesions

Cancer Research

Volumn 76, Issue 5, 2016, Pages 1009-1018

  Poleszczuk, Jan T ^a   Luddy, Kimberly A ^a   Prokopiou, Sotiris ^a   Robertson Tessi, Mark ^a   Moros, Eduardo G ^a   Fishman, Mayer ^a   Djeu, Julie Y ^a   Finkelstein, Steven E ^b   Enderling, Heiko ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b 21ST CENTURY ONCOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER RADIOTHERAPY; CELL MIGRATION; CONTROLLED STUDY; IMMUNOGENICITY; IMMUNOSURVEILLANCE; MATHEMATICAL MODEL; METASTASIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIATION RESPONSE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TUMOR SEEDING; CELL MOTION; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; NEOPLASMS; PATHOLOGY; PHYSIOLOGY;

CELL MOVEMENT; HUMANS; LYMPHOCYTE ACTIVATION; NEOPLASM METASTASIS; NEOPLASMS; T-LYMPHOCYTES;

EID: 84961842064     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-1423     Document Type: Article

References (50)

1. Kuznetsov VA, Knott GD. Modeling tumor regrowth and immunotherapy. Math Comput Model 2001;33:1275-87.
2. Mikhak Z, Strassner JP, Luster AD. Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4. J Exp Med 2013;210:1855-69.
3. Calzascia T, Masson F, Di Berardino-Besson W, Contassot E, Wilmotte R, Aurrand-Lions M, et al. Homing phenotypes of tumor-specific CD8 T cells are predetermined at the tumor site by crosspresenting APCs. Immunity 2005;22:175-84.
4. Zitvogel L, Apetoh L, Ghiringhelli F, Kroemer G. Immunological aspects of cancer chemotherapy. Nat Rev Immunol 2008;8:59-73.
5. Couzin-Frankel J. Breakthrough of the year 2013. Cancer immunotherapy. Science 2013;342:1432-3.
6. Reits EA, Hodge JW, Herberts CA, Groothuis TA, Chakraborty M, Wansley EK, et al. Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med 2006;203:1259-71.
7. Lugade AA, Moran JP, Gerber SA, Rose RC, Frelinger JG, Lord EM. Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor. J Immunol 2005;174:7516-23.
8. Finkelstein SE, Fishman M. Clinical opportunities in combining immunotherapy with radiation therapy. Front Oncol 2012;2:169.
9. Finkelstein SE, Iclozan C, Bui MM, Cotter MJ, Ramakrishnan R, Ahmed J, et al. Combination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue sarcoma patients. Int J Radiat Oncol Biol Phys 2012;82:924-32.
10. Finkelstein SE, Rodriguez F, Dunn M, Farmello MJ, Smilee R, Janssen W, et al. Serial assessment of lymphocytes and apoptosis in the prostate during coordinated intraprostatic dendritic cell injection and radiotherapy. Immunotherapy 2012;4:373-82.
11. Finkelstein SE, Timmerman R, McBride WH, Schaue D, Hoffe SE, Mantz CA, et al. The confluence of stereotactic ablative radiotherapy and tumor immunology. Clin Dev Immunol 2011;2011:439752.
12. Vatner RE, Cooper BT, Vanpouille-Box C, Demaria S, Formenti SC. Combinations of immunotherapy and radiation in cancer therapy. Front Oncol 2014;4:325.
13. Demaria S, Ng B, Devitt ML, Babb JS, Kawashima N, Liebes L, etal. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys 2004;58:862-70.
14. Wersall PJ, Blomgren H, Pisa P, Lax I, Kalkner KM, Svedman C. Regression of non-irradiated metastases after extracranial stereotactic radiotherapy in metastatic renal cell carcinoma. Acta Oncol 2006;45:493-7.
15. Ehlers G, Fridman M. Abscopal effect of radiation in papillary adenocarcinoma. Br J Radiol 1973;46:220-2.
16. Kaminski JM, Shinohara E, Summers JB, Niermann KJ, Morimoto A, Brousal J. The controversial abscopal effect. Cancer Treat Rev 2005;31:159-72.
17. Akutsu Y, Matsubara H, Urashima T, Komatsu A, Sakata H, Nishimori T, et al. Combination of direct intratumoral administration of dendritic cells and irradiation induces strong systemic antitumor effect mediated by GRP94/gp96 against squamous cell carcinoma in mice. Int J Oncol 2007;31:509-15.
18. Kuznetsov VA, Makalkin IA, Taylor MA, Perelson AS. Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis. Bull Math Biol 1994;56:295-321.
19. Wilkie KP. A review of mathematical models of cancer-immune interactions in the context of tumor dormancy. Adv Exp Med Biol 2013;734:201-34.
20. d'Onofrio A, Ciancio A. Simple biophysical model of tumor evasion from immune system control. Phys Rev E Stat Nonlin Soft Matter Phys 2011;84:031910.
21. Arciero JC, Jackson TL, Kirchner DE. A mathematical model of tumorimmune evasion ans siRNA treatment. Discret Contin Dyn S 2004;4:39-58.
22. Kirchner D, Panetta JC. Modeling immunotherapy of the tumor-immune interaction. J Math Biol 1998;37:235-52.
23. Kronik N, Kogan Y, Elishmereni M, Halevi-Tobias K, Vuk-Pavlovic S, Agur Z. Predicting outcomes of prostate cancer immunotherapybypersonalized mathematical models. PLoS One 2010;5:e15482.
24. Kronik N, Kogan Y, Vainstein V, Agur Z. Improving alloreactive CTL immunotherapy for malignant gliomas using a simulation model of their interactive dynamics. Cancer Immunol Immunother 2008;57:425-39.
25. Cappuccio A, Elishmereni M, Agur Z. Cancer immunotherapy by interleukin-21: potential treatment strategies evaluated in a mathematical model. Cancer Res 2006;66:7293-300.
26. Dunn GP, Old LJ, Schreiber RD. The three Es of cancer immunoediting. Annu Rev Immunol 2004;22:329-60.
27. Lange PH, Hekmat K, Bosl G, Kennedy BJ, Fraley EE. Accelerated growth of testicular cancer after cytoreductive surgery. Cancer 1980;45:1498-506.
28. De Giorgi V, Massi D, Gerlini G, Mannone F, Quercioli E, Carli P. Immediate local and regional recurrence after the excision of a polypoid melanoma: tumor dormancy or tumoractivation? Dermatol Surg 2003;29:664-7.
29. Deylgat B, Van Rooy F, Vansteenkiste F, Devriendt D, George C. Postsurgery activation of dormant liver micrometastasis: a case report and review of literature. J Gastrointest Cancer 2011;42:1-4.
30. Okada K, Makihara K, Okada M, Hayashi EI, Fukino S, Fukata T, et al. A case of primary squamous cell carcinoma of the breast with rapid progression. Breast Cancer 2000;7:160-4.
31. Valentin J. Basic anatomical and physiological data for use in radiological protection: reference values: ICRP Publication 89. Ann ICRP 2002;32:5-265.
32. Hausmann H, Photiadis J, Hetzer R. Blood flow in the internal mammary artery after the administration of papaverine during coronary artery bypass grafting. Tex Heart Inst J 1996;23:279-83.
33. Vorherr H. The breast: morphology, physiology, and lactation. New York, NY: Academic Press; 1974.
34. Abduljalil K, Furness P, Johnson TN, Rostami-Hodjegan A, Soltani H. Anatomical, physiological and metabolic changes with gestational age during normal pregnancy: a database for parameters required in physiologically based pharmacokinetic modelling. Clin Pharmacokinet 2012;51:365-96.
35. Puskas Z, Schuierer G. [Determination of blood circulation time for optimizing contrast medium administration in CT angiography]. Radiologe 1996;36:750-7.
36. McGuire A, Brown JA, Kerin MJ. Metastatic breast cancer: the potential of miRNA for diagnosis and treatment monitoring. Cancer Metastasis Rev 2015;34:145-55.
37. Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, et al. SEER Cancer Statistics Review, 1975-2012, National Cancer Institute. Bethesda, MD. Available from: http://seer.cancer.gov/csr/1975-2012/.
38. O'Brien MA, Power DG, Clover AJ, Bird B, Soden DM, Forde PF. Local tumour ablative therapies: opportunities for maximising immune engagement and activation. Biochim Biophys Acta 2014;1846:510-23.
39. Simone CB, Jones JA. Multidisciplinary approaches to palliative oncology care. Ann Palliat Med 2014;3:126-28.
40. Norton L. Conceptual and practical implications of breast tissue geometry: toward a more effective, less toxic therapy. Oncologist 2005;10:370-81.
41. Demicheli R, Retsky MW, Hrushesky WJ, Baum M, Gukas ID. The effects of surgery on tumor growth: a century of investigations. Ann Oncol 2008;19:1821-8.
42. Qadri SSA, Wang J-H, Coffey JC, Alam M, O'Donnell A, Aherne T, et al. Can surgery for cancer accelerate the progression of secondary tumors within residual minimal disease at both local and systemic levels? Ann Thorac Surg 2005;80:1046-51.
43. Shafirstein G, Kaufmann Y, Hennings L, Siegel E, Griffin RJ, Novak P, et al. Conductive interstitial thermal therapy (CITT) inhibits recurrence and metastasis in rabbit VX2 carcinoma model. Int J Hyperthermia 2009;25:446-54.
44. Kim Y, Boushaba K. Regulation of tumor dormancy and role of microenvironment: a mathematical model. Adv Exp Med Biol 2013;734:237-59.
45. Hanin L. Seeing the invisible: how mathematical models uncover tumor dormancy, reconstruct the natural history of cancer, and assess the effects of treatment. Adv Exp Med Biol 2013;734:261-82.
46. Siegel R, De Santis C, Virgo K, Stein K, Mariotto A, Smith T, et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin 2012;62:220-41.
47. Scott J, Kuhn P, Anderson AR. Unifying metastasis-integrating intravasation, circulation and end-organ colonization. Nat Rev Cancer 2012;12:445-6.
48. Henderson JM, Heymsfield SB, Horowitz J, Kutner MH. Measurement of liver and spleen volume by computed tomography. Assessment of reproducibility and changes found followinga selective distal splenorenal shunt. Radiology 1981;141:525-7.
49. Puybasset L, Cluzel P, Chao N, Slutsky AS, Coriat P, Rouby JJ. A computed tomography scan assessment of regional lung volume in acute lung injury. The CT Scan ARDS Study Group. Am J Respir Crit Care Med 1998;158:1644-55.
50. Poggio ED, Hila S, Stephany B, Fatica R, Krishnamurthi V, del Bosque C, et al. Donor kidney volume and outcomes following live donor kidney transplantation. Am J Transplant 2006;6:616-24.